Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions

Relationship of Sequence and Phase Separation in Protein Low-Complexity Regions

(2018) Erik W. Martin et al.   BIOCHEMISTRY

Theories for Sequence-Dependent Phase Behaviors of Biomolecular Condensates

(2018) Yi-Hsuan Lin et al.   BIOCHEMISTRY

Tau protein liquid–liquid phase separation can initiate tau aggregation

(2018) Susanne Wegmann et al.   EMBO JOURNAL

Acetylation Disfavors Tau Phase Separation

(2018) Josephine Ferreon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TAR DNA-binding protein 43 (TDP-43) liquid–liquid phase separation is mediated by just a few aromatic residues

(2018) Hao-Ru Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Lattice Model of Charge-Pattern-Dependent Polyampholyte Phase Separation

(2018) Suman Das et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Phase Behavior and Salt Partitioning in Polyelectrolyte Complex Coacervates

(2018) Lu Li et al.   MACROMOLECULES

Polyelectrolyte Chain Structure and Solution Phase Behavior

(2018) Kevin Shen et al.   MACROMOLECULES

Electrostatic correlations and the polyelectrolyte self energy

(2017) Kevin Shen et al.   JOURNAL OF CHEMICAL PHYSICS

Theory of polyelectrolyte complexation—Complex coacervates are self-coacervates

(2017) Kris T. Delaney et al.   JOURNAL OF CHEMICAL PHYSICS

Random-phase-approximation theory for sequence-dependent, biologically functional liquid-liquid phase separation of intrinsically disordered proteins

(2017) Yi-Hsuan Lin et al.   JOURNAL OF MOLECULAR LIQUIDS

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics

(2017) Steven Boeynaems et al.   MOLECULAR CELL

Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation

(2017) Jacob P. Brady et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the Tau phosphorylation pattern that drives its aggregation

(2017) Clément Despres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transfer matrix theory of polymer complex coacervation

(2017) Tyler K. Lytle et al.   Soft Matter

Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

(2017) Susmitha Ambadipudi et al.   Nature Communications

Sequence and entropy-based control of complex coacervates

(2017) Li-Wei Chang et al.   Nature Communications

Signature of an aggregation-prone conformation of tau

(2017) Neil A. Eschmann et al.   Scientific Reports

Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase

(2017) Amayra Hernández-Vega et al.   Cell Reports

RNA stores tau reversibly in complex coacervates

(2017) Xuemei Zhang et al.   PLOS BIOLOGY

FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease

(2016) Waltraud Mair et al.   ANALYTICAL CHEMISTRY

C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles

(2016) Kyung-Ha Lee et al.   CELL

Recent Developments in Fully Fluctuating Field-Theoretic Simulations of Polymer Melts and Solutions

(2016) Kris T. Delaney et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Driving Forces for Oppositely Charged Polyion Association in Aqueous Solutions: Enthalpic, Entropic, but Not Electrostatic

(2016) Jingcheng Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Criticality and Connectivity in Macromolecular Charge Complexation

(2016) Jian Qin et al.   MACROMOLECULES

Sequence-Specific Polyampholyte Phase Separation in Membraneless Organelles

(2016) Yi-Hsuan Lin et al.   PHYSICAL REVIEW LETTERS

Complexation and coacervation of like-charged polyelectrolytes inspired by mussels

(2016) Sangsik Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of molecular crowding and confinement on the spatial organization of a biopolymer

(2016) Chanil Jeon et al.   Soft Matter

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Quantitative Assessments of the Distinct Contributions of Polypeptide Backbone Amides versus Side Chain Groups to Chain Expansion via Chemical Denaturation

(2015) Alex S. Holehouse et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Theoretical Analysis of Multiple Phase Coexistence in Polyelectrolyte Blends

(2015) Ha-Kyung Kwon et al.   MACROMOLECULES

Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II

(2015) Kathleen A. Burke et al.   MOLECULAR CELL

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

Polymer physics of intracellular phase transitions

(2015) Clifford P. Brangwynne et al.   Nature Physics

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

(2015) Tetsuro Murakami et al.   NEURON

Protein structural and surface water rearrangement constitute major events in the earliest aggregation stages of tau

(2015) Anna Pavlova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck

(2015) Sudeep Banjade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA transcription modulates phase transition-driven nuclear body assembly

(2015) Joel Berry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics

(2015) Shana Elbaum-Garfinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Entropic Mechanism for the Lower Critical Solution Temperature of Poly(ethylene oxide) in a Room Temperature Ionic Liquid

(2015) Eunsong Choi et al.   ACS Macro Letters

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Complex coacervates of hyaluronic acid and lysozyme: Effect on protein structure and physical stability

(2014) Jorrit J. Water et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Intrinsically disordered proteins as crucial constituents of cellular aqueous two phase systems and coacervates

(2014) Vladimir N. Uversky et al.   FEBS LETTERS

A multi-species exchange model for fully fluctuating polymer field theory simulations

(2014) Dominik Düchs et al.   JOURNAL OF CHEMICAL PHYSICS

Efficient field-theoretic simulation of polymer solutions

(2014) Michael C. Villet et al.   JOURNAL OF CHEMICAL PHYSICS

Pressure-Dependent Properties of Elementary Hydrophobic Interactions: Ramifications for Activation Properties of Protein Folding

(2014) Cristiano L. Dias et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells

(2014) I. Kwon et al.   SCIENCE

Phase transitions of multivalent proteins can promote clustering of membrane receptors

(2014) Sudeep Banjade et al.   eLife

Dual Specificity Kinase DYRK3 Couples Stress Granule Condensation/Dissolution to mTORC1 Signaling

(2013) Frank Wippich et al.   CELL

Proteomic data from human cell cultures refine mechanisms of chaperone-mediated protein homeostasis

(2013) Andrija Finka et al.   CELL STRESS & CHAPERONES

Stress granules as crucibles of ALS pathogenesis

(2013) Yun R. Li et al.   JOURNAL OF CELL BIOLOGY

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

Role of Water in Protein Aggregation and Amyloid Polymorphism

(2011) D. Thirumalai et al.   ACCOUNTS OF CHEMICAL RESEARCH

Temperature and solvent dependence of the dynamical landscape of tau protein conformations

(2011) Antonio Bianconi et al.   JOURNAL OF BIOLOGICAL PHYSICS

Phase Behavior and Coacervation of Aqueous Poly(acrylic acid)−Poly(allylamine) Solutions

(2010) Rungsima Chollakup et al.   MACROMOLECULES

Binodal Compositions of Polyelectrolyte Complexes

(2010) Evan Spruijt et al.   MACROMOLECULES

Site-specific dynamic nuclear polarization of hydration water as a generally applicable approach to monitor protein aggregation

(2009) Anna Pavlova et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

A Soluble Oligomer of Tau Associated with Fiber Formation Analyzed by NMR

(2008) Dylan W. Peterson et al.   BIOCHEMISTRY

Complex coacervation: A field theoretic simulation study of polyelectrolyte complexation

(2008) Jonghoon Lee et al.   JOURNAL OF CHEMICAL PHYSICS