Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review
出版年份 2020 全文链接
标题
Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review
作者
关键词
-
出版物
Brain Sciences
Volume 10, Issue 4, Pages 232
出版商
MDPI AG
发表日期
2020-04-13
DOI
10.3390/brainsci10040232
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Global, regional, and national burden of multiple sclerosis 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- (2019) Mitchell T Wallin et al. LANCET NEUROLOGY
- α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson’s disease
- (2019) Paul M. Levine et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis
- (2019) Archana Prasad et al. Frontiers in Molecular Neuroscience
- The debated toxic role of aggregated TDP-43 in amyotrophic lateral sclerosis: a resolution in sight?
- (2019) Rudolf C Hergesheimer et al. BRAIN
- Alpha-Synuclein Is a Target of Fic-Mediated Adenylylation/AMPylation: Possible Implications for Parkinson's Disease
- (2019) Anwesha Sanyal et al. JOURNAL OF MOLECULAR BIOLOGY
- Bassoon proteinopathy drives neurodegeneration in multiple sclerosis
- (2019) Benjamin Schattling et al. NATURE NEUROSCIENCE
- Identification of N-linked glycans as specific mediators of neuronal uptake of acetylated α-Synuclein
- (2019) Melissa Birol et al. PLOS BIOLOGY
- Familial multiple sclerosis patients have a shorter delay in diagnosis than sporadic cases
- (2019) Maria Steenhof et al. Multiple Sclerosis and Related Disorders
- Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification
- (2019) Philip R. Lindstedt et al. ACS Central Science
- Mechanism of aggregation and membrane interactions of mammalian prion protein
- (2018) Sabareesan Ambadi Thody et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- The amyloidogenicity of a C-terminal region of TDP-43 implicated in Amyotrophic Lateral Sclerosis can be affected by anions, acetylation and homodimerization
- (2018) Archana Prasad et al. BIOCHIMIE
- Acetylation Disfavors Tau Phase Separation
- (2018) Josephine Ferreon et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- SOD1 in Amyotrophic Lateral Sclerosis: “Ambivalent” Behavior Connected to the Disease
- (2018) Orietta Pansarasa et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Glycation affects fibril formation of Aβ peptides
- (2018) Alesandro Emendato et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States
- (2018) Mahmood Haj-Yahya et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Amyotrophic Lateral Sclerosis: An Update for 2018
- (2018) Björn Oskarsson et al. MAYO CLINIC PROCEEDINGS
- Tau-targeting therapies for Alzheimer disease
- (2018) Erin E. Congdon et al. Nature Reviews Neurology
- N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation
- (2018) Laura E. Bowie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Physiological Roles of Amyloid-β Peptide Hint at New Ways to Treat Alzheimer's Disease
- (2018) Holly M. Brothers et al. Frontiers in Aging Neuroscience
- DnaJ/Hsp40 Family and Parkinson's Disease
- (2018) Takafumi Hasegawa et al. Frontiers in Neuroscience
- Phosphorylation of different tau sites during progression of Alzheimer’s disease
- (2018) Joerg Neddens et al. Acta Neuropathologica Communications
- Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer’s disease
- (2018) Maria Luisa Moro et al. Acta Neuropathologica Communications
- Carbamylation promotes amyloidogenesis and induces structural changes in Tau-core hexapeptide fibrils
- (2018) V. Guru KrishnaKumar et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting
- (2018) Sean M. Deguire et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis
- (2018) Danilo B. Medinas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Roles of Post-translational Modifications in Spinocerebellar Ataxias
- (2018) Linlin Wan et al. Frontiers in Cellular Neuroscience
- PTMD: A Database of Human Disease-associated Post-translational Modifications
- (2018) Haodong Xu et al. GENOMICS PROTEOMICS & BIOINFORMATICS
- Spinocerebellar ataxia: an update
- (2018) Roisin Sullivan et al. JOURNAL OF NEUROLOGY
- Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- (2018) Emma Nichols et al. LANCET NEUROLOGY
- Global, regional, and national burden of motor neuron diseases 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- (2018) Giancarlo Logroscino et al. LANCET NEUROLOGY
- Tau protein aggregation in Alzheimer's disease: An attractive target for the development of novel therapeutic agents
- (2017) Marie Jouanne et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Alzheimer's disease
- (2017) C. A. Lane et al. EUROPEAN JOURNAL OF NEUROLOGY
- Recent Progress in Alzheimer’s Disease Research, Part 3: Diagnosis and Treatment
- (2017) Francis T. Hane et al. JOURNAL OF ALZHEIMERS DISEASE
- Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seeding
- (2017) Sanaz Rasouli et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An acetylation–phosphorylation switch that regulates tau aggregation propensity and function
- (2017) Yari Carlomagno et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Epidemiology of Parkinson’s disease
- (2017) Ole-Bjørn Tysnes et al. JOURNAL OF NEURAL TRANSMISSION
- Phosphorylation of a full length amyloid-β peptide modulates its amyloid aggregation, cell binding and neurotoxic properties
- (2017) Elaheh Jamasbi et al. Molecular BioSystems
- Enzymatic O -GlcNAcylation of α-synuclein reduces aggregation and increases SDS-resistant soluble oligomers
- (2017) Jiaming Zhang et al. NEUROSCIENCE LETTERS
- Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation
- (2017) Cristina Cariulo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pathology of Neurodegenerative Diseases
- (2017) Brittany N. Dugger et al. Cold Spring Harbor Perspectives in Biology
- Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases
- (2017) Michael G. Erkkinen et al. Cold Spring Harbor Perspectives in Biology
- Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program
- (2017) Ping Wang et al. Nature Communications
- The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease
- (2017) Rita Machado de Oliveira et al. PLOS BIOLOGY
- Thioflavin T as an amyloid dye: fibril quantification, optimal concentration and effect on aggregation
- (2017) Christine Xue et al. Royal Society Open Science
- A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy
- (2017) Hanna Trzeciakiewicz et al. Scientific Reports
- Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity
- (2016) Sathish Kumar et al. ACTA NEUROPATHOLOGICA
- 2016 Alzheimer's disease facts and figures
- (2016) Alzheimers & Dementia
- Glycation alter the process of Tau phosphorylation to change Tau isoforms aggregation property
- (2016) Kefu Liu et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Acetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding
- (2016) Maxmore Chaibva et al. BIOPHYSICAL JOURNAL
- Halting of Caspase Activity Protects Tau from MC1-Conformational Change and Aggregation
- (2016) Emma Mead et al. JOURNAL OF ALZHEIMERS DISEASE
- Modification of Tau by 8-Nitroguanosine 3′,5′-Cyclic Monophosphate (8-Nitro-cGMP)
- (2016) Jun Yoshitake et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers
- (2016) Cathryn L. Ugalde et al. JOURNAL OF NEUROCHEMISTRY
- Amyloid-β Peptide Nitrotyrosination Stabilizes Oligomers and Enhances NMDAR-Mediated Toxicity
- (2016) Biuse Guivernau et al. JOURNAL OF NEUROSCIENCE
- Huntington's disease: Molecular basis of pathology and status of current therapeutic approaches
- (2016) Wen-Juan Huang et al. Experimental and Therapeutic Medicine
- Epidemiological characteristics of human prion diseases
- (2016) Cao Chen et al. Infectious Diseases of Poverty
- Toxic species in amyloid disorders: Oligomers or mature fibrils
- (2015) Vibha Taneja et al. Annals of Indian Academy of Neurology
- Brain propagation of transduced α-synuclein involves non-fibrillar protein species and is enhanced in α-synuclein null mice
- (2015) Michael Helwig et al. BRAIN
- Neuronal Aggregates: Formation, Clearance, and Spreading
- (2015) Junghyun Lim et al. DEVELOPMENTAL CELL
- An understanding of spinocerebellar ataxia
- (2015) NB Ramachandra et al. INDIAN JOURNAL OF MEDICAL RESEARCH
- Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization
- (2015) Filsy Samuel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson’s Disease via Protein Semisynthesis and Mutagenesis
- (2015) Ritwik Burai et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity
- (2015) Wei Xiang et al. Molecular Neurodegeneration
- O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease
- (2015) Nicholas P. Marotta et al. Nature Chemistry
- Inhibition of Pathogenic Mutant SOD1 Aggregation in Cultured Motor Neuronal Cells by Prevention of Its SUMOylation on Lysine 75
- (2015) Audrey Dangoumau et al. Neurodegenerative Diseases
- An acetylation switch controls TDP-43 function and aggregation propensity
- (2015) Todd J. Cohen et al. Nature Communications
- The Synaptic Function of α-Synuclein
- (2015) Jacqueline Burré Journal of Parkinsons Disease
- Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?
- (2014) Amy Reeve et al. AGEING RESEARCH REVIEWS
- One-Pot Semisynthesis of Exon 1 of the Huntingtin Protein: New Tools for Elucidating the Role of Posttranslational Modifications in the Pathogenesis of Huntington’s Disease
- (2014) Annalisa Ansaloni et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity
- (2014) Kristen E. Funk et al. BIOCHEMICAL JOURNAL
- Nuclear Magnetic Resonance Analysis of the Acetylation Pattern of the Neuronal Tau Protein
- (2014) Amina Kamah et al. BIOCHEMISTRY
- Nitration of Y10 in Aβ1–40: Is It a Compensatory Reaction against Oxidative/Nitrative Stress and Aβ Aggregation?
- (2014) Jie Zhao et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Relapsing and progressive forms of multiple sclerosis
- (2014) Ranjan Dutta et al. CURRENT OPINION IN NEUROLOGY
- O-GlcNAc Modification of tau Directly Inhibits Its Aggregation without Perturbing the Conformational Properties of tau Monomers
- (2014) Scott A. Yuzwa et al. JOURNAL OF MOLECULAR BIOLOGY
- Huntingtin Is Required for Normal Excitatory Synapse Development in Cortical and Striatal Circuits
- (2014) S. U. McKinstry et al. JOURNAL OF NEUROSCIENCE
- Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones
- (2014) J. Robin Highley et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- β-amyloid Peptides and Amyloid Plaques in Alzheimer’s Disease
- (2014) Gunnar K. Gouras et al. Neurotherapeutics
- Casein Kinase II Induced Polymerization of Soluble TDP-43 into Filaments Is Inhibited by Heat Shock Proteins
- (2014) Yari Carlomagno et al. PLoS One
- SUMO3 Modification Accelerates the Aggregation of ALS-Linked SOD1 Mutants
- (2014) Takako Niikura et al. PLoS One
- N-Alpha-Acetylation of α-Synuclein Increases Its Helical Folding Propensity, GM1 Binding Specificity and Resistance to Aggregation
- (2014) Tim Bartels et al. PLoS One
- SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination
- (2014) Hong-Bin Luo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Structure of Human Prions: From Biology to Structural Models—Considerations and Pitfalls
- (2014) Claudia Acevedo-Morantes et al. Viruses-Basel
- Detection of Protein Aggregates in Brain and Cerebrospinal Fluid Derived from Multiple Sclerosis Patients
- (2014) Monique Antoinette David et al. Frontiers in Neurology
- Protein aggregation in amyotrophic lateral sclerosis
- (2013) Anna M. Blokhuis et al. ACTA NEUROPATHOLOGICA
- Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid β and the Asn23Iowa mutation
- (2013) Silvia Fossati et al. BIOCHEMICAL JOURNAL
- Oxidative stress-induced posttranslational modifications of alpha-synuclein: Specific modification of alpha-synuclein by 4-hydroxy-2-nonenal increases dopaminergic toxicity
- (2013) Wei Xiang et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Molecular Ageing of Alpha- and Beta-Synucleins: Protein Damage and Repair Mechanisms
- (2013) Vasanthy Vigneswara et al. PLoS One
- Beta conformation of polyglutamine track revealed by a crystal structure of Huntingtin N-terminal region with insertion of three histidine residues
- (2013) Meewhi Kim Prion
- Characterization of forebrain neurons derived from late-onset Huntington's disease human embryonic stem cell lines
- (2013) Jonathan C. Niclis et al. Frontiers in Cellular Neuroscience
- Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure
- (2012) María Soledad Celej et al. BIOCHEMICAL JOURNAL
- Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons
- (2012) Ji Won Um et al. NATURE NEUROSCIENCE
- N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer
- (2012) Lijuan Kang et al. PROTEIN SCIENCE
- Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease
- (2011) Sathish Kumar et al. EMBO JOURNAL
- Protein aggregates in Huntington's disease
- (2011) Montserrat Arrasate et al. EXPERIMENTAL NEUROLOGY
- Effect ofN-homocysteinylation on physicochemical and cytotoxic properties of amyloid β-peptide
- (2011) Sirus Khodadadi et al. FEBS LETTERS
- Sumoylation inhibits α-synuclein aggregation and toxicity
- (2011) Petranka Krumova et al. JOURNAL OF CELL BIOLOGY
- Enhanced Phosphatase Activity Attenuates -Synucleinopathy in a Mouse Model
- (2011) K.-W. Lee et al. JOURNAL OF NEUROSCIENCE
- Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation
- (2011) Markus P. Kummer et al. NEURON
- Huntington's disease: a clinical review
- (2011) Raymund A.C. Roos Orphanet Journal of Rare Diseases
- The C-Terminal TDP-43 Fragments Have a High Aggregation Propensity and Harm Neurons by a Dominant-Negative Mechanism
- (2011) Chunxing Yang et al. PLoS One
- Hyperphosphorylation as a Defense Mechanism to Reduce TDP-43 Aggregation
- (2011) Huei-Ying Li et al. PLoS One
- In vivo demonstration that -synuclein oligomers are toxic
- (2011) B. Winner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A novel molecular mechanism for nitrated α-synuclein-induced cell death
- (2011) Yanying Liu et al. Journal of Molecular Cell Biology
- Huntington's Disease
- (2011) S. Finkbeiner Cold Spring Harbor Perspectives in Biology
- The acetylation of tau inhibits its function and promotes pathological tau aggregation
- (2011) Todd J. Cohen et al. Nature Communications
- Oxidative stress-enhanced SUMOylation and aggregation of ataxin-1: Implication of JNK pathway
- (2010) Joohyun Ryu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Pseudophosphorylation of tau protein directly modulates its aggregation kinetics
- (2010) Edward Chang et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Regulation of TDP-43 aggregation by phosphorylation andp62/SQSTM1
- (2010) Owen A. Brady et al. JOURNAL OF NEUROCHEMISTRY
- Neuropathology of Alzheimer's Disease
- (2010) Daniel P. Perl MOUNT SINAI JOURNAL OF MEDICINE
- α-Synuclein and dopamine at the crossroads of Parkinson's disease
- (2010) Lara Lourenço Venda et al. TRENDS IN NEUROSCIENCES
- Antiparallel β-sheet: a signature structure of the oligomeric amyloid β-peptide
- (2009) Emilie Cerf et al. BIOCHEMICAL JOURNAL
- Molecular Pathology of Human Prion Diseases
- (2009) Gabor Kovacs et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Mimicking proteasomal release of polyglutamine peptides initiates aggregation and toxicity
- (2009) M. Raspe et al. JOURNAL OF CELL SCIENCE
- The Spinocerebellar Ataxias
- (2009) Henry L Paulson JOURNAL OF NEURO-OPHTHALMOLOGY
- Phosphorylation of Prion Protein at Serine 43 Induces Prion Protein Conformational Change
- (2009) P. N. Giannopoulos et al. JOURNAL OF NEUROSCIENCE
- α-Synuclein and neuronal cell death
- (2009) Mark R Cookson Molecular Neurodegeneration
- Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice
- (2009) Xiaofeng Gu et al. NEURON
- Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
- (2009) Y.-J. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
- (2008) Masato Hasegawa et al. ANNALS OF NEUROLOGY
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