PERK signaling activation restores nucleus pulposus degeneration by activating autophagy under hypoxia environment

Integrated transcriptome and proteome analyses identify novel regulatory network of nucleus pulposus cells in intervertebral disc degeneration

(2021) Chen Xu et al.   BMC Medical Genomics

Inflammatory‐sensitive CHI3L1 protects nucleus pulposus via AKT3 signaling during intervertebral disc degeneration

(2020) Ruizhe Wang et al.   FASEB JOURNAL

Chondroitin synthase‐3 regulates nucleus pulposus degeneration through actin‐induced YAP signaling

(2020) Leixin Wei et al.   FASEB JOURNAL

Hypoxia Helps Maintain Nucleus Pulposus Homeostasis by Balancing Autophagy and Apoptosis

(2020) Han-Jun Kim et al.   Oxidative Medicine and Cellular Longevity

Targeting autophagy using natural compounds for cancer prevention and therapy

(2019) Shuo Deng et al.   CANCER

Effects of Oxygen Concentration and Culture Time on Porcine Nucleus Pulposus Cell Metabolism: An in vitro Study

(2019) Lukas M. Jaworski et al.   Frontiers in Bioengineering and Biotechnology

Intervertebral disc regeneration: From cell therapy to the development of novel bioinspired endogenous repair strategies

(2018) Johann Clouet et al.   ADVANCED DRUG DELIVERY REVIEWS

Autophagy in health and disease: A comprehensive review

(2018) Sarbari Saha et al.   BIOMEDICINE & PHARMACOTHERAPY

Autophagy attenuates compression-induced apoptosis of human nucleus pulposus cells via MEK/ERK/NRF1/Atg7 signaling pathways during intervertebral disc degeneration

(2018) Shuai Li et al.   EXPERIMENTAL CELL RESEARCH

Protein kinase RNA-like ER kinase/eukaryotic translation initiation factor 2α pathway attenuates tumor necrosis factor alpha-induced apoptosis in nucleus pulposus cells by activating autophagy

(2018) Lu Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Autologous bone marrow concentrate intradiscal injection for the treatment of degenerative disc disease with three-year follow-up

(2017) Kenneth A. Pettine et al.   INTERNATIONAL ORTHOPAEDICS

Cartilage-Specific Autophagy Deficiency Promotes ER Stress and Impairs Chondrogenesis in PERK-ATF4-CHOP-Dependent Manner

(2017) Xiaomin Kang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Crosstalk of ER stress-mediated autophagy and ER-phagy: Involvement of UPR and the core autophagy machinery

(2017) Shuling Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Role of Hypoxia in Angiogenesis and Extracellular Matrix Regulation of Intervertebral Disc Cells During Inflammatory Reactions

(2017) Woo-Keun Kwon et al.   NEUROSURGERY

Intervertebral Disc Repair by Allogeneic Mesenchymal Bone Marrow Cells

(2017) David C. Noriega et al.   TRANSPLANTATION

Activation of the EIF2AK4-EIF2A/eIF2α-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasiveEscherichia coliinfection

(2016) Alexis Bretin et al.   Autophagy

Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling

(2016) Hyowon Choi et al.   Autophagy

Hypoxia facilitates the survival of nucleus pulposus cells in serum deprivation by down-regulating excessive autophagy through restricting ROS generation

(2015) Jiang-Wei Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Translational Control during Endoplasmic Reticulum Stress beyond Phosphorylation of the Translation Initiation Factor eIF2α

(2014) Bo-Jhih Guan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Regulation of autophagy by ATF4 in response to severe hypoxia

(2010) T Rzymski et al.   ONCOGENE

Four-year follow-up of surgical versus non-surgical therapy for chronic low back pain

(2009) J. I. Brox et al.   ANNALS OF THE RHEUMATIC DISEASES

The Role of ATF4 Stabilization and Autophagy in Resistance of Breast Cancer Cells Treated with Bortezomib

(2009) M. Milani et al.   CANCER RESEARCH

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

Behavior of Mesenchymal Stem Cells in the Chemical Microenvironment of the Intervertebral Disc

(2009) Karin Wuertz et al.   SPINE