FGF19/FGFR4 signaling axis confines and switches the role of melatonin in head and neck cancer metastasis

Circumventing AKT-Associated Radioresistance in Oral Cancer by Novel Nanoparticle-Encapsulated Capivasertib

(2020) Liwei Lang et al.   Cells

Very low intensity ultrasounds as a new strategy to improve selective delivery of nanoparticles-complexes in cancer cells

(2019) Rossella Loria et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Fibroblast Growth Factor Receptor 4 Targeting in Cancer: New Insights into Mechanisms and Therapeutic Strategies

(2019) Liwei Lang et al.   Cells

Melatonin Enhances Cisplatin and Radiation Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Stimulating Mitochondrial ROS Generation, Apoptosis, and Autophagy

(2019) Beatriz I. Fernandez-Gil et al.   Oxidative Medicine and Cellular Longevity

Nck-associated protein 1 associates with HSP90 to drive metastasis in human non-small-cell lung cancer

(2019) Yuanping Xiong et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

First-in-Human Phase I Study of Fisogatinib (BLU-554) Validates Aberrant Fibroblast Growth Factor 19 Signaling as a Driver Event in Hepatocellular Carcinoma

(2019) Richard D Kim et al.   Cancer Discovery

Serum fibroblast growth factor 19 serves as a potential novel biomarker for hepatocellular carcinoma

(2019) Takahiro Maeda et al.   BMC CANCER

Potential of Melatonin as Adjuvant Therapy of Oral Cancer in the Era of Epigenomics

(2019) Capote-Moreno et al.   Cancers

Simultaneously inactivating Src and AKT by saracatinib/capivasertib co-delivery nanoparticles to improve the efficacy of anti-Src therapy in head and neck squamous cell carcinoma

(2019) Liwei Lang et al.   Journal of Hematology & Oncology

Combating head and neck cancer metastases by targeting Src using multifunctional nanoparticle-based saracatinib

(2018) Liwei Lang et al.   Journal of Hematology & Oncology

Autophagy blockade sensitizes human head and neck squamous cell carcinoma towards CYT997 through enhancing excessively high reactive oxygen species-induced apoptosis

(2018) Lixia Gao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation

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Melatonin and Cancer Hallmarks

(2018) Wamidh Talib   MOLECULES

Melatonin and cancer: From the promotion of genomic stability to use in cancer treatment

(2018) Bagher Farhood et al.   JOURNAL OF CELLULAR PHYSIOLOGY

FGFR4 provides the conduit to facilitate FGF19 signaling in breast cancer progression

(2018) Xiangdong Zhao et al.   MOLECULAR CARCINOGENESIS

Molecular Classification of Lymph Node Metastases Subtypes Predict for Survival in Head and Neck Cancer

(2018) Lei Huang et al.   CLINICAL CANCER RESEARCH

Making way for suppressing the FGF19/FGFR4 axis in cancer

(2018) Nestor Prieto-Dominguez et al.   Future Medicinal Chemistry

Therapeutic potential of melatonin related to its role as an autophagy regulator: A review

(2018) Jose A. Boga et al.   JOURNAL OF PINEAL RESEARCH

FGF19 amplification reveals an oncogenic dependency upon autocrine FGF19/FGFR4 signaling in head and neck squamous cell carcinoma

(2018) Lixia Gao et al.   ONCOGENE

Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine

(2017) Makoto Isono et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Augmentation of the anticancer activity of CYT997 in human prostate cancer by inhibiting Src activity

(2017) Yong Teng et al.   Journal of Hematology & Oncology

Zbtb38 is a novel target for spinal cord injury

(2017) Yafei Cai et al.   Oncotarget

Melatonin for the prevention and treatment of cancer

(2017) Ya Li et al.   Oncotarget

The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress

(2016) W. Rozpedek et al.   CURRENT MOLECULAR MEDICINE

Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy

(2016) Néstor Prieto-Domínguez et al.   JOURNAL OF PINEAL RESEARCH

Cancer metastasis: Mechanisms of inhibition by melatonin

(2016) Shih-Chi Su et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

(2015) Anna Fernández et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

(2015) Lucien C. Manchester et al.   JOURNAL OF PINEAL RESEARCH

Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23

(2015) Chiara Degirolamo et al.   NATURE REVIEWS DRUG DISCOVERY

Melatonin: Physiological effects in humans

(2015) B. Claustrat et al.   NEUROCHIRURGIE

FGF19 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells by modulating the GSK3β/β- catenin signaling cascade via FGFR4 activation

(2015) Huakan Zhao et al.   Oncotarget

Bile acid diarrhoea and FGF19: new views on diagnosis, pathogenesis and therapy

(2014) Julian R. F. Walters   Nature Reviews Gastroenterology & Hepatology

Genome engineering using the CRISPR-Cas9 system

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A review of the molecular aspects of melatonin’s anti-inflammatory actions: recent insights and new perspectives

(2012) José L. Mauriz et al.   JOURNAL OF PINEAL RESEARCH

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening

(2011) Eric T. Sawey et al.   CANCER CELL

Assembly and Initial Characterization of a Panel of 85 Genomically Validated Cell Lines from Diverse Head and Neck Tumor Sites

(2011) M. Zhao et al.   CLINICAL CANCER RESEARCH

ER Stress and Its Functional Link to Mitochondria: Role in Cell Survival and Death

(2011) J. D. Malhotra et al.   Cold Spring Harbor Perspectives in Biology

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7α-hydroxylase gene expression

(2008) Kwang-Hoon Song et al.   HEPATOLOGY