Review
Biochemistry & Molecular Biology
Andrea Bernetti, Francesco Agostini, Marco Paoloni, Maria Vittoria Raele, Giacomo Fari, Marisa Megna, Massimiliano Mangone
Summary: Knee osteoarthritis (KOA) is a common cause of disability in the elderly, leading to significant societal and healthcare burden. Intra-articular hyaluronic acid (IAHA) injections have shown therapeutic efficacy in relieving pain, improving joint function, and slowing the progression of joint degeneration in KOA patients.
Article
Biochemistry & Molecular Biology
Christoph Bauer, Lukas B. Moser, Vivek Jeyakumar, Eugenia Niculescu-Morzsa, Daniela Kern, Stefan Nehrer
Summary: This study investigated the effect of GC, HA, and a mixture of both on cytokine-treated chondrocytes in vitro. Results showed that adding HA or GC/HA increased metabolic activity of chondrocytes, reduced the side effects of GC supplementation, and decreased the release of pro-inflammatory cytokines.
Article
Orthopedics
Teng-Le Huang, Chun-Hao Tsai
Summary: The study showed that a single injection of CHAP-HA is more effective and safe in knee osteoarthritis patients compared to three injections of linear HA, with pain relief effects lasting up to 52 weeks. CHAP-HA was found to be more preferable for patients with more severe OA, and repeat treatment or use of CHAP-HA after a three-injection HA was proven to be safe.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Pharmacology & Pharmacy
Andrea Bernetti, Francesco Agostini, Federica Alviti, Nicola Giordan, Federica Martella, Valter Santilli, Marco Paoloni, Massimiliano Mangone
Summary: The study demonstrates that a single intra-articular injection of the new HA derivative hydrogel, Hymovis MO.RE., provides significant efficacy and safety in improving knee function, pain, and quality of life for adult regular sports players with osteoarthritis. No severe adverse events were detected, indicating it may be a viable therapeutic option for this patient subgroup. Further investigations are needed to confirm these findings.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Carlos Gavin, Francisco J. Blanco, Jose L. Pablos, Miguel A. Caracuel, Jose Rosas, Enrique Gomez-Barrena, Francisco Navarro, Maria Pilar Coronel, Mercedes Gimeno
Summary: The study demonstrates that a new formulation of hyaluronic acid with a single injection is effective in treating patients with knee osteoarthritis, significantly improving pain, stiffness, and physical function. Patient tolerability and safety were also optimal.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Alexandre Porcello, Paula Gonzalez-Fernandez, Annick Jeannerat, Cedric Peneveyre, Philippe Abdel-Sayed, Corinne Scaletta, Wassim Raffoul, Nathalie Hirt-Burri, Lee Ann Applegate, Eric Allemann, Alexis Laurent, Olivier Jordan
Summary: The first aim of this study was to characterize the performance of various combination product formulas through in vitro testing, while the second aim was to assess the effectiveness of these combinations in a rodent model of knee osteoarthritis. The results showed that the combination of modified hyaluronan-based hydrogels and FE002 human chondroprogenitor cells was suitable and resistant to degradation, and it showed potential in inhibiting the development of knee osteoarthritis.
Article
Chemistry, Multidisciplinary
Dalila Scaturro, Fabio Vitagliani, Pietro Terrana, Daniele Cuntrera, Vincenzo Falco, Sofia Tomasello, Giulia Letizia Mauro
Summary: This study found that intra-articular injections of hybrid hyaluronic acid (HA) complexes can significantly improve pain, disease severity, cardiopulmonary function, and quality of life in overweight patients with knee osteoarthritis (KOA). Additionally, it can help control pain by reducing analgesic intake.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Emiliano Bedini, Elisabetta Cassese, Antonella D'Agostino, Marcella Cammarota, Maria Assunta Frezza, Maria Lepore, Marianna Portaccio, Chiara Schiraldi, Annalisa La Gatta
Summary: A new solid-state reaction method for self-esterifying hyaluronan has been developed, leading to products that gradually release hyaluronan for more effective tissue repair. This method is more efficient and avoids side reactions compared to traditional methods, and allows for the tuning of the released biopolymer's molecular weight.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Orthopedics
Pomme Boissier, Pierre Mainil-Varlet, Giuseppe R. Mautone
Summary: The study showed a dose-dependent protective effect on cartilage after injection of hyaluronic acid solutions. The control group exhibited the highest uptake of India ink, while the 2.4% HA treatment group significantly reduced modified Mankin scores compared to the control group.
Article
Orthopedics
Yves Henrotin, Cedric Tits, Jerome Paul, Pierre Gramme, Thibault Helleputte, Alberto Migliore, Pascal Richette, Xavier Chevalier, Jordi Monfort, Demirhan Diracoglu, Herve Bard, Joerg Jerosch, Dominique Baron, Raman Raghu, Thierry Conrozier
Summary: In current clinical practice, physicians tended to retreat their patients with hyaluronic acid viscosupplementation less often than recommended by EUROVISCO guidelines. However, these guidelines align with decision criteria such as patients' willingness to be treated and their perception of treatment effectiveness, reflecting real-life practitioner considerations.
Article
Biochemistry & Molecular Biology
Kummara Madhusudana Rao, Eunbi Kim, Hyeon Jin Kim, Uluvangada Thammaiah Uthappa, Sung Soo Han
Summary: A water-soluble hyaluronic acid-quercetin (HA-Q) pendant drug conjugate was synthesized and evaluated for its potential wound-healing properties. The conjugation was confirmed using FTIR, UV-Vis, and NMR spectroscopy techniques. HA-Q showed good biocompatibility, supported cell growth and migration, and exhibited improved radical scavenging capacity compared to quercetin alone. These results confirm the potential role of HA-Q in wound healing applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Huda S. AlSalem, Abeer Abdulaziz H. Bukhari
Summary: Three biodegradable wound dressings were successfully prepared using freeze drying technique. The dressings were based on binary Collagen (COL), Hyaluronic acid (HA) crosslinked and loaded with silver nanoparticles (AgNPs), Gentamicin (GENT), or AgNPs/GENT. The dressings showed physically interaction between polymer network and the loaded antibiotic, superior swelling properties, and rapid degradation. They exhibited antibacterial activity against G+, G-, yeast, and fungi. Cytotoxicity and wound healing evaluations showed superior results for all dressings except the one mixed with AgNPs and Gentamicin. The results recommended individually loaded COL/HA with either AgNPs or Gentamicin as antibacterial and wound healing dressings.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Jolana Kubickova, Tomas Medek, Jarmila Husby, Jana Matonohova, Hana Vagnerova, Lucie Marholdova, Vladimir Velebny, Josef Chmelar
Summary: This study aimed to develop biocompatible and biodegradable hyaluronan textiles for wound healing applications. The microscale fiber structure of the textiles can be adjusted by selected process parameters, affecting their mechanical properties and hydration. Cell viability testing confirmed the non-cytotoxicity and biocompatibility of the textiles. The high moisture absorption and convenient handling make hyaluronan textiles a promising material for wound healing.
Article
Nanoscience & Nanotechnology
Min Wang, Juanjuan Hu, Yangcen Ou, Xueling He, Yanjun Wang, Chenyu Zou, Yanlin Jiang, Feng Luo, Dan Lu, Zhen Li, Jiehua Li, Hong Tan
Summary: There is an urgent need for wound dressings that can promote quick hemostasis and efficient wound healing in response to increasing clinical demands. This study presents a versatile method for constructing biodegradable hybrid cryogels that can rapidly stop bleeding. The cryogel's specific macroporous structure allows for stable fixation and quick swelling, making it ideal for minimally invasive surgery. Furthermore, the cryogel exhibits excellent biocompatibility and activates the endogenous coagulation system, leading to fast blood coagulation. In in vivo evaluations, the cryogel demonstrated great potential in promoting wound healing, reducing immune inflammation, and inducing angiogenesis and hair follicle regeneration. These findings highlight the high-performance capabilities of the cryogel as a wound dressing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Multidisciplinary
Qiusheng Wang, Shuiqing Zhou, Lu Wang, Renchuan You, Shuqin Yan, Qiang Zhang, Mingzhong Li
Summary: This study presents a novel bioactive scaffold designed with biomimetic technology by mimicking the chemical components and biophysical nanostructures of extracellular matrix. The scaffold showed better cytocompatibility to support cell spread, proliferation and differentiation. In vivo experiments demonstrated that the scaffold with nanofibers as a template not only accelerated wound healing but also regulated collagen arrangement to inhibit scar formation.
COMPOSITES PART B-ENGINEERING
(2021)