The Human Vaccines Project: A roadmap for cancer vaccine development

Why has active immunotherapy not worked in lung cancer?

(2015) A. Thomas et al.   ANNALS OF ONCOLOGY

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity

(2015) Michael S. Rooney et al.   CELL

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

(2015) Petter Brodin et al.   CELL

Building the Human Vaccines Project: strategic management recommendations and summary report of the 15–16 July 2014 business workshop

(2015) Theodore Schenkelberg et al.   Expert Review of Vaccines

Therapeutic cancer vaccines

(2015) Cornelis J.M. Melief et al.   JOURNAL OF CLINICAL INVESTIGATION

On-demand drug delivery from local depots

(2015) Yevgeny Brudno et al.   JOURNAL OF CONTROLLED RELEASE

Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial

(2015) Cornelia L Trimble et al.   LANCET

Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer

(2015) Edward B. Garon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

(2015) B. M. Carreno et al.   SCIENCE

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

Global transcriptional characterization of CD8+ T cell memory

(2015) Jan Böttcher et al.   SEMINARS IN IMMUNOLOGY

Vaccines, Adjuvants, and Dendritic Cell Activators—Current Status and Future Challenges

(2015) Joseph Obeid et al.   SEMINARS IN ONCOLOGY

The Next Hurdle in Cancer Immunotherapy: Overcoming the Non–T-Cell–Inflamed Tumor Microenvironment

(2015) Thomas F. Gajewski   SEMINARS IN ONCOLOGY

Trial Watch: Peptide-based anticancer vaccines

(2015) Jonathan Pol et al.   OncoImmunology

Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study

(2015) Hubert Kübler et al.   Journal for ImmunoTherapy of Cancer

Myeloid-derived suppressor cell heterogeneity in human cancers

(2014) Samantha Solito et al.   Annals of the New York Academy of Sciences

Vaccine-Induced Tumor Necrosis Factor-Producing T Cells Synergize with Cisplatin to Promote Tumor Cell Death

(2014) T. C. van der Sluis et al.   CLINICAL CANCER RESEARCH

Improving DNA Vaccine Performance Through Vector Design

(2014) James Williams   CURRENT GENE THERAPY

Deciphering the unusual HLA-A2/Melan-A/MART-1-specific TCR repertoire in humans

(2014) Pedro Romero et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Misinitiation of intrathymicMART-1transcription and biased TCR usage explain the high frequency of MART-1-specific T cells

(2014) Sheena Pinto et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Functional Analysis via Standardized Whole-Blood Stimulation Systems Defines the Boundaries of a Healthy Immune Response to Complex Stimuli

(2014) Darragh Duffy et al.   IMMUNITY

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing

(2014) Mahesh Yadav et al.   NATURE

Toward a Human Vaccines Project

(2014) Wayne C Koff et al.   NATURE IMMUNOLOGY

Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors

(2014) Gregory T Motz et al.   NATURE MEDICINE

Therapeutic vaccines for cancer: an overview of clinical trials

(2014) Ignacio Melero et al.   Nature Reviews Clinical Oncology

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

(2014) Alexandra Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systems vaccinology: Probing humanity's diverse immune systems with vaccines

(2014) B. Pulendran   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Current status of granulocyte–macrophage colony-stimulating factor in the immunotherapy of melanoma

(2014) Howard L Kaufman et al.   Journal for ImmunoTherapy of Cancer

Adjuvants That Improve the Ratio of Antigen-Specific Effector to Regulatory T Cells Enhance Tumor Immunity

(2013) R. Perret et al.   CANCER RESEARCH

Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation

(2013) Rodney A. Rosalia et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Live-attenuatedListeria-based immunotherapy

(2013) John Rothman et al.   Expert Review of Vaccines

Deciphering and Reversing Tumor Immune Suppression

(2013) Greg T. Motz et al.   IMMUNITY

Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity

(2013) Alexey Berezhnoy et al.   JOURNAL OF CLINICAL INVESTIGATION

T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion

(2013) Daniel T Utzschneider et al.   NATURE IMMUNOLOGY

Accelerating Next-Generation Vaccine Development for Global Disease Prevention

(2013) W. C. Koff et al.   SCIENCE

Regulatory T-cell Modulation Using Cyclophosphamide in Vaccine Approaches: A Current Perspective

(2012) D. T. Le et al.   CANCER RESEARCH

Transcription Factor Foxo1 Represses T-bet-Mediated Effector Functions and Promotes Memory CD8+ T Cell Differentiation

(2012) Rajesh R. Rao et al.   IMMUNITY

Understanding and learning from the success of prophylactic human papillomavirus vaccines

(2012) John T. Schiller et al.   NATURE REVIEWS MICROBIOLOGY

DNA fusion vaccines enter the clinic

(2011) Freda K. Stevenson et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A

(2011) J. Idoyaga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR

(2010) E. Klechevsky et al.   BLOOD

Designing CD8+ T cell vaccines: it's not rocket science (yet)

(2010) Jonathan W Yewdell   CURRENT OPINION IN IMMUNOLOGY

Overall Survival Analysis of a Phase II Randomized Controlled Trial of a Poxviral-Based PSA-Targeted Immunotherapy in Metastatic Castration-Resistant Prostate Cancer

(2010) Philip W. Kantoff et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecularly defined vaccines for cancer immunotherapy, and protective T cell immunity

(2010) Daniel E. Speiser et al.   SEMINARS IN IMMUNOLOGY

The Prioritization of Cancer Antigens: A National Cancer Institute Pilot Project for the Acceleration of Translational Research

(2009) M. A. Cheever et al.   CLINICAL CANCER RESEARCH

Therapeutic vaccines in solid tumours: Can they be harmful?

(2009) Alexander M.M. Eggermont   EUROPEAN JOURNAL OF CANCER

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia

(2009) Gemma G. Kenter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism

(2008) J. Derbinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigens for cancer immunotherapy

(2008) Michelle A. Neller et al.   SEMINARS IN IMMUNOLOGY