The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1)

Structure of Gcn1 bound to stalled and colliding 80S ribosomes

(2021) Agnieszka A. Pochopien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GCN2 adapts protein synthesis to scavenging-dependent growth

(2021) Michel Nofal et al.   Cell Systems

Global analysis of LARP1 translation targets reveals tunable and dynamic features of 5′ TOP motifs

(2020) Lucas Philippe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate

(2020) Colin Chih-Chien Wu et al.   CELL

Ribosome collisions trigger cis-acting feedback inhibition of translation initiation

(2020) Szymon Juszkiewicz et al.   eLife

EDF1 coordinates cellular responses to ribosome collisions

(2020) Niladri K Sinha et al.   eLife

Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility

(2020) Mridu Kapur et al.   NEURON

Ribosome quality control antagonizes the activation of the integrated stress response on colliding ribosomes

(2020) Liewei L. Yan et al.   MOLECULAR CELL

mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1

(2020) Jian-Jun Jia et al.   NUCLEIC ACIDS RESEARCH

Single-Molecule Imaging of mRNA Localization and Regulation during the Integrated Stress Response

(2019) Johannes H. Wilbertz et al.   MOLECULAR CELL

Activation of GCN2 by the ribosomal P-stalk

(2019) Alison J. Inglis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

(2019) Heather P Harding et al.   eLife

Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver

(2018) Inna A. Nikonorova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies

(2018) Ji-Young Youn et al.   MOLECULAR CELL

Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells

(2018) Alicia M. Darnell et al.   MOLECULAR CELL

LARP1 on TOP of ribosome production

(2018) Bruno D. Fonseca et al.   Wiley Interdisciplinary Reviews-RNA

Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins

(2018) Ben B. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autogenous Control of 5′TOP mRNA Stability by 40S Ribosomes

(2017) Antonio Gentilella et al.   MOLECULAR CELL

ProHits-viz: a suite of web tools for visualizing interaction proteomics data

(2017) James D R Knight et al.   NATURE METHODS

LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

(2017) Sungki Hong et al.   eLife

La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs

(2017) Roni M Lahr et al.   eLife

Translational control by 5'-untranslated regions of eukaryotic mRNAs

(2016) A. G. Hinnebusch et al.   SCIENCE

Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation

(2016) Ryuta Ishimura et al.   eLife

The race to decipher the top secrets of TOP mRNAs

(2015) Oded Meyuhas et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2

(2015) Jiangbin Ye et al.   GENES & DEVELOPMENT

Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element

(2015) Rebecca R. Crawford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)

(2015) Bruno D. Fonseca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C/EBPγ Is a Critical Regulator of Cellular Stress Response Networks through Heterodimerization with ATF4

(2015) Christopher J. Huggins et al.   MOLECULAR AND CELLULAR BIOLOGY

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5′TOP sequence

(2015) Roni M. Lahr et al.   NUCLEIC ACIDS RESEARCH

Keeping the eIF2 alpha kinase Gcn2 in check

(2014) Beatriz A. Castilho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

genomation: a toolkit to summarize, annotate and visualize genomic intervals

(2014) A. Akalin et al.   BIOINFORMATICS

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner

(2014) Rachel Miloslavski et al.   Journal of Molecular Cell Biology

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale

(2014) Valentina Gandin et al.   Jove-Journal of Visualized Experiments

LARP1 specifically recognizes the 3′ terminus of poly(A) mRNA

(2013) Kazuma Aoki et al.   FEBS LETTERS

CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

(2013) Brian F. Teske et al.   MOLECULAR BIOLOGY OF THE CELL

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

(2013) Dattatreya Mellacheruvu et al.   NATURE METHODS

Software for Computing and Annotating Genomic Ranges

(2013) Michael Lawrence et al.   PLoS Computational Biology

ATF4-dependent Regulation of the JMJD3 Gene during Amino Acid Deprivation Can Be Rescued in Atf4-deficient Cells by Inhibition of Deacetylation

(2012) Jixiu Shan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR

(2011) C. K. Damgaard et al.   GENES & DEVELOPMENT

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

Molecular mechanisms involved in the adaptation to amino acid limitation in mammals

(2010) Cédric Chaveroux et al.   BIOCHIMIE

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

SAINT: probabilistic scoring of affinity purification–mass spectrometry data

(2010) Hyungwon Choi et al.   NATURE METHODS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

ATF4-Mediated Induction of 4E-BP1 Contributes to Pancreatic β Cell Survival under Endoplasmic Reticulum Stress

(2008) Suguru Yamaguchi et al.   Cell Metabolism

Comprehensive detection of human terminal oligo-pyrimidine (TOP) genes and analysis of their characteristics

(2008) Riu Yamashita et al.   NUCLEIC ACIDS RESEARCH

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY