Nanomedicinal delivery of stimulator of interferon genes agonists: recent advances in virus vaccination

Pulmonary surfactant–biomimetic nanoparticles potentiate heterosubtypic influenza immunity

(2020) Ji Wang et al.   SCIENCE

Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer

(2020) Kuan-Wei Huang et al.   Science Advances

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

Induction of Robust Immune Responses by CpG-ODN-Loaded Hollow Polymeric Nanoparticles for Antiviral and Vaccine Applications in Chickens

(2020) Shu-Yi Lin et al.   International Journal of Nanomedicine

Synthetic Immunogenic Cell Death Mediated by Intracellular Delivery of STING Agonist Nanoshells Enhances Anticancer Chemo-immunotherapy

(2020) Saborni Chattopadhyay et al.   NANO LETTERS

The COVID-19 vaccine development landscape

(2020) Tung Thanh Le et al.   NATURE REVIEWS DRUG DISCOVERY

News Feature: Avoiding pitfalls in the pursuit of a COVID-19 vaccine

(2020) Lynne Peeples   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multifunctional STING‐Activating Mn 3 O 4 @Au‐dsDNA/DOX Nanoparticle for Antitumor Immunotherapy

(2020) Min Zhou et al.   Advanced Healthcare Materials

Co-delivery of Peptide Neoantigens and Stimulator of Interferon Genes Agonists Enhances Response to Cancer Vaccines

(2020) Daniel Shae et al.   ACS Nano

The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

(2020) Lakshmanane Premkumar et al.   Science Immunology

SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant

(2020) Yoriyuki Konno et al.   Cell Reports

Nanoparticle-enhanced chemo-immunotherapy to trigger robust antitumor immunity

(2020) Jingjing Liang et al.   Science Advances

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

(2019) Daniel Shae et al.   Nature Nanotechnology

Viromimetic STING Agonist‐Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus

(2019) Leon Chien‐Wei Lin et al.   ADVANCED FUNCTIONAL MATERIALS

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

Beneficial and Adverse Effects of cART Affect Neurocognitive Function in HIV-1 Infection: Balancing Viral Suppression against Neuronal Stress and Injury

(2019) Nina Y. Yuan et al.   Journal of Neuroimmune Pharmacology

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation

(2019) Lei Miao et al.   NATURE BIOTECHNOLOGY

STING is required for host defense against neuropathological West Nile virus infection

(2019) Kathryn McGuckin Wuertz et al.   PLoS Pathogens

Broadly protective human antibodies that target the active site of influenza virus neuraminidase

(2019) Daniel Stadlbauer et al.   SCIENCE

An inhalable nanoparticulate STING agonist synergizes with radiotherapy to confer long-term control of lung metastases

(2019) Yang Liu et al.   Nature Communications

A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination

(2018) Robert D. Junkins et al.   JOURNAL OF CONTROLLED RELEASE

Estimates of global seasonal influenza-associated respiratory mortality: a modelling study

(2018) A Danielle Iuliano et al.   LANCET

Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy

(2018) David R. Wilson et al.   Nanomedicine-Nanotechnology Biology and Medicine

Advances and Opportunities in Nanoparticle- and Nanomaterial-Based Vaccines against Bacterial Infections

(2018) Leon Chien-Wei Lin et al.   Advanced Healthcare Materials

Universal Vaccines and Vaccine Platforms to Protect against Influenza Viruses in Humans and Agriculture

(2018) Daniela S. Rajão et al.   Frontiers in Microbiology

Investigation of tunable acetalated dextran microparticle platform to optimize M2e-based influenza vaccine efficacy

(2018) Naihan Chen et al.   JOURNAL OF CONTROLLED RELEASE

Induction of necrotic cell death and activation of STING in the tumor microenvironment via cationic silica nanoparticles leading to enhanced antitumor immunity

(2018) Myunggi An et al.   Nanoscale

Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

(2018) Kelsey E. Sivick et al.   Cell Reports

Innate Immune Activation by cGMP-AMP Nanoparticles Leads to Potent and Long-Acting Antiretroviral Response against HIV-1

(2017) Chukwuemika Aroh et al.   JOURNAL OF IMMUNOLOGY

A STING-activating nanovaccine for cancer immunotherapy

(2017) Min Luo et al.   Nature Nanotechnology

Opportunistic Infections in HIV-Infected Patients Differ Strongly in Frequencies and Spectra between Patients with Low CD4+ Cell Counts Examined Postmortem and Compensated Patients Examined Antemortem Irrespective of the HAART Era

(2016) Marta K. Powell et al.   PLoS One

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

(2016) Christian K. Holm et al.   Nature Communications

Temporally Programmed CD8α + DC Activation Enhances Combination Cancer Immunotherapy

(2016) Alice Tzeng et al.   Cell Reports

Nanoparticulate STING agonists are potent lymph node–targeted vaccine adjuvants

(2015) Melissa C. Hanson et al.   JOURNAL OF CLINICAL INVESTIGATION

Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma

(2015) Takashi Nakamura et al.   JOURNAL OF CONTROLLED RELEASE

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Liposomal vaccines incorporating molecular adjuvants and intrastructural T-cell help promote the immunogenicity of HIV membrane-proximal external region peptides

(2015) Melissa C. Hanson et al.   VACCINE

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

A new adjuvant delivery system ‘cyclic di-GMP/YSK05 liposome’ for cancer immunotherapy

(2014) Hiroko Miyabe et al.   JOURNAL OF CONTROLLED RELEASE

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF- B Activation through TBK1

(2014) T. Abe et al.   JOURNAL OF VIROLOGY

HIV infection: epidemiology, pathogenesis, treatment, and prevention

(2014) Gary Maartens et al.   LANCET

SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex

(2014) Xiaojuan Chen et al.   Protein & Cell

Neutralizing antibodies to HIV-1 induced by immunization

(2013) Laura E. McCoy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Evidence for cyclic diguanylate as a vaccine adjuvant with novel immunostimulatory activities

(2012) Peter M. Gray et al.   CELLULAR IMMUNOLOGY

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Host type I IFN signals are required for antitumor CD8+T cell responses through CD8α+dendritic cells

(2011) Mercedes B. Fuertes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A 2020 vision for vaccines against HIV, tuberculosis and malaria

(2011) Rino Rappuoli et al.   NATURE

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Development of Antiretroviral Drug Resistance

(2011) Mark A. Wainberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice

(2011) Abdullah S. Madhun et al.   VACCINE

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE