Characterization of Semisynthetic and NaturallyNα-Acetylated α-Synucleinin Vitroand in Intact Cells

α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elucidating the Role of C-Terminal Post-Translational Modifications Using Protein Semisynthesis Strategies: α-Synuclein Phosphorylation at Tyrosine 125

(2012) Mirva Hejjaoui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-terminal acetylation is critical for forming α-helical oligomer of α-synuclein

(2012) Adam J. Trexler et al.   PROTEIN SCIENCE

N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer

(2012) Lijuan Kang et al.   PROTEIN SCIENCE

Protein N-terminal acetyltransferases: when the start matters

(2012) Kristian K. Starheim et al.   TRENDS IN BIOCHEMICAL SCIENCES

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Identification of Novel α-Synuclein Isoforms in Human Brain Tissue by using an Online NanoLC-ESI-FTICR-MS Method

(2011) Annika Öhrfelt et al.   NEUROCHEMICAL RESEARCH

A soluble  -synuclein construct forms a dynamic tetramer

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Towards a Functional Understanding of Protein N-Terminal Acetylation

(2011) Thomas Arnesen   PLOS BIOLOGY

Towards Elucidation of the Role of Ubiquitination in the Pathogenesis of Parkinson’s Disease with Semisynthetic Ubiquitinated α-Synuclein

(2010) Mirva Hejjaoui et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cellular structural biology

(2010) Yutaka Ito et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits  -Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions

(2010) K. E. Paleologou et al.   JOURNAL OF NEUROSCIENCE

Targeted Amino-Terminal Acetylation of Recombinant Proteins in E. coli

(2010) Matthew Johnson et al.   PLoS One

In-cell NMR spectroscopy

(2010) Andres Y. Maldonado et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Co- and post-translational modifications of the 26S proteasome in yeast

(2010) Julia Kikuchi et al.   PROTEOMICS

Protein Acetylation in Archaea, Bacteria, and Eukaryotes

(2010) Jörg Soppa   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

Methionine oxidation stabilizes non-toxic oligomers of α-synuclein through strengthening the auto-inhibitory intra-molecular long-range interactions

(2009) Wenbo Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Expressed protein ligation: a resourceful tool to study protein structure and function

(2009) Luis Berrade et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Biophysics of Parkinsons Disease: Structure and Aggregation of α- Synuclein

(2009) Vladimir Uversky et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Phosphorylation of Synucleins by Members of the Polo-like Kinase Family

(2009) Martial K. Mbefo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The First N-terminal Amino Acids of α-Synuclein Are Essential for α-Helical Structure Formation In Vitro and Membrane Binding in Yeast

(2009) Katherina Vamvaca et al.   JOURNAL OF MOLECULAR BIOLOGY

Knockdown of Human N -Terminal Acetyltransferase Complex C Leads to p53-Dependent Apoptosis and Aberrant Human Arl8b Localization

(2009) K. K. Starheim et al.   MOLECULAR AND CELLULAR BIOLOGY

Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans

(2009) T. Arnesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and Functional Characterization of N-Terminally Acetylated Proteins in Drosophila melanogaster

(2009) Sandra Goetze et al.   PLOS BIOLOGY

An Efficient Fmoc-SPPS Approach for the Generation of Thioester Peptide Precursors for Use in Native Chemical Ligation

(2008) Juan B. Blanco-Canosa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of the humanNα-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression

(2008) Kristian K. Starheim et al.   BIOCHEMICAL JOURNAL

Phosphorylation, lipid raft interaction and traffic of α-synuclein in a yeast model for Parkinson

(2008) Piotr Zabrocki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors

(2008) Sabine Wislet-Gendebien et al.   BMC NEUROSCIENCE

Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein

(2008) Katerina E. Paleologou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Dynamical Effects of Macromolecular Crowding on an Intrinsically Disordered Protein and a Globular Protein: Implications for In-Cell NMR Spectroscopy

(2008) Conggang Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cell systems and the toxic mechanism(s) of α-synuclein

(2007) Mark R. Cookson et al.   EXPERIMENTAL NEUROLOGY