Innate Immune Activation by cGMP-AMP Nanoparticles Leads to Potent and Long-Acting Antiretroviral Response against HIV-1

Toll-Like Receptor 7 Agonist GS-9620 Induces HIV Expression and HIV-Specific Immunity in Cells from HIV-Infected Individuals on Suppressive Antiretroviral Therapy

(2017) Angela Tsai et al.   JOURNAL OF VIROLOGY

A STING-activating nanovaccine for cancer immunotherapy

(2017) Min Luo et al.   Nature Nanotechnology

cGAS is essential for the antitumor effect of immune checkpoint blockade

(2017) Hua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Redox-Activatable Fluorescent Sensor for the High-Throughput Quantification of Cytosolic Delivery of Macromolecules

(2016) Zhaohui Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Novel Toll-Like Receptor 9 Agonist, MGN1703, Enhances HIV-1 Transcription and NK Cell-Mediated Inhibition of HIV-1-Infected Autologous CD4+T Cells

(2016) Rasmus Offersen et al.   JOURNAL OF VIROLOGY

Molecular basis of cooperativity in pH-triggered supramolecular self-assembly

(2016) Yang Li et al.   Nature Communications

The promise and pitfalls of long-acting injectable agents for HIV prevention

(2016) Raphael J. Landovitz et al.   Current Opinion in HIV and AIDS

TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice

(2016) Lee Adam Wheeler et al.   Cell Reports

Innate Immune Recognition of Cancer

(2015) Seng-Ryong Woo et al.   Annual Review of Immunology

STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease

(2015) Nicole Dobbs et al.   Cell Host & Microbe

STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

(2015) Juan Fu et al.   Science Translational Medicine

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

Inhibiting the Host Exonuclease TREX1 Induces a Localized and Protective Host Interferon Response against Acute HIV Infection In Vivo

(2014) Lee Adam Wheeler et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

(2014) Lingyin Li et al.   Nature Chemical Biology

Safeguard against DNA sensing: the role of TREX1 in HIV-1 infection and autoimmune diseases

(2014) Maroof Hasan et al.   Frontiers in Microbiology

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Multicolored pH-Tunable and Activatable Fluorescence Nanoplatform Responsive to Physiologic pH Stimuli

(2012) Kejin Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intrinsic antiviral immunity

(2012) Nan Yan et al.   NATURE IMMUNOLOGY

Quantification of Reverse Transcriptase Activity by Real-Time PCR as a Fast and Accurate Method for Titration of HIV, Lenti- and Retroviral Vectors

(2012) Jolien Vermeire et al.   PLoS One

Innate Immune Activation in Primary HIV‐1 Infection

(2010) J. Judy Chang et al.   JOURNAL OF INFECTIOUS DISEASES

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

(2010) Nan Yan et al.   NATURE IMMUNOLOGY

A one-step SYBR Green I-based product-enhanced reverse transcriptase assay for the quantitation of retroviruses in cell culture supernatants

(2008) Massimo Pizzato et al.   JOURNAL OF VIROLOGICAL METHODS