Viromimetic STING Agonist‐Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus

A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination

(2018) Robert D. Junkins et al.   JOURNAL OF CONTROLLED RELEASE

Type I interferons in tuberculosis: Foe and occasionally friend

(2018) Lúcia Moreira-Teixeira et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy

(2018) David R. Wilson et al.   Nanomedicine-Nanotechnology Biology and Medicine

Engineering a stable CHO cell line for the expression of a MERS-coronavirus vaccine antigen

(2018) Mun Peak Nyon et al.   VACCINE

Immune response elicited by two rBCG strains devoid of genes involved in c-di-GMP metabolism affect protection versus challenge with M. tuberculosis strains of different virulence

(2018) Cristian Alfredo Segura-Cerda et al.   VACCINE

Inhibitor analysis revealed that clathrin-mediated endocytosis is involed in cellular entry of type III grass carp reovirus

(2018) Hao Wang et al.   Virology Journal

Advances and Opportunities in Nanoparticle- and Nanomaterial-Based Vaccines against Bacterial Infections

(2018) Leon Chien-Wei Lin et al.   Advanced Healthcare Materials

Heterosubtypic influenza protection elicited by double-layered polypeptide nanoparticles in mice

(2018) Lei Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Block copolymer crystalsomes with an ultrathin shell to extend blood circulation time

(2018) Hao Qi et al.   Nature Communications

Acetalated Dextran Microparticles for Codelivery of STING and TLR7/8 Agonists

(2018) Michael A. Collier et al.   MOLECULAR PHARMACEUTICS

Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

(2018) Kelsey E. Sivick et al.   Cell Reports

Innate Immune Activation by cGMP-AMP Nanoparticles Leads to Potent and Long-Acting Antiretroviral Response against HIV-1

(2017) Chukwuemika Aroh et al.   JOURNAL OF IMMUNOLOGY

ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice

(2017) Naif Khalaf Alharbi et al.   VACCINE

MERS-CoV spike nanoparticles protect mice from MERS-CoV infection

(2017) Christopher M. Coleman et al.   VACCINE

Investigation of phosphorylated adjuvants co-encapsulated with a model cancer peptide antigen for the treatment of colorectal cancer and liver metastasis

(2017) Tyler J. Goodwin et al.   VACCINE

Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody

(2017) Katherine V. Houser et al.   PLoS Pathogens

The Roles of Type I Interferon in Bacterial Infection

(2016) Gayle M. Boxx et al.   Cell Host & Microbe

Airway Memory CD4 + T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses

(2016) Jincun Zhao et al.   IMMUNITY

Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus–Derived CD8+T Cell Epitopes and Host MHC

(2016) William J. Liu et al.   JOURNAL OF IMMUNOLOGY

pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation

(2016) Lutz Nuhn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporally Programmed CD8α + DC Activation Enhances Combination Cancer Immunotherapy

(2016) Alice Tzeng et al.   Cell Reports

Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus

(2016) Anurodh Shankar Agrawal et al.   Human Vaccines & Immunotherapeutics

Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus

(2015) Naru Zhang et al.   Cellular & Molecular Immunology

Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus

(2015) Xiaojuan Guo et al.   IMMUNOLOGY

Nanoparticulate STING agonists are potent lymph node–targeted vaccine adjuvants

(2015) Melissa C. Hanson et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanistic profiling of the siRNA delivery dynamics of lipid–polymer hybrid nanoparticles

(2015) Stefano Colombo et al.   JOURNAL OF CONTROLLED RELEASE

Interfering with Immunity: Detrimental Role of Type I IFNs during Infection

(2015) Sebastian A. Stifter et al.   JOURNAL OF IMMUNOLOGY

Characterization and Demonstration of the Value of a Lethal Mouse Model of Middle East Respiratory Syndrome Coronavirus Infection and Disease

(2015) Xinrong Tao et al.   JOURNAL OF VIROLOGY

Protective Efficacy of Recombinant Modified Vaccinia Virus Ankara Delivering Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein

(2015) Asisa Volz et al.   JOURNAL OF VIROLOGY

Generation of a Transgenic Mouse Model of Middle East Respiratory Syndrome Coronavirus Infection and Disease

(2015) Anurodh Shankar Agrawal et al.   JOURNAL OF VIROLOGY

In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity

(2015) Geoffrey M Lynn et al.   NATURE BIOTECHNOLOGY

An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels

(2015) B. L. Haagmans et al.   SCIENCE

A synthetic consensus anti–spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates

(2015) Karuppiah Muthumani et al.   Science Translational Medicine

Evaluation of candidate vaccine approaches for MERS-CoV

(2015) Lingshu Wang et al.   Nature Communications

Optimization of antigen dose for a receptor-binding domain-based subunit vaccine against MERS coronavirus

(2015) Jian Tang et al.   Human Vaccines & Immunotherapeutics

Recombinant Receptor Binding Domain Protein Induces Partial Protective Immunity in Rhesus Macaques Against Middle East Respiratory Syndrome Coronavirus Challenge

(2015) Jiaming Lan et al.   EBioMedicine

STING Agonists Induce an Innate Antiviral Immune Response against Hepatitis B Virus

(2014) Fang Guo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

T cell-mediated immune response to respiratory coronaviruses

(2014) Rudragouda Channappanavar et al.   IMMUNOLOGIC RESEARCH

Severe Acute Respiratory Syndrome-Associated Coronavirus Vaccines Formulated with Delta Inulin Adjuvants Provide Enhanced Protection while Ameliorating Lung Eosinophilic Immunopathology

(2014) Yoshikazu Honda-Okubo et al.   JOURNAL OF VIROLOGY

Development of functionalized nanoparticles for vaccine delivery to dendritic cells: a mechanistic approach

(2014) Joana M Silva et al.   Nanomedicine

Rapid generation of a mouse model for Middle East respiratory syndrome

(2014) Jincun Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlled analysis of nanoparticle charge on mucosal and systemic antibody responses following pulmonary immunization

(2014) Catherine A. Fromen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice

(2014) Eun Kim et al.   VACCINE

Searching for an ideal vaccine candidate among different MERS coronavirus receptor-binding fragments—The importance of immunofocusing in subunit vaccine design

(2014) Cuiqing Ma et al.   VACCINE

Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: Implication for designing novel mucosal MERS vaccines

(2014) Cuiqing Ma et al.   VACCINE

Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release

(2014) Petr O. Ilyinskii et al.   VACCINE

Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice

(2014) Christopher M. Coleman et al.   VACCINE

A new adjuvanted nanoparticle-based H1N1 influenza vaccine induced antigen-specific local mucosal and systemic immune responses after administration into the lung

(2014) Vanessa Neuhaus et al.   VACCINE

Middle East Respiratory Syndrome Coronavirus Spike Protein Delivered by Modified Vaccinia Virus Ankara Efficiently Induces Virus-Neutralizing Antibodies

(2013) F. Song et al.   JOURNAL OF VIROLOGY

Engineering synthetic vaccines using cues from natural immunity

(2013) Darrell J. Irvine et al.   NATURE MATERIALS

A Truncated Receptor-Binding Domain of MERS-CoV Spike Protein Potently Inhibits MERS-CoV Infection and Induces Strong Neutralizing Antibody Responses: Implication for Developing Therapeutics and Vaccines

(2013) Lanying Du et al.   PLoS One

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

Formation of Stable Nanocarriers by in Situ Ion Pairing during Block-Copolymer-Directed Rapid Precipitation

(2012) Nathalie M. Pinkerton et al.   MOLECULAR PHARMACEUTICS

Development of a nanoparticle-based influenza vaccine using the PRINT® technology

(2012) Ashley L. Galloway et al.   Nanomedicine-Nanotechnology Biology and Medicine

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

(2012) Chien-Te Tseng et al.   PLoS One

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile

(2012) J. Hrkach et al.   Science Translational Medicine

A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

(2011) M. Bolles et al.   JOURNAL OF VIROLOGY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

A liquid chromatography-coupled tandem mass spectrometry method for quantitation of cyclic di-guanosine monophosphate

(2010) Christian Spangler et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes

(2010) Santiago F Gonzalez et al.   NATURE IMMUNOLOGY

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Characterization of Murine Dendritic Cell Line JAWS II and Primary Bone Marrow-Derived Dendritic Cells in Chlamydia muridarum Antigen Presentation and Induction of Protective Immunity

(2008) X. Jiang et al.   INFECTION AND IMMUNITY

Porin-incorporated liposome induces Toll-like receptors 2- and 6-dependent maturation and type 1 response of dendritic cell

(2008) P. Banerjee et al.   INTERNATIONAL IMMUNOLOGY