Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging

Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors

(2016) Guanglin Luo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging

(2016) Mukesh K. Pandey et al.   Theranostics

Radiosynthesis and preliminary PET evaluation of glycogen synthase kinase 3β (GSK-3β) inhibitors containing [11C]methylsulfanyl, [11C]methylsulfinyl or [11C]methylsulfonyl groups

(2015) Katsushi Kumata et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Synthesis and Initial in Vivo Studies with [11C]SB-216763: The First Radiolabeled Brain Penetrative Inhibitor of GSK-3

(2015) Lei Li et al.   ACS Medicinal Chemistry Letters

Lessons Learnt from Glycogen Synthase Kinase 3 Inhibitors Development for Alzheimer’s Disease

(2014) Ana Martinez et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

GSK-3 modulates cellular responses to a broad spectrum of kinase inhibitors

(2014) Curtis A Thorne et al.   Nature Chemical Biology

Synthesis and evaluation of [11C]PyrATP-1, a novel radiotracer for PET imaging of glycogen synthase kinase-3β (GSK-3β)

(2014) Erin L. Cole et al.   NUCLEAR MEDICINE AND BIOLOGY

Alternative approaches for PET radiotracer development in Alzheimer's disease: imaging beyond plaque

(2013) Jason P. Holland et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [11C-carbonyl] AR-A014418 by [11C]CO2 fixation

(2012) Justin W. Hicks et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

5-Aryl-4-carboxamide-1,3-oxazoles: Potent and selective GSK-3 inhibitors

(2012) Gabriella Gentile et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selectively Silencing GSK-3 Isoforms Reduces Plaques and Tangles in Mouse Models of Alzheimer's Disease

(2012) D. E. Hurtado et al.   JOURNAL OF NEUROSCIENCE

Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease

(2011) B. DaRocha-Souto et al.   NEUROBIOLOGY OF DISEASE

Different Susceptibility to Neurodegeneration of Dorsal and Ventral Hippocampal Dentate Gyrus: A Study with Transgenic Mice Overexpressing GSK3β

(2011) Almudena Fuster-Matanzo et al.   PLoS One

Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties

(2010) Travis T. Wager et al.   ACS Chemical Neuroscience

The first synthesis of [11C]SB-216763, a new potential PET agent for imaging of glycogen synthase kinase-3 (GSK-3)

(2010) Min Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Radiolabeled Small Molecule Protein Kinase Inhibitors for Imaging with PET or SPECT

(2010) Justin W. Hicks et al.   MOLECULES