标题
Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration
作者
关键词
-
出版物
JOURNAL OF CLINICAL INVESTIGATION
Volume 130, Issue 9, Pages 4954-4968
出版商
American Society for Clinical Investigation
发表日期
2020-06-17
DOI
10.1172/jci138179
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease
- (2020) Yingyue Zhou et al. NATURE MEDICINE
- Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model
- (2020) Lynn van Olst et al. NEUROBIOLOGY OF AGING
- SEQUIN Multiscale Imaging of Mammalian Central Synapses Reveals Loss of Synaptic Connectivity Resulting from Diffuse Traumatic Brain Injury
- (2020) Andrew D. Sauerbeck et al. NEURON
- Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology
- (2019) Hassan El Hajj et al. Journal of Neuroinflammation
- Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice
- (2019) Liang Sheng et al. FASEB JOURNAL
- TREM2 function impedes tau seeding in neuritic plaques
- (2019) Cheryl E. G. Leyns et al. NATURE NEUROSCIENCE
- CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
- (2019) Renzo Mancuso et al. BRAIN
- The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk
- (2019) Yuetiva Deming et al. Science Translational Medicine
- Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
- (2019) Justin M. Long et al. CELL
- Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model
- (2019) Yang Shi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity
- (2018) Fabia Filipello et al. IMMUNITY
- Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism
- (2018) Wilbur M. Song et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease
- (2018) Paul J. Cheng-Hathaway et al. Molecular Neurodegeneration
- Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy
- (2018) Faten A. Sayed et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- New insights into the role of TREM2 in Alzheimer’s disease
- (2018) Maud Gratuze et al. Molecular Neurodegeneration
- Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies
- (2018) Borislav Dejanovic et al. NEURON
- The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
- (2017) Susanne Krasemann et al. IMMUNITY
- TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway
- (2017) Honghua Zheng et al. JOURNAL OF NEUROSCIENCE
- Glial contributions to neurodegeneration in tauopathies
- (2017) Cheryl E. G. Leyns et al. Molecular Neurodegeneration
- TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy
- (2017) Shane M. Bemiller et al. Molecular Neurodegeneration
- ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
- (2017) Yang Shi et al. NATURE
- Neurotoxic reactive astrocytes are induced by activated microglia
- (2017) Shane A. Liddelow et al. NATURE
- Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
- (2017) Rebecca Sims et al. NATURE GENETICS
- TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy
- (2017) Cheryl E. G. Leyns et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status
- (2016) Laura Piccio et al. ACTA NEUROPATHOLOGICA
- 2016 Alzheimer's disease facts and figures
- (2016) Alzheimers & Dementia
- sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers
- (2016) Marc Suárez‐Calvet et al. EMBO Molecular Medicine
- Dark microglia: A new phenotype predominantly associated with pathological states
- (2016) Kanchan Bisht et al. GLIA
- Complement and microglia mediate early synapse loss in Alzheimer mouse models
- (2016) S. Hong et al. SCIENCE
- The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease
- (2015) Christina M. Lill et al. Alzheimers & Dementia
- Inflammation in Alzheimer’s Disease and Molecular Genetics: Recent Update
- (2015) Zhi-Gang Zhang et al. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
- Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain
- (2015) Nicole Maphis et al. BRAIN
- TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
- (2015) Yaming Wang et al. CELL
- miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregationin vivo
- (2015) Pascal Y. Smith et al. HUMAN MOLECULAR GENETICS
- Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
- (2015) Yuka Atagi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models
- (2015) Taylor R. Jay et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Mapping Synapses by Conjugate Light-Electron Array Tomography
- (2015) F. Collman et al. JOURNAL OF NEUROSCIENCE
- Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke
- (2015) M. Kawabori et al. JOURNAL OF NEUROSCIENCE
- Depletion of microglia and inhibition of exosome synthesis halt tau propagation
- (2015) Hirohide Asai et al. NATURE NEUROSCIENCE
- R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia
- (2014) Catherine F. Slattery et al. Alzheimers & Dementia
- Coding variants in TREM2 increase risk for Alzheimer's disease
- (2014) Sheng Chih Jin et al. HUMAN MOLECULAR GENETICS
- Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2
- (2014) Jason D Ulrich et al. Molecular Neurodegeneration
- Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo
- (2013) Kiran Yanamandra et al. NEURON
- GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s Disease
- (2013) Carlos Cruchaga et al. NEURON
- Tumor necrosis factor alpha maintains denervation-induced homeostatic synaptic plasticity of mouse dentate granule cells
- (2013) Denise Becker et al. Frontiers in Cellular Neuroscience
- Neuropathological Alterations in Alzheimer Disease
- (2013) A. Serrano-Pozo et al. Cold Spring Harbor Perspectives in Medicine
- Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice
- (2013) Nadine A Hoffmann et al. Acta Neuropathologica Communications
- Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices
- (2012) Marie-Ève Tremblay et al. GLIA
- Synaptic alterations in the rTg4510 mouse model of tauopathy
- (2012) Katherine J. Kopeikina et al. JOURNAL OF COMPARATIVE NEUROLOGY
- The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice
- (2012) B. Zhang et al. JOURNAL OF NEUROSCIENCE
- Variant of TREM2 Associated with the Risk of Alzheimer's Disease
- (2012) Thorlakur Jonsson et al. NEW ENGLAND JOURNAL OF MEDICINE
- TREM2 Variants in Alzheimer's Disease
- (2012) Rita Guerreiro et al. NEW ENGLAND JOURNAL OF MEDICINE
- Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal -Catenin Pathway Function in an Alzheimer's Disease Model
- (2011) M. Kitazawa et al. JOURNAL OF IMMUNOLOGY
- The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis
- (2011) Jie Zhao et al. Journal of Neuroinflammation
- Alzheimer's Disease: The Challenge of the Second Century
- (2011) D. M. Holtzman et al. Science Translational Medicine
- Alzheimer Disease
- (2010) Rudy J. Castellani et al. DM DISEASE-A-MONTH
- Preparation of Mouse Brain Tissue for Immunoelectron Microscopy
- (2010) Marie-Éve Tremblay et al. Jove-Journal of Visualized Experiments
- A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia
- (2009) Christine L. Hsieh et al. JOURNAL OF NEUROCHEMISTRY
- Cholinergic innervation and thalamic input in rat nucleus accumbens
- (2008) Michael Ligorio et al. JOURNAL OF CHEMICAL NEUROANATOMY
- Interleukin-1β up-regulates TACE to enhance α-cleavage of APP in neurons: resulting decrease in Aβ production
- (2008) Yuriko Tachida et al. JOURNAL OF NEUROCHEMISTRY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started