Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPβ

Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation

(2019) GuoXiao Wang et al.   MOLECULAR CELL

Skeletal Muscle Atrophy: Discovery of Mechanisms and Potential Therapies

(2019) Scott M. Ebert et al.   PHYSIOLOGY

Simultaneous Quantification of the Acetylome and Succinylome by ‘One-Pot’ Affinity Enrichment

(2018) Nathan Basisty et al.   PROTEOMICS

The CDK inhibitor p21 is a novel target gene of ATF4 and contributes to cell survival under ER stress

(2017) Yasumichi Inoue et al.   FEBS LETTERS

Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival

(2017) Marco Segatto et al.   Nature Communications

Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry

(2017) Ben C. Collins et al.   Nature Communications

Combinatorial bZIP dimers display complex DNA-binding specificity landscapes

(2017) José A Rodríguez-Martínez et al.   eLife

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4

(2016) Steven A. Bullard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy

(2015) Scott M. Ebert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Dual Kinase Function of the RET Proto-oncogene Negatively Regulates Activating Transcription Factor 4-mediated Apoptosis

(2015) Rozita Bagheri-Yarmand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deep Proteomics of Mouse Skeletal Muscle Enables Quantitation of Protein Isoforms, Metabolic Pathways, and Transcription Factors

(2015) Atul S. Deshmukh et al.   MOLECULAR & CELLULAR PROTEOMICS

C/EBPγ Is a Critical Regulator of Cellular Stress Response Networks through Heterodimerization with ATF4

(2015) Christopher J. Huggins et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein acetylation dynamics in response to carbon overflow inEscherichia coli

(2015) Birgit Schilling et al.   MOLECULAR MICROBIOLOGY

ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis

(2015) Daniel M Cohen et al.   eLife

Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia

(2015) Sarah M Judge et al.   BMC CANCER

p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization

(2014) Daniel K. Fox et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition

(2014) Junwei Shi et al.   MOLECULAR CELL

Structural, Kinetic and Proteomic Characterization of Acetyl Phosphate-Dependent Bacterial Protein Acetylation

(2014) Misty L. Kuhn et al.   PLoS One

Skeletal muscle denervation causes skeletal muscle atrophy through a pathway that involves both Gadd45a and HDAC4

(2013) Kale S. Bongers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Networks of bZIP Protein-Protein Interactions Diversified Over a Billion Years of Evolution

(2013) A. W. Reinke et al.   SCIENCE

Functional interaction of protein kinase CK2 and activating transcription factor 4 (ATF4), a key player in the cellular stress response

(2012) Emmanuel Ampofo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Stress-induced Skeletal Muscle Gadd45a Expression Reprograms Myonuclei and Causes Muscle Atrophy

(2012) Scott M. Ebert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis

(2012) Ludovic C. Gillet et al.   MOLECULAR & CELLULAR PROTEOMICS

Genomic and Proteomic Profiling Reveals Reduced Mitochondrial Function and Disruption of the Neuromuscular Junction Driving Rat Sarcopenia

(2012) C. Ibebunjo et al.   MOLECULAR AND CELLULAR BIOLOGY

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting

(2012) M. C. Humbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eukaryotic Initiation Factor 2 Phosphorylation and Translational Control in Metabolism

(2012) Thomas D. Baird et al.   Advances in Nutrition

Altered REDD1, myostatin, and Akt/mTOR/FoxO/MAPK signaling in streptozotocin-induced diabetic muscle atrophy

(2011) Juha J. Hulmi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Muscle wasting and the temporal gene expression pattern in a novel rat intensive care unit model

(2011) Monica Llano-Diez et al.   BMC GENOMICS

The CCAAT/enhancer (C/EBP) family of basic-leucine zipper (bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation

(2011) Junichi Tsukada et al.   CYTOKINE

C/EBPβ mediates tumour-induced ubiquitin ligase atrogin1/MAFbx upregulation and muscle wasting

(2011) Guohua Zhang et al.   EMBO JOURNAL

ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes

(2010) Arnaud R Krebs et al.   EMBO REPORTS

Solution Structure of Human Growth Arrest and DNA Damage 45α (Gadd45α) and Its Interactions with Proliferating Cell Nuclear Antigen (PCNA) and Aurora A Kinase

(2010) Ricardo Sánchez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transcription Factor ATF4 Promotes Skeletal Myofiber Atrophy during Fasting

(2010) Scott M. Ebert et al.   MOLECULAR ENDOCRINOLOGY

Smad2 and 3 transcription factors control muscle mass in adulthood

(2009) Roberta Sartori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes

(2009) Michele Bastiani et al.   JOURNAL OF CELL BIOLOGY

Gene expression and muscle fiber function in a porcine ICU model

(2009) Varuna C. Banduseela et al.   PHYSIOLOGICAL GENOMICS

ATF4-dependent transcription mediates signaling of amino acid limitation

(2009) Michael S. Kilberg et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

CCAAT/Enhancer-binding Protein β Promotes Osteoblast Differentiation by Enhancing Runx2 Activity with ATF4

(2008) Hiroyuki Tominaga et al.   MOLECULAR BIOLOGY OF THE CELL

Gene profiling of skeletal muscle in an amyotrophic lateral sclerosis mouse model

(2007) Jose-Luis Gonzalez de Aguilar et al.   PHYSIOLOGICAL GENOMICS