The role of hypothalamic endoplasmic reticulum stress in schizophrenia and antipsychotic-induced weight gain: A narrative review

Weight gain and comorbidities associated with oral second-generation antipsychotics: analysis of real-world data for patients with schizophrenia or bipolar I disorder

(2022) Michael J. Doane et al.   BMC Psychiatry

Gold nanoclusters eliminate obesity induced by antipsychotics

(2022) Meng He et al.   Scientific Reports

NLRP3/Caspase-1-Mediated Pyroptosis of Astrocytes Induced by Antipsychotics Is Inhibited by a Histamine H1 Receptor-Selective Agonist

(2022) Meng He et al.   Frontiers in Aging Neuroscience

Attenuation of Olanzapine-Induced Endoplasmic Reticulum Stress Improves Insulin Secretion in Pancreatic Beta Cells

(2022) Diana Grajales et al.   Metabolites

Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain

(2021) Meng He et al.   Frontiers in Neuroscience

Effects of Haloperidol, Risperidone, and Aripiprazole on the Immunometabolic Properties of BV-2 Microglial Cells

(2021) Valentino Racki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The atypical antipsychotic risperidone targets hypothalamic melanocortin 4 receptors to cause weight gain

(2021) Li Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Novel Tools and Investigative Approaches for the Study of Oligodendrocyte Precursor Cells (NG2-Glia) in CNS Development and Disease

(2021) Christophe Galichet et al.   Frontiers in Cellular Neuroscience

A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome

(2021) Mark J. Henderson et al.   Cell Reports

Effects of Atypical Antipsychotics, Clozapine, Quetiapine and Brexpiprazole on Astroglial Transmission Associated with Connexin43

(2021) Kouji Fukuyama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interleukin-6 actions in the hypothalamus protects against obesity and is involved in the regulation of neurogenesis

(2021) Vanessa C. Bobbo et al.   Journal of Neuroinflammation

Roles of XBP1s in Transcriptional Regulation of Target Genes

(2021) Sung-Min Park et al.   Biomedicines

Mechanistic insight into high-fat diet-induced metabolic inflammation in the arcuate nucleus of the hypothalamus

(2021) Rahim Ullah et al.   BIOMEDICINE & PHARMACOTHERAPY

AgRP/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity

(2021) Muhammad Sufyan Vohra et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cevimeline co-treatment attenuates olanzapine-induced metabolic disorders via modulating hepatic M3 muscarinic receptor: AMPKα signalling pathway in female rats

(2021) Mei Han et al.   JOURNAL OF PSYCHOPHARMACOLOGY

TLR4 deletion increases basal energy expenditure and attenuates heart apoptosis and ER stress but mitigates the training-induced cardiac function and performance improvement

(2021) Larissa G. de Vicente et al.   LIFE SCIENCES

Salvianolic acid A relieves cognitive disorder after chronic cerebral ischemia: Involvement of Drd2/Cryab/NF-κB pathway

(2021) Yujiao Yang et al.   PHARMACOLOGICAL RESEARCH

Clozapine Induces an Acute Proinflammatory Response That Is Attenuated by Inhibition of Inflammasome Signaling: Implications for Idiosyncratic Drug-Induced Agranulocytosis

(2021) Samantha Christine Sernoskie et al.   TOXICOLOGICAL SCIENCES

ER stress in obesity pathogenesis and management

(2021) Amir Ajoolabady et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Astrocytic lipid metabolism determines susceptibility to diet-induced obesity

(2021) Luis Varela et al.   Science Advances

Crosstalk Between ER Stress, Autophagy and Inflammation

(2021) Sandhya Chipurupalli et al.   Frontiers in Medicine

Metformin attenuates hypothalamic inflammation via downregulation of RIPK1-independent microglial necroptosis in diet-induced obese mice

(2021) Xuan Li et al.   Cell Death Discovery

Update on weight-gain caused by antipsychotics: a systematic review and meta-analysis

(2020) Barbara B Barton et al.   Expert Opinion On Drug Safety

Olanzapine increases AMPK-NPY orexigenic signaling by disrupting H1R-GHSR1a interaction in the hypothalamic neurons of mice

(2020) Xiaoqi Chen et al.   PSYCHONEUROENDOCRINOLOGY

Clozapine Prevents Poly (I:C) Induced Inflammation by Modulating NLRP3 Pathway in Microglial Cells

(2020) Vijayasree V. Giridharan et al.   Cells

The hypothalamus as a primary coordinator of memory updating

(2020) Denis Burdakov et al.   PHYSIOLOGY & BEHAVIOR

The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates

(2020) Soyoung Park et al.   Nature Communications

Dietary fat exacerbates postprandial hypothalamic inflammation involving glial fibrillary acidic protein-positive cells and microglia in male mice

(2020) Céline Cansell et al.   GLIA

Function of astrocyte MyD88 in high-fat-diet-induced hypothalamic inflammation

(2020) Sungho Jin et al.   Journal of Neuroinflammation

Aripiprazole cytotoxicity coincides with activation of the unfolded protein response in human hepatic cells

(2020) Francesca Forno et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Hypothalamic glial cells isolated by MACS reveal that microglia and astrocytes induce hypothalamic inflammation via different processes under high-fat diet conditions

(2020) Mariko Sugiyama et al.   NEUROCHEMISTRY INTERNATIONAL

Insulin sensing by astrocytes is critical for normal thermogenesis and body temperature regulation

(2020) Iyad H Manaserh et al.   JOURNAL OF ENDOCRINOLOGY

Endoplasmic reticulum stress-related neuroinflammation and neural stem cells decrease in mice exposure to paraquat

(2020) Zhengli Yang et al.   Scientific Reports

AMPK in the Ventromedial Nucleus of the Hypothalamus: A Key Regulator for Thermogenesis

(2020) Hailan Liu et al.   Frontiers in Endocrinology

Metformin alleviates high glucose-induced ER stress and inflammation by inhibiting the interaction between caveolin1 and AMPKα in rat astrocytes

(2020) Gang Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TIR-Domain-Containing Adaptor-Inducing Interferon-β (TRIF) Is Involved in Glucose Metabolism in Adipose Tissue through the Insulin/AKT Signaling Pathway

(2020) Junling Yang et al.   International Journal of Endocrinology

Central dopamine D2 receptors regulate plasma glucose levels in mice through autonomic nerves

(2020) Hiroko Ikeda et al.   Scientific Reports

Quetiapine Attenuates the Neuroinflammation and Executive Function Deficit in Streptozotocin-Induced Diabetic Mice

(2019) Kexin Wang et al.   MEDIATORS OF INFLAMMATION

Endoplasmic Reticulum Stress, the Hypothalamus, and Energy Balance

(2019) Isin Cakir et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Ganoderic acid A alleviates hypoxia-induced apoptosis, autophagy, and inflammation in rat neural stem cells through the PI3K/AKT/mTOR pathways

(2019) Yanhua Chang et al.   PHYTOTHERAPY RESEARCH

Morin has protective potential against ER stress induced apoptosis in renal proximal tubular HK-2 cells

(2019) Jung-Soon Mo et al.   BIOMEDICINE & PHARMACOTHERAPY

Morin decreases cortical pyramidal neuron degeneration via inhibition of neuroinflammation in mouse model of schizophrenia

(2019) Benneth Ben-Azu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Endoplasmic Reticulum Stress Is Involved in Stress-Induced Hypothalamic Neuronal Injury in Rats via the PERK-ATF4-CHOP and IRE1-ASK1-JNK Pathways

(2019) Shanyong Yi et al.   Frontiers in Cellular Neuroscience

Dopaminergic Pathways in Obesity-Associated Inflammation

(2019) Fernanda Leite et al.   Journal of Neuroimmune Pharmacology

Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway

(2019) Morena Zusso et al.   Journal of Neuroinflammation

Olanzapine-induced endoplasmic reticulum stress and inflammation in the hypothalamus were inhibited by an ER stress inhibitor 4-phenylbutyrate

(2019) Meng He et al.   PSYCHONEUROENDOCRINOLOGY

Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2α–ATF4 Pathway in Mouse Microglia

(2019) Takayuki Inoue et al.   Cells

Detrimental Effects of HMGB-1 Require Microglial-Astroglial Interaction: Implications for the Status Epilepticus -Induced Neuroinflammation

(2019) Gerardo Rosciszewski et al.   Frontiers in Cellular Neuroscience

Dopaminergic mechanisms in the lateral hypothalamus regulate feeding behavior in association with neuropeptides

(2019) Naomi Yonemochi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dysregulation of the unfolded protein response (UPR) in the dorsolateral prefrontal cortex in elderly patients with schizophrenia

(2019) Pitna Kim et al.   MOLECULAR PSYCHIATRY

Positive association between cerebral grey matter metabolism and dopamine D2/D3 receptor availability in healthy and schizophrenia subjects: An 18F-fluorodeoxyglucose and 18F-fallypride positron emission tomography study

(2019) Serge A. Mitelman et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Role of POMC and AgRP neuronal activities on glycaemia in mice

(2019) Aykut Göktürk Üner et al.   Scientific Reports

Schizophrenia—An Overview

(2019) Robert A. McCutcheon et al.   JAMA Psychiatry

Risperidone stimulates food intake and induces body weight gain via the hypothalamic arcuate nucleus 5‐HT2c receptor—NPY pathway

(2019) Xiao‐Qin Wan et al.   CNS Neuroscience & Therapeutics

Cytokine Alterations in Schizophrenia: An Updated Review

(2019) Sara Momtazmanesh et al.   Frontiers in Psychiatry

Dopamine D2 receptor restricts astrocytic NLRP3 inflammasome activation via enhancing the interaction of β-arrestin2 and NLRP3

(2018) Jialei Zhu et al.   CELL DEATH AND DIFFERENTIATION

ER stress and unfolded protein response in ocular health and disease

(2018) Heike Kroeger et al.   FEBS Journal

Differential effects of typical and atypical antipsychotics on astroglial cells in vitro

(2018) Larissa Daniele Bobermin et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Histamine upregulates the expression of histamine receptors and increases the neuroprotective effect of astrocytes

(2018) Jiawen Xu et al.   Journal of Neuroinflammation

Prebiotic attenuation of olanzapine-induced weight gain in rats: analysis of central and peripheral biomarkers and gut microbiota

(2018) Amy Chia-Ching Kao et al.   Translational Psychiatry

Metformin for Weight Gain Associated with Second-Generation Antipsychotics in Children and Adolescents: A Systematic Review and Meta-Analysis

(2018) Pierre Ellul et al.   CNS DRUGS

Mild Endoplasmic Reticulum Stress Protects Against Lipopolysaccharide-Induced Astrocytic Activation and Blood-Brain Barrier Hyperpermeability

(2018) Yiwei Wang et al.   Frontiers in Cellular Neuroscience

Regulation of IL-6 Secretion by Astrocytes via TLR4 in the Fragile X Mouse Model

(2018) Victoria Krasovska et al.   Frontiers in Molecular Neuroscience

Endoplasmic reticulum stress is transmissible in vitro between cells of the central nervous system

(2018) Neil T. Sprenkle et al.   JOURNAL OF NEUROCHEMISTRY

Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress

(2018) Ismael González-García et al.   Cell Reports

Hypothalamic Microglial Activation in Obesity: A Mini-Review

(2018) Natália F. Mendes et al.   Frontiers in Neuroscience

Metabolic side effects induced by olanzapine treatment are neutralized by CB1 receptor antagonist compounds co-administration in female rats

(2017) P. Lazzari et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

LPS-Induced Low-Grade Inflammation Increases Hypothalamic JNK Expression and Causes Central Insulin Resistance Irrespective of Body Weight Changes

(2017) Rodrigo Rorato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The atypical antipsychotic olanzapine causes weight gain by targeting serotonin receptor 2C

(2017) Caleb C. Lord et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypothalamic inflammation in obesity and metabolic disease

(2017) Alexander Jais et al.   JOURNAL OF CLINICAL INVESTIGATION

Pretreatment Cardiometabolic Status in Youth With Early-Onset Psychosis

(2017) Karsten G. Jensen et al.   JOURNAL OF CLINICAL PSYCHIATRY

Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization

(2017) Yi-wei Wang et al.   Journal of Neuroinflammation

Levodopa (L-DOPA) attenuates endoplasmic reticulum stress response and cell death signaling through DRD2 in SH-SY5Y neuronal cells under α-synuclein-induced toxicity

(2017) Juhyun Song et al.   NEUROSCIENCE

Crosstalk between endoplasmic reticulum stress and oxidative stress in schizophrenia: The dawn of new therapeutic approaches

(2017) Shivangi Patel et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Cannabinoid Receptor Type 1 Agonist ACEA Protects Neurons from Death and Attenuates Endoplasmic Reticulum Stress-Related Apoptotic Pathway Signaling

(2017) Talita A. Vrechi et al.   NEUROTOXICITY RESEARCH

Toll-like receptor 4 mediates fat, sugar, and umami taste preference and food intake and body weight regulation

(2017) Simonetta Camandola et al.   Obesity

Unraveling the role of ER stress inhibitors in the context of metabolic diseases

(2017) Chodisetty Sarvani et al.   PHARMACOLOGICAL RESEARCH

Astrocytes and endoplasmic reticulum stress: A bridge between obesity and neurodegenerative diseases

(2017) Cynthia A. Martin-Jiménez et al.   PROGRESS IN NEUROBIOLOGY

Clozapine, chlorpromazine and risperidone dose-dependently reduce emotional hyperthermia, a biological marker of salience

(2017) William W. Blessing et al.   PSYCHOPHARMACOLOGY

Intrinsic and Antipsychotic Drug-Induced Metabolic Dysfunction in Schizophrenia

(2017) Zachary Freyberg et al.   Frontiers in Neuroscience

Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation

(2017) J.D. Douglass et al.   Molecular Metabolism

Hypothalamic Inflammation and Energy Balance Disruptions: Spotlight on Chemokines

(2017) Ophélia Le Thuc et al.   Frontiers in Endocrinology

Knockdown of Tlr4 in the Arcuate Nucleus Improves Obesity Related Metabolic Disorders

(2017) Yongli Zhao et al.   Scientific Reports

Hypothalamic AMPK-induced autophagy increases food intake by regulating NPY and POMC expression

(2016) Tae Seok Oh et al.   Autophagy

Astemizole–Histamine induces Beclin-1-independent autophagy by targeting p53-dependent crosstalk between autophagy and apoptosis

(2016) Rekha Jakhar et al.   CANCER LETTERS

Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity

(2016) Cristina Contreras et al.   DIABETES

Deletion of ATF4 in AgRP Neurons Promotes Fat Loss Mainly via Increasing Energy Expenditure

(2016) Jiali Deng et al.   DIABETES

The effects of pioglitazone adjuvant therapy on negative symptoms of patients with chronic schizophrenia: a double-blind and placebo-controlled trial

(2016) Negar Iranpour et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

High fat induces acute and chronic inflammation in the hypothalamus: effect of high-fat diet, palmitate and TNF-α on appetite-regulating NPY neurons

(2016) P S Dalvi et al.   INTERNATIONAL JOURNAL OF OBESITY

Postnatal activation of TLR4 in astrocytes promotes excitatory synaptogenesis in hippocampal neurons

(2016) Yi Shen et al.   JOURNAL OF CELL BIOLOGY

A small molecule inhibitor of NFκB blocks ER stress and the NLRP3 inflammasome and prevents progression of pancreatitis

(2016) Mazhar A. Kanak et al.   JOURNAL OF GASTROENTEROLOGY

Bimodal modulation of store-operated Ca2+ channels by clozapine in astrocytes

(2016) Yuzuki Kanda et al.   NEUROSCIENCE LETTERS

Endoplasmic reticulum stress-induced neuronal inflammatory response and apoptosis likely plays a key role in the development of diabetic encephalopathy

(2016) Zhouguang Wang et al.   Oncotarget

Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding

(2016) Naiyan Chen et al.   eLife

Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis

(2016) Mina Thon et al.   Frontiers in Endocrinology

Endoplasmic Reticulum Stress May Play a Pivotal Role in Lipid Metabolic Disorders in a Novel Mouse Model of Subclinical Hypothyroidism

(2016) Lingyan Zhou et al.   Scientific Reports

Hepatic TLR4 signaling in obese NAFLD

(2015) Torfay Sharifnia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mechanisms of insulin resistance in the amygdala: Influences on food intake

(2015) Maria Fernanda Condes Areias et al.   BEHAVIOURAL BRAIN RESEARCH

Ca2+ homeostasis and endoplasmic reticulum (ER) stress: An integrated view of calcium signaling

(2015) Joachim Krebs et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Brain Innate Immunity Regulates Hypothalamic Arcuate Neuronal Activity and Feeding Behavior

(2015) Wagner L. Reis et al.   ENDOCRINOLOGY

Microglial activation in the rat brain following chronic antipsychotic treatment at clinically relevant doses

(2015) Marie-Caroline Cotel et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Hypothalamic ER stress: A bridge between leptin resistance and obesity

(2015) Sara Ramírez et al.   FEBS LETTERS

Saturated fatty acids enhance TLR4 immune pathways in human trophoblasts

(2015) Xiaohua Yang et al.   HUMAN REPRODUCTION

De Novo Expression of Dopamine D2 Receptors on Microglia after Stroke

(2015) Jojanneke HJ Huck et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Amyloid-β pathology is attenuated by tauroursodeoxycholic acid treatment in APP/PS1 mice after disease onset

(2015) Pedro A. Dionísio et al.   NEUROBIOLOGY OF AGING

Risperidone-induced weight gain and reduced locomotor activity in juvenile female rats: The role of histaminergic and NPY pathways

(2015) Jiamei Lian et al.   PHARMACOLOGICAL RESEARCH

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

(2015) Andre Kleinridders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes Control Food Intake by Inhibiting AGRP Neuron Activity via Adenosine A1 Receptors

(2015) Liang Yang et al.   Cell Reports

Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss

(2015) Fredrick E Henry et al.   eLife

Dopamine D2/3 receptor antagonism reduces activity-based anorexia

(2015) S J Klenotich et al.   Translational Psychiatry

Risperidone-induced weight gain is mediated through shifts in the gut microbiome and suppression of energy expenditure

(2015) Sarah M. Bahr et al.   EBioMedicine

Quetiapine Attenuates Glial Activation and Proinflammatory Cytokines in APP/PS1 Transgenic Mice via Inhibition of Nuclear Factor- B Pathway

(2015) S. Zhu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Toll-Like Receptor 4 Promotes Autonomic Dysfunction, Inflammation and Microglia Activation in the Hypothalamic Paraventricular Nucleus: Role of Endoplasmic Reticulum Stress

(2015) Gustavo S. Masson et al.   PLoS One

The -116C/G polymorphism inXBP1gene is associated with psychiatric illness in Asian population: A meta-analysis

(2014) Dan Cheng et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

The role of MAPK signalling pathways in the response to endoplasmic reticulum stress

(2014) Nicola J. Darling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis

(2014) Kevin W. Williams et al.   Cell Metabolism

Hypothalamic ghrelin signalling mediates olanzapine-induced hyperphagia and weight gain in female rats

(2014) Qingsheng Zhang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Astrocyte-dependent protective effect of quetiapine on GABAergic neuron is associated with the prevention of anxiety-like behaviors in aging mice after long-term treatment

(2014) Junhui Wang et al.   JOURNAL OF NEUROCHEMISTRY

Tauroursodeoxycholic acid reduces glial cell activation in an animal model of acute neuroinflammation

(2014) Natalia Yanguas-Casás et al.   Journal of Neuroinflammation

ER Stress Response in Human Cellular Models of Senescence

(2014) Liliana Matos et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Histamine Induces Upregulated Expression of Histamine Receptors and Increases Release of Inflammatory Mediators from Microglia

(2014) Hongquan Dong et al.   MOLECULAR NEUROBIOLOGY

Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding

(2014) Jae Geun Kim et al.   NATURE NEUROSCIENCE

Metformin and Berberine Prevent Olanzapine-Induced Weight Gain in Rats

(2014) Yueshan Hu et al.   PLoS One

Hypothalamic histamine H1 receptor-AMPK signaling time-dependently mediates olanzapine-induced hyperphagia and weight gain in female rats

(2014) Meng He et al.   PSYCHONEUROENDOCRINOLOGY

Molecular pathophysiology of metabolic effects of antipsychotic medications

(2014) Jacob S. Ballon et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function

(2014) Martin Valdearcos et al.   Cell Reports

Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance

(2014) Cristina Contreras et al.   Cell Reports

Heat shock protein 70 gene polymorphisms are associated with paranoid schizophrenia in the Polish population

(2013) Malgorzata Kowalczyk et al.   CELL STRESS & CHAPERONES

The Antipsychotic Olanzapine Induces Apoptosis in Insulin-secreting Pancreatic β Cells by Blocking PERK-mediated Translational Attenuation

(2013) Riwa Ozasa et al.   CELL STRUCTURE AND FUNCTION

Mechanism of dopamine D2 receptor-induced Ca2+ release in PC-12 cells

(2013) Marc-Olivier Frégeau et al.   CELLULAR SIGNALLING

Olanzapine induces glucose intolerance through the activation of AMPK in the mouse hypothalamus

(2013) Megumi Ikegami et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways

(2013) Sena Kim et al.   Innate Immunity

Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing

(2013) Isin Çakir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia

(2013) Linli Yao et al.   Journal of Neuroinflammation

Toll-Like Receptor 4 Knockout Mice Are Protected against Endoplasmic Reticulum Stress Induced by a High-Fat Diet

(2013) Nicolas Pierre et al.   PLoS One

Ketamine Inhibits Lipopolysaccharide-Induced Astrocytes Activation by Suppressing TLR4/NF-?B Pathway

(2012) Yuqing Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Endoplasmic Reticulum Stress and Insulin Biosynthesis: A Review

(2012) Mi-Kyung Kim et al.   Experimental Diabetes Research

Increased Tenascin C And Toll-Like Receptor 4 Levels in Visceral Adipose Tissue as a Link between Inflammation and Extracellular Matrix Remodeling in Obesity

(2012) Victoria Catalán et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Reducing olanzapine-induced weight gain side effect by using betahistine: a study in the rat model

(2012) Chao Deng et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin

(2012) Wei Shao et al.   NATURE

A potential link between obesity and neural stem cell dysfunction

(2012) Frederick J. Livesey   NATURE CELL BIOLOGY

Central Dopaminergic Activity Influences Metabolic Parameters in Healthy Men

(2012) Ludmila Brunerova et al.   NEUROENDOCRINOLOGY

Alterations to Melanocortinergic, GABAergic and Cannabinoid Neurotransmission Associated with Olanzapine-Induced Weight Gain

(2012) Katrina Weston-Green et al.   PLoS One

Schizophrenia: Metabolic aspects of aetiology, diagnosis and future treatment strategies

(2012) Laura W. Harris et al.   PSYCHONEUROENDOCRINOLOGY

Reducing antipsychotic-induced weight gain in schizophrenia: a double-blind placebo-controlled study of reboxetine–betahistine combination

(2012) Michael Poyurovsky et al.   PSYCHOPHARMACOLOGY

ER stress-induced inflammation: does it aid or impede disease progression?

(2012) Abhishek D. Garg et al.   TRENDS IN MOLECULAR MEDICINE

Influence of resting energy expenditure on weight gain in adolescents taking second-generation antipsychotics

(2011) Cristina Cuerda et al.   CLINICAL NUTRITION

Defining the Mechanism of Action of 4-Phenylbutyrate to Develop a Small-Molecule-Based Therapy for Alzheimers Disease

(2011) M. Cuadrado-Tejedor et al.   CURRENT MEDICINAL CHEMISTRY

Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis

(2011) Kazunori Tanaka et al.   EXPERIMENTAL NEUROLOGY

Clozapine Protects Dopaminergic Neurons from Inflammation-Induced Damage by Inhibiting Microglial Overactivation

(2011) Xiaoming Hu et al.   Journal of Neuroimmune Pharmacology

Does endoplasmic reticulum stress participate in APD-induced hepatic metabolic dysregulation?

(2011) Emilie Lauressergues et al.   NEUROPHARMACOLOGY

Olanzapine-Induced Hyperphagia and Weight Gain Associate with Orexigenic Hypothalamic Neuropeptide Signaling without Concomitant AMPK Phosphorylation

(2011) Johan Fernø et al.   PLoS One

Atypical antipsychotics and effects of muscarinic, serotonergic, dopaminergic and histaminergic receptor binding on insulin secretion in vivo: An animal model

(2011) Margaret Hahn et al.   SCHIZOPHRENIA RESEARCH

Endoplasmic reticulum stress, obesity and diabetes

(2011) Miriam Cnop et al.   TRENDS IN MOLECULAR MEDICINE

Neuron–astrocyte communication and synaptic plasticity

(2010) Sónia Paixão et al.   CURRENT OPINION IN NEUROBIOLOGY

Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

(2010) Marleen Kars et al.   DIABETES

Disruption of the Dopamine D2 Receptor Impairs Insulin Secretion and Causes Glucose Intolerance

(2010) Isabel García-Tornadú et al.   ENDOCRINOLOGY

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

(2010) Roser Gorina et al.   GLIA

TNF-α transiently induces endoplasmic reticulum stress and an incomplete unfolded protein response in the hypothalamus

(2010) R.G. Denis et al.   NEUROSCIENCE

IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition

(2010) Eduardo R. Ropelle et al.   PLOS BIOLOGY

Dopamine D2receptor knockout mice develop features of Parkinson disease

(2009) Rogan B. Tinsley et al.   ANNALS OF NEUROLOGY

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response

(2009) Sana Basseri et al.   JOURNAL OF LIPID RESEARCH

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Central Administration of an Endoplasmic Reticulum Stress Inducer Inhibits the Anorexigenic Effects of Leptin and Insulin

(2009) Jong Chul Won et al.   Obesity

Olanzapine-induced weight gain in the rat: role of 5-HT2C and histamine H1 receptors

(2009) Shona L. Kirk et al.   PSYCHOPHARMACOLOGY

Metformin Addition Attenuates Olanzapine-Induced Weight Gain in Drug-Naive First-Episode Schizophrenia Patients: A Double-Blind, Placebo-Controlled Study

(2008) Ren-Rong Wu et al.   AMERICAN JOURNAL OF PSYCHIATRY

Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia

(2008) Satoko Hattori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Association analysis of heat shock protein 70 gene polymorphisms in schizophrenia

(2008) Jung Jin Kim et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

The Role of Thermogenesis in Antipsychotic Drug-induced Weight Gain

(2008) Aneta Stefanidis et al.   Obesity

Targeting TNF-α receptors for neurotherapeutics

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