Article
Medicine, Research & Experimental
Carolina Henriques Cavalcante, Renata Salgado Fernandes, Juliana de Oliveira Silva, Caroline Mari Ramos Oda, Elaine Amaral Leite, Geovanni Dantas Cassali, Ives Charlie-Silva, Bianca Helena Ventura Fernandes, Lucas Antonio Miranda Ferreira, Andre Luis Branco de Barros
Summary: The developed pH-sensitive micelles encapsulating DOX showed promising results with small diameter, high stability, low toxicity, and significantly better inhibition of tumor growth compared to other forms of DOX.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Yang Han, Jieyi Pan, Na Liang, Xianfeng Gong, Shaoping Sun
Summary: The study synthesized an amphiphilic conjugate based on mPEG and cholesterol-modified chitosan with hydrazone bonds, which was used to prepare PTX-loaded micelles. These micelles exhibited promising therapeutic efficacy of PTX and reduced side effects, indicating potential as pH-sensitive nanocarriers for drug delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Dong Wan, Yujun Liu, Xinhao Guo, Jianxin Zhang, Jie Pan
Summary: By introducing MMPs responsive peptide chain GPLGVRGDG, the polymeric prodrug can be endowed with smart properties through a safe and simple method. In this study, it was found that during the doxorubicin delivery in TPGS(3350)-GPLGVRGDG-DOX&DOX micelles, the cleavage of the peptide chain triggers de-PEGylation, retaining the VRGDG sequence on the micelles' surface, which acts as a ligand to facilitate cell uptake and enhances cytotoxicity against 4T1 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mohamed Alaa Mohamed, Ajay Singh, Paras N. Prasad, Chong Cheng
Summary: Delivery of chemotherapeutics to cancer cells using polymeric micelles is a promising strategy for cancer treatment. However, the limited stability of micelles, premature drug release, and off-target effect hinder their utilization as effective drug delivery systems. In this study, pH-sensitive crosslinked polymeric micelles were designed to address these challenges and showed remarkable promise as smart drug delivery systems for cancer therapy.
Article
Engineering, Biomedical
Bon Il Koo, Seon-Mi Jin, Hayeon Kim, Dong Jae Lee, Eunji Lee, Yoon Sung Nam
Summary: The study introduced robust conjugation-free multilamellar protein antigen-lipid hybrid nanovesicles (MPLVs) for efficient antigen-specific immune responses, increasing immunological surface markers and cytokines in dendritic cells. Vaccination with MPLVs significantly enhanced anti-antigen antibody and interferon-gamma production by activating CD4(+) and CD8(+) T cells, suggesting MPLVs as a promising nanovaccine delivery platform for efficient antigen cross-presentation.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Physical
Peng Ding, Wei Liu, Xuhong Guo, Martien A. Cohen Stuart, Junyou Wang
Summary: The study systematically investigates the effects of pH, salt concentration, and cross-linker fractions on the formation and properties of PDMAEMA nanogels, achieving important breakthroughs in optimizing and controlling the synthesis of nanogels. The obtained PDMAEMA nanogel exhibits dual-responses to pH and salt, allowing for selective loading and controlled release of substances.
Article
Biochemistry & Molecular Biology
Min Li, Ling'e Zhang, Yang Xuan, Defu Zhi, Wei Wang, Wenjun Zhang, Yinan Zhao, Shufen Zhang, Shubiao Zhang
Summary: This study developed a pH-responsive tumor prodrug using hyaluronic acid as a targeting carrier. The prodrug micelles demonstrated excellent stability, blood compatibility, and drug release properties. In vivo experiments showed that the prodrug micelles had significant tumor inhibition activity with minimal systemic toxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Jie Li, Zhongshi Wang, Han Han, Zhonghua Xu, Shasha Li, Ying Zhu, Yuejian Chen, Liang Ge, Yuan Zhang
Summary: A novel injectable drug delivery platform using self-assembled peptide hydrogels as carrier materials was developed. The pH-responsive ionic-complementary octapeptide FOE allows for sustained drug release.
CHINESE CHEMICAL LETTERS
(2022)
Review
Biochemistry & Molecular Biology
Farzana Hossain, Shruthi Kandalai, Xiaozhuang Zhou, Nan Zhang, Qingfei Zheng
Summary: In this review, synthetic approaches for antigen-based cancer vaccines are highlighted, along with the discussion of various bioconjugation strategies. The progress of genetically modified cancer vaccines in clinical research is also summarized. Additionally, the synthesis of adjuvants and utilization of biomaterial scaffolds for enhancing immune responses are mentioned.
Article
Biotechnology & Applied Microbiology
Lin Liu, Wendong Yao, Xiaowei Xie, Jianqing Gao, Xiaoyang Lu
Summary: A novel dual drug delivery system was designed to achieve synergistic analgesia between najanajaatra venom protein and resveratrol. The Janus nanoparticles were able to pass through intestinal epithelial cells and showed significant synergistic analgesic effects in animal models. This study provides new insights into the oral administration and analgesic treatment of dual drug delivery systems containing peptide drugs.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Oren Ben-Zvi, Itzhak Grinberg, Asuka A. Orr, Dror Noy, Phanourios Tamamis, Iftach Yacoby, Lihi Adler-Abramovich
Summary: The study demonstrates that a specific dipeptide hydrogelator can encapsulate oxygen, restrict its diffusion and penetration in the hydrogel. The mechanism involves pockets formed between aromatic rings in the supramolecular structure to bind oxygen, maintaining the activity of oxygen-sensitive enzymes.
Article
Materials Science, Multidisciplinary
Leilei Chen, Jun Xu, Yi Wang, Rongqin Huang
Summary: A facile one-step solvothermal reaction was used to achieve the homogeneously incorporation of ultra-small and monodispersed MoS2 nanodots in mesoporous silica nanospheres (MSN), forming UsMSND@MSN with good biocompatibility. The well-dispersed UsMSND in MSN showed great potential as a non-toxic contrast agent for sensitive in vivo CT imaging in various tumors, promising a good strategy for cancer imaging and therapy.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gadi Slor, Alis R. Olea, Silvia Pujals, Ali Tigrine, Victor R. De La Rosa, Richard Hoogenboom, Lorenzo Albertazzi, Roey J. Amir
Summary: Research suggests that the properties of enzymatically degradable polymeric micelles are influenced by the composition of their hydrophilic shell and hydrophobic core. Micelle diameter is mainly dependent on the hydrophobicity of the dendritic hydrophobic core, while the enzymatic degradation rate relies on the composition of both blocks. Additionally, drug encapsulation capacity is highly sensitive to the type of the hydrophilic shell, indicating that the shell also plays a significant role in drug encapsulation.
Article
Chemistry, Physical
Zhongjie Fei, Mehdi Yoosefian
Summary: This study investigates the assembly mechanism of Ribociclib encapsulated by DPC micelle using all-atom molecular dynamics simulations. The main forces involved in the drug encapsulation process are hydrophobic and van der Waals interactions, with hydrogen bonding and electrostatic interactions also contributing. Solvent accessible surface area and radial distribution function analyses show that DPC micelles can improve the aqueous solubility of hydrophobic drugs, providing a new pathway for designing drug delivery systems with necessary properties.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Polymer Science
Zahn Stanvliet, Yiyi Deng, Dietmar Appelhans, Silvia Moreno, Susanne Boye, Jens Gaitzsch, Albena Lederer
Summary: This study investigates the temperature sensitivity of polymeric nanoparticles based on tertiary amine methacrylate block copolymers. The research shows that these nanoparticles can undergo a reversible morphological transformation in response to changes in pH and temperature. The findings also demonstrate the ability to lock their intermediate self-assembly structures through cross-linking and validate the morphology transition using analytical tools, which opens up new possibilities for responsive nanocarriers.
Review
Chemistry, Multidisciplinary
Qiang Feng, Jonathan Wilhelm, Jinming Gao
ACCOUNTS OF CHEMICAL RESEARCH
(2019)
Article
Engineering, Biomedical
Tongyi Huang, Qiang Feng, Zhaohui Wang, Wei Li, Zhichen Sun, Jonathan Wilhelm, Gang Huang, Tram Vo, Baran D. Sumer, Jinming Gao
Summary: A pH-activatable nanodrug for tumor-targeted inhibition of MCT1 has been developed to reverse lactic acid-induced tumor immunosuppression. In animal studies, this nanodrug demonstrated potent tumor growth inhibition and increased survival, with reduced drug distribution in heart and liver tissues.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Jonathan Wilhelm, Zhaohui Wang, Baran D. Sumer, Jinming Gao
ADVANCED DRUG DELIVERY REVIEWS
(2020)
Article
Multidisciplinary Sciences
Xu Wang, Jonathan Wilhelm, Wei Li, Suxin Li, Zhaohui Wang, Gang Huang, Jian Wang, Houliang Tang, Sina Khorsandi, Zhichen Sun, Bret Evers, Jinming Gao
NATURE COMMUNICATIONS
(2020)
Article
Engineering, Biomedical
Suxin Li, Min Luo, Zhaohui Wang, Qiang Feng, Jonathan Wilhelm, Xu Wang, Wei Li, Jian Wang, Agnieszka Cholka, Yang-xin Fu, Baran D. Sumer, Hongtao Yu, Jinming Gao
Summary: A novel polyvalent STING agonist extends the activation of innate-immunity pathways through the formation of STING condensates and leads to synergistic therapeutic outcomes in vivo when combined with the STING ligand cGAMP.
NATURE BIOMEDICAL ENGINEERING
(2021)
Correction
Engineering, Biomedical
Suxin Li, Min Luo, Zhaohui Wang, Qiang Feng, Jonathan Wilhelm, Xu Wang, Wei Li, Jian Wang, Agnieszka Cholka, Yang-xin Fu, Baran D. Sumer, Hongtao Yu, Jinming Gao
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Oncology
Mitchell S. von Itzstein, Amrit S. Gonugunta, Thomas Sheffield, Jade Homsi, Jonathan E. Dowell, Andrew Y. Koh, Prithvi Raj, Farjana Fattah, Yiqing Wang, Vijay S. Basava, Shaheen Khan, Jason Y. Park, Vinita Popat, Jessica M. Saltarski, Yvonne Gloria-McCutchen, David Hsiehchen, Jared Ostmeyer, Yang Xie, Quan-Zhen Li, Edward K. Wakeland, David E. Gerber
Summary: Patients treated with antibiotics have worse outcomes from cancer immunotherapy, potentially due to the impact of antibiotics on the gut microbiome. This study found significant differences in immune parameters, including antibodies and cytokines, according to antibiotic exposure.
Article
Multidisciplinary Sciences
Qiang Feng, Zhida Liu, Xuexin Yu, Tongyi Huang, Jiahui Chen, Jian Wang, Jonathan Wilhelm, Suxin Li, Jiwon Song, Wei Li, Zhichen Sun, Baran D. Sumer, Bo Li, Yang-Xin Fu, Jinming Gao
Summary: Lactate increases stemness of CD8(+) T cells and enhances anti-tumor immunity. It inhibits histone deacetylase activity, leading to increased expression of Tcf7 gene, and affects the stemness of T cells.
NATURE COMMUNICATIONS
(2022)
Meeting Abstract
Oncology
Mitchell S. von Itzstein, Amrit S. Gonugunta, Thomas Sheffield, Jade Homsi, Jonathan E. Dowell, Andrew Y. Koh, Prithvi Raj, Farjana Fattah, Vijay S. Basava, Jason Y. Park, Vinita Popat, Jessica M. Saltarski, Yvonne Gloria-McCutchen, David Hsiehchen, Jared Ostmeyer, Shaheen Khan, Yang Xie, Quan-Zhen Li, Edward K. Wakeland, David E. Gerber
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)