Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation
出版年份 2016 全文链接
标题
Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation
作者
关键词
Multiple Sclerosis, Systemic Lupus Erythematosus, Experimental Autoimmune Encephalomyelitis, Multiple Sclerosis Patient, Fingolimod
出版物
DRUGS
Volume 76, Issue 11, Pages 1067-1079
出版商
Springer Nature
发表日期
2016-06-18
DOI
10.1007/s40265-016-0603-2
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Ozanimod Induction and Maintenance Treatment for Ulcerative Colitis
- (2016) William J. Sandborn et al. NEW ENGLAND JOURNAL OF MEDICINE
- S1PR4 is required for plasmacytoid dendritic cell differentiation
- (2015) Christina Dillmann et al. BIOLOGICAL CHEMISTRY
- Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases
- (2015) Michael S. Donoviel et al. FASEB JOURNAL
- Effect of ceralifimod (ONO-4641) on lymphocytes and cardiac function: Randomized, double-blind, placebo-controlled trial with an open-label fingolimod arm
- (2015) Sonja Krösser et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Cutting Edge: CD69 Interference with Sphingosine-1-Phosphate Receptor Function Regulates Peripheral T Cell Retention
- (2015) Laura K. Mackay et al. JOURNAL OF IMMUNOLOGY
- Long-term (up to 4.5 years) treatment with fingolimod in multiple sclerosis: results from the extension of the randomised TRANSFORMS study
- (2015) Jeffrey A Cohen et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation
- (2015) Victoria A. Blaho et al. NATURE
- Fingolimod treatment promotes proliferation and differentiation of oligodendrocyte progenitor cells in mice with experimental autoimmune encephalomyelitis
- (2015) Jing Zhang et al. NEUROBIOLOGY OF DISEASE
- Long-term effects of fingolimod in multiple sclerosis: The randomized FREEDOMS extension trial
- (2015) L. Kappos et al. NEUROLOGY
- HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1to limit vascular inflammation
- (2015) Sylvain Galvani et al. Science Signaling
- Sphingosine 1-phosphate signaling at the blood–brain barrier
- (2015) Briana Prager et al. TRENDS IN MOLECULAR MEDICINE
- Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment
- (2015) Antonio Checa et al. Scientific Reports
- HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1to limit vascular inflammation
- (2015) Sylvain Galvani et al. Science Signaling
- Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli?
- (2015) Simona F. Spampinato et al. PLoS One
- AKP-11 - A Novel S1P1 Agonist with Favorable Safety Profile Attenuates Experimental Autoimmune Encephalomyelitis in Rat Model of Multiple Sclerosis
- (2015) Devadoss J. Samuvel et al. PLoS One
- Fingolimod exerts neuroprotective effects in a mouse model of intracerebral hemorrhage
- (2014) Lei Lu et al. BRAIN RESEARCH
- Sphingosine-1-Phosphate Modulates Dendritic Cell Function: Focus on Non-Migratory Effects in Vitro and in Vivo
- (2014) Olga Arlt et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond
- (2014) Christopher S. Garris et al. IMMUNOLOGY
- Individual variation of human S1P1coding sequence leads to heterogeneity in receptor function and drug interactions
- (2014) Hideru Obinata et al. JOURNAL OF LIPID RESEARCH
- An update on the biology of sphingosine 1-phosphate receptors
- (2014) Victoria A. Blaho et al. JOURNAL OF LIPID RESEARCH
- Changes in Th17 and regulatory T cells after fingolimod initiation to treat multiple sclerosis
- (2014) Douglas Kazutoshi Sato et al. JOURNAL OF NEUROIMMUNOLOGY
- Oral ponesimod in relapsing-remitting multiple sclerosis: a randomised phase II trial
- (2014) T. Olsson et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Oral ponesimod in patients with chronic plaque psoriasis: a randomised, double-blind, placebo-controlled phase 2 trial
- (2014) Andrea Vaclavkova et al. LANCET
- The influence of patient demographics, disease characteristics and treatment on brain volume loss in Trial Assessing Injectable Interferon vs FTY720 Oral in Relapsing–Remitting Multiple Sclerosis (TRANSFORMS), a phase 3 study of fingolimod in multiple sclerosis
- (2014) Frederik Barkhof et al. Multiple Sclerosis Journal
- Sphingolipid metabolites in inflammatory disease
- (2014) Michael Maceyka et al. NATURE
- Distinct Roles for Hematopoietic and Extra-Hematopoietic Sphingosine Kinase-1 in Inflammatory Bowel Disease
- (2014) Ashley J. Snider et al. PLoS One
- Impact of an immune modulator fingolimod on acute ischemic stroke
- (2014) Ying Fu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fingolimod for the treatment of neurological diseases—state of play and future perspectives
- (2014) Robert Brunkhorst et al. Frontiers in Cellular Neuroscience
- Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor
- (2014) Daniel J. Buzard et al. ACS Medicinal Chemistry Letters
- Fingolimod for the Treatment of Intracerebral Hemorrhage
- (2014) Ying Fu et al. JAMA Neurology
- Network-Based Multiple Sclerosis Pathway Analysis with GWAS Data from 15,000 Cases and 30,000 Controls
- (2013) Sergio E. Baranzini et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Sphingosine Kinase 1 Regulates Tumor Necrosis Factor-mediated RANTES Induction through p38 Mitogen-activated Protein Kinase but Independently of Nuclear Factor κB Activation
- (2013) Mohamad M. Adada et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sphingosine Kinases Are Not Required for Inflammatory Responses in Macrophages
- (2013) Yuquan Xiong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis
- (2013) Katrin Schaper et al. JOURNAL OF DERMATOLOGICAL SCIENCE
- S1P1localizes to the colonic vasculature in ulcerative colitis and maintains blood vessel integrity
- (2013) David C. Montrose et al. JOURNAL OF LIPID RESEARCH
- Siponimod for patients with relapsing-remitting multiple sclerosis (BOLD): an adaptive, dose-ranging, randomised, phase 2 study
- (2013) Krzysztof Selmaj et al. LANCET NEUROLOGY
- Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation
- (2013) Christopher S Garris et al. NATURE IMMUNOLOGY
- Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond
- (2013) Gregory T. Kunkel et al. NATURE REVIEWS DRUG DISCOVERY
- Immunohistochemical detection of sphingosine-1-phosphate receptor 1 and 5 in human multiple sclerosis lesions
- (2013) Corinne Brana et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- FTY720 Treatment in the Convalescence Period Improves Functional Recovery and Reduces Reactive Astrogliosis in Photothrombotic Stroke
- (2013) Robert Brunkhorst et al. PLoS One
- Fingolimod Therapy for Multiple Sclerosis
- (2013) Mary Willis et al. SEMINARS IN NEUROLOGY
- FTY720 Ameliorates Acute Ischemic Stroke in Mice by Reducing Thrombo-Inflammation but Not by Direct Neuroprotection
- (2013) Peter Kraft et al. STROKE
- Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs
- (2012) Jason G. Cyster et al. Annual Review of Immunology
- Brain-Immune Interactions and Ischemic Stroke
- (2012) Costantino Iadecola ARCHIVES OF NEUROLOGY
- Shaping the landscape: Metabolic regulation of S1P gradients
- (2012) Ana Olivera et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer
- (2012) Jie Liang et al. CANCER CELL
- A Potent and Selective S1P1 Antagonist with Efficacy in Experimental Autoimmune Encephalomyelitis
- (2012) Jean Quancard et al. CHEMISTRY & BIOLOGY
- Immune mechanisms of stroke
- (2012) Tim Magnus et al. CURRENT OPINION IN NEUROLOGY
- Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage
- (2012) William B. Rolland et al. EXPERIMENTAL NEUROLOGY
- Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network
- (2012) Masayuki Nagahashi et al. FASEB JOURNAL
- Increased Serum Concentration of Sphingosine-1-phosphate in Juvenile-onset Systemic Lupus Erythematosus
- (2012) L. Watson et al. JOURNAL OF CLINICAL IMMUNOLOGY
- Optimization of current and future therapy for autoimmune diseases
- (2012) Lawrence Steinman et al. NATURE MEDICINE
- Fingolimod treatment in multiple sclerosis leads to increased macular volume
- (2012) R. Nolan et al. NEUROLOGY
- Fingolimod and multiple sclerosis: Four cautionary tales
- (2012) D. Bourdette et al. NEUROLOGY
- Tumefactive multiple sclerosis lesions under fingolimod treatment
- (2012) F. Visser et al. NEUROLOGY
- Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis
- (2012) DeAnna A. Baker et al. RHEUMATOLOGY INTERNATIONAL
- Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis
- (2011) Jeffrey A. Cohen et al. ANNALS OF NEUROLOGY
- A Phase I Clinical Trial of Safingol in Combination with Cisplatin in Advanced Solid Tumors
- (2011) M. A. Dickson et al. CLINICAL CANCER RESEARCH
- Sphingosine-1-phospate receptor 4 (S1P4) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model
- (2011) Tobias Schulze et al. FASEB JOURNAL
- Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis
- (2011) Bianca Weinstock-Guttman et al. Journal of Neuroinflammation
- Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis
- (2011) M. Mehling et al. NEUROLOGY
- Systemic Lupus Erythematosus
- (2011) George C. Tsokos NEW ENGLAND JOURNAL OF MEDICINE
- Sphingosine Kinase 1 and Sphingosine 1-Phosphate Receptor 3 Are Functionally Upregulated on Astrocytes under Pro-Inflammatory Conditions
- (2011) Iris Fischer et al. PLoS One
- Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
- (2011) C. Christoffersen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GRK2-Dependent S1PR1 Desensitization Is Required for Lymphocytes to Overcome Their Attraction to Blood
- (2011) T. I. Arnon et al. SCIENCE
- Fingolimod provides long-term protection in rodent models of cerebral ischemia
- (2010) Ying Wei et al. ANNALS OF NEUROLOGY
- Sphingosine-1-Phosphate Receptor-2 Function in Myeloid Cells Regulates Vascular Inflammation and Atherosclerosis
- (2010) Athanasia Skoura et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- FTY720 exerts a survival advantage through the prevention of end-stage glomerular inflammation in lupus-prone BXSB mice
- (2010) Seiichiro Ando et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model
- (2010) Sachi Tsunemi et al. CLINICAL IMMUNOLOGY
- Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis
- (2010) Jerold Chun et al. CLINICAL NEUROPHARMACOLOGY
- CD69 Suppresses Sphingosine 1-Phosophate Receptor-1 (S1P1) Function through Interaction with Membrane Helix 4
- (2010) Alexander J. Bankovich et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics
- (2010) Shobha Thangada et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Kruppel-Like Factor 2 Is Required for Trafficking but Not Quiescence in Postactivated T Cells
- (2010) K. Takada et al. JOURNAL OF IMMUNOLOGY
- Genetic Sphingosine Kinase 1 Deficiency Significantly Decreases Synovial Inflammation and Joint Erosions in Murine TNF- -Induced Arthritis
- (2010) D. A. Baker et al. JOURNAL OF IMMUNOLOGY
- Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone Oxime (LX2931) and (1R,2S,3R)-1-(2-(Isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932)
- (2010) Jeffrey T. Bagdanoff et al. JOURNAL OF MEDICINAL CHEMISTRY
- Abl Tyrosine Kinase Phosphorylates Nonmuscle Myosin Light Chain Kinase to Regulate Endothelial Barrier Function
- (2010) Steven M. Dudek et al. MOLECULAR BIOLOGY OF THE CELL
- Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
- (2010) Sergio E. Alvarez et al. NATURE
- The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells
- (2010) Guangwei Liu et al. NATURE IMMUNOLOGY
- STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors
- (2010) Heehyoung Lee et al. NATURE MEDICINE
- Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
- (2010) Volker Brinkmann et al. NATURE REVIEWS DRUG DISCOVERY
- Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis
- (2010) M. Mehling et al. NEUROLOGY
- Intrathecal increase of sphingosine 1-phosphate at early stage multiple sclerosis
- (2010) Alina Kułakowska et al. NEUROSCIENCE LETTERS
- A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis
- (2010) Ludwig Kappos et al. NEW ENGLAND JOURNAL OF MEDICINE
- Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis
- (2010) Jeffrey A. Cohen et al. NEW ENGLAND JOURNAL OF MEDICINE
- FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation
- (2010) J. W. Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase
- (2010) Leo R. Fitzpatrick et al. INFLAMMOPHARMACOLOGY
- Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn’s disease
- (2010) Lynn W. Maines et al. INFLAMMOPHARMACOLOGY
- Differential Effects of Sphingosine 1–Phosphate Receptors on Airway and Vascular Barrier Function in the Murine Lung
- (2009) Saad Sammani et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality
- (2009) F. Niessen et al. BLOOD
- Regulation of macrophage function by sphingosine-1-phosphate
- (2009) Andreas Weigert et al. IMMUNOBIOLOGY
- Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning
- (2009) Trung H.M. Pham et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Distinct Roles of Sphingosine Kinase 1 and 2 in Murine Collagen-Induced Arthritis
- (2009) W.-Q. Lai et al. JOURNAL OF IMMUNOLOGY
- The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR
- (2009) Guangwei Liu et al. NATURE IMMUNOLOGY
- Expression of sphingosine kinase 2 in synovial fibroblasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analogue, FTY720
- (2009) Kazuo Kamada et al. PATHOLOGY INTERNATIONAL
- Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate
- (2009) N. C. Hait et al. SCIENCE
- Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate
- (2008) Krishnan Venkataraman et al. CIRCULATION RESEARCH
- A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis
- (2008) Ashley J. Snider et al. FASEB JOURNAL
- S1P1 Receptor Signaling Overrides Retention Mediated by Gαi-Coupled Receptors to Promote T Cell Egress
- (2008) Trung H.M. Pham et al. IMMUNITY
- Increased survival and reduced renal injury in MRL/lpr mice treated with a novel sphingosine-1-phosphate receptor agonist
- (2008) Scott E. Wenderfer et al. KIDNEY INTERNATIONAL
- Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation
- (2008) Frank Niessen et al. NATURE
- Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells
- (2008) Irina L Grigorova et al. NATURE IMMUNOLOGY
- Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns
- (2008) Eric Sebzda et al. NATURE IMMUNOLOGY
- Antagonism of Sphingosine 1-Phosphate Receptor-2 Enhances Migration of Neural Progenitor Cells Toward an Area of Brain Infarction
- (2008) Atsushi Kimura et al. STROKE
- FTY720 modulates human oligodendrocyte progenitor process extension and survival
- (2007) Veronique E. Miron et al. ANNALS OF NEUROLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search