Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses

Nucleic Acid Recognition Orchestrates the Anti-Viral Response to Retroviruses

(2015) Spyridon Stavrou et al.   Cell Host & Microbe

Nanoparticulate STING agonists are potent lymph node–targeted vaccine adjuvants

(2015) Melissa C. Hanson et al.   JOURNAL OF CLINICAL INVESTIGATION

Different STAT Transcription Complexes Drive Early and Delayed Responses to Type I IFNs

(2015) Ali A. Abdul-Sater et al.   JOURNAL OF IMMUNOLOGY

Evasion of Innate Cytosolic DNA Sensing by a Gammaherpesvirus Facilitates Establishment of Latent Infection

(2015) Chenglong Sun et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Chikungunya on the move

(2015) Michael A. Johansson   TRENDS IN PARASITOLOGY

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

STING Agonists Induce an Innate Antiviral Immune Response against Hepatitis B Virus

(2014) Fang Guo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pushing to a cure by harnessing innate immunity against hepatitis C virus

(2014) Reneé C. Ireton et al.   ANTIVIRAL RESEARCH

Message in a bottle: lessons learned from antagonism of STING signalling during RNA virus infection

(2014) Kevin Maringer et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Listeria monocytogenes induces IFN  expression through an IFI16-, cGAS- and STING-dependent pathway

(2014) K. Hansen et al.   EMBO JOURNAL

Dendritic cell specific targeting of MyD88 signalling pathways in vivo

(2014) Catharina Arnold-Schrauf et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inhibition of Dengue and Chikungunya Virus Infections by RIG-I-Mediated Type I Interferon-Independent Stimulation of the Innate Antiviral Response

(2014) D. Olagnier et al.   JOURNAL OF VIROLOGY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants

(2014) C. Maisonneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modified Vaccinia Virus Ankara Triggers Type I IFN Production in Murine Conventional Dendritic Cells via a cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway

(2014) Peihong Dai et al.   PLoS Pathogens

Anticancer Flavonoids Are Mouse-Selective STING Agonists

(2013) Sujeong Kim et al.   ACS Chemical Biology

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

(2013) Pu Gao et al.   CELL

Species-specific detection of the antiviral small-molecule compound CMA by STING

(2013) Taner Cavlar et al.   EMBO JOURNAL

Identification of a negative feedback loop between cyclic di-GMP-induced levels of IFI16 and p202 cytosolic DNA sensors and STING

(2013) Ravichandran Panchanathan et al.   Innate Immunity

Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid

(2013) J. Conlon et al.   JOURNAL OF IMMUNOLOGY

MPYS/STING-Mediated TNF- , Not Type I IFN, Is Essential for the Mucosal Adjuvant Activity of (3'-5')-Cyclic-Di-Guanosine-Monophosphate In Vivo

(2013) S. M. Blaauboer et al.   JOURNAL OF IMMUNOLOGY

Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors

(2013) K. A. Horan et al.   JOURNAL OF IMMUNOLOGY

Chronic Joint Disease Caused by Persistent Chikungunya Virus Infection Is Controlled by the Adaptive Immune Response

(2013) D. W. Hawman et al.   JOURNAL OF VIROLOGY

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

The Chemotherapeutic Agent DMXAA as a Unique IRF3-Dependent Type-2 Vaccine Adjuvant

(2013) Choon Kit Tang et al.   PLoS One

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity

(2013) Marie-Line Goulet et al.   PLoS Pathogens

Defining critical roles for NF-κB p65 and type I interferon in innate immunity to rhinovirus

(2012) Nathan W. Bartlett et al.   EMBO Molecular Medicine

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

5,6-Dimethylxanthenone-4-acetic Acid (DMXAA) Activates Stimulator of Interferon Gene (STING)-dependent Innate Immune Pathways and Is Regulated by Mitochondrial Membrane Potential

(2012) Daniel Prantner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STING and the innate immune response to nucleic acids in the cytosol

(2012) Dara L Burdette et al.   NATURE IMMUNOLOGY

Mechanism of substrate selection by a highly specific CRISPR endoribonuclease

(2012) S. H. Sternberg et al.   RNA

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation

(2012) Laura Tornatore et al.   TRENDS IN CELL BIOLOGY

Regulators of innate immunity as novel targets for panviral therapeutics

(2012) Salwa Es-Saad et al.   Current Opinion in Virology

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

Pharmacologic Activation of the Innate Immune System to Prevent Respiratory Viral Infections

(2010) Guanjun Cheng et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

IL-6 in human cytomegalovirus secretome promotes angiogenesis and survival of endothelial cells through the stimulation of survivin

(2010) S. Botto et al.   BLOOD

The differential activity of interferon-α subtypes is consistent among distinct target genes and cell types

(2010) Herwig P. Moll et al.   CYTOKINE

Persistent Chronic Inflammation and Infection by Chikungunya Arthritogenic Alphavirus in Spite of a Robust Host Immune Response

(2010) J. J. Hoarau et al.   JOURNAL OF IMMUNOLOGY

NF- B RelA Subunit Is Crucial for Early IFN-  Expression and Resistance to RNA Virus Replication

(2010) J. Wang et al.   JOURNAL OF IMMUNOLOGY

The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-β-mediated antiviral activity in vitro and in vivo

(2010) Kari Ann Shirey et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Chikungunya Virus Arthritis in Adult Wild-Type Mice

(2010) J. Gardner et al.   JOURNAL OF VIROLOGY

Activation of the Interferon Response by Human Cytomegalovirus Occurs via Cytoplasmic Double-Stranded DNA but Not Glycoprotein B

(2010) V. R. DeFilippis et al.   JOURNAL OF VIROLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Cowpox Virus Inhibits the Transporter Associated with Antigen Processing to Evade T Cell Recognition

(2009) Dina Alzhanova et al.   Cell Host & Microbe

Synthetic and Natural Immunomodulators Acting as Interferon Inducers

(2009) Dmytro Silin et al.   CURRENT PHARMACEUTICAL DESIGN

Human Cytomegalovirus Induces the Interferon Response via the DNA Sensor ZBP1

(2009) V. R. DeFilippis et al.   JOURNAL OF VIROLOGY

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

(2009) W. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of toll-like receptor signaling pathway for protection against influenza virus infection

(2009) J.P. Wong et al.   VACCINE

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE