The Repertoire of Small-Molecule PET Probes for Neuroinflammation Imaging: Challenges and Opportunities beyond TSPO

In Vitro Evaluation of [3H]CPPC as a Tool Radioligand for CSF-1R

(2021) Ashley C. Knight et al.   ACS Chemical Neuroscience

Discovery of carbon-11 labeled sulfonamide derivative: A PET tracer for imaging brain NLRP3 inflammasome

(2021) Yulong Xu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

First-in-human neuroimaging of soluble epoxide hydrolase using [18F]FNDP PET

(2021) Jennifer M. Coughlin et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A first-in-human study of 11C-MTP38, a novel PET ligand for phosphodiesterase 7

(2021) Manabu Kubota et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Synthesis and preclinical evaluation of [11C]MTP38 as a novel PET ligand for phosphodiesterase 7 in the brain

(2021) Naoyuki Obokata et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey

(2021) Xiaoyun Zhou et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Emerging Role of the Interplay Among Astrocytes, Microglia, and Neurons in the Hippocampus in Health and Disease

(2021) Daniele Lana et al.   Frontiers in Aging Neuroscience

The Expression Regulation and Biological Function of Autotaxin

(2021) Xiaotian Zhang et al.   Cells

Advances in Cyclic Nucleotide Phosphodiesterase-Targeted PET Imaging and Drug Discovery

(2021) Jiyun Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex

(2020) Changrui Xing et al.   CELL

Radiolabeling of [11C]FPS-ZM1, a receptor for advanced glycation end products-targeting positron emission tomography radiotracer, using a [11C]CO2-to-[11C]CO chemical conversion

(2020) Federico Luzi et al.   Future Medicinal Chemistry

Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer’s Disease Brains

(2020) Douglas G. Walker et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Radiosynthesis and preliminary evaluation of 11C-labeled 4-cyclopropyl-7-(3-methoxyphenoxy)-3,4-dihydro-2H-benzo[e] [1,2,4] thiadiazine 1,1-dioxide for PET imaging AMPA receptors

(2020) Jiahui Chen et al.   TETRAHEDRON LETTERS

Discovery, Radiolabeling, and Evaluation of Subtype-Selective Inhibitors for Positron Emission Tomography Imaging of Brain Phosphodiesterase-4D

(2020) Yuichi Wakabayashi et al.   ACS Chemical Neuroscience

Targeting monoamine oxidase to dampen NLRP3 inflammasome activation in inflammation

(2020) Ricardo Sánchez-Rodríguez et al.   Cellular & Molecular Immunology

First-in-human evaluation of [11C]PS13, a novel PET radioligand, to quantify cyclooxygenase-1 in the brain

(2020) Min-Jeong Kim et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study

(2020) Stal Shrestha et al.   Journal of Neuroinflammation

Synthesis and preliminary evaluation of novel 11C-labeled GluN2B-selective NMDA receptor negative allosteric modulators

(2020) Ji-yun Sun et al.   ACTA PHARMACOLOGICA SINICA

Synthesis and evaluation of NLRP3-inhibitory sulfonylurea [11C]MCC950 in healthy animals

(2020) James R. Hill et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors

(2020) Ahmed Haider et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rh-CSF1 attenuates neuroinflammation via the CSF1R/PLCG2/PKCε pathway in a rat model of neonatal HIE

(2020) Xiao Hu et al.   Journal of Neuroinflammation

18F-SMBT-1: A Selective and Reversible Positron-Emission Tomography Tracer for Monoamine Oxidase-B Imaging

(2020) Ryuichi Harada et al.   JOURNAL OF NUCLEAR MEDICINE

Neuroinflammation PET Imaging: Current Opinion and Future Directions

(2020) Poorva Jain et al.   JOURNAL OF NUCLEAR MEDICINE

PET imaging of soluble epoxide hydrolase in non-human primate brain with [18F]FNDP

(2020) Yong Du et al.   EJNMMI Research

Phosphodiesterase 4D Gene Modifies the Functional Network of Patients With Mild Cognitive Impairment and Alzheimer’s Disease

(2020) Jie Xiang et al.   Frontiers in Genetics

Strategies for PET Imaging of the Receptor for Advanced Glycation Endproducts (RAGE)

(2020) Lindsey R. Drake et al.   Journal of Pharmaceutical Analysis

Synthesis and characterization of [125I]TZ6544, a promising radioligand for investigating sphingosine-1-phosphate receptor 2

(2020) Zonghua Luo et al.   NUCLEAR MEDICINE AND BIOLOGY

CSF1R signaling is a regulator of pathogenesis in progressive MS

(2020) Nellwyn Hagan et al.   Cell Death & Disease

Recent developments on PET radiotracers for TSPO and their applications in neuroimaging

(2020) Lingling Zhang et al.   Acta Pharmaceutica Sinica B

Evaluation of the novel 18 F‐labeled PET tracer SMBT‐1 for imaging astrogliosis in healthy elderly controls and A+/T+/(N+) Alzheimer's disease patients

(2020) Victor LL Villemagne et al.   Alzheimers & Dementia

Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development

(2020) Lu Hou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery

(2020) Robert W. Pipal et al.   NATURE

Myeloperoxidase: A versatile mediator of endothelial dysfunction and therapeutic target during cardiovascular disease

(2020) Sophie L. Maiocchi et al.   PHARMACOLOGY & THERAPEUTICS

PET Imaging of the P2X7 Ion Channel with a Novel Tracer [18F]JNJ-64413739 in a Rat Model of Neuroinflammation

(2019) Tamara Berdyyeva et al.   MOLECULAR IMAGING AND BIOLOGY

The Role of Ceramide and Sphingosine-1-Phosphate in Alzheimer’s Disease and Other Neurodegenerative Disorders

(2019) Kinga Czubowicz et al.   MOLECULAR NEUROBIOLOGY

PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R)

(2019) Andrew G. Horti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte Biomarkers in Alzheimer’s Disease

(2019) Stephen F. Carter et al.   TRENDS IN MOLECULAR MEDICINE

Preclinical evaluation and non-human primate receptor occupancy study of 18F-JNJ-64413739, a novel PET radioligand for P2X7 receptors

(2019) Hartmuth Kolb et al.   JOURNAL OF NUCLEAR MEDICINE

Role of epoxy-fatty acids and epoxide hydrolases in the pathology of neuro-inflammation

(2019) Sean D. Kodani et al.   BIOCHIMIE

New and Old TSPO PET Radioligands for Imaging Brain Microglial Activation in Neurodegenerative Disease

(2019) Laura Best et al.   Current Neurology and Neuroscience Reports

An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo

(2019) Cuihua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

[11C]JNJ54173717, a novel P2X7 receptor radioligand as marker for neuroinflammation: human biodistribution, dosimetry, brain kinetic modelling and quantification of brain P2X7 receptors in patients with Parkinson’s disease and healthy volunteers

(2019) Donatienne Van Weehaeghe et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Recent Developments in TSPO PET Imaging as A Biomarker of Neuroinflammation in Neurodegenerative Disorders

(2019) Eryn L. Werry et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Myeloid sphingosine-1-phosphate receptor 1 is important for CNS autoimmunity and neuroinflammation

(2019) Hsing-Chuan Tsai et al.   JOURNAL OF AUTOIMMUNITY

Synthesis and characterization of novel radiofluorinated probes for positron emission tomography imaging of monoamine oxidase B

(2019) Mitsuyoshi Yoshimoto et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke

(2019) Ruslan Rust et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TAM Receptor Pathways at the Crossroads of Neuroinflammation and Neurodegeneration

(2019) Giacomo Tondo et al.   DISEASE MARKERS

Structural Basis for Achieving GSK-3 Inhibition with High Potency, Selectivity and Brain Exposure for PET Imaging and Drug Discovery

(2019) Vadim Bernard-Gauthier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phosphodiesterase 7 Regulation in Cellular and Rodent Models of Parkinson’s Disease

(2019) Jose A. Morales-Garcia et al.   MOLECULAR NEUROBIOLOGY

Neuroinflammation as a Common Feature of Neurodegenerative Disorders

(2019) Leonardo Guzman-Martinez et al.   Frontiers in Pharmacology

Automated production of a sphingosine-1 phosphate receptor 1 (S1P1) PET radiopharmaceutical [11C]CS1P1 for human use

(2019) Zonghua Luo et al.   APPLIED RADIATION AND ISOTOPES

The P2X7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study

(2019) Marloes H. J. Hagens et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Attenuation of Ischemic Stroke-Caused Brain Injury by a Monoamine Oxidase Inhibitor Involves Improved Proteostasis and Reduced Neuroinflammation

(2019) Yanying Liu et al.   MOLECULAR NEUROBIOLOGY

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

(2019) Elizabeth Spangenberg et al.   Nature Communications

Structure–Activity Relationship Studies of Pyridine-Based Ligands and Identification of a Fluorinated Derivative for Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors

(2019) Ahmed Haider et al.   JOURNAL OF MEDICINAL CHEMISTRY

Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis

(2019) Joachim W. Deitmer et al.   Frontiers in Neuroscience

3-Substituted 1,5-Diaryl-1H-1,2,4-triazoles as Prospective PET Radioligands for Imaging Brain COX-1 in Monkey. Part 1: Synthesis and Pharmacology

(2018) Prachi Singh et al.   ACS Chemical Neuroscience

3-Substituted 1,5-Diaryl-1H-1,2,4-triazoles as Prospective PET Radioligands for Imaging Brain COX-1 in Monkey. Part 2: Selection and Evaluation of [11C]PS13 for Quantitative Imaging

(2018) Stal Shrestha et al.   ACS Chemical Neuroscience

T80. Novel PET Radioligands Show That COX-2, but not COX-1, is Induced by Neuroinflammation in Rhesus Macaque

(2018) Evan Gallagher et al.   BIOLOGICAL PSYCHIATRY

Synthesis and preliminary biological evaluation of a novel P2X7R radioligand [ 18 F]IUR-1601

(2018) Mingzhang Gao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Radiosynthesis and in vivo evaluation of [ 11 C]MOV as a PET imaging agent for COX-2

(2018) Jaya Prabhakaran et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Syntheses and in vitro evaluation of new S1PR1 compounds and initial evaluation of a lead F-18 radiotracer in rodents

(2018) Zonghua Luo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of 4-oxo-quinoline-based CB2 PET radioligands in R6/2 chorea huntington mouse model and human ALS spinal cord tissue

(2018) Ahmed Haider et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Extracellular α-synuclein drives sphingosine 1-phosphate receptor subtype 1 out of lipid rafts, leading to impaired inhibitory G-protein signaling

(2018) Shaymaa Mohamed Mohamed Badawy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cannabinoid CB2 receptors in the mouse brain: relevance for Alzheimer’s disease

(2018) Alicia López et al.   Journal of Neuroinflammation

Evaluation of Two Potent and Selective PET Radioligands to Image COX-1 and COX-2 in Rhesus Monkeys

(2018) Min-Jeong Kim et al.   JOURNAL OF NUCLEAR MEDICINE

Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3

(2018) Celeste Sassi et al.   NEUROBIOLOGY OF AGING

Identification of the allosteric P2X7 receptor antagonist [11C]SMW139 as a PET tracer of microglial activation

(2018) Bieneke Janssen et al.   Scientific Reports

Chemistry for Positron Emission Tomography: Recent Advances in 11C-, 18F-, 13N- and 15O-labeling Reactions

(2018) Xiaoyun Deng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis, pharmacology and preclinical evaluation of 11C-labeled 1,3-dihydro-2H-benzo[d]imidazole-2-ones for imaging γ8-dependent transmembrane AMPA receptor regulatory protein

(2018) Zhen Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N-Methyl-d-aspartate (NMDA), α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA), and Kainate Receptors

(2018) Hualong Fu et al.   JOURNAL OF MEDICINAL CHEMISTRY

18F-JNJ-64413739, a novel PET ligand for the P2X7 ion channel: radiation dosimetry, kinetic modeling, test-retest variability and occupancy of the P2X7 antagonist JNJ-54175446

(2018) Michel Koole et al.   JOURNAL OF NUCLEAR MEDICINE

In Vivo Brain Imaging, Biodistribution, and Radiation Dosimetry Estimation of [11C]Celecoxib, a COX-2 PET Ligand, in Nonhuman Primates

(2018) J. Kumar et al.   MOLECULES

New approaches and challenges to targeting the endocannabinoid system

(2018) Vincenzo Di Marzo   NATURE REVIEWS DRUG DISCOVERY

Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO

(2018) Vidya Narayanaswami et al.   Molecular Imaging

In vivo evaluation of [11C]TMI, a COX-2 selective PET tracer, in baboons

(2018) J.S. Dileep Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Preclinical evaluation of [18 F]MA3, a CB2 receptor agonist radiotracer for Positron Emission Tomography

(2018) Bala Attili et al.   BRITISH JOURNAL OF PHARMACOLOGY

Design of selective COX-2 inhibitors in the (aza)indazole series. Chemistry, in vitro studies, radiochemistry and evaluations in rats of a [18F] PET tracer

(2018) Jonathan Elie et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

2-(4-Methylsulfonylphenyl)pyrimidines as Prospective Radioligands for Imaging Cyclooxygenase-2 with PET—Synthesis, Triage, and Radiolabeling

(2018) Michelle Cortes-Salva et al.   MOLECULES

Treatment of multiple sclerosis — success from bench to bedside

(2018) Mar Tintore et al.   Nature Reviews Neurology

PET imaging of cannabinoid type 2 receptors with [11C]A-836339 did not evidence changes following neuroinflammation in rats

(2017) Geraldine Pottier et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging

(2017) Lei Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vivo PET imaging of neuroinflammation in Alzheimer’s disease

(2017) Julien Lagarde et al.   JOURNAL OF NEURAL TRANSMISSION

Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis

(2017) Wissam Beaino et al.   Journal of Neuroinflammation

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Cannabinoid receptor type 2 (CB2) as one of the candidate genes in human carotid plaque imaging: Evaluation of the novel radiotracer [ 11 C]RS-016 targeting CB2 in atherosclerosis

(2017) Romana Meletta et al.   NUCLEAR MEDICINE AND BIOLOGY

Evaluation of a novel radiotracer for positron emission tomography imaging of reactive oxygen species in the central nervous system

(2017) Alan A. Wilson et al.   NUCLEAR MEDICINE AND BIOLOGY

Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response

(2017) Junbin Han et al.   NUCLEAR MEDICINE COMMUNICATIONS

Development of [18F]Maleimide-Based Glycogen Synthase Kinase-3β Ligands for Positron Emission Tomography Imaging

(2017) Kongzhen Hu et al.   ACS Medicinal Chemistry Letters

Studies on Colony Stimulating Factor Receptor-1 and Ligands Colony Stimulating Factor-1 and Interleukin-34 in Alzheimer's Disease Brains and Human Microglia

(2017) Douglas G. Walker et al.   Frontiers in Aging Neuroscience

A Coordinate-Based Meta-Analysis of Overlaps in Regional Specialization and Functional Connectivity across Subjective Value and Default Mode Networks

(2017) M. Yavuz Acikalin et al.   Frontiers in Neuroscience

Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7

(2017) Enrico Raffaele Fantoni et al.   EJNMMI Research

Radiochemistry on electrodes: Synthesis of an 18F-labelled and in vivo stable COX-2 inhibitor

(2017) Artem Lebedev et al.   PLoS One

Synthesis and Evaluation of [18F]RAGER: A First Generation Small-Molecule PET Radioligand Targeting the Receptor for Advanced Glycation Endproducts

(2016) Brian P. Cary et al.   ACS Chemical Neuroscience

Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging

(2016) Steven H. Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

(2016) Adrian Olmos-Alonso et al.   BRAIN

CSF1 Overexpression Promotes High-Grade Glioma Formation without Impacting the Polarization Status of Glioma-Associated Microglia and Macrophages

(2016) I. De et al.   CANCER RESEARCH

The CB2 receptor and its role as a regulator of inflammation

(2016) Caroline Turcotte et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

[11C]Ascorbic and [11C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography

(2016) V. N. Carroll et al.   CHEMICAL COMMUNICATIONS

Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation

(2016) Hsing-Chuan Tsai et al.   DRUGS

Decreased in vivo availability of the cannabinoid type 2 receptor in Alzheimer’s disease

(2016) Rawaha Ahmad et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

P2Y12receptor is expressed on human microglia under physiological conditions throughout development and is sensitive to neuroinflammatory diseases

(2016) Alexander Mildner et al.   GLIA

PDE4B as a microglia target to reduce neuroinflammation

(2016) Damien D. Pearse et al.   GLIA

Development of a High-Affinity PET Radioligand for Imaging Cannabinoid Subtype 2 Receptor

(2016) Rareş-Petru Moldovan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and In Vitro and In Vivo Evaluation of an 18F-Labeled Sphingosine 1-Phosphate Receptor 1 (S1P1) PET Tracer

(2016) Adam J. Rosenberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a fluorinated 4-oxo-quinoline derivative as a potential positron emission tomography radiotracer for imaging cannabinoid receptor type 2

(2016) Roger Slavik et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation: the devil is in the details

(2016) Damon J. DiSabato et al.   JOURNAL OF NEUROCHEMISTRY

A promising carbon-11-labeled sphingosine-1-phosphate receptor 1-specific PET tracer for imaging vascular injury

(2016) Hongjun Jin et al.   JOURNAL OF NUCLEAR CARDIOLOGY

18F-FNDP for PET Imaging of Soluble Epoxide Hydrolase

(2016) A. G. Horti et al.   JOURNAL OF NUCLEAR MEDICINE

Preclinical Evaluation of a P2X7 Receptor-Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates

(2016) D. Ory et al.   JOURNAL OF NUCLEAR MEDICINE

Characterization of 11 C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation

(2016) Paul R. Territo et al.   JOURNAL OF NUCLEAR MEDICINE

The 5-HT1A Receptor PET Radioligand 11C-CUMI-101 Has Significant Binding to  1-Adrenoceptors in Human Cerebellum, Limiting Its Use as a Reference Region

(2016) S. S. Shrestha et al.   JOURNAL OF NUCLEAR MEDICINE

PET/CT Imaging of Chemokine Receptors in Inflammatory Atherosclerosis Using Targeted Nanoparticles

(2016) H. P. Luehmann et al.   JOURNAL OF NUCLEAR MEDICINE

Role of neuroinflammation in neurodegenerative diseases (Review)

(2016) WEI-WEI CHEN et al.   Molecular Medicine Reports

Novel Radioligands for Cyclic Nucleotide Phosphodiesterase Imaging with Positron Emission Tomography: An Update on Developments Since 2012

(2016) Susann Schröder et al.   MOLECULES

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Purinergic mechanisms in neuroinflammation: An update from molecules to behavior

(2016) Edward Beamer et al.   NEUROPHARMACOLOGY

An introduction to the roles of purinergic signalling in neurodegeneration, neuroprotection and neuroregeneration

(2016) Geoffrey Burnstock   NEUROPHARMACOLOGY

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structural basis for subtype-specific inhibition of the P2X7 receptor

(2016) Akira Karasawa et al.   eLife

Synthesis, Biodistribution and In vitro Evaluation of Brain Permeable High Affinity Type 2 Cannabinoid Receptor Agonists [11C]MA2 and [18F]MA3

(2016) Muneer Ahamed et al.   Frontiers in Neuroscience

Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders

(2016) Gemma Navarro et al.   Frontiers in Neuroscience

PET imaging of cyclooxygenase-2 (COX-2) in a pre-clinical colorectal cancer model

(2016) Ole Tietz et al.   EJNMMI Research

Cyclooxygenase-1 null mice show reduced neuroinflammation in response to β-amyloid

(2016) Sang-Ho Choi et al.   Aging-US

In Vivo Metabolic Trapping Radiotracers for Imaging Monoamine Oxidase-A and -B Enzymatic Activity

(2015) Allen F. Brooks et al.   ACS Chemical Neuroscience

Emerging role of P2X7 receptors in CNS health and disease

(2015) Manju Tewari et al.   AGEING RESEARCH REVIEWS

Radiosynthesis and preliminary PET evaluation of glycogen synthase kinase 3β (GSK-3β) inhibitors containing [11C]methylsulfanyl, [11C]methylsulfinyl or [11C]methylsulfonyl groups

(2015) Katsushi Kumata et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of [11C]GSK1482160 as a new PET agent for targeting P2X7 receptor

(2015) Mingzhang Gao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Radiosynthesis and ex vivo evaluation of [18F]-(S)-3-(6-(3-fluoropropoxy)benzo[d]isoxazol-3-yl)-5-(methoxymethyl)oxazolidin-2-one for imaging MAO-B with PET

(2015) Justin W. Hicks et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson’s disease

(2015) Aurelija Jucaite et al.   BRAIN

Design, Synthesis, and Evaluation of an18F-Labeled Radiotracer Based on Celecoxib-NBD for Positron Emission Tomography (PET) Imaging of Cyclooxygenase-2 (COX-2)

(2015) Jatinder Kaur et al.   ChemMedChem

Synthesis, radiolabeling and evaluation of novel 4-oxo-quinoline derivatives as PET tracers for imaging cannabinoid type 2 receptor

(2015) Roger Slavik et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists

(2015) Sari Yrjölä et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Imaging S1P1 activation in vivo

(2015) Mari Kono et al.   EXPERIMENTAL CELL RESEARCH

A 11C-Labeled 1,4-Dihydroquinoline Derivative as a Potential PET Tracer for Imaging of Redox Status in Mouse Brain

(2015) Toshimitsu Okamura et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy

(2015) Richard L. Proia et al.   JOURNAL OF CLINICAL INVESTIGATION

Synthesis and Evaluation of Fluorinated Fingolimod (FTY720) Analogues for Sphingosine-1-Phosphate Receptor Molecular Imaging by Positron Emission Tomography

(2015) Rizwan S. Shaikh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a High Affinity and Selective Pyridine Analog as a Potential Positron Emission Tomography Imaging Agent for Cannabinoid Type 2 Receptor

(2015) Roger Slavik et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Vivo and In Vitro Characterization of a Novel MAO-B Inhibitor Radioligand, 18F-Labeled Deuterated Fluorodeprenyl

(2015) S. Nag et al.   JOURNAL OF NUCLEAR MEDICINE

18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease

(2015) R. Harada et al.   JOURNAL OF NUCLEAR MEDICINE

Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia

(2015) Alessio Molfino et al.   MEDIATORS OF INFLAMMATION

Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus

(2015) Asheebo Rojas et al.   NEUROPHARMACOLOGY

The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders

(2015) G.Z. Réus et al.   NEUROSCIENCE

Synthesis and preclinical evaluation of an 18 F labeled PDE7 inhibitor for PET neuroimaging

(2015) David Thomae et al.   NUCLEAR MEDICINE AND BIOLOGY

A potent and selective C-11 labeled PET tracer for imaging sphingosine-1-phosphate receptor 2 in the CNS demonstrates sexually dimorphic expression

(2015) Xuyi Yue et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and Initial in Vivo Studies with [11C]SB-216763: The First Radiolabeled Brain Penetrative Inhibitor of GSK-3

(2015) Lei Li et al.   ACS Medicinal Chemistry Letters

Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation

(2015) Alena V. Savonenko et al.   PLoS One

Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance

(2014) Ana I. Rojo et al.   ANTIOXIDANTS & REDOX SIGNALING

Synthesis of fluorinated analogues of sphingosine-1-phosphate antagonists as potential radiotracers for molecular imaging using positron emission tomography

(2014) Vysakh Pushpa Prasad et al.   BIOORGANIC & MEDICINAL CHEMISTRY

5-(4-((4-[18F]fluorobenzyl)oxy)-3-methoxybenzyl)pyrimidine-2,4-diamine: A selective dual inhibitor for potential PET imaging of Trk/CSF-1R

(2014) Vadim Bernard-Gauthier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Radioligand development for molecular imaging of the central nervous system with positron emission tomography

(2014) Michael Honer et al.   DRUG DISCOVERY TODAY

Astrocytosis measured by 11C-deprenyl PET correlates with decrease in gray matter density in the parahippocampus of prodromal Alzheimer’s patients

(2014) IL Han Choo et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Kinetic Modeling of the Monoamine Oxidase B Radioligand [11C]SL25.1188 in Human Brain with High-Resolution Positron Emission Tomography

(2014) Pablo M Rusjan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility

(2014) Lillian Cruz-Orengo et al.   JOURNAL OF CLINICAL INVESTIGATION

Synthesis and initial preclinical evaluation of the P2X7receptor antagonist [11C]A-740003 as a novel tracer of neuroinflammation

(2014) Bieneke Janssen et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

An update on the biology of sphingosine 1-phosphate receptors

(2014) Victoria A. Blaho et al.   JOURNAL OF LIPID RESEARCH

Positron Emission Tomography in CNS Drug Discovery and Drug Monitoring

(2014) Markus Piel et al.   JOURNAL OF MEDICINAL CHEMISTRY

P2Y12Receptor on the Verge of a Neuroinflammatory Breakdown

(2014) Susanna Amadio et al.   MEDIATORS OF INFLAMMATION

Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity

(2014) Gabriel Olmos et al.   MEDIATORS OF INFLAMMATION

Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses

(2014) Yanyan Yang et al.   MEDIATORS OF INFLAMMATION

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Emerging targets in neuroinflammation-driven chronic pain

(2014) Ru-Rong Ji et al.   NATURE REVIEWS DRUG DISCOVERY

Human whole-body biodistribution and dosimetry of a new PET tracer, [11C]ketoprofen methyl ester, for imagings of neuroinflammation

(2014) Akihito Ohnishi et al.   NUCLEAR MEDICINE AND BIOLOGY

Synthesis and evaluation of [11C]PyrATP-1, a novel radiotracer for PET imaging of glycogen synthase kinase-3β (GSK-3β)

(2014) Erin L. Cole et al.   NUCLEAR MEDICINE AND BIOLOGY

Development of a PET radiotracer for non-invasive imaging of the reactive oxygen species, superoxide, in vivo

(2014) Wenhua Chu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease

(2014) Johnatan Ceccom et al.   Acta Neuropathologica Communications

Development of a novel fluorine-18 labeled deuterated fluororasagiline ([18F]fluororasagiline-D2) radioligand for PET studies of monoamino oxidase B (MAO-B)

(2013) S. Nag et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and preliminary evaluation of a new fluorine-18 labelled triazine derivative for PET imaging of cannabinoid CB2 receptor

(2013) Laurent Hortala et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Assessment of radioligands for PET imaging of cyclooxygenase-2 in an ischemic neuronal injury model

(2013) Bin Ji et al.   BRAIN RESEARCH

TAM receptor tyrosine kinases: Expression, disease and oncogenesis in the central nervous system

(2013) Angela M. Pierce et al.   BRAIN RESEARCH

Neuroinflammation and the generation of neuropathic pain

(2013) A Ellis et al.   BRITISH JOURNAL OF ANAESTHESIA

Recent Development of CB2 Selective and Peripheral CB1/CB2 Cannabinoid Receptor Ligands

(2013) Tapio Nevalainen   CURRENT MEDICINAL CHEMISTRY

Synthesis, structure–property relationships and pharmacokinetic evaluation of ethyl 6-aminonicotinate sulfonylureas as antagonists of the P2Y12 receptor

(2013) Peter Bach et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Microglia release ATP by exocytosis

(2013) Yoshio Imura et al.   GLIA

Distribution of Monoamine Oxidase Proteins in Human Brain: Implications for Brain Imaging Studies

(2013) Junchao Tong et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Substituted 7-Amino-5-thio-thiazolo[4,5-d]pyrimidines as Potent and Selective Antagonists of the Fractalkine Receptor (CX3CR1)

(2013) Sofia Karlström et al.   JOURNAL OF MEDICINAL CHEMISTRY

Radiolabeling andin vitro/in vivoevaluation of N-(1-adamantyl)-8-methoxy-4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxamide as a PET probe for imaging cannabinoid type 2 receptor

(2013) Linjing Mu et al.   JOURNAL OF NEUROCHEMISTRY

Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury

(2013) I. B. Wanner et al.   JOURNAL OF NEUROSCIENCE

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Whole-Body Biodistribution and Radiation Dosimetry of the Cannabinoid Type 2 Receptor Ligand [11C]-NE40 in Healthy Subjects

(2013) Rawaha Ahmad et al.   MOLECULAR IMAGING AND BIOLOGY

Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation

(2013) Christopher S Garris et al.   NATURE IMMUNOLOGY

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Emerging roles of astrocytes in neural circuit development

(2013) Laura E. Clarke et al.   NATURE REVIEWS NEUROSCIENCE

The structure and function of the S1P1 receptor

(2013) Catherine O'Sullivan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1

(2013) C Rutherford et al.   Cell Death & Disease

Role of Redox Signaling in Neuroinflammation and Neurodegenerative Diseases

(2013) Hsi-Lung Hsieh et al.   Biomed Research International

Synthesis and evaluation of [18F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B)

(2012) S. Nag et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [11C-carbonyl] AR-A014418 by [11C]CO2 fixation

(2012) Justin W. Hicks et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

P2Y Receptors in the Mammalian Nervous System: Pharmacology, Ligands and Therapeutic Potential

(2012) Gary A. Weisman et al.   CNS & Neurological Disorders-Drug Targets

Multitarget-Directed Benzylideneindanone Derivatives: Anti-β-Amyloid (Aβ) Aggregation, Antioxidant, Metal Chelation, and Monoamine Oxidase B (MAO-B) Inhibition Properties against Alzheimer’s Disease

(2012) Ling Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease

(2012) Sang-Ho Choi et al.   JOURNAL OF NEUROCHEMISTRY

Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor

(2012) Chao Li et al.   JOURNAL OF NEUROPHYSIOLOGY

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by 11C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining 11C-Pittsburgh Compound B and 18F-FDG

(2012) S. F. Carter et al.   JOURNAL OF NUCLEAR MEDICINE

Neuromodulation by Extracellular ATP and P2X Receptors in the CNS

(2012) Baljit S. Khakh et al.   NEURON

Robust spinal neuroinflammation mediates mechanical allodynia in Walker 256 induced bone cancer rats

(2012) Qi-Liang Mao-Ying et al.   Molecular Brain

Knowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug Discovery

(2011) Arup K. Ghose et al.   ACS Chemical Neuroscience

Inflammation Induced by Infection Potentiates Tau Pathological Features in Transgenic Mice

(2011) Michael Sy et al.   AMERICAN JOURNAL OF PATHOLOGY

Efficient synthesis and chiral separation of 11C-labeled ibuprofen assisted by DMSO for imaging of in vivo behavior of the individual isomers by positron emission tomography

(2011) Tatsuya Kikuchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

BZM055, an Iodinated Radiotracer Candidate for PET and SPECT Imaging of Myelin and FTY720 Brain Distribution

(2011) Emmanuelle Briard et al.   ChemMedChem

Monoamine Oxidase A Expression Is Vital for Embryonic Brain Development by Modulating Developmental Apoptosis

(2011) Chi Chiu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Radiosynthesis of [11C]SL25.1188 via [11C]CO2 fixation for imaging monoamine oxidase B

(2011) Neil Vasdev et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Transcriptional regulation and multiple functions of MAO genes

(2011) Jean C. Shih et al.   JOURNAL OF NEURAL TRANSMISSION

In Vivo Expression of Cyclooxygenase-1 in Activated Microglia and Macrophages During Neuroinflammation Visualized by PET with 11C-Ketoprofen Methyl Ester

(2011) M. Shukuri et al.   JOURNAL OF NUCLEAR MEDICINE

Preclinical evaluation of [11C]NE40, a type 2 cannabinoid receptor PET tracer

(2011) Nele Evens et al.   NUCLEAR MEDICINE AND BIOLOGY

Polymorphisms in the Receptor Tyrosine Kinase MERTK Gene Are Associated with Multiple Sclerosis Susceptibility

(2011) Gerry Z. M. Ma et al.   PLoS One

In vivo evaluation in cynomolgus monkey brain and metabolism of [18F]fluorodeprenyl: A new MAO-B pet radioligand

(2011) Sangram Nag et al.   SYNAPSE

Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior

(2010) Michael M. Halassa et al.   Annual Review of Physiology

P2X7 Receptor Signaling Pathway as a Therapeutic Target for Neurodegenerative Diseases

(2010) Takato Takenouchi et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Lipid mediators in the nucleus: Their potential contribution to Alzheimer's disease

(2010) Akhlaq A. Farooqui et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Targeting cyclooxygenases-1 and -2 in neuroinflammation: Therapeutic implications

(2010) Saba Aïd et al.   BIOCHIMIE

Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2)

(2010) Andrew G. Horti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions

(2010) Ruben Van Doorn et al.   GLIA

Microglia: Proliferation and activation driven by the P2X7 receptor

(2010) Mastura Monif et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cyclooxygenase-1 mediates prostaglandin E2 elevation and contextual memory impairment in a model of sustained hippocampal interleukin-1β expression

(2010) Sarah B. Matousek et al.   JOURNAL OF NEUROCHEMISTRY

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Activated MAO-B in the brain of Alzheimer patients, demonstrated by [11C]-l-deprenyl using whole hemisphere autoradiography

(2010) Balázs Gulyás et al.   NEUROCHEMISTRY INTERNATIONAL

Uptake and regional distribution of [11C]rofecoxib in human brain

(2010) Robert A. Comley et al.   NEUROIMAGE

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

(2010) Jeffrey A. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

(2010) J. W. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changing Face of Microglia

(2010) M. B. Graeber   SCIENCE

Up-Regulation of Soluble Axl and Mer Receptor Tyrosine Kinases Negatively Correlates with Gas6 in Established Multiple Sclerosis Lesions

(2009) Jason G. Weinger et al.   AMERICAN JOURNAL OF PATHOLOGY

Assessment of MAO-B Occupancy in the Brain With PET and [11C]-L-Deprenyl-D2: A Dose-Finding Study With a Novel MAO-B Inhibitor, EVT 301

(2009) J Hirvonen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

CX3CR1+CD115+CD135+common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation

(2009) Cedric Auffray et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential gene expression in LPS/IFNγ activated microglia and macrophages:in vitroversusin vivo

(2009) Christoph D. Schmid et al.   JOURNAL OF NEUROCHEMISTRY

Synthesis and biological evaluation of carbon-11- and fluorine-18-labeled 2-oxoquinoline derivatives for type 2 cannabinoid receptor positron emission tomography imaging

(2009) Nele Evens et al.   NUCLEAR MEDICINE AND BIOLOGY

[11C]SL25.1188, a new reversible radioligand to study the monoamine oxidase type B with PET: Preclinical characterisation in nonhuman primate

(2009) Wadad Saba et al.   SYNAPSE

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Monoamine oxidase inactivation: From pathophysiology to therapeutics☆

(2008) Marco Bortolato et al.   ADVANCED DRUG DELIVERY REVIEWS

Synthesis of11C,18F,15O, and13N Radiolabels for Positron Emission Tomography

(2008) Philip W. Miller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and evaluation in vitro and in vivo of a 11C-labeled cyclooxygenase-2 (COX-2) inhibitor

(2008) Frank Wuest et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular Imaging with PET

(2008) Simon M. Ametamey et al.   CHEMICAL REVIEWS

Cyclooxygenase-2 in Synaptic Signaling

(2008) Hongwei Yang et al.   CURRENT PHARMACEUTICAL DESIGN

Role of CX3CR1 (Fractalkine Receptor) in Brain Damage and Inflammation Induced by Focal Cerebral Ischemia in Mouse

(2008) Ádám Dénes et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2

(2008) Saba Aid et al.   Journal of Neuroinflammation

STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

(2008) J. E. Herrmann et al.   JOURNAL OF NEUROSCIENCE

Molecular imaging in drug development

(2008) Jürgen K. Willmann et al.   NATURE REVIEWS DRUG DISCOVERY

Purinergic signalling and disorders of the central nervous system

(2008) Geoffrey Burnstock   NATURE REVIEWS DRUG DISCOVERY

Can the immune system be harnessed to repair the CNS?

(2008) Phillip G. Popovich et al.   NATURE REVIEWS NEUROSCIENCE

MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology

(2008) Jyothi K. Mallajosyula et al.   PLoS One

Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury

(2007) Sang-Ho Choi et al.   FASEB JOURNAL

Evaluation of [11C]rofecoxib as PET tracer for cyclooxygenase 2 overexpression in rat models of inflammation

(2007) Erik F.J. de Vries et al.   NUCLEAR MEDICINE AND BIOLOGY

Temperature-dependent thermomechanical noise spectra of doped silicon microcantilevers

(2007) Jungchul Lee et al.   SENSORS AND ACTUATORS A-PHYSICAL