Novel Radioligands for Cyclic Nucleotide Phosphodiesterase Imaging with Positron Emission Tomography: An Update on Developments Since 2012
出版年份 2016 全文链接
标题
Novel Radioligands for Cyclic Nucleotide Phosphodiesterase Imaging with Positron Emission Tomography: An Update on Developments Since 2012
作者
关键词
-
出版物
MOLECULES
Volume 21, Issue 5, Pages 650
出版商
MDPI AG
发表日期
2016-05-20
DOI
10.3390/molecules21050650
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Phosphodiesterase 10A in Schizophrenia: A PET Study Using [11C]IMA107
- (2016) Tiago Reis Marques et al. AMERICAN JOURNAL OF PSYCHIATRY
- Development of highly potent phosphodiesterase 10A (PDE10A) inhibitors: Synthesis and in vitro evaluation of 1,8-dipyridinyl- and 1-pyridinyl-substituted imidazo[1,5-a]quinoxalines
- (2016) Sally Wagner et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Identification andin vivoevaluation of a fluorine-18 rolipram analogue, [18F]MNI-617, as a radioligand for PDE4 imaging in mammalian brain
- (2016) David Thomae et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- A business of some heat: molecular imaging of phosphodiesterase 5
- (2016) Paul Cumming JOURNAL OF NEUROCHEMISTRY
- Pharmacokinetic investigation of sildenafil using positron emission tomography and determination of its effect on cerebrospinal fluid cGMP levels
- (2016) Vanessa Gómez-Vallejo et al. JOURNAL OF NEUROCHEMISTRY
- First-in-Human Assessment of the Novel PDE2A PET Radiotracer 18F-PF-05270430
- (2016) M. Naganawa et al. JOURNAL OF NUCLEAR MEDICINE
- Change in PDE10 across early Huntington disease assessed by [18F]MNI-659 and PET imaging
- (2016) David S. Russell et al. NEUROLOGY
- Brain PET measurement of PDE10A occupancy by TAK-063, a new PDE10A inhibitor, using [11C]T-773 in nonhuman primates
- (2016) Akihiro Takano et al. SYNAPSE
- Synthesis, SAR study, and biological evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors with reduced CYP3A4 inhibition
- (2015) Wataru Hamaguchi et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Discovery of [ 11 C ] MK - 8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors
- (2015) Christopher D. Cox et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Altered PDE10A expression detectable early before symptomatic onset in Huntington’s disease
- (2015) Flavia Niccolini et al. BRAIN
- Loss of phosphodiesterase 10A expression is associated with progression and severity in Parkinson’s disease
- (2015) Flavia Niccolini et al. BRAIN
- Inhibition of breast cancer cell migration by activation of cAMP signaling
- (2015) Hongli Dong et al. BREAST CANCER RESEARCH AND TREATMENT
- Novel Approaches to Imaging Tumor Metabolism
- (2015) Sui-Seng Tee et al. CANCER JOURNAL
- Advantages in functional imaging of the brain
- (2015) Walter Mier et al. Frontiers in Human Neuroscience
- Development of a series of novel carbon-11 labeled PDE10A inhibitors
- (2015) Vladimir Stepanov et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Synthesis of Fluorine-Containing Phosphodiesterase 10A (PDE10A) Inhibitors and the In Vivo Evaluation of F-18 Labeled PDE10A PET Tracers in Rodent and Nonhuman Primate
- (2015) Junfeng Li et al. JOURNAL OF MEDICINAL CHEMISTRY
- Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition
- (2015) Christina Alves Peixoto et al. MEDIATORS OF INFLAMMATION
- Preclinical Characterization of the Phosphodiesterase 10A PET Tracer [11C]MK-8193
- (2015) Eric D. Hostetler et al. MOLECULAR IMAGING AND BIOLOGY
- Molecular Imaging of PDE10A Knockout Mice with a Novel PET Radiotracer: [11C]T-773
- (2015) Miklós Tóth et al. MOLECULAR IMAGING AND BIOLOGY
- Synthesis, 18F-Radiolabelling and Biological Characterization of Novel Fluoroalkylated Triazine Derivatives for in Vivo Imaging of Phosphodiesterase 2A in Brain via Positron Emission Tomography
- (2015) Susann Schröder et al. MOLECULES
- Methods to Increase the Metabolic Stability of 18F-Radiotracers
- (2015) Manuela Kuchar et al. MOLECULES
- Preclinical evaluation of a promising C-11 labeled PET tracer for imaging phosphodiesterase 10A in the brain of living subject
- (2015) Hui Liu et al. NEUROIMAGE
- Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A
- (2015) Akina Harada et al. NUCLEAR MEDICINE AND BIOLOGY
- Radiosynthesis and initial characterization of a PDE10A specific PET tracer [18F]AMG 580 in non-human primates
- (2015) Dah-Ren Hwang et al. NUCLEAR MEDICINE AND BIOLOGY
- Synthesis and preclinical evaluation of an 18 F labeled PDE7 inhibitor for PET neuroimaging
- (2015) David Thomae et al. NUCLEAR MEDICINE AND BIOLOGY
- PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer
- (2015) Anindita Das et al. PHARMACOLOGY & THERAPEUTICS
- Inhibition of PDE2A, but not PDE9A, modulates presynaptic short-term plasticity measured by paired-pulse facilitation in the CA1 region of the hippocampus
- (2015) Diego Fernández-Fernández et al. SYNAPSE
- Evaluation of a novel PDE10APET radioligand, [11C]T-773, in nonhuman primates: Brain and whole body PET and brain autoradiography
- (2015) Akihiro Takano et al. SYNAPSE
- A comparison of the available phosphodiesterase-5 inhibitors in the treatment of erectile dysfunction: a focus on avanafil
- (2015) Jeffrey Evans et al. Patient Preference and Adherence
- Radiosyntheses and in vivo evaluation of carbon-11 PET tracers for PDE10A in the brain of rodent and nonhuman primate
- (2014) Jinda Fan et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis and in Vivo Evaluation of Novel Quinoline Derivatives as Phosphodiesterase 10A Inhibitors
- (2014) Wataru Hamaguchi et al. CHEMICAL & PHARMACEUTICAL BULLETIN
- Fluorine-Containing 6,7-Dialkoxybiaryl-Based Inhibitors for Phosphodiesterase 10 A: Synthesis and in vitro Evaluation of Inhibitory Potency, Selectivity, and Metabolism
- (2014) Gregor Schwan et al. ChemMedChem
- Phosphodiesterase: An Interface Connecting Cognitive Deficits to Neuropsychiatric and Neurodegenerative Diseases
- (2014) Zhen-Zhen Wang et al. CURRENT PHARMACEUTICAL DESIGN
- The Roles of Phosphodiesterase 2 in the Central Nervous and Peripheral Systems
- (2014) Chong Zhang et al. CURRENT PHARMACEUTICAL DESIGN
- Targeting PDE10A in schizophrenia
- (2014) N. Hoefgen et al. DRUGS OF THE FUTURE
- Discovery of 1-[2-Fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor
- (2014) Jun Kunitomo et al. JOURNAL OF MEDICINAL CHEMISTRY
- In Vivo Assessment and Dosimetry of 2 Novel PDE10A PET Radiotracers in Humans: 18F-MNI-659 and 18F-MNI-654
- (2014) O. Barret et al. JOURNAL OF NUCLEAR MEDICINE
- Discovery and Development of 11C-Lu AE92686 as a Radioligand for PET Imaging of Phosphodiesterase10A in the Brain
- (2014) J. Kehler et al. JOURNAL OF NUCLEAR MEDICINE
- Phosphodiesterase 10A PET Radioligand Development Program: From Pig to Human
- (2014) C. Plisson et al. JOURNAL OF NUCLEAR MEDICINE
- Early decrease of type 1 cannabinoid receptor binding and phosphodiesterase 10A activity in vivo in R6/2 Huntington mice
- (2014) Maarten Ooms et al. NEUROBIOLOGY OF AGING
- Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer’s Disease
- (2014) Mark E. Gurney et al. Neurotherapeutics
- Initial characterization of a PDE10A selective positron emission tomography tracer [11C]AMG 7980 in non-human primates
- (2014) Dah-Ren Hwang et al. NUCLEAR MEDICINE AND BIOLOGY
- Synthesis and biological evaluation of carbon-11 and fluorine-18 labeled tracers for in vivo visualization of PDE10A
- (2014) Maarten Ooms et al. NUCLEAR MEDICINE AND BIOLOGY
- Further evaluation of [11C]MP-10 as a radiotracer for phosphodiesterase 10A: PET imaging study in rhesus monkeys and brain tissue metabolite analysis
- (2014) Shu-Fei Lin et al. SYNAPSE
- Development of 18F-labeled radiotracers for neuroreceptor imaging with positron emission tomography
- (2014) Peter Brust et al. Neuroscience Bulletin
- The Phosphodiesterase 10 Positron Emission Tomography Tracer, [18F]MNI-659, as a Novel Biomarker for Early Huntington Disease
- (2014) David S. Russell et al. JAMA Neurology
- Effect of chronic antipsychotic treatment on striatal phosphodiesterase 10A levels: a [11C]MP-10 PET rodent imaging study with ex vivo confirmation
- (2014) S Natesan et al. Translational Psychiatry
- Positron Emission Tomography (PET) in Oncology
- (2014) Andrea Gallamini et al. Cancers
- The Role of Cyclic Nucleotide Signaling Pathways in Cancer: Targets for Prevention and Treatment
- (2014) Alexandra Fajardo et al. Cancers
- Molecular imaging of myocardial infarction
- (2013) Naheed Jivraj et al. BASIC RESEARCH IN CARDIOLOGY
- PDE2 inhibition: Potential for the treatment of cognitive disorders
- (2013) Laurent Gomez et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Select 3′,5′-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain
- (2013) Michy P. Kelly et al. CELLULAR SIGNALLING
- Genetic Deletion and Pharmacological Inhibition of Phosphodiesterase 10A Protects Mice From Diet-Induced Obesity and Insulin Resistance
- (2013) A. R. Nawrocki et al. DIABETES
- Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand
- (2013) Lei Zhang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Quantification of 18F-JNJ-42259152, a Novel Phosphodiesterase 10A PET Tracer: Kinetic Modeling and Test-Retest Study in Human Brain
- (2013) K. Van Laere et al. JOURNAL OF NUCLEAR MEDICINE
- Preclinical evaluation of [18F]JNJ42259152 as a PET tracer for PDE10A
- (2013) S. Celen et al. NEUROIMAGE
- PET imaging shows loss of striatal PDE10A in patients with Huntington disease
- (2013) R. Ahmad et al. NEUROLOGY
- Evaluation of PET radioligands for in vivo visualization of phosphodiesterase 5 (PDE5)
- (2013) Rufael Chekol et al. NUCLEAR MEDICINE AND BIOLOGY
- Characterization of phosphodiesterase 2A in human malignant melanoma PMP cells
- (2013) HIROSHI MORITA et al. ONCOLOGY REPORTS
- Inhibition of phoshodiesterase type 2 or type 10 reverses object memory deficits induced by scopolamine or MK-801
- (2012) Olga A.H. Reneerkens et al. BEHAVIOURAL BRAIN RESEARCH
- Downregulation of Brain Phosphodiesterase Type IV Measured with 11C-(R)-Rolipram Positron Emission Tomography in Major Depressive Disorder
- (2012) Masahiro Fujita et al. BIOLOGICAL PSYCHIATRY
- Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia
- (2012) Izzat T. Raheem et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Future directions in phosphodiesterase drug discovery
- (2012) Michael P. DeNinno BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Modulation of the ASK1-MKK3/6-p38/MAPK signalling pathway mediates sildenafil protection against chemical hypoxia caused by malonate
- (2012) L Barros-Miñones et al. BRITISH JOURNAL OF PHARMACOLOGY
- Recent Advances in Positron Emission Tomography (PET) Radiotracers for Imaging Phosphodiesterases
- (2012) Jose Ignacio Andres et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Human biodistribution and dosimetry of 18F-JNJ42259152, a radioligand for phosphodiesterase 10A imaging
- (2012) Koen Van Laere et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Phosphodiesterase 10A inhibitors: a 2009 – 2012 patent update
- (2012) Jan Kehler EXPERT OPINION ON THERAPEUTIC PATENTS
- Phosphodiesterases in neurodegenerative disorders
- (2012) Eva Bollen et al. IUBMB LIFE
- Rapid Identification of a Novel Small Molecule Phosphodiesterase 10A (PDE10A) Tracer
- (2012) Essa Hu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Current Landscape of Phosphodiesterase 10A (PDE10A) Inhibition
- (2012) Thomas A. Chappie et al. JOURNAL OF MEDICINAL CHEMISTRY
- The distribution of phosphodiesterase 2A in the rat brain
- (2012) D.T. Stephenson et al. NEUROSCIENCE
- Comparison of cAMP-specific phosphodiesterase mRNAs distribution in mouse and rat brain
- (2012) Emily M. Johansson et al. NEUROSCIENCE LETTERS
- Synthesis and in vitro biological evaluation of pyrazole group-containing analogues for PDE10A
- (2012) Junfeng Li et al. MedChemComm
- Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging
- (2011) Nele Evens et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain
- (2011) Zhude Tu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease
- (2011) M Cuadrado-Tejedor et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments
- (2011) Thérèse Keravis et al. BRITISH JOURNAL OF PHARMACOLOGY
- PDE10A Inhibitors: Novel Therapeutic Drugs for Schizophrenia
- (2011) Jan Kehler et al. CURRENT PHARMACEUTICAL DESIGN
- Activation of PDE10 and PDE11 Phosphodiesterases
- (2011) Ronald Jäger et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Characterization of Differential Gene Expression in Adrenocortical Tumors Harboring β-Catenin (CTNNB1) Mutations
- (2011) Julien Durand et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Synthesis, In Vivo Occupancy, and Radiolabeling of Potent Phosphodiesterase Subtype-10 Inhibitors as Candidates for Positron Emission Tomography Imaging
- (2011) José-Ignacio Andrés et al. JOURNAL OF MEDICINAL CHEMISTRY
- Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors
- (2011) Michael S. Malamas et al. JOURNAL OF MEDICINAL CHEMISTRY
- Long-lasting neuroprotective effect of sildenafil against 3,4-methylenedioxymethamphetamine- induced 5-hydroxytryptamine deficits in the rat brain
- (2011) Elena Puerta et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Analysis of (R)- and (S)-[11C]rolipram Kinetics in Canine Myocardium for the Evaluation of Phosphodiesterase-4 with PET
- (2011) Mireille Lortie et al. MOLECULAR IMAGING AND BIOLOGY
- Radiosynthesis and in vivo evaluation of [11C]MP-10 as a positron emission tomography radioligand for phosphodiesterase 10A
- (2011) Christophe Plisson et al. NUCLEAR MEDICINE AND BIOLOGY
- Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions
- (2011) Sharron H. Francis et al. PHYSIOLOGICAL REVIEWS
- Phosphodiesterase 7 Inhibition Preserves Dopaminergic Neurons in Cellular and Rodent Models of Parkinson Disease
- (2011) Jose A. Morales-Garcia et al. PLoS One
- 1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors
- (2010) Michael B. Tollefson et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- PDE5 Inhibitors and their Applications
- (2010) M.P. Giovannoni et al. CURRENT MEDICINAL CHEMISTRY
- Preclinical Evaluation of 18F-JNJ41510417 as a Radioligand for PET Imaging of Phosphodiesterase-10A in the Brain
- (2010) S. Celen et al. JOURNAL OF NUCLEAR MEDICINE
- Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF
- (2010) Elena Puerta et al. NEUROBIOLOGY OF DISEASE
- Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues
- (2010) Viktor Lakics et al. NEUROPHARMACOLOGY
- Dopamine D1, D2 and mu-opioid receptors are co-expressed with adenylyl cyclase 5 and phosphodiesterase 7B mRNAs in striatal rat cells
- (2009) Patricia de Gortari et al. BRAIN RESEARCH
- Ventricular Phosphodiesterase-5 Expression Is Increased in Patients With Advanced Heart Failure and Contributes to Adverse Ventricular Remodeling After Myocardial Infarction in Mice
- (2009) Peter Pokreisz et al. CIRCULATION
- Patented PDE10A inhibitors: novel compounds since 2007
- (2009) Jan Kehler et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Dual Acylation of PDE2A Splice Variant 3
- (2009) Corina Russwurm et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Immunohistochemical Localization of Phosphodiesterase 2A in Multiple Mammalian Species
- (2009) Diane T. Stephenson et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia†† Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1).
- (2009) Patrick R. Verhoest et al. JOURNAL OF MEDICINAL CHEMISTRY
- Phosphodiesterase 5 Inhibition Improves Synaptic Function, Memory, and Amyloid- Load in an Alzheimer's Disease Mouse Model
- (2009) D. Puzzo et al. JOURNAL OF NEUROSCIENCE
- Phosphodiesterase 10A Inhibitor Activity in Preclinical Models of the Positive, Cognitive, and Negative Symptoms of Schizophrenia
- (2009) S. M. Grauer et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Anxiolytic Effects of Phosphodiesterase-2 Inhibitors Associated with Increased cGMP Signaling
- (2009) A. Masood et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct
- (2009) J. Pandit et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PDE7 inhibitors as new drugs for neurological and inflammatory disorders
- (2008) Carmen Gil et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Phosphodiesterase 5 inhibitors prevent 3,4-methylenedioxymethamphetamine-induced 5-HT deficits in the rat
- (2008) Elena Puerta et al. JOURNAL OF NEUROCHEMISTRY
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