Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO
出版年份 2018 全文链接
标题
Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO
作者
关键词
-
出版物
Molecular Imaging
Volume 17, Issue -, Pages 153601211879231
出版商
SAGE Publications
发表日期
2018-09-11
DOI
10.1177/1536012118792317
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- PET Imaging of Microglial Activation—Beyond Targeting TSPO
- (2018) Bieneke Janssen et al. MOLECULES
- The distribution of the alpha7 nicotinic acetylcholine receptor in healthy aging: An in vivo positron emission tomography study with [ 18 F]ASEM
- (2018) Jennifer M. Coughlin et al. NEUROIMAGE
- Is ‘friendly fire’ in the brain provoking Alzheimer’s disease?
- (2018) Alison Abbott NATURE
- Translocator Protein-18 kDa (TSPO) Positron Emission Tomography (PET) Imaging and Its Clinical Impact in Neurodegenerative Diseases
- (2017) Anne-Claire Dupont et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Sifting through the surfeit of neuroinflammation tracers
- (2017) Paul Cumming et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective
- (2017) Salvatore Bongarzone et al. JOURNAL OF MEDICINAL CHEMISTRY
- Neurodegenerative diseases: The immunological perspective
- (2017) Monica Molteni et al. JOURNAL OF NEUROIMMUNOLOGY
- Tau PET imaging: present and future directions
- (2017) Laure Saint-Aubert et al. Molecular Neurodegeneration
- The tau positron-emission tomography tracer AV-1451 binds with similar affinities to tau fibrils and monoamine oxidases
- (2017) Céline Vermeiren et al. MOVEMENT DISORDERS
- Neurotoxic reactive astrocytes are induced by activated microglia
- (2017) Shane A. Liddelow et al. NATURE
- Evaluation of a novel radiotracer for positron emission tomography imaging of reactive oxygen species in the central nervous system
- (2017) Alan A. Wilson et al. NUCLEAR MEDICINE AND BIOLOGY
- A useful PET probe [11C]BU99008 with ultra-high specific radioactivity for small animal PET imaging of I2-imidazoline receptors in the hypothalamus
- (2017) Kazunori Kawamura et al. NUCLEAR MEDICINE AND BIOLOGY
- Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response
- (2017) Junbin Han et al. NUCLEAR MEDICINE COMMUNICATIONS
- Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation
- (2017) Veit Rothhammer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Should We Stop Saying ‘Glia’ and ‘Neuroinflammation’?
- (2017) Roser Masgrau et al. TRENDS IN MOLECULAR MEDICINE
- Development of [18F]Maleimide-Based Glycogen Synthase Kinase-3β Ligands for Positron Emission Tomography Imaging
- (2017) Kongzhen Hu et al. ACS Medicinal Chemistry Letters
- Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain
- (2017) Kok Pin Ng et al. Alzheimers Research & Therapy
- The Search for a Subtype-Selective PET Imaging Agent for the GABAA Receptor Complex: Evaluation of the Radiotracer [11C]ADO in Nonhuman Primates
- (2017) Shu-fei Lin et al. Molecular Imaging
- Synthesis and Evaluation of [18F]RAGER: A First Generation Small-Molecule PET Radioligand Targeting the Receptor for Advanced Glycation Endproducts
- (2016) Brian P. Cary et al. ACS Chemical Neuroscience
- In Vivo Imaging of Human Neuroinflammation
- (2016) Daniel S. Albrecht et al. ACS Chemical Neuroscience
- Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging
- (2016) Steven H. Liang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- [11C]Ascorbic and [11C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography
- (2016) V. N. Carroll et al. CHEMICAL COMMUNICATIONS
- Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging
- (2016) Victor W. Pike CURRENT MEDICINAL CHEMISTRY
- Selected PET Radioligands for Ion Channel Linked Neuroreceptor Imaging: Focus on GABA, NMDA and nACh Receptors
- (2016) Alina Kassenbrock et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Decreased in vivo availability of the cannabinoid type 2 receptor in Alzheimer’s disease
- (2016) Rawaha Ahmad et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- P2Y12receptor is expressed on human microglia under physiological conditions throughout development and is sensitive to neuroinflammatory diseases
- (2016) Alexander Mildner et al. GLIA
- Neuroinflammation: the devil is in the details
- (2016) Damon J. DiSabato et al. JOURNAL OF NEUROCHEMISTRY
- A promising carbon-11-labeled sphingosine-1-phosphate receptor 1-specific PET tracer for imaging vascular injury
- (2016) Hongjun Jin et al. JOURNAL OF NUCLEAR CARDIOLOGY
- Preclinical Evaluation of a P2X7 Receptor-Selective Radiotracer: PET Studies in a Rat Model with Local Overexpression of the Human P2X7 Receptor and in Nonhuman Primates
- (2016) D. Ory et al. JOURNAL OF NUCLEAR MEDICINE
- 11 C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain
- (2016) Masamichi Ikawa et al. JOURNAL OF NUCLEAR MEDICINE
- Characterization of 11 C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation
- (2016) Paul R. Territo et al. JOURNAL OF NUCLEAR MEDICINE
- PET/CT Imaging of Chemokine Receptors in Inflammatory Atherosclerosis Using Targeted Nanoparticles
- (2016) H. P. Luehmann et al. JOURNAL OF NUCLEAR MEDICINE
- PET Imaging Study of S1PR1 Expression in a Rat Model of Multiple Sclerosis
- (2016) Hui Liu et al. MOLECULAR IMAGING AND BIOLOGY
- Astrocyte scar formation aids central nervous system axon regeneration
- (2016) Mark A. Anderson et al. NATURE
- Therapeutic strategies for Alzheimer's disease in clinical trials
- (2016) Justyna Godyń et al. Pharmacological Reports
- How neuroinflammation contributes to neurodegeneration
- (2016) R. M. Ransohoff SCIENCE
- Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging
- (2016) Mukesh K. Pandey et al. Theranostics
- In vivo markers of inflammatory response in recent-onset schizophrenia: a combined study using [11C]DPA-713 PET and analysis of CSF and plasma
- (2016) J M Coughlin et al. Translational Psychiatry
- Cyclooxygenase-1 null mice show reduced neuroinflammation in response to β-amyloid
- (2016) Sang-Ho Choi et al. Aging-US
- In Vivo Metabolic Trapping Radiotracers for Imaging Monoamine Oxidase-A and -B Enzymatic Activity
- (2015) Allen F. Brooks et al. ACS Chemical Neuroscience
- Radiosynthesis and preliminary PET evaluation of glycogen synthase kinase 3β (GSK-3β) inhibitors containing [11C]methylsulfanyl, [11C]methylsulfinyl or [11C]methylsulfonyl groups
- (2015) Katsushi Kumata et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists
- (2015) Dale A. Rudolph et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis of [11C]GSK1482160 as a new PET agent for targeting P2X7 receptor
- (2015) Mingzhang Gao et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Radiosynthesis and ex vivo evaluation of [18F]-(S)-3-(6-(3-fluoropropoxy)benzo[d]isoxazol-3-yl)-5-(methoxymethyl)oxazolidin-2-one for imaging MAO-B with PET
- (2015) Justin W. Hicks et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Sphingosin-1-phosphate Receptor 1: a Potential Target to Inhibit Neuroinflammation and Restore the Sphingosin-1-phosphate Metabolism
- (2015) Zeynab Kolahdooz et al. CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
- PET tracers for imaging brain α7 nicotinic receptors: an update
- (2015) S. Chalon et al. CHEMICAL COMMUNICATIONS
- Lysophospholipid receptors in drug discovery
- (2015) Yasuyuki Kihara et al. EXPERIMENTAL CELL RESEARCH
- Synthesis and Evaluation of Fluorinated Fingolimod (FTY720) Analogues for Sphingosine-1-Phosphate Receptor Molecular Imaging by Positron Emission Tomography
- (2015) Rizwan S. Shaikh et al. JOURNAL OF MEDICINAL CHEMISTRY
- Rodent models of neuroinflammation for Alzheimer’s disease
- (2015) Amir Nazem et al. Journal of Neuroinflammation
- Imaging Microglial Activation with TSPO PET: Lighting Up Neurologic Diseases?
- (2015) L. Vivash et al. JOURNAL OF NUCLEAR MEDICINE
- In Vivo and In Vitro Characterization of a Novel MAO-B Inhibitor Radioligand, 18F-Labeled Deuterated Fluorodeprenyl
- (2015) S. Nag et al. JOURNAL OF NUCLEAR MEDICINE
- Combination therapies: The next logical Step for the treatment of synucleinopathies?
- (2015) Elvira Valera et al. MOVEMENT DISORDERS
- Immune attack: the role of inflammation in Alzheimer disease
- (2015) Frank L. Heppner et al. NATURE REVIEWS NEUROSCIENCE
- The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders
- (2015) G.Z. Réus et al. NEUROSCIENCE
- Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists
- (2015) Brad M. Savall et al. ACS Medicinal Chemistry Letters
- Synthesis and Initial in Vivo Studies with [11C]SB-216763: The First Radiolabeled Brain Penetrative Inhibitor of GSK-3
- (2015) Lei Li et al. ACS Medicinal Chemistry Letters
- A Philosophy for CNS Radiotracer Design
- (2014) Genevieve C. Van de Bittner et al. ACCOUNTS OF CHEMICAL RESEARCH
- Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance
- (2014) Ana I. Rojo et al. ANTIOXIDANTS & REDOX SIGNALING
- The Chemokine CX3CL1 (Fractalkine) and its Receptor CX3CR1: Occurrence and Potential Role in Osteoarthritis
- (2014) Piotr Wojdasiewicz et al. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
- Synthesis of fluorinated analogues of sphingosine-1-phosphate antagonists as potential radiotracers for molecular imaging using positron emission tomography
- (2014) Vysakh Pushpa Prasad et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Radioligand development for molecular imaging of the central nervous system with positron emission tomography
- (2014) Michael Honer et al. DRUG DISCOVERY TODAY
- P2X and P2Y Receptors—Role in the Pathophysiology of the Nervous System
- (2014) Kamila Puchałowicz et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- GSK-3 - at the crossroads of cell death and survival
- (2014) U. Maurer et al. JOURNAL OF CELL SCIENCE
- In Vivo Imaging of Reactive Oxygen Species in Mouse Brain by using [3H]Hydromethidine as a Potential Radical Trapping Radiotracer
- (2014) Kohji Abe et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Kinetic Modeling of the Monoamine Oxidase B Radioligand [11C]SL25.1188 in Human Brain with High-Resolution Positron Emission Tomography
- (2014) Pablo M Rusjan et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Lithium Prevents and Ameliorates Experimental Autoimmune Encephalomyelitis
- (2014) P. De Sarno et al. JOURNAL OF IMMUNOLOGY
- Synthesis and initial preclinical evaluation of the P2X7receptor antagonist [11C]A-740003 as a novel tracer of neuroinflammation
- (2014) Bieneke Janssen et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- An update on the biology of sphingosine 1-phosphate receptors
- (2014) Victoria A. Blaho et al. JOURNAL OF LIPID RESEARCH
- Positron Emission Tomography in CNS Drug Discovery and Drug Monitoring
- (2014) Markus Piel et al. JOURNAL OF MEDICINAL CHEMISTRY
- Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases
- (2014) Hugo González et al. JOURNAL OF NEUROIMMUNOLOGY
- Neuroinflammation and M2 microglia: the good, the bad, and the inflamed
- (2014) Jonathan D Cherry et al. Journal of Neuroinflammation
- Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline2 Binding Sites in Rhesus Brain
- (2014) C. A. Parker et al. JOURNAL OF NUCLEAR MEDICINE
- Microglial and macrophage polarization—new prospects for brain repair
- (2014) Xiaoming Hu et al. Nature Reviews Neurology
- Human whole-body biodistribution and dosimetry of a new PET tracer, [11C]ketoprofen methyl ester, for imagings of neuroinflammation
- (2014) Akihito Ohnishi et al. NUCLEAR MEDICINE AND BIOLOGY
- Synthesis and evaluation of [11C]PyrATP-1, a novel radiotracer for PET imaging of glycogen synthase kinase-3β (GSK-3β)
- (2014) Erin L. Cole et al. NUCLEAR MEDICINE AND BIOLOGY
- Pharmacological inhibition of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for multiple sclerosis
- (2014) A. Ridderstad Wollberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Alzheimer’s disease drug-development pipeline: few candidates, frequent failures
- (2014) Jeffrey L Cummings et al. Alzheimers Research & Therapy
- Development of a novel fluorine-18 labeled deuterated fluororasagiline ([18F]fluororasagiline-D2) radioligand for PET studies of monoamino oxidase B (MAO-B)
- (2013) S. Nag et al. BIOORGANIC & MEDICINAL CHEMISTRY
- TAM receptor tyrosine kinases: Expression, disease and oncogenesis in the central nervous system
- (2013) Angela M. Pierce et al. BRAIN RESEARCH
- Alternative approaches for PET radiotracer development in Alzheimer's disease: imaging beyond plaque
- (2013) Jason P. Holland et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- PET radioligands targeting the brain GABAA/benzodiazepine receptor complex
- (2013) Jan D. Andersson et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Substituted 7-Amino-5-thio-thiazolo[4,5-d]pyrimidines as Potent and Selective Antagonists of the Fractalkine Receptor (CX3CR1)
- (2013) Sofia Karlström et al. JOURNAL OF MEDICINAL CHEMISTRY
- Fingolimod phosphate promotes the neuroprotective effects of microglia
- (2013) Hiromi Noda et al. JOURNAL OF NEUROIMMUNOLOGY
- Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury
- (2013) I. B. Wanner et al. JOURNAL OF NEUROSCIENCE
- Fingolimod: Direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy
- (2013) Aran Groves et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Emerging roles of astrocytes in neural circuit development
- (2013) Laura E. Clarke et al. NATURE REVIEWS NEUROSCIENCE
- Microglia, seen from the CX3CR1 angle
- (2013) Yochai Wolf et al. Frontiers in Cellular Neuroscience
- Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases
- (2012) I-Ta Lee et al. BIOCHEMICAL PHARMACOLOGY
- Early detection of neurodegenerative diseases
- (2012) Kira S. Sheinerman et al. CELL CYCLE
- Fingolimod-A sphingosine-like molecule inhibits vesicle mobility and secretion in astrocytes
- (2012) Saša Trkov et al. GLIA
- Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease
- (2012) Sang-Ho Choi et al. JOURNAL OF NEUROCHEMISTRY
- Reactive Astrocytes Overexpress TSPO and Are Detected by TSPO Positron Emission Tomography Imaging
- (2012) S. Lavisse et al. JOURNAL OF NEUROSCIENCE
- Genomic Analysis of Reactive Astrogliosis
- (2012) J. L. Zamanian et al. JOURNAL OF NEUROSCIENCE
- Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by 11C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining 11C-Pittsburgh Compound B and 18F-FDG
- (2012) S. F. Carter et al. JOURNAL OF NUCLEAR MEDICINE
- Animal Models of Neurological Disorders
- (2012) Marie-Francoise Chesselet et al. Neurotherapeutics
- Efficient synthesis and chiral separation of 11C-labeled ibuprofen assisted by DMSO for imaging of in vivo behavior of the individual isomers by positron emission tomography
- (2011) Tatsuya Kikuchi et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans
- (2011) Mireille Basselin et al. BRAIN RESEARCH BULLETIN
- Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)
- (2011) Cris S Constantinescu et al. BRITISH JOURNAL OF PHARMACOLOGY
- Radiosynthesis of [11C]SL25.1188 via [11C]CO2 fixation for imaging monoamine oxidase B
- (2011) Neil Vasdev et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Fingolimod modulates microglial activation to augment markers of remyelination
- (2011) Samuel J Jackson et al. Journal of Neuroinflammation
- In Vivo Expression of Cyclooxygenase-1 in Activated Microglia and Macrophages During Neuroinflammation Visualized by PET with 11C-Ketoprofen Methyl Ester
- (2011) M. Shukuri et al. JOURNAL OF NUCLEAR MEDICINE
- Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease
- (2011) B. DaRocha-Souto et al. NEUROBIOLOGY OF DISEASE
- Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation
- (2011) T. Hla et al. NEUROLOGY
- Development of new radiopharmaceuticals for imaging monoamine oxidase B
- (2011) Neil Vasdev et al. NUCLEAR MEDICINE AND BIOLOGY
- Preclinical evaluation of [11C]NE40, a type 2 cannabinoid receptor PET tracer
- (2011) Nele Evens et al. NUCLEAR MEDICINE AND BIOLOGY
- Physiology of Microglia
- (2011) Helmut Kettenmann et al. PHYSIOLOGICAL REVIEWS
- Polymorphisms in the Receptor Tyrosine Kinase MERTK Gene Are Associated with Multiple Sclerosis Susceptibility
- (2011) Gerry Z. M. Ma et al. PLoS One
- In vivo evaluation in cynomolgus monkey brain and metabolism of [18F]fluorodeprenyl: A new MAO-B pet radioligand
- (2011) Sangram Nag et al. SYNAPSE
- The human P2X7 receptor and its role in innate immunity
- (2011) J. S. Wiley et al. TISSUE ANTIGENS
- Astrocyte–neuron metabolic relationships: for better and for worse
- (2011) Igor Allaman et al. TRENDS IN NEUROSCIENCES
- Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior
- (2010) Michael M. Halassa et al. Annual Review of Physiology
- P2X7 Receptor Signaling Pathway as a Therapeutic Target for Neurodegenerative Diseases
- (2010) Takato Takenouchi et al. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
- The first synthesis of [11C]SB-216763, a new potential PET agent for imaging of glycogen synthase kinase-3 (GSK-3)
- (2010) Min Wang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- CB2: a cannabinoid receptor with an identity crisis
- (2010) Brady K Atwood et al. BRITISH JOURNAL OF PHARMACOLOGY
- Mechanisms Underlying Inflammation in Neurodegeneration
- (2010) Christopher K. Glass et al. CELL
- In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer’s disease
- (2010) Masamichi Yokokura et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Microglia: Proliferation and activation driven by the P2X7 receptor
- (2010) Mastura Monif et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Radiolabeled Small Molecule Protein Kinase Inhibitors for Imaging with PET or SPECT
- (2010) Justin W. Hicks et al. MOLECULES
- Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
- (2010) Volker Brinkmann et al. NATURE REVIEWS DRUG DISCOVERY
- Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders
- (2010) Rainer Rupprecht et al. NATURE REVIEWS DRUG DISCOVERY
- Microglia in neurodegenerative disease
- (2010) V. Hugh Perry et al. Nature Reviews Neurology
- Activated MAO-B in the brain of Alzheimer patients, demonstrated by [11C]-l-deprenyl using whole hemisphere autoradiography
- (2010) Balázs Gulyás et al. NEUROCHEMISTRY INTERNATIONAL
- FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation
- (2010) J. W. Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease
- (2009) Wolfgang J. Streit et al. ACTA NEUROPATHOLOGICA
- Astrocytes: biology and pathology
- (2009) Michael V. Sofroniew et al. ACTA NEUROPATHOLOGICA
- Up-Regulation of Soluble Axl and Mer Receptor Tyrosine Kinases Negatively Correlates with Gas6 in Established Multiple Sclerosis Lesions
- (2009) Jason G. Weinger et al. AMERICAN JOURNAL OF PATHOLOGY
- Microglial Physiology: Unique Stimuli, Specialized Responses
- (2009) Richard M. Ransohoff et al. Annual Review of Immunology
- Differential gene expression in LPS/IFNγ activated microglia and macrophages:in vitroversusin vivo
- (2009) Christoph D. Schmid et al. JOURNAL OF NEUROCHEMISTRY
- Sphingosine-1-phosphate and its receptors as a possible therapeutic target in autoimmune diseases of the nervous system
- (2009) Aiden Haghikia et al. JOURNAL OF NEUROIMMUNOLOGY
- Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia
- (2009) D. Nayak et al. NEUROSCIENCE
- Physiological and pathological functions of P2X7 receptor in the spinal cord
- (2009) Maria Luisa Cotrina et al. Purinergic Signalling
- [11C]SL25.1188, a new reversible radioligand to study the monoamine oxidase type B with PET: Preclinical characterisation in nonhuman primate
- (2009) Wadad Saba et al. SYNAPSE
- Molecular dissection of reactive astrogliosis and glial scar formation
- (2009) Michael V. Sofroniew TRENDS IN NEUROSCIENCES
- The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: implications for translational research
- (2009) Sang-Ho Choi et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- PET radiotracers: crossing the blood–brain barrier and surviving metabolism
- (2009) Victor W. Pike TRENDS IN PHARMACOLOGICAL SCIENCES
- Molecular Imaging with PET
- (2008) Simon M. Ametamey et al. CHEMICAL REVIEWS
- Evidence for Altered LRP/RAGE Expression in Alzheimer Lesion Pathogenesis
- (2008) Brian Jeynes et al. Current Alzheimer Research
- Cyclooxygenase-2 in Synaptic Signaling
- (2008) Hongwei Yang et al. CURRENT PHARMACEUTICAL DESIGN
- Radiosynthesis of (S)-5-methoxymethyl-3-[6-(4,4,4-trifluorobutoxy)benzo[d]isoxazol-3-yl] oxazolidin-2-[11C]one ([11C]SL25.1188), a novel radioligand for imaging monoamine oxidase-B with PET
- (2008) Yann Bramoullé et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Decreased plasma levels of soluble receptor for advanced glycation end products in mild cognitive impairment
- (2008) R. Ghidoni et al. JOURNAL OF NEURAL TRANSMISSION
- Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2
- (2008) Saba Aid et al. Journal of Neuroinflammation
- STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury
- (2008) J. E. Herrmann et al. JOURNAL OF NEUROSCIENCE
- A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function
- (2008) J. D. Cahoy et al. JOURNAL OF NEUROSCIENCE
- Imaging Neuroinflammation in Alzheimer's Disease with Radiolabeled Arachidonic Acid and PET
- (2008) G. Esposito et al. JOURNAL OF NUCLEAR MEDICINE
- Central nervous system-directed effects of FTY720 (fingolimod)
- (2008) Veronique E. Miron et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Origin and physiological roles of inflammation
- (2008) Ruslan Medzhitov NATURE
- Can the immune system be harnessed to repair the CNS?
- (2008) Phillip G. Popovich et al. NATURE REVIEWS NEUROSCIENCE
- In vivo site-directed radiotracers: a mini-review
- (2008) Shil Patel et al. NUCLEAR MEDICINE AND BIOLOGY
- "Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets
- (2008) K. Takabe et al. PHARMACOLOGICAL REVIEWS
- Cannabinoid CB2receptors in human brain inflammation
- (2007) C Benito et al. BRITISH JOURNAL OF PHARMACOLOGY
- Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury
- (2007) Sang-Ho Choi et al. FASEB JOURNAL
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