标题
Acetylation: a new key to unlock tau’s role in neurodegeneration
作者
关键词
HDAC6 Inhibition, Chronic Traumatic Encephalopathy, HDAC6 Activity, Tauopathy, rTg4510 Mouse
出版物
Alzheimers Research & Therapy
Volume 6, Issue 3, Pages 29
出版商
Springer Nature
发表日期
2014-05-29
DOI
10.1186/alzrt259
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation
- (2013) Lea Tenenholz Grinberg et al. ACTA NEUROPATHOLOGICA
- Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance
- (2013) Casey Cook et al. HUMAN MOLECULAR GENETICS
- Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS
- (2013) Ines Taes et al. HUMAN MOLECULAR GENETICS
- Molecular mechanisms of Tau binding to microtubules and its role in microtubule dynamics in live cells
- (2013) G. Breuzard et al. JOURNAL OF CELL SCIENCE
- The microtubule-associated tau protein has intrinsic acetyltransferase activity
- (2013) Todd J Cohen et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation
- (2013) Georges Mairet-Coello et al. NEURON
- HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila
- (2013) Y. Xiong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Brain homogenates from human tauopathies induce tau inclusions in mouse brain
- (2013) Florence Clavaguera et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Degradation of tau protein by autophagy and proteasomal pathways: Figure 1
- (2012) Yipeng Wang et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies
- (2012) David J. Irwin et al. BRAIN
- Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease
- (2012) Nambirajan Govindarajan et al. EMBO Molecular Medicine
- Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation
- (2012) Casey Cook et al. HUMAN MOLECULAR GENETICS
- Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons
- (2012) Jessica W. Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Trans-cellular Propagation of Tau Aggregation by Fibrillar Species
- (2012) Najla Kfoury et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Paired Helical Filaments from Alzheimer Disease Brain Induce Intracellular Accumulation of Tau Protein in Aggresomes
- (2012) Ismael Santa-Maria et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hyperdynamic Microtubules, Cognitive Deficits, and Pathology Are Improved in Tau Transgenic Mice with Low Doses of the Microtubule-Stabilizing Agent BMS-241027
- (2012) D. M. Barten et al. JOURNAL OF NEUROSCIENCE
- The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice
- (2012) B. Zhang et al. JOURNAL OF NEUROSCIENCE
- Trans-Synaptic Spread of Tau Pathology In Vivo
- (2012) Li Liu et al. PLoS One
- HDAC6 Inhibitor Blocks Amyloid Beta-Induced Impairment of Mitochondrial Transport in Hippocampal Neurons
- (2012) Chaeyoung Kim et al. PLoS One
- Peroxynitrite-Induced Nitrative and Oxidative Modifications Alter Tau Filament Formation
- (2011) Laurel Vana et al. BIOCHEMISTRY
- Hydrophobic, Aromatic, and Electrostatic Interactions Play a Central Role in Amyloid Fibril Formation and Stability
- (2011) Karen E. Marshall et al. BIOCHEMISTRY
- A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines
- (2011) Wendou Yu et al. HUMAN MOLECULAR GENETICS
- Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles
- (2011) Jing L. Guo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins
- (2011) Sharmistha Sinha et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Seeded Aggregation and Toxicity of α-Synuclein and Tau
- (2010) Takashi Nonaka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy
- (2010) Sang-Won Min et al. NEURON
- Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration
- (2010) Brian R. Hoover et al. NEURON
- HDAC6 Regulates Mitochondrial Transport in Hippocampal Neurons
- (2010) Sigeng Chen et al. PLoS One
- Propagation of Tau Misfolding from the Outside to the Inside of a Cell
- (2009) Bess Frost et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases
- (2009) Yang Yu et al. JOURNAL OF NEUROCHEMISTRY
- Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau
- (2009) Wenkai Li et al. JOURNAL OF NEUROCHEMISTRY
- The role of tau in neurodegeneration
- (2009) Tania F Gendron et al. Molecular Neurodegeneration
- Transmission and spreading of tauopathy in transgenic mouse brain
- (2009) Florence Clavaguera et al. NATURE CELL BIOLOGY
- Aging Analysis Reveals Slowed Tau Turnover and Enhanced Stress Response in a Mouse Model of Tauopathy
- (2008) Chad Dickey et al. AMERICAN JOURNAL OF PATHOLOGY
- Histone deacetylase 6 interacts with the microtubule-associated protein tau
- (2008) Huiping Ding et al. JOURNAL OF NEUROCHEMISTRY
- Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease
- (2008) B. Boland et al. JOURNAL OF NEUROSCIENCE
- Lysine Acetylation: Codified Crosstalk with Other Posttranslational Modifications
- (2008) Xiang-Jiao Yang et al. MOLECULAR CELL
- Akt and CHIP coregulate tau degradation through coordinated interactions
- (2008) C. A. Dickey et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started