Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies

Decreased pH in aging brain and Alzheimer's disease

(2021) Yann Decker et al.   NEUROBIOLOGY OF AGING

Molecular mechanisms of neurodegeneration in the entorhinal cortex that underlie its selective vulnerability during the pathogenesis of Alzheimer's disease

(2021) Olayemi Joseph Olajide et al.   Biology Open

Does Impairment of Adult Neurogenesis Contribute to Pathophysiology of Alzheimer's Disease? A Still Open Question

(2021) Domenica Donatella Li Puma et al.   Frontiers in Molecular Neuroscience

Molecular Imaging of Tau Protein: New Insights and Future Directions

(2021) Rocco Pizzarelli et al.   Frontiers in Molecular Neuroscience

Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation

(2021) Carolina Alquezar et al.   Frontiers in Neurology

Tau Oligomers Neurotoxicity

(2021) Grazyna Niewiadomska et al.   Life-Basel

A theoretical study of polymorphism in VQIVYK fibrils

(2021) Jaehoon Yang et al.   BIOPHYSICAL JOURNAL

Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies

(2021) Che-Wei Chang et al.   SCIENCE

Tau Pathology and Adult Hippocampal Neurogenesis: What Tau Mouse Models Tell us?

(2021) Sarah Houben et al.   Frontiers in Neurology

Critical Molecular and Cellular Contributors to Tau Pathology

(2021) Liqing Song et al.   Biomedicines

Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607

(2021) Yang Shi et al.   ACTA NEUROPATHOLOGICA

Combating deleterious phase transitions in neurodegenerative disease

(2021) April L. Darling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tau secretion and propagation: Perspectives for potential preventive interventions in Alzheimer's disease and other tauopathies

(2021) Narendran Annadurai et al.   EXPERIMENTAL NEUROLOGY

Tau Is Truncated in Five Regions of the Normal Adult Human Brain

(2021) Michael G. Friedrich et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aging and Alzheimer’s disease connection: Nuclear Tau and lamin A

(2021) Laura Gil et al.   NEUROSCIENCE LETTERS

GSK-3 and Tau: A Key Duet in Alzheimer’s Disease

(2021) Carmen Laura Sayas et al.   Cells

Role of the Lipid Membrane and Membrane Proteins in Tau Pathology

(2021) Eugene Bok et al.   Frontiers in Cell and Developmental Biology

The Sulfation Code of Tauopathies: Heparan Sulfate Proteoglycans in the Prion Like Spread of Tau Pathology

(2021) Dylan Mah et al.   Frontiers in Molecular Biosciences

Dissecting the Binding Profile of PET Tracers to Corticobasal Degeneration Tau Fibrils

(2021) Yang Zhou et al.   ACS Chemical Neuroscience

Decoding perineuronal net glycan sulfation patterns in the Alzheimer's disease brain

(2021) Aric F. Logsdon et al.   Alzheimers & Dementia

Deconstructing Alzheimer’s Disease: How to Bridge the Gap between Experimental Models and the Human Pathology?

(2021) Anaïs Vignon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protein Aggregation Landscape in Neurodegenerative Diseases: Clinical Relevance and Future Applications

(2021) Niccolò Candelise et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cellular and pathological heterogeneity of primary tauopathies

(2021) Dah-eun Chloe Chung et al.   Molecular Neurodegeneration

The human connectome in Alzheimer disease — relationship to biomarkers and genetics

(2021) Meichen Yu et al.   Nature Reviews Neurology

Tau in the brain interstitial fluid is fragmented and seeding-competent

(2021) Erica Barini et al.   NEUROBIOLOGY OF AGING

Revisiting FDA Approval of Aducanumab

(2021) G. Caleb Alexander et al.   NEW ENGLAND JOURNAL OF MEDICINE

Approval of Aducanumab for Alzheimer Disease—the FDA’s Perspective

(2021) Billy Dunn et al.   JAMA Internal Medicine

Dendritic/Post-synaptic Tau and Early Pathology of Alzheimer’s Disease

(2021) Xiaomin Yin et al.   Frontiers in Molecular Neuroscience

Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates

(2021) François-Xavier Cantrelle et al.   Frontiers in Molecular Neuroscience

Synaptic tau: A pathological or physiological phenomenon?

(2021) Miranda Robbins et al.   Acta Neuropathologica Communications

Possible Mechanisms of Tau Spread and Toxicity in Alzheimer’s Disease

(2021) Huiqin Zhang et al.   Frontiers in Cell and Developmental Biology

Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?

(2021) Hilal A. Lashuel   CURRENT OPINION IN CHEMICAL BIOLOGY

Structure-based classification of tauopathies

(2021) Yang Shi et al.   NATURE

Binding of Metal-Ion-Induced Tau Oligomers to Lipid Surfaces Is Enhanced by GSK-3β-Mediated Phosphorylation

(2020) Georg S. Nuebling et al.   ACS Chemical Neuroscience

Electrostatically Driven Complex Coacervation and Amyloid Aggregation of Tau Are Independent Processes with Overlapping Conditions

(2020) Yanxian Lin et al.   ACS Chemical Neuroscience

Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains

(2020) Tamta Arakhamia et al.   CELL

A synthetic heparinoid blocks Tau aggregate cell uptake and amplification

(2020) Barbara E. Stopschinski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel tau filament fold in corticobasal degeneration

(2020) Wenjuan Zhang et al.   NATURE

Extracellular matrix proteins involved in Alzheimer’s disease

(2020) Jun Ma et al.   CHEMISTRY-A EUROPEAN JOURNAL

Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau

(2020) Nadine Ait-Bouziad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liquid–Liquid Phase Separation and Its Mechanistic Role in Pathological Protein Aggregation

(2020) W. Michael Babinchak et al.   JOURNAL OF MOLECULAR BIOLOGY

Physiological Tau Interactome in Brain and Its Link to Tauopathies

(2020) Jakub Sinsky et al.   JOURNAL OF PROTEOME RESEARCH

The Positive Side of the Alzheimer’s Disease Amyloid Cross-Interactions: The Case of the Aβ 1-42 Peptide with Tau, TTR, CysC, and ApoA1

(2020) Lidia Ciccone et al.   MOLECULES

Tau immunotherapies: Lessons learned, current status and future considerations

(2020) L.A. Sandusky-Beltran et al.   NEUROPHARMACOLOGY

An investigation of the correlation between the S-glutathionylated GAPDH levels in blood and Alzheimer’s disease progression

(2020) Chen Wei Tsai et al.   PLoS One

Cell-to-Cell Transmission of Tau and α-Synuclein

(2020) Norihito Uemura et al.   TRENDS IN MOLECULAR MEDICINE

PROTAC Technology: Opportunities and Challenges

(2020) Hongying Gao et al.   ACS Medicinal Chemistry Letters

Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease

(2020) Jacob W. Vogel et al.   Nature Communications

Astroglia and Tau: New Perspectives

(2020) Gabor G. Kovacs   Frontiers in Aging Neuroscience

Behavioral Abnormalities in Knockout and Humanized Tau Mice

(2020) Rafaella Araujo Gonçalves et al.   Frontiers in Endocrinology

Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review

(2020) Larissa-Nele Schaffert et al.   Brain Sciences

Tau and Alpha Synuclein Synergistic Effect in Neurodegenerative Diseases: When the Periphery Is the Core

(2020) Elena Vacchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Truncation of tau selectively facilitates its pathological activities

(2020) Jianlan Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy

(2020) Xiaohai Wang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Unsaturated Fatty Acid-Induced Conformational Transitions and Aggregation of the Repeat Domain of Tau

(2020) Carlo Giorgio Barracchia et al.   MOLECULES

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

(2020) Simon Dujardin et al.   NATURE MEDICINE

Beneficial effects of low-dose lithium on cognitive ability and pathological alteration of Alzheimer’s disease transgenic mice model

(2020) Meng Liu et al.   NEUROREPORT

Targeting tau: Clinical trials and novel therapeutic approaches

(2020) Lawren VandeVrede et al.   NEUROSCIENCE LETTERS

Screening of tau protein kinase inhibitors in a tauopathy-relevant cell-based model of tau hyperphosphorylation and oligomerization

(2020) Hamad Yadikar et al.   PLoS One

Liquid-liquid phase separation induces pathogenic tau conformations in vitro

(2020) Nicholas M. Kanaan et al.   Nature Communications

Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein

(2020) Jaroslaw Majewski et al.   Scientific Reports

Phosphorylated tau interactome in the human Alzheimer’s disease brain

(2020) Eleanor Drummond et al.   BRAIN

Site‐Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases

(2020) Anass Chiki et al.   CHEMBIOCHEM

Cryo-EM structures of tau filaments

(2020) Sjors HW Scheres et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Phase Separation and Neurodegenerative Diseases: A Disturbance in the Force

(2020) Aurélie Zbinden et al.   DEVELOPMENTAL CELL

Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration

(2020) Maud Gratuze et al.   JOURNAL OF CLINICAL INVESTIGATION

α-Synuclein modulates tau spreading in mouse brains

(2020) Fares Bassil et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anti-tau scFvs targeted to the cytoplasm or secretory pathway variably modify pathology and neurodegenerative phenotypes

(2020) Marshall S. Goodwin et al.   MOLECULAR THERAPY

Mechanisms of Pathogenic Tau and Aβ Protein Spreading in Alzheimer’s Disease

(2020) Paolo d‘Errico et al.   Frontiers in Aging Neuroscience

A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human tau but minimal levels of other key modifications

(2020) Friedel Drepper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

(2020) Hendrik Wesseling et al.   CELL

Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies

(2020) M. Catarina Silva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulatory mechanisms of tau protein fibrillation under the conditions of liquid–liquid phase separation

(2020) Solomiia Boyko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsic electronic conductivity of individual atomically resolved amyloid crystals reveals micrometer-long hole hopping via tyrosines

(2020) Catharine Shipps et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Insights Into Drug Discovery Targeting Tau Protein

(2020) Yoshiyuki Soeda et al.   Frontiers in Molecular Neuroscience

Alterations in Tau Metabolism in ALS and ALS-FTSD

(2020) Michael J. Strong et al.   Frontiers in Neurology

Longitudinal tau accumulation and atrophy in aging and alzheimer disease

(2019) Theresa M. Harrison et al.   ANNALS OF NEUROLOGY

A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response

(2019) Tong Guo et al.   Acta Neuropathologica Communications

Novel Mouse Tauopathy Model for Repetitive Mild Traumatic Brain Injury: Evaluation of Long-Term Effects on Cognition and Biomarker Levels After Therapeutic Inhibition of Tau Phosphorylation

(2019) Richard Rubenstein et al.   Frontiers in Neurology

Novel model of secreted human tau protein reveals the impact of the abnormal N-glycosylation of tau on its aggregation propensity

(2019) Yelena Losev et al.   Scientific Reports

Treatment of Alzheimer’s by PROTAC-Tau Protein Degradation

(2019) Robert B. Kargbo   ACS Medicinal Chemistry Letters

Soluble tau aggregates inhibit synaptic long-term depression and amyloid β-facilitated LTD in vivo

(2019) Tomas Ondrejcak et al.   NEUROBIOLOGY OF DISEASE

Glycosylation in health and disease

(2019) Colin Reily et al.   Nature Reviews Nephrology

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

(2019) Benjamin Falcon et al.   NATURE

Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions

(2019) Johannes Popow et al.   JOURNAL OF MEDICINAL CHEMISTRY

Methylene Blue Inhibits Formation of Tau Fibrils but not of Granular Tau Oligomers: A Plausible Key to Understanding Failure of a Clinical Trial for Alzheimer’s Disease

(2019) Yoshiyuki Soeda et al.   JOURNAL OF ALZHEIMERS DISEASE

Elucidating Tau function and dysfunction in the era of cryo-EM

(2019) Guy Lippens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH

(2019) Rabab A. Charafeddine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions

(2019) Yanxian Lin et al.   eLife

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

(2019) Wenjuan Zhang et al.   eLife

LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer’s disease brains

(2019) Gábor M. Mórotz et al.   Acta Neuropathologica Communications

Tau pathology reduction with SM07883, a novel, potent, and selective oral DYRK1A inhibitor: A potential therapeutic for Alzheimer's disease

(2019) Benoît Melchior et al.   AGING CELL

Regulation of neuronal microtubule dynamics by tau: Implications for tauopathies

(2019) Anuradha Venkatramani et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults

(2019) Val J. Lowe et al.   NEUROLOGY

In vitro 0N4R tau fibrils contain a monomorphic β-sheet core enclosed by dynamically heterogeneous fuzzy coat segments

(2019) Aurelio J. Dregni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting IRAK4 for Degradation with PROTACs

(2019) Joao Nunes et al.   ACS Medicinal Chemistry Letters

Proteome-wide analysis of chaperone-mediated autophagy targeting motifs

(2019) Philipp Kirchner et al.   PLOS BIOLOGY

Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease

(2019) Christopher H. van Dyck et al.   JAMA Neurology

Clinical use of lithium salts: guide for users and prescribers

(2019) Leonardo Tondo et al.   International Journal of Bipolar Disorders

Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory

(2019) Ramesh C. Gupta et al.   Frontiers in Veterinary Science

Identification of a Novel Selective and Potent Inhibitor of Glycogen Synthase Kinase-3

(2019) Mahboubeh S Noori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Recent tau-targeted clinical strategies for the treatment of Alzheimer's disease

(2019) Ha E Lee et al.   Future Medicinal Chemistry

Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies

(2019) Harold G. Selnick et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects

(2019) Pascale Barbier et al.   Frontiers in Aging Neuroscience

The Evolution of Tau Phosphorylation and Interactions

(2019) Nataliya I. Trushina et al.   Frontiers in Aging Neuroscience

Tau Secretion: Good and Bad for Neurons

(2019) Camille Pernègre et al.   Frontiers in Neuroscience

Degradation of proteins by PROTACs and other strategies

(2019) Yang Wang et al.   Acta Pharmaceutica Sinica B

From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy

(2019) Morvane Colin et al.   ACTA NEUROPATHOLOGICA

Acetylation changes tau interactome to degrade tau in Alzheimer’s disease animal and organoid models

(2019) Heesun Choi et al.   AGING CELL

Propagation of Tau Pathology: Integrating Insights From Postmortem and In Vivo Studies

(2019) Thomas Vogels et al.   BIOLOGICAL PSYCHIATRY

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

(2019) Longchuan Bai et al.   CANCER CELL

Mechanisms of secretion and spreading of pathological tau protein

(2019) Cecilia A. Brunello et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Zinc Binding to Tau Influences Aggregation Kinetics and Oligomer Distribution

(2019) Moreira et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Membrane-mediated fibrillation and toxicity of the tau hexapeptide PHF6

(2019) Adeline M. Fanni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-based inhibitors halt prion-like seeding by Alzheimer's disease–and tauopathy–derived brain tissue samples

(2019) Paul Matthew Seidler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding

(2019) Mahmood Haj-Yahya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age

(2019) Tobey J Betthauser et al.   BRAIN

Glycan biomarkers for Alzheimer disease correlate with T‐tau and P‐tau in cerebrospinal fluid in subjective cognitive impairment

(2019) Sophia Schedin‐Weiss et al.   FEBS Journal

NP03, a Microdose Lithium Formulation, Blunts Early Amyloid Post-Plaque Neuropathology in McGill-R-Thy1-APP Alzheimer-Like Transgenic Rats

(2019) Edward N. Wilson et al.   JOURNAL OF ALZHEIMERS DISEASE

Human tau pathology transmits glial tau aggregates in the absence of neuronal tau

(2019) Sneha Narasimhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Optimizing intracellular antibodies (intrabodies/nanobodies) to treat neurodegenerative disorders

(2019) Anne Messer et al.   NEUROBIOLOGY OF DISEASE

Tau-Cofactor Complexes as Building Blocks of Tau Fibrils

(2019) Yann Fichou et al.   Frontiers in Neuroscience

Advanced Glycation End Products Modulate Amyloidogenic APP Processing and Tau Phosphorylation: A Mechanistic Link between Glycation and the Development of Alzheimer’s Disease

(2018) Kedar Batkulwar et al.   ACS Chemical Neuroscience

α-Synuclein Oligomers Induce a Unique Toxic Tau Strain

(2018) Diana L. Castillo-Carranza et al.   BIOLOGICAL PSYCHIATRY

Efficacy and safety of methylene blue in the treatment of malaria: a systematic review

(2018) G. Lu et al.   BMC Medicine

Spreading of Tau Pathology in Sporadic Alzheimer’s Disease Along Cortico-cortical Top-Down Connections

(2018) Heiko Braak et al.   CEREBRAL CORTEX

The Involvement of Post-Translational Modifications in Alzheimer’s Disease

(2018) Serena Marcelli et al.   Current Alzheimer Research

Tau Does Not Stabilize Axonal Microtubules but Rather Enables Them to Have Long Labile Domains

(2018) Liang Qiang et al.   CURRENT BIOLOGY

Tau protein liquid–liquid phase separation can initiate tau aggregation

(2018) Susanne Wegmann et al.   EMBO JOURNAL

Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway

(2018) Mengchen Lu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tau ablation in mice leads to pancreatic β cell dysfunction and glucose intolerance

(2018) Nadeeja Wijesekara et al.   FASEB JOURNAL

The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration

(2018) Auriane Maïza et al.   FEBS LETTERS

Acetylation Disfavors Tau Phase Separation

(2018) Josephine Ferreon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Conundrum of GSK3 Inhibitors: Is it the Dawn of a New Beginning?

(2018) Ratan V. Bhat et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers

(2018) James P. Quinn et al.   JOURNAL OF ALZHEIMERS DISEASE

Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tauversusα-synuclein and β-amyloid aggregates

(2018) Barbara E. Stopschinski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States

(2018) Mahmood Haj-Yahya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Tau Kinetics in Neurons and the Human Central Nervous System

(2018) Chihiro Sato et al.   NEURON

Disease-modifying benefit of Fyn blockade persists after washout in mouse Alzheimer's model

(2018) Levi M. Smith et al.   NEUROPHARMACOLOGY

Delineating the role of cooperativity in the design of potent PROTACs for BTK

(2018) Adelajda Zorba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unconventional Secretion Mediates the Trans-cellular Spreading of Tau

(2018) Taxiarchis Katsinelos et al.   Cell Reports

Association Between Groundwater Lithium and the Diagnosis of Bipolar Disorder and Dementia in the United States

(2018) William F. Parker et al.   JAMA Psychiatry

A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies

(2018) Caterina Giacomini et al.   Acta Neuropathologica Communications

Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach

(2018) Zuni I. Bassi et al.   ACS Chemical Biology

Glycans and glycosaminoglycans in neurobiology: key regulators of neuronal cell function and fate

(2018) Anthony J. Hayes et al.   BIOCHEMICAL JOURNAL

Conformational heterogeneity of tau: Implication on intrinsic disorder, acid stability and fibrillation in Alzheimer's disease

(2018) Benita Jebarupa et al.   BIOPHYSICAL CHEMISTRY

Activation of Protein Phosphatase 2B and Hyperphosphorylation of Tau in Alzheimer's Disease

(2018) Wei Qian et al.   JOURNAL OF ALZHEIMERS DISEASE

Identification of Polypeptides in Neurofibrillary Tangles and Total Homogenates of Brains with Alzheimer's Disease by Tandem Mass Spectrometry

(2018) Benito Minjarez et al.   JOURNAL OF ALZHEIMERS DISEASE

Distinct Chronology of Neuronal Cell Cycle Re-Entry and Tau Pathology in the 3xTg-AD Mouse Model and Alzheimer's Disease Patients

(2018) Alex C. Hradek et al.   JOURNAL OF ALZHEIMERS DISEASE

N-terminal Truncation of Microtubule Associated Protein Tau Dysregulates its Cellular Localization

(2018) Kristina Paholikova et al.   JOURNAL OF ALZHEIMERS DISEASE

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting

(2018) Sean M. Deguire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine-Independent Inhibition of Alzheimer's Disease-like Paired Helical Filament Assembly by Leuco-Methylthioninium (LMT)

(2018) Youssra K. Al-Hilaly et al.   JOURNAL OF MOLECULAR BIOLOGY

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Quantitative Analysis of the Brain Ubiquitylome in Alzheimer's Disease

(2018) Measho H. Abreha et al.   PROTEOMICS

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs)

(2018) Jennifer N. Rauch et al.   Scientific Reports

Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6

(2018) William McCoull et al.   ACS Chemical Biology

Quantifying Co-Oligomer Formation by α-Synuclein

(2018) Marija Iljina et al.   ACS Nano

Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer’s disease

(2018) Claudia Cicognola et al.   ACTA NEUROPATHOLOGICA

PIP2 Phospholipid-Induced Aggregation of Tau Filaments Probed by Tip-Enhanced Raman Spectroscopy

(2018) David Talaga et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding

(2018) Doris Ellmer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diminished O-GlcNAcylation in Alzheimer's disease is strongly correlated with mitochondrial anomalies

(2018) Tiffany S. Pinho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Therapeutic potential of rescuing protein O-GlcNAcylation in tau-related pathologies

(2018) Fabio Di Domenico et al.   Expert Review of Neurotherapeutics

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brains

(2018) Hans-Ulrich Klein et al.   NATURE NEUROSCIENCE

A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology

(2018) Hongjun Fu et al.   NATURE NEUROSCIENCE

RNAct: Protein–RNA interaction predictions for model organisms with supporting experimental data

(2018) Benjamin Lang et al.   NUCLEIC ACIDS RESEARCH

The BioGRID interaction database: 2019 update

(2018) Rose Oughtred et al.   NUCLEIC ACIDS RESEARCH

Cofactors are essential constituents of stable and seeding-active tau fibrils

(2018) Yann Fichou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secretion of Tau via an Unconventional Non-vesicular Mechanism

(2018) Maria Merezhko et al.   Cell Reports

Direct Crosstalk Between O-GlcNAcylation and Phosphorylation of Tau Protein Investigated by NMR Spectroscopy

(2018) Gwendoline Bourré et al.   Frontiers in Endocrinology

Dual Mechanism of Toxicity for Extracellular Injection of Tau Oligomers versus Monomers in Human Tau Mice

(2017) Giusi Manassero et al.   JOURNAL OF ALZHEIMERS DISEASE

Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies

(2017) Kevin H. Strang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An acetylation–phosphorylation switch that regulates tau aggregation propensity and function

(2017) Yari Carlomagno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau deletion promotes brain insulin resistance

(2017) Elodie Marciniak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Entorhinal Tau Pathology, Episodic Memory Decline, and Neurodegeneration in Aging

(2017) Anne Maass et al.   JOURNAL OF NEUROSCIENCE

Methylene blue and its analogues as antidepressant compounds

(2017) Anzelle Delport et al.   METABOLIC BRAIN DISEASE

Tau-imaging in neurodegeneration

(2017) Gérard N. Bischof et al.   METHODS

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

(2017) Nicholas B. Hastings et al.   Molecular Neurodegeneration

A validated antibody panel for the characterization of tau post-translational modifications

(2017) Ebru Ercan et al.   Molecular Neurodegeneration

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

Review: Tau in biofluids - relation to pathology, imaging and clinical features

(2017) H. Zetterberg   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Identification of the Tau phosphorylation pattern that drives its aggregation

(2017) Clément Despres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

(2017) Cheryl E. G. Leyns et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes

(2017) Nadine Ait-Bouziad et al.   Nature Communications

Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

(2017) Susmitha Ambadipudi et al.   Nature Communications

RNA stores tau reversibly in complex coacervates

(2017) Xuemei Zhang et al.   PLOS BIOLOGY

Association of Lithium in Drinking Water With the Incidence of Dementia

(2017) Lars Vedel Kessing et al.   JAMA Psychiatry

Atypical, non-standard functions of the microtubule associated Tau protein

(2017) Ioannis Sotiropoulos et al.   Acta Neuropathologica Communications

Truncation of Tau Protein and its Pathological Significance in Alzheimer's Disease

(2017) Francisco García-Sierra et al.   JOURNAL OF ALZHEIMERS DISEASE

Lithium Treatment Arrests the Development of Neurofibrillary Tangles in Mutant Tau Transgenic Mice with Advanced Neurofibrillary Pathology

(2017) Karelle Leroy et al.   JOURNAL OF ALZHEIMERS DISEASE

A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy

(2017) Hanna Trzeciakiewicz et al.   Scientific Reports

Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo

(2016) Bruno Vasconcelos et al.   ACTA NEUROPATHOLOGICA

Characterization of tau positron emission tomography tracer [ 18 F]AV-1451 binding to postmortem tissue in Alzheimer's disease, primary tauopathies, and other dementias

(2016) Kerstin Sander et al.   Alzheimers & Dementia

Glycation alter the process of Tau phosphorylation to change Tau isoforms aggregation property

(2016) Kefu Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Regional profiles of the candidate tau PET ligand18F-AV-1451 recapitulate key features of Braak histopathological stages

(2016) Adam J. Schwarz et al.   BRAIN

Population Studies of Association Between Lithium and Risk of Neurodegenerative Disorders

(2016) Markus Donix et al.   Current Alzheimer Research

Comprehensive Quantitative Profiling of Tau and Phosphorylated Tau Peptides in Cerebrospinal Fluid by Mass Spectrometry Provides New Biomarker Candidates

(2016) Claire L. Russell et al.   JOURNAL OF ALZHEIMERS DISEASE

Differential Mass Spectrometry Profiles of Tau Protein in the Cerebrospinal Fluid of Patients with Alzheimer’s Disease, Progressive Supranuclear Palsy, and Dementia with Lewy Bodies

(2016) Nicolas R. Barthélemy et al.   JOURNAL OF ALZHEIMERS DISEASE

The Dynamics and Turnover of Tau Aggregates in Cultured Cells

(2016) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

(2016) Jing L. Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Presence of cerebral amyloid modulates phenotype and pattern of neurodegeneration in early Parkinson's disease

(2016) Corey T McMillan et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Semi-synthesis of a tag-freeO-GlcNAcylated tau protein by sequential chemoselective ligation

(2016) Sergej Schwagerus et al.   JOURNAL OF PEPTIDE SCIENCE

Caspase-2 cleavage of tau reversibly impairs memory

(2016) Xiaohui Zhao et al.   NATURE MEDICINE

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

(2016) Tara E. Tracy et al.   NEURON

PET Imaging of Tau Deposition in the Aging Human Brain

(2016) Michael Schöll et al.   NEURON

Loss ofO-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration

(2016) Andrew C. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8

(2016) Thomas J. Malia et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Immune pathogenesis of heparin-induced thrombocytopenia

(2016) Sanjay Khandelwal et al.   THROMBOSIS AND HAEMOSTASIS

Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity

(2016) Kotaro Shirakawa et al.   eLife

Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

(2016) Valentina Cappello et al.   Scientific Reports

Propagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

(2015) Jada Lewis et al.   ACTA NEUROPATHOLOGICA

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice

(2015) Adam C. Kaufman et al.   ANNALS OF NEUROLOGY

Tau positron emission tomographic imaging in aging and early Alzheimer disease

(2015) Keith A. Johnson et al.   ANNALS OF NEUROLOGY

Inflammation in Alzheimer’s Disease and Molecular Genetics: Recent Update

(2015) Zhi-Gang Zhang et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models

(2015) Valeria Melis et al.   BEHAVIOURAL PHARMACOLOGY

RNA Binds to Tau Fibrils and Sustains Template-Assisted Growth

(2015) Paul D. Dinkel et al.   BIOCHEMISTRY

Native chemical ligation between asparagine and valine: Application and limitations for the synthesis of tri-phosphorylated C-terminal tau

(2015) Oliver Reimann et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease

(2015) Heiko Braak et al.   BRAIN

Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients withMAPTmutations

(2015) Mariangela Iovino et al.   BRAIN

Synthetic approaches to protein phosphorylation

(2015) Zan Chen et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Electrochemistry of heparin binding to tau protein on Au surfaces

(2015) Hanna Trzeciakiewicz et al.   ELECTROCHIMICA ACTA

The twenty-four KDa C-terminal tau fragment increases with aging in tauopathy mice: implications of prion-like properties

(2015) Shin-Ei Matsumoto et al.   HUMAN MOLECULAR GENETICS

Monitoring of Intracellular Tau Aggregation Regulated by OGA/OGT Inhibitors

(2015) Sungsu Lim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease

(2015) Charles R. Harrington et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease

(2015) Sophie Sokolow et al.   JOURNAL OF NEUROCHEMISTRY

C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death

(2015) D. Kanmert et al.   JOURNAL OF NEUROSCIENCE

Tau Aggregation Propensity Engrained in Its Solution State

(2015) Neil A. Eschmann et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Tau Binds to Multiple Tubulin Dimers with Helical Structure

(2015) Xiao-Han Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome

(2015) C. Geeth Gunawardana et al.   MOLECULAR & CELLULAR PROTEOMICS

Analysis of in vivo turnover of tau in a mouse model of tauopathy

(2015) Kaoru Yamada et al.   Molecular Neurodegeneration

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

(2015) Harindranath Kadavath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms

(2015) Maxime Derisbourg et al.   Scientific Reports

Sensitivity to change and prediction of global change for the Alzheimer’s Questionnaire

(2015) Michael Malek-Ahmadi et al.   Alzheimers Research & Therapy

Primary age-related tauopathy (PART): a common pathology associated with human aging

(2014) John F. Crary et al.   ACTA NEUROPATHOLOGICA

Effects of Post-Session Administration of Methylene Blue on Fear Extinction and Contextual Memory in Adults With Claustrophobia

(2014) Michael J. Telch et al.   AMERICAN JOURNAL OF PSYCHIATRY

Inhibition of tau aggregation by a rosamine derivative that blocks tau intermolecular disulfide cross-linking

(2014) Md. Mamunul Haque et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

A functional fragment of Tau forms fibers without the need for an intermolecular cysteine bridge

(2014) Isabelle Huvent et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nuclear Magnetic Resonance Analysis of the Acetylation Pattern of the Neuronal Tau Protein

(2014) Amina Kamah et al.   BIOCHEMISTRY

Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding

(2014) Katharina Flach et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Tau Binds to Lipid Membrane Surfaces via Short Amphipathic Helices Located in Its Microtubule-Binding Repeats

(2014) Elka R. Georgieva et al.   BIOPHYSICAL JOURNAL

Structure and Mechanism of Action of Tau Aggregation Inhibitors

(2014) Katryna Cisek et al.   Current Alzheimer Research

Development of dual targeting inhibitors against aggregations of amyloid-β and tau protein

(2014) Shinichiro Fuse et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity

(2014) Cliona Stack et al.   HUMAN MOLECULAR GENETICS

Tau Protein Modifications and Interactions: Their Role in Function and Dysfunction

(2014) Anna Mietelska-Porowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

O-GlcNAc Modification of tau Directly Inhibits Its Aggregation without Perturbing the Conformational Properties of tau Monomers

(2014) Scott A. Yuzwa et al.   JOURNAL OF MOLECULAR BIOLOGY

Clearance of the intracellular high level of the Tau protein directed by an artificial synthetic hydrolase

(2014) Ting-Ting Chu et al.   Molecular BioSystems

Motor and cognitive deficits in aged tau knockout mice in two background strains

(2014) Peng Lei et al.   Molecular Neurodegeneration

A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy

(2014) Eduardo Tolosa et al.   MOVEMENT DISORDERS

Tideglusib reduces progression of brain atrophy in progressive supranuclear palsy in a randomized trial

(2014) Günter U. Höglinger et al.   MOVEMENT DISORDERS

Huntington's disease is a four-repeat tauopathy with tau nuclear rods

(2014) Marta Fernández-Nogales et al.   NATURE MEDICINE

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination

(2014) Hong-Bin Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions

(2014) Marie Violet et al.   Frontiers in Cellular Neuroscience

Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias

(2014) Melissa E Murray et al.   Alzheimers Research & Therapy

Acetylation: a new key to unlock tau’s role in neurodegeneration

(2014) Casey Cook et al.   Alzheimers Research & Therapy

Physiological and pathological phosphorylation of tau by Cdk5

(2014) Taeko Kimura et al.   Frontiers in Molecular Neuroscience

Caspase-mediated cleavage of actin and tubulin is a common feature and sensitive marker of axonal degeneration in neural development and injury

(2014) Jennifer D Sokolowski et al.   Acta Neuropathologica Communications

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

(2013) Casey Cook et al.   HUMAN MOLECULAR GENETICS

Aminothienopyridazines and Methylene Blue Affect Tau Fibrillization via Cysteine Oxidation

(2013) Alex Crowe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-  signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease

(2013) M. E. Seward et al.   JOURNAL OF CELL SCIENCE

Cerebrospinal Fluid Tau Cleaved by Caspase-6 Reflects Brain Levels and Cognition in Aging and Alzheimer Disease

(2013) Jasmine Ramcharitar et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Inhibition of Tau Filament Formation by Conformational Modulation

(2013) Elias Akoury et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy

(2013) Danielle L. Graham et al.   NEUROPHARMACOLOGY

Microtubule-associated protein tau is essential for long-term depression in the hippocampus

(2013) T. Kimura et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Efficacy and Safety of A Liposome-Based Vaccine against Protein Tau, Assessed in Tau.P301L Mice That Model Tauopathy

(2013) Clara Theunis et al.   PLoS One

Identification of the Sites of Tau Hyperphosphorylation and Activation of Tau Kinases in Synucleinopathies and Alzheimer’s Diseases

(2013) Valeriy Duka et al.   PLoS One

Increasing Brain Protein O-GlcNAc-ylation Mitigates Breathing Defects and Mortality of Tau.P301L Mice

(2013) Peter Borghgraef et al.   PLoS One

Synthetic polyubiquitinated  -Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology

(2013) M. Haj-Yahya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau degradation: The ubiquitin–proteasome system versus the autophagy-lysosome system

(2013) Min Jae Lee et al.   PROGRESS IN NEUROBIOLOGY

Perturbation of the heparin/heparin-sulfate interactome of human breast cancer cells modulates pro-tumourigenic effects associated with PI3K/Akt and MAPK/ERK signalling

(2013) Yunliang Chen et al.   THROMBOSIS AND HAEMOSTASIS

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Tau Clearance Mechanisms and Their Possible Role in the Pathogenesis of Alzheimer Disease

(2013) Adrianne S. Chesser et al.   Frontiers in Neurology

Tau protein kinases: Involvement in Alzheimer's disease

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

(2012) Erin E. Congdon et al.   Autophagy

Luminescent conjugated poly- and oligo-thiophenes: optical ligands for spectral assignment of a plethora of protein aggregates

(2012) Therése Klingstedt et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Degradation of tau protein by autophagy and proteasomal pathways: Figure 1

(2012) Yipeng Wang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Aminothienopyridazine inhibitors of tau aggregation: Evaluation of structure–activity relationship leads to selection of candidates with desirable in vivo properties

(2012) Carlo Ballatore et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies

(2012) David J. Irwin et al.   BRAIN

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

The Alzheimer’s Disease Related Tau Protein as a New Target for Chemical Protein Engineering

(2012) Malgorzata Broncel et al.   CHEMISTRY-A EUROPEAN JOURNAL

On the ‘classification’ of neurodegenerative disorders: discrete entities, overlap or continuum?

(2012) Richard A. Armstrong   FOLIA NEUROPATHOLOGICA

MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies

(2012) Daniah Trabzuni et al.   HUMAN MOLECULAR GENETICS

Characterization of Semisynthetic and NaturallyNα-Acetylated α-Synucleinin Vitroand in Intact Cells

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Introduction to Proteoglycans and Their Localization

(2012) John R. Couchman et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Identification of an Aggregation-Prone Structure of Tau

(2012) Shana Elbaum-Garfinkle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

(2012) Scott A Yuzwa et al.   Nature Chemical Biology

Calcyclin binding protein and Siah-1 interacting protein in Alzheimer's disease pathology: neuronal localization and possible function

(2012) Urszula Wasik et al.   NEUROBIOLOGY OF AGING

Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation

(2012) Yang Yu et al.   PLoS One

“Clicked” Sugar–Curcumin Conjugate: Modulator of Amyloid-β and Tau Peptide Aggregation at Ultralow Concentrations

(2011) Sukanta Dolai et al.   ACS Chemical Neuroscience

Methylene blue inhibits function of the 5-HT transporter

(2011) Murat Oz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau

(2011) Alessia Usardi et al.   FEBS Journal

Glial cells in adult neurogenesis

(2011) Joachim Morrens et al.   GLIA

Understanding the Kinetic Roles of the Inducer Heparin and of Rod-like Protofibrils during Amyloid Fibril Formation by Tau Protein

(2011) Gayathri Ramachandran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)

(2011) Dennis W. Dickson et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

c-Abl in Neurodegenerative Disease

(2011) Sarah D. Schlatterer et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

In Vivo Microdialysis Reveals Age-Dependent Decrease of Brain Interstitial Fluid Tau Levels in P301S Human Tau Transgenic Mice

(2011) K. Yamada et al.   JOURNAL OF NEUROSCIENCE

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

(2011) Sharmistha Sinha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation

(2011) Caroline Smet-Nocca et al.   Molecular BioSystems

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

New mutations in MAPT gene causing frontotemporal lobar degeneration: biochemical and structural characterization

(2011) Giacomina Rossi et al.   NEUROBIOLOGY OF AGING

Dynamic association of tau with neuronal membranes is regulated by phosphorylation

(2011) Amy M. Pooler et al.   NEUROBIOLOGY OF AGING

Post-translational modifications of tau protein: Implications for Alzheimer's disease

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

The IntAct molecular interaction database in 2012

(2011) S. Kerrien et al.   NUCLEIC ACIDS RESEARCH

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

The acetylation of tau inhibits its function and promotes pathological tau aggregation

(2011) Todd J. Cohen et al.   Nature Communications

Towards a Pharmacophore for Amyloid

(2011) Meytal Landau et al.   PLOS BIOLOGY

AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies

(2010) Valérie Vingtdeux et al.   ACTA NEUROPATHOLOGICA

Selective Cell Death of Hyperploid Neurons in Alzheimer’s Disease

(2010) Thomas Arendt et al.   AMERICAN JOURNAL OF PATHOLOGY

Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody

(2010) Scott A. Yuzwa et al.   AMINO ACIDS

Towards Elucidation of the Role of Ubiquitination in the Pathogenesis of Parkinson’s Disease with Semisynthetic Ubiquitinated α-Synuclein

(2010) Mirva Hejjaoui et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phosphorylation of Tau at Thr212, Thr231, and Ser262Combined Causes Neurodegeneration

(2010) Alejandra D. Alonso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Tau, a Key Player in Neuronal DNA Protection

(2010) Audrey Sultan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment

(2010) Sarika Garg et al.   NEUROBIOLOGY OF AGING

Tau Phosphorylation and Cleavage in Ethanol-Induced Neurodegeneration in the Developing Mouse Brain

(2010) Mariko Saito et al.   NEUROCHEMICAL RESEARCH

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

(2009) F. Liu et al.   BRAIN

Heparin regulates colon cancer cell growth through p38 mitogen-activated protein kinase signalling

(2009) G. Chatzinikolaou et al.   CELL PROLIFERATION

New Age of Neuroproteomics in Alzheimer’s Disease Research

(2009) Branislav Kovacech et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Quantitative Characterization of Heparin Binding to Tau Protein

(2009) Hai-Li Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau

(2009) Wenkai Li et al.   JOURNAL OF NEUROCHEMISTRY

Accumulation of Aspartic Acid421- and Glutamic Acid391-Cleaved Tau in Neurofibrillary Tangles Correlates With Progression in Alzheimer Disease

(2009) Gustavo Basurto-Islas et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein or Presenilin I or Presenilin II Mutations

(2009) Steffen Albrecht et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cellular and molecular actions of Methylene Blue in the nervous system

(2009) Murat Oz et al.   MEDICINAL RESEARCH REVIEWS

The role of tau in neurodegeneration

(2009) Tania F Gendron et al.   Molecular Neurodegeneration

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE

O -GlcNAcylation modulates the self-aggregation ability of the fourth microtubule-binding repeat of tau

(2008) Chun-Hui Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Co-localization of hyperphosphorylated tau and caspases in the brainstem of Alzheimer’s disease patients

(2008) Maria Sen Mun Wai et al.   BIOGERONTOLOGY

Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer’s disease

(2008) Siddhartha Mondragón-Rodríguez et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Nucleation-dependent Tau Filament Formation

(2008) Erin E. Congdon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein

(2008) Katerina E. Paleologou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct analysis of tau from PSP brain identifies new phosphorylation sites and a major fragment of N-terminally cleaved tau containing four microtubule-binding repeats

(2008) Selina Wray et al.   JOURNAL OF NEUROCHEMISTRY

Characterization of Tau in Cerebrospinal Fluid Using Mass Spectrometry

(2008) Erik Portelius et al.   JOURNAL OF PROTEOME RESEARCH

Identification of a caspase-derived N-terminal tau fragment in cellular and animal Alzheimer's disease models

(2008) V. Corsetti et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons

(2008) Roxana C. Sinjoanu et al.   NEUROCHEMISTRY INTERNATIONAL

Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease

(2008) Hyoung-gon Lee et al.   NEUROCHEMISTRY INTERNATIONAL

What determines the molecular composition of abnormal protein aggregates in neurodegenerative disease?

(2008) Richard A. Armstrong et al.   NEUROPATHOLOGY

Spatial Relational Memory Requires Hippocampal Adult Neurogenesis

(2008) David Dupret et al.   PLoS One

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE

Pattern of Tau forms in CSF is altered in progressive supranuclear palsy

(2007) B. Borroni et al.   NEUROBIOLOGY OF AGING