Delivery of STING agonists for adjuvanting subunit vaccines

Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action

(2021) Carlo Pifferi et al.   Nature Reviews Chemistry

Maintaining manganese in tumor to activate cGAS-STING pathway evokes a robust abscopal anti-tumor effect

(2021) Chao Wang et al.   JOURNAL OF CONTROLLED RELEASE

Prolonged activation of innate immune pathways by a polyvalent STING agonist

(2021) Suxin Li et al.   Nature Biomedical Engineering

Manganese salts function as potent adjuvants

(2021) Rui Zhang et al.   Cellular & Molecular Immunology

Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING

(2021) Run Fang et al.   IMMUNITY

Chitosan-based Colloidal Polyelectrolyte Complexes for Drug Delivery: A Review

(2020) Danjun Wu et al.   CARBOHYDRATE POLYMERS

Advancement on modification of chitosan biopolymer and its potential applications

(2020) Nabel A. Negm et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Chitosan Derivatives and Their Application in Biomedicine

(2020) Wenqian Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens

(2020) Geoffrey M. Lynn et al.   NATURE BIOTECHNOLOGY

Pulmonary surfactant–biomimetic nanoparticles potentiate heterosubtypic influenza immunity

(2020) Ji Wang et al.   SCIENCE

Integrating Biomaterials and Immunology to Improve Vaccines Against Infectious Diseases

(2020) Lampouguin Yenkoidiok-Douti et al.   ACS Biomaterials-Science & Engineering

C-di-GMP with influenza vaccine showed enhanced and shifted immune responses in microneedle vaccination in the skin

(2020) Ju-Hyung Shin et al.   Drug Delivery and Translational Research

Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer

(2020) Kuan-Wei Huang et al.   Science Advances

Manganese-Based Nanoactivator Optimizes Cancer Immunotherapy via Enhancing Innate Immunity

(2020) Lin Hou et al.   ACS Nano

Nanomedicine-mediated alteration of the pharmacokinetic profile of small molecule cancer immunotherapeutics

(2020) Simon Van Herck et al.   ACTA PHARMACOLOGICA SINICA

Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

(2020) Chun Zhou et al.   IMMUNITY

The incorporation of cationic property and immunopotentiator in poly (lactic acid) microparticles promoted the immune response against chronic hepatitis B

(2020) Ting Lu et al.   JOURNAL OF CONTROLLED RELEASE

Engineering Polymeric Prodrug Nanoplatform for Vaccination Immunotherapy of Cancer

(2020) Lei Zhou et al.   NANO LETTERS

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

(2020) Daniel S. Leventhal et al.   Nature Communications

Multifunctional STING‐Activating Mn 3 O 4 @Au‐dsDNA/DOX Nanoparticle for Antitumor Immunotherapy

(2020) Min Zhou et al.   Advanced Healthcare Materials

Co-delivery of Peptide Neoantigens and Stimulator of Interferon Genes Agonists Enhances Response to Cancer Vaccines

(2020) Daniel Shae et al.   ACS Nano

cGAS-STING, an important pathway in cancer immunotherapy

(2020) Minlin Jiang et al.   Journal of Hematology & Oncology

Induction of antibody responses in mice immunized intranasally with type I interferon as adjuvant and synergistic effect of chitosan

(2020) Jun‐ichi Maeyama et al.   MICROBIOLOGY AND IMMUNOLOGY

Mucosal Vaccination for Influenza Protection Enhanced by Catalytic Immune‐Adjuvant

(2020) Tao Qin et al.   Advanced Science

Self-assembled cGAMP-STINGΔTM signaling complex as a bioinspired platform for cGAMP delivery

(2020) Yanpu He et al.   Science Advances

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

(2020) Mengze Lv et al.   CELL RESEARCH

Manganese enhances the antitumor function of CD8+ T cells by inducing type I interferon production

(2020) Yuan Song et al.   Cellular & Molecular Immunology

Structural mechanism of cGAS inhibition by the nucleosome

(2020) Ganesh R. Pathare et al.   NATURE

G10 is a direct activator of human STING

(2020) Monali Banerjee et al.   PLoS One

PARP inhibitors unleash the antitumor immune response

(2020) Ecaterina Ileana-Dumbrava   Science Translational Medicine

Mn2+ Directly Activates cGAS and Structural Analysis Suggests Mn2+ Induces a Noncanonical Catalytic Synthesis of 2′3′-cGAMP

(2020) Zhen Zhao et al.   Cell Reports

PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response

(2020) Chiho Kim et al.   eLife

Nanoparticle-enhanced chemo-immunotherapy to trigger robust antitumor immunity

(2020) Jingjing Liang et al.   Science Advances

Intranasal Delivery of a Chitosan-Hydrogel Vaccine Generates Nasal Tissue Resident Memory CD8+ T Cells That Are Protective against Influenza Virus Infection

(2020) James G. Bedford et al.   Vaccines

STING Activator c-di-GMP-Loaded Mesoporous Silica Nanoparticles Enhance Immunotherapy Against Breast Cancer

(2020) Yi-Ping Chen et al.   ACS Applied Materials & Interfaces

In situ activation of STING pathway with polymeric SN38 for cancer chemoimmunotherapy

(2020) Jiayu Zhao et al.   BIOMATERIALS

The discovery of potent small molecule activators of human STING

(2020) David C. Pryde et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antigen folding improves loading efficiency and antitumor efficacy of PC7A nanoparticle vaccine

(2020) Jonathan Wilhelm et al.   JOURNAL OF CONTROLLED RELEASE

Nanomedicinal delivery of stimulator of interferon genes agonists: recent advances in virus vaccination

(2020) Saborni Chattopadhyay et al.   Nanomedicine

Polycarbonate-based ultra-pH sensitive nanoparticles improve therapeutic window

(2020) Xu Wang et al.   Nature Communications

STING, a promising target for small molecular immune modulator: A review

(2020) Yijun Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

(2019) Daniel Shae et al.   Nature Nanotechnology

The Combination Vaccine Adjuvant System Alum/c-di-AMP Results in Quantitative and Qualitative Enhanced Immune Responses Post Immunization

(2019) Thomas Ebensen et al.   Frontiers in Cellular and Infection Microbiology

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP

(2019) Guijun Shang et al.   NATURE

Viromimetic STING Agonist‐Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus

(2019) Leon Chien‐Wei Lin et al.   ADVANCED FUNCTIONAL MATERIALS

PARP inhibitors need an extra STING for therapeutic efficacy

(2019) Anand D. Jeyasekharan   Science Translational Medicine

Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes Agonist

(2019) Xiaohui Zhang et al.   ACS Infectious Diseases

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

(2019) Christian Zierhut et al.   CELL

STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition

(2019) Sabrina L. Ergun et al.   CELL

Single-injecting, bioinspired nanocomposite hydrogel that can recruit host immune cells in situ to elicit potent and long-lasting humoral immune responses

(2019) Chiranjeevi Korupalli et al.   BIOMATERIALS

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation

(2019) Lei Miao et al.   NATURE BIOTECHNOLOGY

Enhancing Immune Response and Heterosubtypic Protection Ability of Inactivated H7N9 Vaccine by Using STING Agonist as a Mucosal Adjuvant

(2019) Jian Luo et al.   Frontiers in Immunology

Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy

(2019) Casey R. Ager et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

cGAS/STING axis mediates a topoisomerase II inhibitor–induced tumor immunogenicity

(2019) Zining Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity

(2019) Linda Schadt et al.   Cell Reports

The Role of TLRs in Anti-cancer Immunity and Tumor Rejection

(2019) Zuzanna Urban-Wojciuk et al.   Frontiers in Immunology

A novel GSH responsive poly(alpha-lipoic acid) nanocarrier bonding with the honokiol-DMXAA conjugate for combination therapy

(2019) Zhilin Liu et al.   Science China-Materials

Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonists

(2019) Shi Hou et al.   BIOORGANIC CHEMISTRY

Adjuvants and delivery systems based on polymeric nanoparticles for mucosal vaccines

(2019) Zheng Jin et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective

(2019) Han Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Amidobenzimidazole Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists

(2019) Qiumu Xi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulation of cGAS- and RLR-mediated immunity to nucleic acids

(2019) Andrea Ablasser et al.   NATURE IMMUNOLOGY

Combination of STING Pathway Agonist With Saponin Is an Effective Adjuvant in Immunosenescent Mice

(2019) Elena V. Vassilieva et al.   Frontiers in Immunology

Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance

(2018) Wen Zhou et al.   CELL

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

(2018) Chenguang Wang et al.   IMMUNITY

A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination

(2018) Robert D. Junkins et al.   JOURNAL OF CONTROLLED RELEASE

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Mucosal Immunity and Protective Efficacy of Intranasal Inactivated Influenza Vaccine Is Improved by Chitosan Nanoparticle Delivery in Pigs

(2018) Santosh Dhakal et al.   Frontiers in Immunology

Immunomodulatory properties of chitosan polymers

(2018) Hannah B.T. Moran et al.   BIOMATERIALS

Targeting STING with cyclic di-GMP greatly augmented immune responses of glycopeptide cancer vaccines

(2018) Jun-Jun Wu et al.   CHEMICAL COMMUNICATIONS

Identification of α-Mangostin as an Agonist of Human STING

(2018) Yibo Zhang et al.   ChemMedChem

Investigation of tunable acetalated dextran microparticle platform to optimize M2e-based influenza vaccine efficacy

(2018) Naihan Chen et al.   JOURNAL OF CONTROLLED RELEASE

Design, synthesis, and biological evaluation of C7-functionalized DMXAA derivatives as potential human-STING agonists

(2018) Jihyun Hwang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Acetalated Dextran Microparticles for Codelivery of STING and TLR7/8 Agonists

(2018) Michael A. Collier et al.   MOLECULAR PHARMACEUTICS

Design of amidobenzimidazole STING receptor agonists with systemic activity

(2018) Joshi M. Ramanjulu et al.   NATURE

Cisplatin-induced immune modulation in ovarian cancer mouse models with distinct inflammation profiles

(2018) Shannon Grabosch et al.   ONCOGENE

Synthesis of xanthone derivatives and studies on the inhibition against cancer cells growth and synergistic combinations of them

(2017) Jie Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Innate Immune Activation by cGMP-AMP Nanoparticles Leads to Potent and Long-Acting Antiretroviral Response against HIV-1

(2017) Chukwuemika Aroh et al.   JOURNAL OF IMMUNOLOGY

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

A STING-activating nanovaccine for cancer immunotherapy

(2017) Min Luo et al.   Nature Nanotechnology

Signalling strength determines proapoptotic functions of STING

(2017) Muhammet F. Gulen et al.   Nature Communications

Trafficking-Mediated STING Degradation Requires Sorting to Acidified Endolysosomes and Can Be Targeted to Enhance Anti-tumor Response

(2017) Vijay K. Gonugunta et al.   Cell Reports

Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization

(2017) Francesco Borriello et al.   Frontiers in Immunology

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells

(2016) Chih-Hang Anthony Tang et al.   CANCER RESEARCH

Mitochondrial DNA sensing by STING signaling participates in inflammation, cancer and beyond

(2016) Song Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Design, Synthesis, and Biological Evaluation of Novel Cyclic Adenosine–Inosine Monophosphate (cAIMP) Analogs That Activate Stimulator of Interferon Genes (STING)

(2016) Thierry Lioux et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

The Human Vaccines Project: A roadmap for cancer vaccine development

(2016) Pedro Romero et al.   Science Translational Medicine

STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice

(2015) Zili Wang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Therapeutic cancer vaccines

(2015) Cornelis J.M. Melief et al.   JOURNAL OF CLINICAL INVESTIGATION

Nanoparticulate STING agonists are potent lymph node–targeted vaccine adjuvants

(2015) Melissa C. Hanson et al.   JOURNAL OF CLINICAL INVESTIGATION

STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity

(2015) Olivier Demaria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

(2015) Juan Fu et al.   Science Translational Medicine

The STING pathway and the T cell-inflamed tumor microenvironment

(2015) Seng-Ryong Woo et al.   TRENDS IN IMMUNOLOGY

Liposomal vaccines incorporating molecular adjuvants and intrastructural T-cell help promote the immunogenicity of HIV membrane-proximal external region peptides

(2015) Melissa C. Hanson et al.   VACCINE

Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses

(2015) Tina M. Sali et al.   PLoS Pathogens

Chitosan-based vaccine adjuvants: incomplete characterization complicates preclinical and clinical evaluation

(2014) Yuri M Vasiliev   Expert Review of Vaccines

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

Ultra-pH-Sensitive Nanoprobe Library with Broad pH Tunability and Fluorescence Emissions

(2014) Xinpeng Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

(2014) Lingyin Li et al.   Nature Chemical Biology

Therapeutic vaccines for cancer: an overview of clinical trials

(2014) Ignacio Melero et al.   Nature Reviews Clinical Oncology

Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release

(2014) Petr O. Ilyinskii et al.   VACCINE

Anticancer Flavonoids Are Mouse-Selective STING Agonists

(2013) Sujeong Kim et al.   ACS Chemical Biology

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

Species-specific detection of the antiviral small-molecule compound CMA by STING

(2013) Taner Cavlar et al.   EMBO JOURNAL

Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid

(2013) J. Conlon et al.   JOURNAL OF IMMUNOLOGY

Structural mechanism of cytosolic DNA sensing by cGAS

(2013) Filiz Civril et al.   NATURE

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

(2013) Andrea Ablasser et al.   NATURE

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

(2013) Baoxu Pang et al.   Nature Communications

Evidence for cyclic diguanylate as a vaccine adjuvant with novel immunostimulatory activities

(2012) Peter M. Gray et al.   CELLULAR IMMUNOLOGY

Tunable, Ultrasensitive pH-Responsive Nanoparticles Targeting Specific Endocytic Organelles in Living Cells

(2011) Kejin Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Host type I IFN signals are required for antitumor CD8+T cell responses through CD8α+dendritic cells

(2011) Mercedes B. Fuertes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I interferon is selectively required by dendritic cells for immune rejection of tumors

(2011) Mark S. Diamond et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Immunological mechanisms of vaccination

(2011) Bali Pulendran et al.   NATURE IMMUNOLOGY

DNA released from dying host cells mediates aluminum adjuvant activity

(2011) Thomas Marichal et al.   NATURE MEDICINE

Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice

(2011) Abdullah S. Madhun et al.   VACCINE

Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo

(2010) M. W. Munks et al.   BLOOD

Immune mechanisms of protection: can adjuvants rise to the challenge?

(2010) Amy S McKee et al.   BMC BIOLOGY

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

The potential of 3′,5′-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant

(2010) Wangxue Chen et al.   VACCINE

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

CD8+ T cell efficacy in vaccination and disease

(2008) Victor Appay et al.   NATURE MEDICINE