标题
Design of amidobenzimidazole STING receptor agonists with systemic activity
作者
关键词
-
出版物
NATURE
Volume 564, Issue 7736, Pages 439-443
出版商
Springer Nature
发表日期
2018-11-06
DOI
10.1038/s41586-018-0705-y
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
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- Can innate immune system targets turn up the heat on 'cold' tumours?
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- Disease-associated mutations identify a novel region in human STING necessary for the control of type I interferon signaling
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- cGAS is essential for the antitumor effect of immune checkpoint blockade
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- Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
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- STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors
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- Activated STING in a Vascular and Pulmonary Syndrome
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- Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA
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- Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
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- Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid
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- Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING
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- The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING
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- Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding
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- Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system
- (2012) Chang Shu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Host type I IFN signals are required for antitumor CD8+T cell responses through CD8α+dendritic cells
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- Type I interferon is selectively required by dendritic cells for immune rejection of tumors
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- STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
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- STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
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