ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma

(2018) Roland Schmitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Development of a stress response therapy targeting aggressive prostate cancer

(2018) Hao G. Nguyen et al.   Science Translational Medicine

Increased phosphorylation of 4E-binding protein 1 predicts poor prognosis for patients with colorectal cancer

(2017) Yufeng Miao et al.   Molecular Medicine Reports

Alteration of protein function by a silent polymorphism linked to tRNA abundance

(2017) Sebastian Kirchner et al.   PLOS BIOLOGY

ATF4 regulates SREBP1c expression to control fatty acids synthesis in 3T3-L1 adipocytes differentiation

(2016) Hu Chen et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

4E-BP is a target of the GCN2–ATF4 pathway duringDrosophiladevelopment and aging

(2016) Min-Ji Kang et al.   JOURNAL OF CELL BIOLOGY

Discharging tRNAs: a tug of war between translation and detoxification inEscherichia coli

(2016) Irem Avcilar-Kucukgoze et al.   NUCLEIC ACIDS RESEARCH

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma

(2016) Dariusz Pytel et al.   PLoS Genetics

ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis

(2015) Souvik Dey et al.   JOURNAL OF CLINICAL INVESTIGATION

Glycosylation-directed quality control of protein folding

(2015) Chengchao Xu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy

(2015) Feven Tameire et al.   SEMINARS IN CANCER BIOLOGY

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

EIF4EBP1 Overexpression Is Associated with Poor Survival and Disease Progression in Patients with Hepatocellular Carcinoma

(2015) Yin-Lian Cha et al.   PLoS One

Amino Acid Deprivation Promotes Tumor Angiogenesis through the GCN2/ATF4 Pathway

(2015) Yugang Wang et al.   NEOPLASIA

Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer

(2014) John T. Cunningham et al.   CELL

The UCSC Cancer Genomics Browser: update 2015

(2014) Mary Goldman et al.   NUCLEIC ACIDS RESEARCH

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers

(2013) M. Pourdehnad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum Stress Sensing in the Unfolded Protein Response

(2013) B. M. Gardner et al.   Cold Spring Harbor Perspectives in Biology

Myc-Driven Overgrowth Requires Unfolded Protein Response-Mediated Induction of Autophagy and Antioxidant Responses in Drosophila melanogaster

(2013) Péter Nagy et al.   PLoS Genetics

Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome

(2012) Abdenour Soufi et al.   CELL

ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth

(2012) Lori S. Hart et al.   JOURNAL OF CLINICAL INVESTIGATION

PERK Is Required in the Adult Pancreas and Is Essential for Maintenance of Glucose Homeostasis

(2012) Y. Gao et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting Synthetic Lethal Interactions between Myc and the eIF4F Complex Impedes Tumorigenesis

(2012) Chen-Ju Lin et al.   Cell Reports

Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E

(2010) Andrew C. Hsieh et al.   CANCER CELL

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

(2010) Jiangbin Ye et al.   EMBO JOURNAL

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

The Role of Myc-Induced Protein Synthesis in Cancer

(2009) D. Ruggero   CANCER RESEARCH

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

ATF4-Mediated Induction of 4E-BP1 Contributes to Pancreatic β Cell Survival under Endoplasmic Reticulum Stress

(2008) Suguru Yamaguchi et al.   Cell Metabolism

Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

(2008) Umut Ozcan et al.   MOLECULAR CELL

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

(2008) Maria Barna et al.   NATURE