Article
Oncology
Lisbeth Marner, Michael Lundemann, Astrid Sehested, Karsten Nysom, Lise Borgwardt, Rene Mathiasen, Peder S. Wehner, Otto M. Henriksen, Carsten Thomsen, Jane Skjoth-Rasmussen, Helle Broholm, Olga Ostrup, Julie L. Forman, Liselotte Hojgaard, Ian Law
Summary: The study found that adding [F-18]FET PET to MRI in pediatric CNS tumor patients significantly improved diagnostic accuracy, especially in treated lesions. This combination imaging technique helps differentiate tumor from non-tumor lesions more effectively, with a substantial impact on clinical management and decision-making.
Article
Biochemistry & Molecular Biology
Isaac M. Jackson, E. William Webb, Peter J. H. Scott, Michelle L. James
Summary: This article discusses the importance of PET technology and its applications in studying the central nervous system. It also highlights the challenges and limitations in developing CNS PET tracers. Additionally, it explores the potential applications and impact of computational methods in the design of CNS radiotracers.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Chaitanya Rojulpote, Abhijit Bhattaru, Christopher Jean, Sarah L. Adams, Vandan Patel, Mahesh K. Vidula, Senthil Selvaraj, Jacob Dubroff, Eliot Peyster, Caitlin B. Clancy, Karen Patterson, Francis E. Marchlinski, Milton Rossman, Lee Goldberg, Paco E. Bravo
Summary: This study investigated the effect of immunosuppressive therapy and biopsy status on myocardial FDG-PET/CT in assessing treatment response in patients with suspected cardiac sarcoidosis. The results showed that a favorable treatment response was more common when using moderate-to-high intensity prednisone dose, and individuals with biopsy-proven sarcoidosis and preserved systolic function were less likely to experience adverse outcomes during follow-up.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Chemistry, Multidisciplinary
Libor Kostka, Lenka Kotrchova, Eva Randarova, Carolina A. Ferreira, Iva Malatova, Hye Jin Lee, Aeli P. Olson, Jonathan W. Engle, Marek Kovar, Weibo Cai, Milada Sirova, Tomas Etrych
Summary: nanomedicines are being developed as an improved therapeutic option with reduced side effects, and this study introduces tailored nanosystems for the treatment of solid tumors or hematological malignancies. The relationship between the structure of the nanosystem and its distribution in the body was evaluated through independent assessments of the polymer carrier and drug pharmacokinetics. The results showed enhanced tumor accumulation of the polymer carriers in mice with solid tumors, as well as significant accumulation of doxorubicin bound to the polymer carriers in specific tumor types.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wipawee Morakote, Lucia Baratto, Shakthi K. Ramasamy, Lisa C. Adams, Tie Liang, Amir H. Sarrami, Heike E. Daldrup-Link
Summary: Whole-body diffusion-weighted imaging (WB-DWI) and 18F-fluorodeoxyglucose ([F-18]FDG) PET/MRI can be used to compare tumor therapy response assessments in pediatric patients with Hodgkin lymphoma and non-Hodgkin lymphoma. The study found that therapy response of Hodgkin lymphoma can be evaluated with either [F-18]FDG PET or WB-DWI, whereas patients with non-Hodgkin lymphoma may benefit from a combined approach.
EUROPEAN RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Ou Yamaguchi, Kyoichi Kaira, Ichiro Naruse, Yukihiro Umeda, Takeshi Honda, Satoshi Watanabe, Kosuke Ichikawa, Kazunari Tateishi, Norimitsu Kasahara, Tetsuya Higuchi, Kosuke Hashimoto, Shun Shinomiya, Yu Miura, Ayako Shiono, Atsuto Mouri, Hisao Imai, Kunihiko Iizuka, Tamotsu Ishizuka, Koichi Minato, Satoshi Suda, Hiroshi Kagamu, Keita Mori, Ichiei Kuji, Nobuhiko Seki
Summary: This study aimed to investigate the clinical relevance of F-18-FDG PET/CT compared to CT in predicting the response to PD-1 blockade in the early phase. The results showed that metabolic assessment by MTV or TLG was superior to morphological changes on CT for predicting the therapeutic response and survival.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Ying Zhang, Tao Wang, Xiaojun Zhang, Winnie Deuther-Conrad, Hualong Fu, Mengchao Cui, Jinming Zhang, Peter Brust, Yiyun Huang, Hongmei Jia
Summary: In this study, a series of indole-based derivatives were synthesized as novel sigma-2 receptor ligands, and two ligands with high affinity and selectivity were radiolabeled with F-18. Biodistribution studies in rodents showed that the radioligand [F-18]9 displayed high brain uptake and brain-to-blood ratio. Pre-treatment experiments and ex vivo autoradiography confirmed the specific binding of [F-18]9 to sigma-2 receptors in the brain. Dynamic positron emission tomography imaging further confirmed the regional distribution and specific binding of [F-18]9 in the rat brain.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Biochemistry & Molecular Biology
Sonia Balestri, Alice Del Giovane, Carola Sposato, Marta Ferrarelli, Antonella Ragnini-Wilson
Summary: The myelin sheath wraps around axons for saltatory currents transmission and can be damaged by various factors, leading to neurodegeneration. Drugs promoting CNS remyelination are promising but face challenges, such as timing of administration and failure in neurodegenerative pathologies, as well as the need to recreate disease-relevant environments for drug screening. Recent biological findings on oligodendrocyte maturation and brain repair post-myelin injury may impact future drug screening campaigns for CNS regenerative drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Emily A. Largent, Joshua D. Grill, Kyra O'Brien, David Wolk, Kristin Harkins, Jason Karlawish
Summary: Alzheimer's Disease (AD) is characterized by three pathologic processes: beta-amyloid, hyperphosphorylated tau, and neurodegeneration. Advances in measuring biomarkers of these processes have led to a growing interest in using AD biomarker tests in care and research. Therefore, a 5-step approach is proposed, including determining the appropriateness of testing, providing pretest education and consent, administering the test, disclosing the results, and follow-up for well-being.
Review
Biochemistry & Molecular Biology
Christophe van de Wiele, Sezgin Ustmert, Bart De Spiegeleer, Pieter-Jan De Jonghe, Mike Sathekge, Maes Alex
Summary: Various potential PET-apoptosis imaging radiopharmaceuticals have been developed to assess the response to cancer treatment. Some of these radiopharmaceuticals showed enhanced uptake in xenografted tumors in mice, but to varying degrees. Two validated radioligands showed favorable characteristics in healthy individuals, but did not significantly affect bone marrow. Further research is needed to evaluate the clinical value of these radiopharmaceuticals for apoptosis imaging in cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ivan Ho Shon, Thomas Hennessy, Jennifer Guille, Michael P. Gotsbacher, Angelina J. Lay, Bruce McBride, Rachel Codd, Philip J. Hogg
Summary: This study evaluates the biodistribution, radiation dosimetry, safety, and tumor uptake of the novel radiopharmaceutical GA-68 ([GA-68] GA-CDI) for imaging multiple forms of cell death. The results demonstrate that GA-68 ([GA-68] GA-CDI) is safe, has low radiation dosimetry, and excellent biodistribution and imaging characteristics. It shows potential advantages over previous radiopharmaceuticals for imaging cell death and has progressed to a proof-of-concept trial.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Biology
Benjamin Haenisch, Justine Y. Hansen, Boris C. Bernhardt, Simon B. Eickhoff, Juergen Dukart, Bratislav Misic, Sofie Louise Valk
Summary: This study investigates the role of neurotransmitter transporter and receptor molecules in the structure-function relationships in the human brain. Using positron-emission tomography imaging studies of 19 different neurotransmitter transporters and receptors, the researchers discovered three main spatial gradients of chemoarchitectural similarity in the cortical and subcortical regions of the brain. The findings show that the organization of the receptome shares similarities with functional and structural brain anatomy.
Article
Chemistry, Multidisciplinary
Irene Hernandez-Lozano, Severin Mairinger, Thomas Filip, Michael Sauberer, Thomas Wanek, Johann Stanek, Johannes A. Sake, Thomas Pekar, Carsten Ehrhardt, Oliver Langer
Summary: The study demonstrates that P-glycoprotein can affect the pulmonary disposition of inhaled drugs, with decreased P-gp activity potentially leading to lower lung exposure and decreased therapeutic efficacy. PET imaging with intratracheally aerosolized radiotracers shows promise for assessing the impact of membrane transporters on pulmonary drug delivery in both rodents and potentially in humans.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Inorganic & Nuclear
Sebastien Schmitt, Emmanuel Moreau
Summary: This article reviews all the radiolabeling conditions with chelators used since 2009, aiming to determine the most efficient conditions for the rapid development of future radiotracers. Additionally, it focuses on the limitations of this strategy, particularly in terms of automation.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Freba Grawe, Franziska Blom, Michael Winkelmann, Caroline Burgard, Christine Schmid-Tannwald, Lena M. Unterrainer, Gabriel T. Sheikh, Paulo L. Pfitzinger, Philipp Kazmierczak, Clemens C. Cyran, Jens Ricke, Christian G. Stief, Peter Bartenstein, Johannes Ruebenthaler, Matthias P. Fabritius, Thomas Geyer
Summary: PSMA-RADS 1.0 is a reliable method for assessing PSMA-PET/CT with strong consistency and agreement among readers. It shows great potential for establishing a standard approach to diagnosing and planning treatment for prostate cancer patients, and can be used confidently even by readers with less experience.
EUROPEAN RADIOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Lukas Greifenstein, Tilmann Grus, Johannes Nagel, Jean Phillip Sinnes, Frank Roesch
APPLIED RADIATION AND ISOTOPES
(2020)
Review
Chemistry, Inorganic & Nuclear
Zsolt Baranyai, Gyula Tircso, Frank Roesch
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vasko Kramer, Carlos Juri, Patrick J. Riss, Rossana Pruzzo, Cristian Soza-Ried, Jonathan Flores, Ana Hurtado, Frank Roesch, Pedro Chana-Cuevas, Horacio Amaral
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Divya Yadav, Sanjana Ballal, Madhav Prasad Yadav, Madhavi Tripathi, Frank Roesch, Chandrasekhar Bal
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2020)
Article
Chemistry, Medicinal
Lukas Greifenstein, Nils Engelbogen, Hanane Lahnif, Jean-Philippe Sinnes, Ralf Bergmann, Michael Bachmann, Frank Roesch
Article
Biochemistry & Molecular Biology
Giulia Orteca, Jean-Philippe Sinnes, Sara Rubagotti, Michele Iori, Pier Cesare Capponi, Markus Piel, Frank Roesch, Erika Ferrari, Mattia Asti
JOURNAL OF INORGANIC BIOCHEMISTRY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ismaheel O. Lawal, Kgomotso M. G. Mokoala, Johncy Mahapane, Janke Kleyhans, Marian Meckel, Mariza Vorster, Thomas Ebenhan, Frank Roesch, Mike M. Sathekge
Summary: This study compared the lesion detection rate of [Ga-68]Ga-PSMA-11 PET/CT, [Ga-68]Ga-NODAGA(ZOL) PET/CT, and [Tc-99m]Tc-MDP bone scan in assessing bone metastases in patients with advanced prostate cancer. The results showed that in the staging of skeletal metastases, [Ga-68]Ga-PSMA-11 PET/CT may detect more lesions than [Ga-68]Ga-NODAGA(ZOL) PET/CT and [Tc-99m]Tc-MDP bone scan.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Barbara Kreppel, Florian Christoph Gaertner, Hojjat Ahmadzadehfar, Ambreen Khawar, Frank Roesch, Stefan Kuerpig, Michael Meisenheimer, Markus Essler, Ralph Alexander Bundschuh
NUKLEARMEDIZIN-NUCLEAR MEDICINE
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Florian Rosar, Hans-Georg Buchholz, Sebastian Michels, Manuela A. Hoffmann, Markus Piel, Christopher M. Waldmann, Frank Roesch, Stefan Reuss, Mathias Schreckenberger
Article
Chemistry, Medicinal
Sascha Haeseli, Marion Holy, Markus Joksch, Carina Bergner, Andreas Wree, Jens Kurth, Aylin Cankaya, Markus Piel, Bernd J. Krause, Harald H. Sitte, Frank Roesch
Summary: The research indicates that introducing a chelator onto the lead structure through a simple hydrocarbon-linker can maintain high affinity while achieving adequate lipophilicity. However, in vivo studies show rapid clearance of the tracer and lack of specific uptake in the rodent brain, suggesting an inability to penetrate the blood-brain barrier.
Article
Radiology, Nuclear Medicine & Medical Imaging
Rene Fernandez, Elisabeth Eppard, Wencke Lehnert, Luis David Jimenez-Franco, Cristian Soza-Ried, Matias Ceballos, Jessica Ribbeck, Andreas Kluge, Frank Roesch, Marian Meckel, Konstantin Zhernosekov, Vasko Kramer, Horacio Amaral
Summary: The study evaluated the safety and dosimetry of a new therapeutic radiopharmaceutical, 177Lu-DOTA-ZOL, for bone metastasis through a series of SPECT/CT images and blood samples. Results showed fast uptake and high retention in bone lesions, with a stable average retention rate in tumor lesions after injection. The red marrow was identified as the dose-limiting organ for all patients, suggesting personalized dosimetry should be considered to prevent severe hematotoxicity.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Matthias M. Herth, Simon Ametamey, Dmitrii Antuganov, Andreas Bauman, Mathias Berndt, Allen F. Brooks, Guy Bormans, Yearn Seong Choe, Nic Gillings, Urs O. Hafeli, Michelle L. James, Klaus Kopka, Vasko Kramer, Raisa Krasikova, Jacob Madsen, Linjing Mu, Bernd Neumaier, Markus Piel, Frank Roesch, Tobias Ross, Roger Schibli, Peter J. H. Scott, Vladimir Shalgunov, Neil Vasdev, Wolfgang Wadsak, Brian M. Zeglis
Summary: Radiochemical conversion is crucial in radiopharmaceutical chemistry, measuring the efficiency of reaction by studying the transformation of components in a crude reaction mixture. On the other hand, radiochemical yield is more suited to determining the efficiency of the entire reaction process, including separation, isolation, filtration, and formulation.
NUCLEAR MEDICINE AND BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Panagiotis Kanellopoulos, Berthold A. A. Nock, Lukas Greifenstein, Richard P. P. Baum, Frank Roesch, Theodosia Maina
Summary: In this study, a new hybrid chelator DATA(5m) was introduced for PET/CT imaging of SST2R-positive tumors. The [Ga-68]Ga-DATA(5m)-LM4 tracer showed excellent binding affinity in cell and mouse models, and accurately visualized tumor lesions in a patient.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vasko Kramer, Agnete Dyssegaard, Jonathan Flores, Cristian Soza-Ried, Frank Roesch, Gitte Moos Knudsen, Horacio Amaral, Matthias M. Herth
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2020)