Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses

Anti-inflammatory effects of LASSBio-998, a new drug candidate designed to be a p38 MAPK inhibitor, in an experimental model of acute lung inflammation

(2014) Aline C. Brando Lima et al.   Pharmacological Reports

Floridoside suppresses pro-inflammatory responses by blocking MAPK signaling in activated microglia

(2013) MinJeong Kim et al.   BMB Reports

Activation of p38 signaling increases utrophin A expression in skeletal muscle via the RNA-binding protein KSRP and inhibition of AU-rich element-mediated mRNA decay: implications for novel DMD therapeutics

(2013) A. Amirouche et al.   HUMAN MOLECULAR GENETICS

AP-1 pathway-targeted inhibition of inflammatory responses in LPS-treated macrophages and EtOH/HCl-treated stomach by Archidendron clypearia methanol extract

(2013) Woo Seok Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells

(2013) Pamela Urrutia et al.   JOURNAL OF NEUROCHEMISTRY

Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial

(2013) William MacNee et al.   THORAX

Effects of Korean Red Ginseng extract on tissue plasminogen activator and plasminogen activator inhibitor-1 expression in cultured rat primary astrocytes

(2013) Hyun Myung Ko et al.   Journal of Ginseng Research

Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: Advantages of targeting upstream kinases MKK-3 or MKK-6

(2012) Monica Guma et al.   ARTHRITIS AND RHEUMATISM

3-(4-(tert-Octyl)phenoxy)propane-1,2-diol suppresses inflammatory responses via inhibition of multiple kinases

(2012) Tao Yu et al.   BIOCHEMICAL PHARMACOLOGY

Kalopanaxsaponin B Ameliorates TNBS-Induced Colitis in Mice

(2012) Jun-Ju Jeong et al.   Biomolecules & Therapeutics

Immunomodulation of Fungal β-Glucan in Host Defense Signaling by Dectin-1

(2012) Sainkhuu Batbayar et al.   Biomolecules & Therapeutics

MicroRNA let-7c inhibits Bcl-xl expression and regulates ox-LDL-induced endothelial apoptosis

(2012) Bing Qin et al.   BMB Reports

Traditional Chinese Medicine and Immune Regulation

(2012) Hong-Di Ma et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

TIMP3 Overexpression in Macrophages Protects From Insulin Resistance, Adipose Inflammation, and Nonalcoholic Fatty Liver Disease in Mice

(2012) R. Menghini et al.   DIABETES

Anti-inflammatory effect of Lycium Fruit water extract in lipopolysaccharide-stimulated RAW 264.7 macrophage cells

(2012) You-Chang Oh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Britanin suppresses LPS-induced nitric oxide, PGE2 and cytokine production via NF-κB and MAPK inactivation in RAW 264.7 cells

(2012) Hyo-Hyun Park et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Methanol extract of Osbeckia stellata suppresses lipopolysaccharide- and HCl/ethanol-induced inflammatory responses by inhibiting Src/Syk and IRAK1

(2012) Yanyan Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Methanol extract of Hopea odorata suppresses inflammatory responses via the direct inhibition of multiple kinases

(2012) Yanyan Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-Inflammatory Activity of Sulfur-Containing Compounds from Garlic

(2012) Da Yeon Lee et al.   JOURNAL OF MEDICINAL FOOD

Nanostructured, Self-Assembling Peptide K5 Blocks TNF-αand PGE2Production by Suppression of the AP-1/p38 Pathway

(2012) Woo Seok Yang et al.   MEDIATORS OF INFLAMMATION

The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages

(2012) Tao Yu et al.   MEDIATORS OF INFLAMMATION

Inflammation in Diabetic Nephropathy

(2012) Andy K. H. Lim et al.   MEDIATORS OF INFLAMMATION

Macrophage-Mediated Inflammation and Disease: A Focus on the Lung

(2012) Emily Gwyer Findlay et al.   MEDIATORS OF INFLAMMATION

p38  and p38  kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

(2012) A. Risco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel whole-cell lysate kinase assay identifies substrates of the p38 MAPK in differentiating myoblasts

(2012) James DR Knight et al.   Skeletal Muscle

Role of p38 Mitogen-activated Protein Kinase Isoforms in Murine Skin Inflammation Induced by 12-O-tetradecanoylphorbol 13-acetate

(2011) L Iversen et al.   ACTA DERMATO-VENEREOLOGICA

Inflammation, chronic obstructive pulmonary disease and aging

(2011) Mauro Provinciali et al.   CURRENT OPINION IN PULMONARY MEDICINE

Ethanol Extract of Elaeocarpus petiolatus Inhibits Lipopolysaccharide-Induced Inflammation in Macrophage Cells

(2011) Ok-Kyoung Kwon et al.   INFLAMMATION

An Oral Inhibitor of p38 MAP Kinase Reduces Plasma Fibrinogen in Patients With Chronic Obstructive Pulmonary Disease

(2011) David A. Lomas et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans

(2011) Tao Yu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Suppression of lipopolysaccharide-induced expression of inflammatory indicators in RAW 264.7 macrophage cells by extract prepared fromGinkgo bilobacambial meristematic cells

(2011) Sun-Hee Jang et al.   PHARMACEUTICAL BIOLOGY

Polygoni Rhizoma Inhibits Inflammatory Response through Inactivation of Nuclear Factor-kappaB and Mitogen Activated Protein Kinase Signaling Pathways in RAW264.7 Mouse Macrophage Cells

(2011) Hyuk-Jin Seo et al.   PHYTOTHERAPY RESEARCH

Eriobotryae Folium Extract Suppresses LPS-Induced iNOS and COX-2 Expression by Inhibition of NF-κB and MAPK Activation in Murine Macrophages

(2010) Takuhiro Uto et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Inhibition of p38 Mitogen-Activated Protein Kinase Reduces Inflammation After Coronary Vascular Injury in Humans

(2010) Lea Sarov-Blat et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Interleukin-4, Oxidative Stress, Vascular Inflammation and Atherosclerosis

(2010) Yong-Woo Lee et al.   Biomolecules & Therapeutics

Adalimumab therapy rapidly inhibits p38 mitogen-activated protein kinase activity in lesional psoriatic skin preceding clinical improvement

(2010) L. Soegaard-Madsen et al.   BRITISH JOURNAL OF DERMATOLOGY

Novel p38 MAPK inhibitor ML3403 has potent anti-inflammatory activity in airway smooth muscle

(2010) Lenka Munoz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Gram-scale synthesis of the p38α MAPK-inhibitor VX-745 for preclinical studies into Werner syndrome

(2010) Mark C Bagley et al.   Future Medicinal Chemistry

p38-Targeted inhibition of interleukin-12 expression by ethanol extract fromCordyceps bassianain lipopolysaccharide-activated macrophages

(2010) Se Eun Byeon et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Pro-inflammatory angiogenesis is mediated by p38 MAP kinase

(2010) Gangaraju Rajashekhar et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Proof-of-Concept and Drug-Drug Interaction Study of Pamapimod, a Novel p38 MAP Kinase Inhibitor, With Methotrexate in Patients With Rheumatoid Arthritis

(2010) Xiaoping Zhang et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a Clinical p38α MAP Kinase Inhibitor for the Treatment of Inflammatory Diseases

(2010) Chunjian Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inflammation in Neurological Disorders: A Help or a Hindrance?

(2010) V. Wee Yong   NEUROSCIENTIST

Macrophages: Master Regulators of Inflammation and Fibrosis

(2010) Thomas Wynn et al.   SEMINARS IN LIVER DISEASE

The three-dimensional structure of MAP kinase p38β: different features of the ATP-binding site in p38β compared with p38α

(2009) Sangita B. Patel et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Polyphenols Extracted fromHibiscus sabdariffaL. Inhibited Lipopolysaccharide-Induced Inflammation by Improving Antioxidative Conditions and RegulatingCyclooxygenase-2 Expression

(2009) Erl-Shyh KAO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

p38  Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice

(2009) E. M. Schindler et al.   CANCER RESEARCH

Quaternary alkaloid, pseudocoptisine isolated from tubers of Corydalis turtschaninovi inhibits LPS-induced nitric oxide, PGE2, and pro-inflammatory cytokines production via the down-regulation of NF-κB in RAW 264.7 murine macrophage cells

(2009) Kyung-Jin Yun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules

(2009) Eun Hye Kim et al.   JOURNAL OF ETHNOPHARMACOLOGY

Suppression of lipopolysaccharide-induced inflammatory responses in RAW 264.7 murine macrophages by aqueous extract of Clinopodium vulgare L. (Lamiaceae)

(2009) David R. Burk et al.   JOURNAL OF ETHNOPHARMACOLOGY

Selective p38α Inhibitors Clinically Evaluated for the Treatment of Chronic Inflammatory Disorders

(2009) David M. Goldstein et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-inflammatory activity of 4-methoxyhonokiol is a function of the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-κB, JNK and p38 MAPK inactivation

(2008) Hong Yu Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill

(2008) Lian Yu Guo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pamapimod, a Novel p38 Mitogen-Activated Protein Kinase Inhibitor: Preclinical Analysis of Efficacy and Selectivity

(2008) R. J. Hill et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Effects of hyperin, isoquercitrin and quercetin on lipopolysaccharide-induced nitrite production in rat peritoneal macrophages

(2008) Sanghyun Lee et al.   PHYTOTHERAPY RESEARCH