Olanzapine Induces Inflammation and Immune Response via Activating ER Stress in the Rat Prefrontal Cortex

Baicalin prevents LPS-induced activation of TLR4/NF-κB p65 pathway and inflammation in mice via inhibiting the expression of CD14

(2020) Ya-jun Fu et al.   ACTA PHARMACOLOGICA SINICA

Endoplasmic reticulum stress‐dependent activation of iNOS/NO‐NF‐κB signaling and NLRP3 inflammasome contributes to endothelial inflammation and apoptosis associated with microgravity

(2020) Min Jiang et al.   FASEB JOURNAL

Atypical antipsychotics induce human osteoblasts apoptosis via Wnt/β-catenin signaling

(2019) Peifan Li et al.   BMC Pharmacology & Toxicology

Chronic olanzapine administration causes metabolic syndrome through inflammatory cytokines in rodent models of insulin resistance

(2019) Huqun Li et al.   Scientific Reports

Olanzapine induced autophagy through suppression of NF‐κB activation in human glioma cells

(2019) Ying Zhu et al.   CNS Neuroscience & Therapeutics

The Prefrontal Cortex and Obesity: A Health Neuroscience Perspective

(2019) Cassandra J. Lowe et al.   TRENDS IN COGNITIVE SCIENCES

Postmortem transcriptional profiling reveals widespread increase in inflammation in schizophrenia: a comparison of prefrontal cortex, striatum, and hippocampus among matched tetrads of controls with subjects diagnosed with schizophrenia, bipolar or major depressive disorder

(2019) Thomas A. Lanz et al.   Translational Psychiatry

CD14: Biology and role in the pathogenesis of disease

(2019) Zhenghao Wu et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Role of inflammation in the pathogenesis of schizophrenia: A review of the evidence, proposed mechanisms and implications for treatment

(2019) David Mongan et al.   Early Intervention in Psychiatry

Olanzapine-induced endoplasmic reticulum stress and inflammation in the hypothalamus were inhibited by an ER stress inhibitor 4-phenylbutyrate

(2019) Meng He et al.   PSYCHONEUROENDOCRINOLOGY

Effects of long-term antipsychotics treatment on body weight: A population-based cohort study

(2019) Juan Carlos Bazo-Alvarez et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Immunity and Inflammation: From Jekyll to Hyde

(2018) Weili Xu et al.   EXPERIMENTAL GERONTOLOGY

Dose reduction of risperidone and olanzapine can improve cognitive function and negative symptoms in stable schizophrenic patients: A single-blinded, 52-week, randomized controlled study

(2018) Yanling Zhou et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation

(2018) Xiang Nie et al.   NEURON

Prebiotic attenuation of olanzapine-induced weight gain in rats: analysis of central and peripheral biomarkers and gut microbiota

(2018) Amy Chia-Ching Kao et al.   Translational Psychiatry

Effect of 4-Phenylbutyric Acid and Tauroursodeoxycholic Acid on Magnesium and Calcium Metabolism in Streptozocin-Induced Type 1 Diabetic Mice

(2018) Qi Zhou et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Activation of the immune-inflammatory response system and the compensatory immune-regulatory system in antipsychotic naive first episode psychosis

(2018) Mariane Nunes Noto et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Olanzapine and aripiprazole differentially affect glucose uptake and energy metabolism in human mononuclear blood cells

(2017) Britta Stapel et al.   JOURNAL OF PSYCHIATRIC RESEARCH

4-PBA inhibits LPS-induced inflammation through regulating ER stress and autophagy in acute lung injury models

(2017) Meichun Zeng et al.   TOXICOLOGY LETTERS

CD14 is critical for TLR2-mediated M1 macrophage activation triggered by N-glycan recognition

(2017) Thiago Aparecido da Silva et al.   Scientific Reports

GRP78 Impairs Production of Lipopolysaccharide-Induced Cytokines by Interaction with CD14

(2017) Kai Qin et al.   Frontiers in Immunology

Abnormal gene and protein expression of inflammatory cytokines in the postmortem brain of schizophrenia patients

(2017) Ghanshyam N. Pandey et al.   SCHIZOPHRENIA RESEARCH

NOD1 and NOD2 signalling links ER stress with inflammation

(2016) A. Marijke Keestra-Gounder et al.   NATURE

Ameliorating antipsychotic-induced weight gain by betahistine: Mechanisms and clinical implications

(2016) Jiamei Lian et al.   PHARMACOLOGICAL RESEARCH

Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes

(2016) Vicente Andreu-Fernández et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antidepressant effects of combination of brexpiprazole and fluoxetine on depression-like behavior and dendritic changes in mice after inflammation

(2016) Min Ma et al.   PSYCHOPHARMACOLOGY

Targeting endoplasmic reticulum stress in hypoxia-induced cardiac injury

(2016) William Durante   VASCULAR PHARMACOLOGY

Olanzapine Prevents the PCP-induced Reduction in the Neurite Outgrowth of Prefrontal Cortical Neurons via NRG1

(2016) Qingsheng Zhang et al.   Scientific Reports

The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis

(2015) P.S. Kolb et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Propofol attenuates LPS-induced tumor necrosis factor-α, interleukin-6 and nitric oxide expression in canine peripheral blood mononuclear cells possibly through down-regulation of nuclear factor (NF)-κB activation

(2015) Zengyang PEI et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine

(2015) Ljubica Vucicevic et al.   Autophagy

Naltrexone attenuates endoplasmic reticulum stress induced hepatic injury in mice

(2014) A. Moslehi et al.   ACTA PHYSIOLOGICA HUNGARICA

Antiapoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity

(2014) R. W. Rooswinkel et al.   BLOOD

Olanzapine-Activated AMPK Signaling in the Dorsal Vagal Complex Is Attenuated by Histamine H1 Receptor Agonist in Female Rats

(2014) Meng He et al.   ENDOCRINOLOGY

Effects of olanzapine on the elevation of macrophage infiltration and pro-inflammatory cytokine expression in female rats

(2014) Qingsheng Zhang et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Expression of Inducible Nitric Oxide Synthase (iNOS) in Microglia of the Developing Quail Retina

(2014) Ana Sierra et al.   PLoS One

Hypothalamic histamine H1 receptor-AMPK signaling time-dependently mediates olanzapine-induced hyperphagia and weight gain in female rats

(2014) Meng He et al.   PSYCHONEUROENDOCRINOLOGY

Obesity and cognitive decline: role of inflammation and vascular changes

(2014) Jason C. D. Nguyen et al.   Frontiers in Neuroscience

Meta-analysis of gene coexpression networks in the post-mortem prefrontal cortex of patients with schizophrenia and unaffected controls

(2013) Meeta Mistry et al.   BMC NEUROSCIENCE

Microglial CD14 activated by iNOS contributes to neuroinflammation in cerebral ischemia

(2013) Mian Zhou et al.   BRAIN RESEARCH

Moderate Hypothermia Inhibits Brain Inflammation and Attenuates Stroke-Induced Immunodepression in Rats

(2013) Li-Juan Gu et al.   CNS Neuroscience & Therapeutics

Olanzapine increases hepatic glucose production through the activation of hypothalamic adenosine 5′-monophosphate-activated protein kinase

(2013) M. Ikegami et al.   DIABETES OBESITY & METABOLISM

Association between genetic polymorphisms of Toll-like receptor 2 (TLR2) and schizophrenia in the Korean population

(2013) Won Sub Kang et al.   GENE

Enhanced levels of the apoptotic BAX/BCL-2 ratio in children with acute lymphoblastic leukemia and high-risk features

(2013) Maria Kaparou et al.   GENETICS AND MOLECULAR BIOLOGY

Associations Among Obesity, Acute Weight Gain, and Response to Treatment with Olanzapine in Adolescent Schizophrenia

(2013) David E. Kemp et al.   JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

Markers of inflammation in the prefrontal cortex of individuals with schizophrenia

(2013) S G Fillman et al.   MOLECULAR PSYCHIATRY

Effects of olanzapine and betahistine co-treatment on serotonin transporter, 5-HT2A and dopamine D2 receptor binding density

(2013) Jiamei Lian et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A review of anti-inflammatory agents for symptoms of schizophrenia

(2012) William R Keller et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The endoplasmic reticulum: a sensor of cellular stress that modulates immune responses

(2012) Fabio Martinon   MICROBES AND INFECTION

Parthenolide Inhibits the LPS-induced Secretion of IL-6 and TNF-α and NF-κB Nuclear Translocation in BV-2 Microglia

(2012) Paolo Magni et al.   PHYTOTHERAPY RESEARCH

Regional Susceptibility to TNF-α Induction of Murine Brain Inflammation via Classical IKK/NF-κB Signalling

(2012) Adam M. H. Young et al.   PLoS One

Olanzapine Causes a Leptin-Dependent Increase in Acetylcholine Release in Mouse Prefrontal Cortex

(2012) Asheley B. Wathen et al.   SLEEP

The effect of clozapine on the AMPK-ACC-CPT1 pathway in the rat frontal cortex

(2011) Min Kyung Kim et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Olanzapine-induced accumulation of adipose tissue is associated with an inflammatory state

(2010) Montserrat Victoriano et al.   BRAIN RESEARCH

Effects of 4-phenylbutyric acid on the process and development of diabetic nephropathy induced in rats by streptozotocin: Regulation of endoplasmic reticulum stress-oxidative activation

(2010) Zhi-Feng Luo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

MAPK Signal Transduction Underlying Brain Inflammation and Gliosis as Therapeutic Target

(2009) Bozena Kaminska et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

CD14 Signaling Restrains Chronic Inflammation through Induction of p38-MAPK/SOCS-Dependent Tolerance

(2009) Bikash Sahay et al.   PLoS Pathogens

The effects of antipsychotics on the density of cannabinoid receptors in the dorsal vagal complex of rats: implications for olanzapine-induced weight gain

(2008) Katrina Weston-Green et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

CD14 Works with Toll‐Like Receptor 2 to Contribute to Recognition and Control ofListeria monocytogenesInfection

(2008) Laure Janot et al.   JOURNAL OF INFECTIOUS DISEASES

Differential striatal levels of TNF-α, NFκB p65 subunit and dopamine with chronic typical and atypical neuroleptic treatment: Role in orofacial dyskinesia

(2008) Mahendra Bishnoi et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL