Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action
出版年份 2021 全文链接
标题
Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action
作者
关键词
-
出版物
Nature Reviews Chemistry
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-01-25
DOI
10.1038/s41570-020-00244-3
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Design and Discovery of Covalent α-GalCer Derivatives as Potent CD1d Ligands
- (2020) Junichiro Kishi et al. ACS Chemical Biology
- Recent Advances in Lipopolysaccharide Recognition Systems
- (2020) Lalita Mazgaeen et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Asymmetric Total Synthesis of Mycobacterial Diacyl Trehaloses Demonstrates a Role for Lipid Structure in Immunogenicity
- (2020) Mira Holzheimer et al. ACS Chemical Biology
- In Vivo CD4+ T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm
- (2020) Mikel Ruterbusch et al. Annual Review of Immunology
- Impact of C28 Oligosaccharide on Adjuvant Activity of QS-7 Analogues
- (2020) Đani Škalamera et al. JOURNAL OF ORGANIC CHEMISTRY
- Modulation of immune responses using adjuvants to facilitate therapeutic vaccination
- (2020) Virgil Schijns et al. IMMUNOLOGICAL REVIEWS
- Synthesis and Evaluation of a QS-17/18-Based Vaccine Adjuvant
- (2019) Pengfei Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Saponins from Quillaja saponaria and Quillaja brasiliensis: Particular Chemical Characteristics and Biological Activities
- (2019) Juliane Fleck et al. MOLECULES
- Synthesis and Evaluation of QS-7-Based Vaccine Adjuvants
- (2019) Pengfei Wang et al. ACS Infectious Diseases
- 3,4-Dideoxy-3,3,4,4-tetrafluoro- and 4-OH epimeric 3-deoxy-3,3-difluoro-α-GalCer analogues: Synthesis and biological evaluation on human iNKT cells stimulation
- (2019) Samuel Golten et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Pushing the envelope: LPS modifications and their consequences
- (2019) Brent W. Simpson et al. NATURE REVIEWS MICROBIOLOGY
- Updated insights into the mechanism of action and clinical profile of the immunoadjuvant QS-21: a review
- (2019) Marie-Aleth Lacaille-Dubois PHYTOMEDICINE
- Improved Th17 Selectivity of α-Galactosylceramide via Noncovalent Interactions with Diether Moiety
- (2019) Yoon Soo Hwang et al. ACS Medicinal Chemistry Letters
- Development of α-GalCer Analogues with an α-Fluorocarbonyl Moiety as Th2-Selective Ligands of CD1d
- (2019) Hyunsoo Kim et al. ACS Medicinal Chemistry Letters
- Synthetic, Zwitterionic Sp1 Oligosaccharides Adopt a Helical Structure Crucial for Antibody Interaction
- (2019) Qingju Zhang et al. ACS Central Science
- Total Synthesis of the Congested, Bisphosphorylated Morganella morganii Zwitterionic Trisaccharide Repeating Unit
- (2019) D. Jamin Keith et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- RTS,S/AS01 Vaccine (Mosquirix™) : An overview
- (2019) Matthew B. Laurens Human Vaccines & Immunotherapeutics
- A Glycolipid Adjuvant, 7DW8-5, Enhances the Protective Immune Response to the Current Split Influenza Vaccine in Mice
- (2019) Huapeng Feng et al. Frontiers in Microbiology
- Synthesis and biological activities of amino acids functionalized α-GalCer analogues
- (2019) Weiwei Ma et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Potent Th2 Cytokine Bias of Natural Killer T Cell by CD1d Glycolipid Ligands: Anchoring Effect of Polar Groups in the Lipid Component
- (2018) Shinsuke Inuki et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Synthesis, Liposomal Formulation, and Immunological Evaluation of a Minimalistic Carbohydrate-α-GalCer Vaccine Candidate
- (2018) Felix Broecker et al. JOURNAL OF MEDICINAL CHEMISTRY
- Total Synthesis of Zwitterionic Tetrasaccharide Repeating Unit from Bacteroides fragilis ATCC 25285/NCTC 9343 Capsular Polysaccharide PS A1 with Alternating Charges on Adjacent Monosaccharides
- (2018) Pradheep Eradi et al. ORGANIC LETTERS
- Correlates of adjuvanticity: A review on adjuvants in licensed vaccines
- (2018) Giuseppe Del Giudice et al. SEMINARS IN IMMUNOLOGY
- Elucidating the Mechanisms of Action of Saponin-Derived Adjuvants
- (2018) Dante J. Marciani TRENDS IN PHARMACOLOGICAL SCIENCES
- Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics
- (2018) Florian Adanitsch et al. Chemical Science
- Mannose-capped lipoarabinomannan in Mycobacterium tuberculosis pathogenesis
- (2018) Joanne Turner et al. Pathogens and Disease
- Activation of the endoplasmic reticulum stress sensor IRE1α by the vaccine adjuvant AS03 contributes to its immunostimulatory properties
- (2018) Charlotte Givord et al. npj Vaccines
- Photoactivable Glycolipid Antigens Generate Stable Conjugates with CD1d for Invariant Natural Killer T Cell Activation
- (2018) Natacha Veerapen et al. BIOCONJUGATE CHEMISTRY
- Immunomodulatory properties of chitosan polymers
- (2018) Hannah B.T. Moran et al. BIOMATERIALS
- Investigation of tunable acetalated dextran microparticle platform to optimize M2e-based influenza vaccine efficacy
- (2018) Naihan Chen et al. JOURNAL OF CONTROLLED RELEASE
- β-glucans as potential immunoadjuvants: A review on the adjuvanticity, structure-activity relationship and receptor recognition properties
- (2018) Yiming Jin et al. VACCINE
- Carbohydrate-based adjuvants activate tumor-specific Th1 and CD8+ T-cell responses and reduce the immunosuppressive activity of MDSCs
- (2018) Xiaojing Xu et al. CANCER LETTERS
- 4“-O-Alkylated α-Galactosylceramide Analogues as i NKT-Cell Antigens: Synthetic, Biological, and Structural Studies
- (2018) Jonas Janssens et al. ChemMedChem
- Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want
- (2018) Harm HogenEsch et al. npj Vaccines
- The Role of Carbohydrates in the Lipopolysaccharide (LPS)/Toll-Like Receptor 4 (TLR4) Signalling
- (2017) Florent Cochet et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Development of Clickable Monophosphoryl Lipid A Derivatives toward Semisynthetic Conjugates with Tumor-Associated Carbohydrate Antigens
- (2017) Marcello Ziaco et al. JOURNAL OF MEDICINAL CHEMISTRY
- Progress in the synthesis and biological evaluation of lipid A and its derivatives
- (2017) Jian Gao et al. MEDICINAL RESEARCH REVIEWS
- IgG Antibody Response Elicited by a Fully Synthetic Two-Component Carbohydrate-Based Cancer Vaccine Candidate with α-Galactosylceramide as Built-in Adjuvant
- (2017) Xu-Guang Yin et al. ORGANIC LETTERS
- Rational design of adjuvants targeting the C-type lectin Mincle
- (2017) Alexiane Decout et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Design, synthesis and evaluation of optimized saponin variants derived from the vaccine adjuvant QS-21
- (2017) Alberto Fernández-Tejada PURE AND APPLIED CHEMISTRY
- Recognition of Mycobacterial Lipids by Immune Receptors
- (2017) Eri Ishikawa et al. TRENDS IN IMMUNOLOGY
- Efficient Divergent Synthesis of New Immunostimulant 4″-Modified α-Galactosylceramide Analogues
- (2017) Jonas Janssens et al. ACS Medicinal Chemistry Letters
- A critical appraisal of ‘Shingrix’, a novel herpes zoster subunit vaccine (HZ/Su or GSK1437173A) for varicella zoster virus
- (2017) Tehmina Bharucha et al. Human Vaccines & Immunotherapeutics
- Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21
- (2017) Iain Welsby et al. Frontiers in Immunology
- Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines
- (2017) Masayuki Hayashi et al. EBioMedicine
- Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity
- (2017) Margherita Coccia et al. npj Vaccines
- Delta inulin-based adjuvants promote the generation of polyfunctional CD4+ T cell responses and protection against Mycobacterium tuberculosis infection
- (2017) Claudio Counoupas et al. Scientific Reports
- Synthesis and Evaluation of GM2-Monophosphoryl Lipid A Conjugate as a Fully Synthetic Self-Adjuvant Cancer Vaccine
- (2017) Zhifang Zhou et al. Scientific Reports
- Development of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis
- (2016) Alberto Fernández-Tejada et al. ACCOUNTS OF CHEMICAL RESEARCH
- Isolated Polar Amino Acid Residues Modulate Lipid Binding in the Large Hydrophobic Cavity of CD1d
- (2016) Shinsuke Inuki et al. ACS Chemical Biology
- β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance
- (2016) Boris Novakovic et al. CELL
- A Semisynthetic Approach to New Immunoadjuvant Candidates: Site-Selective Chemical Manipulation of Escherichia coli Monophosphoryl Lipid A
- (2016) Daniele D'Alonzo et al. CHEMISTRY-A EUROPEAN JOURNAL
- Adjuvant system AS01: helping to overcome the challenges of modern vaccines
- (2016) Arnaud M. Didierlaurent et al. Expert Review of Vaccines
- The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons
- (2016) Elizabeth. C. Carroll et al. IMMUNITY
- Human NOD2 Recognizes Structurally Unique Muramyl Dipeptides from Mycobacterium leprae
- (2016) Mirjam Schenk et al. INFECTION AND IMMUNITY
- Novel vaccines targeting dendritic cells by coupling allergoids to nonoxidized mannan enhance allergen uptake and induce functional regulatory T cells through programmed death ligand 1
- (2016) Sofía Sirvent et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Sialyl-Tn Polysaccharide A1 as an Entirely Carbohydrate Immunogen: Synthesis and Immunological Evaluation
- (2016) Mengchao Shi et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events
- (2016) Olga Sobolev et al. NATURE IMMUNOLOGY
- Immunological evaluation of the entirely carbohydrate-based Thomsen-Friedenreich – PS B conjugate
- (2016) Kevin R. Trabbic et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Lipoarabinomannan, and its related glycolipids, induce divergent and opposing immune responses to Mycobacterium tuberculosis depending on structural diversity and experimental variations
- (2016) Gunilla Källenius et al. TUBERCULOSIS
- Human Phase 1 trial of low-dose inactivated seasonal influenza vaccine formulated with Advax™ delta inulin adjuvant
- (2016) David L. Gordon et al. VACCINE
- Quillaja saponin variants with central glycosidic linkage modifications exhibit distinct conformations and adjuvant activities
- (2016) William E. Walkowicz et al. Chemical Science
- Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation
- (2016) Martijn H. den Brok et al. Nature Communications
- Fully Synthetic Self-Adjuvanting α-2,9-Oligosialic Acid Based Conjugate Vaccines against Group C Meningitis
- (2016) Guochao Liao et al. ACS Central Science
- Central Role of CD169+ Lymph Node Resident Macrophages in the Adjuvanticity of the QS-21 Component of AS01
- (2016) Sophie Detienne et al. Scientific Reports
- Glycans in Medicinal Chemistry: An Underexploited Resource
- (2015) Alberto Fernández-Tejada et al. ChemMedChem
- Carbohydrate-based vaccine adjuvants – discovery and development
- (2015) Jing Hu et al. Expert Opinion on Drug Discovery
- Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants
- (2015) Robyn Marty-Roix et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- C-Type Lectin Receptor MCL Facilitates Mincle Expression and Signaling through Complex Formation
- (2015) Yasunobu Miyake et al. JOURNAL OF IMMUNOLOGY
- Rational Design of Adjuvant for Skin Delivery: Conjugation of Synthetic β-Glucan Dectin-1 Agonist to Protein Antigen
- (2015) Agnese Donadei et al. MOLECULAR PHARMACEUTICS
- Recent advances in the molecular design of synthetic vaccines
- (2015) Lyn H. Jones Nature Chemistry
- The burgeoning family of unconventional T cells
- (2015) Dale I Godfrey et al. NATURE IMMUNOLOGY
- Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation
- (2015) Xiaodi Su et al. NATURE IMMUNOLOGY
- Control of adaptive immunity by the innate immune system
- (2015) Akiko Iwasaki et al. NATURE IMMUNOLOGY
- Synthesis and Activity of 6″-Deoxy-6″-thio-α-GalCer and Peptide Conjugates
- (2015) Benjamin J. Compton et al. ORGANIC LETTERS
- Advax™, a novel microcrystalline polysaccharide particle engineered from delta inulin, provides robust adjuvant potency together with tolerability and safety
- (2015) Nikolai Petrovsky et al. VACCINE
- NKT cell-dependent glycolipid–peptide vaccines with potent anti-tumour activity
- (2015) Regan J. Anderson et al. Chemical Science
- A fully synthetic self-adjuvanting globo H-Based vaccine elicited strong T cell-mediated antitumor immunity
- (2015) Zhifang Zhou et al. Chemical Science
- Surface-Modified P(HEMA-co-MAA) Nanogel Carriers for Oral Vaccine Delivery: Design, Characterization, and In Vitro Targeting Evaluation
- (2014) Matilde Durán-Lobato et al. BIOMACROMOLECULES
- Design, synthesis, and immunologic evaluation of vaccine adjuvant conjugates based on QS-21 and tucaresol
- (2014) Alberto Fernández-Tejada et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Mycolic Acids: Structures, Biosynthesis, and Beyond
- (2014) Hedia Marrakchi et al. CHEMISTRY & BIOLOGY
- Chemistry of Lipid A: At the Heart of Innate Immunity
- (2014) Antonio Molinaro et al. CHEMISTRY-A EUROPEAN JOURNAL
- Chitosan-based vaccine adjuvants: incomplete characterization complicates preclinical and clinical evaluation
- (2014) Yuri M Vasiliev Expert Review of Vaccines
- Dectin-2 Is a Direct Receptor for Mannose-Capped Lipoarabinomannan of Mycobacteria
- (2014) Akiko Yonekawa et al. IMMUNITY
- Optimizing NKT cell ligands as vaccine adjuvants
- (2014) Leandro J Carreño et al. Immunotherapy
- Inflammasome-Dependent and -Independent IL-18 Production Mediates Immunity to the ISCOMATRIX Adjuvant
- (2014) N. S. Wilson et al. JOURNAL OF IMMUNOLOGY
- TLR4 Ligands Lipopolysaccharide and Monophosphoryl Lipid A Differentially Regulate Effector and Memory CD8+ T Cell Differentiation
- (2014) W. Cui et al. JOURNAL OF IMMUNOLOGY
- Switching Invariant Natural Killer T (iNKT) Cell Response from Anticancerous to Anti-Inflammatory Effect: Molecular Bases
- (2014) Xavier Laurent et al. JOURNAL OF MEDICINAL CHEMISTRY
- Inflammatory caspases are innate immune receptors for intracellular LPS
- (2014) Jianjin Shi et al. NATURE
- A self-adjuvanting vaccine induces cytotoxic T lymphocytes that suppress allergy
- (2014) Regan J Anderson et al. Nature Chemical Biology
- A semisynthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice
- (2014) Marco Cavallari et al. Nature Chemical Biology
- Development of a minimal saponin vaccine adjuvant based on QS-21
- (2014) Alberto Fernández-Tejada et al. Nature Chemistry
- Immunogenicity and safety of Advax™, a novel polysaccharide adjuvant based on delta inulin, when formulated with hepatitis B surface antigen: A randomized controlled Phase 1 study
- (2014) David Gordon et al. VACCINE
- Design and synthesis of galactose-6-OH-modified α-galactosyl ceramide analogues with Th2-biased immune responses
- (2014) Jung-Tung Hung et al. RSC Advances
- An update on safety and immunogenicity of vaccines containing emulsion-based adjuvants
- (2013) Christopher B Fox et al. Expert Review of Vaccines
- C-type Lectin MCL Is an FcRγ-Coupled Receptor that Mediates the Adjuvanticity of Mycobacterial Cord Factor
- (2013) Yasunobu Miyake et al. IMMUNITY
- Up to 15-year clinical follow-up of a pilot Phase III immunotherapy study in stage II breast cancer patients using oxidized mannan–MUC1
- (2013) Stamatis Vassilaros et al. Immunotherapy
- Mechanism for Recognition of an Unusual Mycobacterial Glycolipid by the Macrophage Receptor Mincle
- (2013) Hadar Feinberg et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Enhanced TCR Footprint by a Novel Glycolipid Increases NKT-Dependent Tumor Protection
- (2013) S. Aspeslagh et al. JOURNAL OF IMMUNOLOGY
- Synthesis of QS-21-Based Immunoadjuvants
- (2013) Pengfei Wang et al. JOURNAL OF ORGANIC CHEMISTRY
- Key roles of adjuvants in modern vaccines
- (2013) Steven G Reed et al. NATURE MEDICINE
- Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis
- (2013) Brittany D. Needham et al. NATURE REVIEWS MICROBIOLOGY
- Inefficient TLR4/MD-2 Heterotetramerization by Monophosphoryl Lipid A
- (2013) Carolyn R. Casella et al. PLoS One
- Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides
- (2013) L. Bai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL
- (2013) A. Furukawa et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer
- (2013) Y.-L. Huang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock
- (2013) J. A. Hagar et al. SCIENCE
- Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4
- (2013) N. Kayagaki et al. SCIENCE
- The Immunobiology of Toll-Like Receptor 4 Agonists
- (2013) Julia K. Bohannon et al. SHOCK
- A novel hepatitis B vaccine containing Advax™, a polysaccharide adjuvant derived from delta inulin, induces robust humoral and cellular immunity with minimal reactogenicity in preclinical testing
- (2013) Fadi Saade et al. VACCINE
- Interaction of the Capsular Polysaccharide A from Bacteroides fragilis with DC-SIGN on Human Dendritic Cells is Necessary for Its Processing and Presentation to T Cells
- (2013) Karien Bloem et al. Frontiers in Immunology
- New CD1d agonists: Synthesis and biological activity of 6″-triazole-substituted α-galactosyl ceramides
- (2012) Peter J. Jervis et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates
- (2012) M. Kwissa et al. BLOOD
- The entirely carbohydrate immunogen Tn-PS A1 induces a cancer cell selective immune response and cytokine IL-17
- (2012) Ravindra A. De Silva et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Molecular basis of lipid antigen presentation by CD1d and recognition by natural killer T cells
- (2012) Enrico Girardi et al. IMMUNOLOGICAL REVIEWS
- Toll or Interleukin-1 Receptor (TIR) Domain-containing Adaptor Inducing Interferon-β (TRIF)-mediated Caspase-11 Protease Production Integrates Toll-like Receptor 4 (TLR4) Protein- and Nlrp3 Inflammasome-mediated Host Defense against Enteropathogens
- (2012) Prajwal Gurung et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- 3-Fluoro- and 3,3-Difluoro-3,4-dideoxy-KRN7000 Analogues as New Potent Immunostimulator Agents: Total Synthesis and Biological Evaluation in Human Invariant Natural Killer T Cells and Mice
- (2012) Julie Hunault et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Preclinical Evaluation of QS-21 Variants Leading to Simplified Vaccine Adjuvants and Mechanistic Probes
- (2012) Eric K. Chea et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Divergent Effects of Mycobacterial Cell Wall Glycolipids on Maturation and Function of Human Monocyte-Derived Dendritic Cells
- (2012) Jolanta Mazurek et al. PLoS One
- Mannosylated Mucin-Type Immunoglobulin Fusion Proteins Enhance Antigen-Specific Antibody and T Lymphocyte Responses
- (2012) Gustaf Ahlén et al. PLoS One
- Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
- (2012) U. Ohto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Carbohydrate-Monophosphoryl Lipid A Conjugates Are Fully Synthetic Self-Adjuvanting Cancer Vaccines Eliciting Robust Immune Responses in the Mouse
- (2011) Qianli Wang et al. ACS Chemical Biology
- Differential pathways regulating innate and adaptive antitumor immune responses by particulate and soluble yeast-derived -glucans
- (2011) C. Qi et al. BLOOD
- An improved synthesis of dansylated α-galactosylceramide and its use as a fluorescent probe for the monitoring of glycolipid uptake by cells
- (2011) Janice M.H. Cheng et al. CARBOHYDRATE RESEARCH
- Activation of human invariant natural killer T cells with a thioglycoside analogue of α-galactosylceramide
- (2011) Andrew E. Hogan et al. CLINICAL IMMUNOLOGY
- Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis
- (2011) Sandrine Aspeslagh et al. EMBO JOURNAL
- Carbohydrate-based immune adjuvants
- (2011) Nikolai Petrovsky et al. Expert Review of Vaccines
- Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer
- (2011) Govind Ragupathi et al. Expert Review of Vaccines
- Recent clinical experience with vaccines using MPL- and QS-21-containing Adjuvant Systems
- (2011) Nathalie Garçon et al. Expert Review of Vaccines
- Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity
- (2011) Taro Kawai et al. IMMUNITY
- ISCOMATRIX vaccines mediate CD8+ T-cell cross-priming by a MyD88-dependent signaling pathway
- (2011) Nicholas S Wilson et al. IMMUNOLOGY AND CELL BIOLOGY
- Chitosan but Not Chitin Activates the Inflammasome by a Mechanism Dependent upon Phagocytosis
- (2011) Chelsea L. Bueter et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Rapid Fluorescence-Based Assay for Classification of iNKT Cell Activating Glycolipids
- (2011) Pooja Arora et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity
- (2011) Tracy L Flach et al. NATURE MEDICINE
- A multistage tuberculosis vaccine that confers efficient protection before and after exposure
- (2011) Claus Aagaard et al. NATURE MEDICINE
- Divergent synthetic approach to 6′′-modified α-GalCer analogues
- (2011) Nora Pauwels et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- The 3-Deoxy Analogue of α-GalCer: Disclosing the Role of the 4-Hydroxyl Group for CD1d-Mediated NKT Cell Activation
- (2011) Dong Jae Baek et al. ACS Medicinal Chemistry Letters
- In Vivo Protection Provided by a Synthetic New Alpha-Galactosyl Ceramide Analog against Bacterial and Viral Infections in Murine Models
- (2010) K.-H. Lin et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Introduction of aromatic group on 4′-OH of α-GalCer manipulated NKT cell cytokine production
- (2010) Wenpeng Zhang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Delta inulin: a novel, immunologically active, stable packing structure comprising -D-[2 -> 1] poly(fructo-furanosyl) -D-glucose polymers
- (2010) P. D. Cooper et al. GLYCOBIOLOGY
- Invariant NK T cells: potential for immunotherapeutic targeting with glycolipid antigens
- (2010) Luc Van Kaer et al. Immunotherapy
- Differential Induction of Innate Immune Responses by Synthetic Lipid A Derivatives
- (2010) Jidnyasa Gaekwad et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate
- (2010) H. Schoenen et al. JOURNAL OF IMMUNOLOGY
- Design and Synthesis of PotentQuillajaSaponin Vaccine Adjuvants
- (2010) Michelle M. Adams et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Carbohydrate vaccines: developing sweet solutions to sticky situations?
- (2010) Rena D. Astronomo et al. NATURE REVIEWS DRUG DISCOVERY
- Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant
- (2010) X. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Innate immune cell populations function as initiators and effectors in Th2 cytokine responses
- (2010) Steven A. Saenz et al. TRENDS IN IMMUNOLOGY
- How Bacterial Carbohydrates Influence the Adaptive Immune System
- (2009) Fikri Y. Avci et al. Annual Review of Immunology
- Synthesis of a monophosphoryl lipid A derivative and its conjugation to a modified form of a tumor-associated carbohydrate antigen GM3
- (2009) Qianli Wang et al. CHEMICAL COMMUNICATIONS
- Synthesis of a Monophosphoryl Derivative ofEscherichia coliLipid A and Its Efficient Coupling to a Tumor-Associated Carbohydrate Antigen
- (2009) Shouchu Tang et al. CHEMISTRY-A EUROPEAN JOURNAL
- Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands
- (2009) William C Florence et al. EMBO JOURNAL
- Chitosan-based systems for the delivery of vaccine antigens
- (2009) H. Çiğdem Arca et al. Expert Review of Vaccines
- Identification of C-glycoside analogues that display a potent biological activity against murine and human invariant natural killer T cells
- (2009) Xiangming Li et al. IMMUNOLOGY
- Fungal Zymosan and Mannan Activate the Cryopyrin Inflammasome
- (2009) Mohamed Lamkanfi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Adjuvanticity of a synthetic cord factor analogue for subunitMycobacterium tuberculosisvaccination requires FcRγ–Syk–Card9–dependent innate immune activation
- (2009) Kerstin Werninghaus et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle
- (2009) Eri Ishikawa et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Clathrin- and Dynamin-Dependent Endocytic Pathway Regulates Muramyl Dipeptide Internalization and NOD2 Activation
- (2009) N. Marina-Garcia et al. JOURNAL OF IMMUNOLOGY
- Tuberculosis Subunit Vaccination Provides Long-Term Protective Immunity Characterized by Multifunctional CD4 Memory T Cells
- (2009) T. Lindenstrom et al. JOURNAL OF IMMUNOLOGY
- Immunological Response from an Entirely Carbohydrate Antigen: Design of Synthetic Vaccines Based on Tn−PS A1 Conjugates
- (2009) Ravindra A. De Silva et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex
- (2009) Beom Seok Park et al. NATURE
- Toll-like receptor 2 dependent immunogenicity of glycoconjugate vaccines containing chemically derived zwitterionic polysaccharides
- (2009) S. Gallorini et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Acetalated dextran is a chemically and biologically tunable material for particulate immunotherapy
- (2009) K. E. Broaders et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Advances in saponin-based adjuvants
- (2009) Hong-Xiang Sun et al. VACCINE
- Synthesis of QS-21-Xylose: Establishment of the Immunopotentiating Activity of Synthetic QS-21 Adjuvant with a Melanoma Vaccine
- (2008) Kai Deng et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Putting endotoxin to work for us: Monophosphoryl lipid A as a safe and effective vaccine adjuvant
- (2008) C. R. Casella et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Synthetic TLR4-active Glycolipids as Vaccine Adjuvants and Stand-alone Immunotherapeutics
- (2008) David Johnson CURRENT TOPICS IN MEDICINAL CHEMISTRY
- LPS/TLR4 signal transduction pathway
- (2008) Yong-Chen Lu et al. CYTOKINE
- Characteristics of carbohydrate antigen binding to the presentation protein HLA-DR
- (2008) Brian A Cobb et al. GLYCOBIOLOGY
- A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR
- (2008) Kwok S. Wun et al. JOURNAL OF EXPERIMENTAL MEDICINE
- 6′-Derivatised α-GalCer Analogues Capable of Inducing Strong CD1d-Mediated Th1-Biased NKT Cell Responses in Mice
- (2008) Matthias Trappeniers et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Synthesis and Structure Verification of the Vaccine Adjuvant QS-7-Api. Synthetic Access to HomogeneousQuillaja saponariaImmunostimulants
- (2008) Kai Deng et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Protein-glycan interactions in the control of innate and adaptive immune responses
- (2008) Yvette van Kooyk et al. NATURE IMMUNOLOGY
- TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β
- (2008) Jonathan C Kagan et al. NATURE IMMUNOLOGY
- Synthesis and In Vivo Evaluation of 4-Deoxy-4,4-difluoro-KRN7000
- (2008) Leo Leung et al. ORGANIC LETTERS
- The First Synthesis of a Thioglycoside Analogue of the Immunostimulant KRN7000
- (2008) Ravindra T. Dere et al. ORGANIC LETTERS
- Cationic Liposomes Formulated with Synthetic Mycobacterial Cordfactor (CAF01): A Versatile Adjuvant for Vaccines with Different Immunological Requirements
- (2008) Else Marie Agger et al. PLoS One
- Immunological decision-making: how does the immune system decide to mount a helper T-cell response?
- (2007) Gerard E. Kaiko et al. IMMUNOLOGY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started