The C/ebp-Atf response element (CARE) location reveals two distinct Atf4-dependent, elongation-mediated mechanisms for transcriptional induction of aminoacyl-tRNA synthetase genes in response to amino acid limitation

RNA polymerase II pausing as a context-dependent reader of the genome

(2016) Adam Scheidegger et al.   Biochemistry and Cell Biology

Enhancers as non-coding RNA transcription units: recent insights and future perspectives

(2016) Wenbo Li et al.   NATURE REVIEWS GENETICS

Getting up to speed with transcription elongation by RNA polymerase II

(2015) Iris Jonkers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA polymerase II pausing can be retained or acquired during activation of genes involved in the epithelial to mesenchymal transition

(2015) Ann Samarakkody et al.   NUCLEIC ACIDS RESEARCH

Ready, pause, go: regulation of RNA polymerase II pausing and release by cellular signaling pathways

(2015) Xiuli Liu et al.   TRENDS IN BIOCHEMICAL SCIENCES

A unified architecture of transcriptional regulatory elements

(2015) Robin Andersson et al.   TRENDS IN GENETICS

Comprehensive Profiling of Amino Acid Response Uncovers Unique Methionine-Deprived Response Dependent on Intact Creatine Biosynthesis

(2015) Xiaohu Tang et al.   PLoS Genetics

The Integrated Stress Response in Lung Disease

(2014) Emily F. A. van 't Wout et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Translational Control during Endoplasmic Reticulum Stress beyond Phosphorylation of the Translation Initiation Factor eIF2α

(2014) Bo-Jhih Guan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhancer Function: Mechanistic and Genome-Wide Insights Come Together

(2014) Jennifer L. Plank et al.   MOLECULAR CELL

Enhancer RNA Facilitates NELF Release from Immediate Early Genes

(2014) Katie Schaukowitch et al.   MOLECULAR CELL

eRNAs Lure NELF from Paused Polymerases

(2014) Brian S. Plosky   MOLECULAR CELL

Enhancer RNAs participate in androgen receptor-driven looping that selectively enhances gene activation

(2014) C.-L. Hsieh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human tRNA synthetase catalytic nulls with diverse functions

(2014) W.-S. Lo et al.   SCIENCE

tRNA synthetase: tRNA aminoacylation and beyond

(2014) Yan Ling Joy Pang et al.   Wiley Interdisciplinary Reviews-RNA

Asparagine synthetase: regulation by cell stress and involvement in tumor biology

(2013) Mukundh N. Balasubramanian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Control of Transcriptional Elongation

(2013) Hojoong Kwak et al.   Annual Review of Genetics

Transcriptional Control by NF-κB: Elongation in Focus

(2013) Gil Diamant et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Brd4 and JMJD6-Associated Anti-Pause Enhancers in Regulation of Transcriptional Pause Release

(2013) Wen Liu et al.   CELL

Aminoacyl-tRNA synthetases in medicine and disease

(2013) Peng Yao et al.   EMBO Molecular Medicine

A Self-defeating Anabolic Program Leads to β-Cell Apoptosis in Endoplasmic Reticulum Stress-induced Diabetes via Regulation of Amino Acid Flux

(2013) Dawid Krokowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling Pathways Differentially Affect RNA Polymerase II Initiation, Pausing, and Elongation Rate in Cells

(2013) Charles G. Danko et al.   MOLECULAR CELL

Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation

(2013) Wenbo Li et al.   NATURE

Activating RNAs associate with Mediator to enhance chromatin architecture and transcription

(2013) Fan Lai et al.   NATURE

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Essential nontranslational functions of tRNA synthetases

(2013) Min Guo et al.   Nature Chemical Biology

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

(2012) Karen Adelman et al.   NATURE REVIEWS GENETICS

Eukaryotic Initiation Factor 2 Phosphorylation and Translational Control in Metabolism

(2012) Thomas D. Baird et al.   Advances in Nutrition

The Transcription Factor Network Associated With the Amino Acid Response in Mammalian Cells

(2012) Michael S. Kilberg et al.   Advances in Nutrition

Molecular mechanisms involved in the adaptation to amino acid limitation in mammals

(2010) Cédric Chaveroux et al.   BIOCHIMIE

c-Myc Regulates Transcriptional Pause Release

(2010) Peter B. Rahl et al.   CELL

Expression profiling after activation of amino acid deprivation response in HepG2 human hepatoma cells

(2010) Jixiu Shan et al.   PHYSIOLOGICAL GENOMICS

The roles of ASK family proteins in stress responses and diseases

(2009) Kazuki Hattori et al.   Cell Communication and Signaling

The transcription elongation factors NELF, DSIF and P-TEFb control constitutive transcription in a gene-specific manner

(2009) Toshitsugu Fujita et al.   FEBS LETTERS

Elevated ATF4 Expression, in the Absence of Other Signals, Is Sufficient for Transcriptional Induction via CCAAT Enhancer-binding Protein-activating Transcription Factor Response Elements

(2009) Jixiu Shan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATF4-dependent transcription mediates signaling of amino acid limitation

(2009) Michael S. Kilberg et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Deprivation of protein or amino acid induces C/EBPβ synthesis and binding to amino acid response elements, but its action is not an absolute requirement for enhanced transcription

(2008) Michelle M. Thiaville et al.   BIOCHEMICAL JOURNAL

Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways

(2008) Christiane Deval et al.   FEBS Journal

C/EBP Homology Protein (CHOP) Interacts with Activating Transcription Factor 4 (ATF4) and Negatively Regulates the Stress-dependent Induction of the Asparagine Synthetase Gene

(2008) Nan Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progesterone Induction of the 11 -Hydroxysteroid Dehydrogenase Type 2 Promoter in Breast Cancer Cells Involves Coordinated Recruitment of STAT5A and Progesterone Receptor to a Distal Enhancer and Polymerase Tracking

(2008) A. Subtil-Rodriguez et al.   MOLECULAR AND CELLULAR BIOLOGY

HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway

(2008) Jeong-In Lee et al.   PHYSIOLOGICAL GENOMICS