Necroptosis: A Novel Pathway in Neuroinflammation

Toll-like Receptors and the Control of Immunity

(2020) Katherine A. Fitzgerald et al.   CELL

Chronic Infiltration of T Lymphocytes into the Brain in a Non-human Primate Model of Parkinson’s Disease

(2020) Jincheol Seo et al.   NEUROSCIENCE

RIP1 kinase inhibitor halts the progression of an immune-induced demyelination disease at the stage of monocyte elevation

(2019) Sitao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration

(2019) Dmitri Lodygin et al.   NATURE

Acute encephalitis in immunocompetent adults

(2019) Arun Venkatesan et al.   LANCET

Osteopontin Mediates Murine Transfusion-Related Acute Lung Injury Via Stimulation of Pulmonary Neutrophil Accumulation

(2019) Rick Kapur et al.   BLOOD

Role of chemokines in Parkinson's disease

(2019) Jia-Qi Liu et al.   BRAIN RESEARCH BULLETIN

Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer’s disease

(2019) Dawling A. Dionisio-Santos et al.   Journal of Neuroinflammation

Alzheimer's disease

(2019) Richard Barnett   LANCET

Flotillin-mediated endocytosis and ALIX–syntenin-1–mediated exocytosis protect the cell membrane from damage caused by necroptosis

(2019) Weiliang Fan et al.   Science Signaling

TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis

(2019) Jie Li et al.   Cell Death & Disease

Montelukast Prevents Early Diabetic Retinopathy in Mice

(2019) Reena Bapputty et al.   DIABETES

Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD

(2019) Yi Rang Na et al.   Nature Reviews Gastroenterology & Hepatology

Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain–barrier disruption after ischemic stroke

(2019) An-Qi Chen et al.   Cell Death & Disease

Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease

(2019) Benjamin G. Trist et al.   AGING CELL

Hoxa5 alleviates obesity‐induced chronic inflammation by reducing ER stress and promoting M2 macrophage polarization in mouse adipose tissue

(2019) Weina Cao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Progressive multiple sclerosis: from pathophysiology to therapeutic strategies

(2019) Simon Faissner et al.   NATURE REVIEWS DRUG DISCOVERY

2-BFI Provides Neuroprotection Against Inflammation and Necroptosis in a Rat Model of Traumatic Brain Injury

(2019) Haibo Ni et al.   Frontiers in Neuroscience

The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease

(2019) Maritza Oñate et al.   CELL DEATH AND DIFFERENTIATION

Complement dysregulation in the central nervous system during development and disease

(2019) John D. Lee et al.   SEMINARS IN IMMUNOLOGY

Destined to Die: Apoptosis and Pediatric Cancers

(2019) Choo et al.   Cancers

Retinal Ganglion Cells Die by Necroptotic Mechanisms in a Site-Specific Manner in a Rat Blunt Ocular Injury Model

(2019) Chloe N. Thomas et al.   Cells

Molecular Insights into the Mechanism of Necroptosis: The Necrosome as a Potential Therapeutic Target

(2019) Jing Chen et al.   Cells

Current Understanding of West Nile Virus Clinical Manifestations, Immune Responses, Neuroinvasion, and Immunotherapeutic Implications

(2019) Fengwei Bai et al.   Pathogens

Imaging correlations of tau, amyloid, metabolism, and atrophy in typical and atypical Alzheimer's disease

(2018) Jennifer L. Whitwell et al.   Alzheimers & Dementia

Neutrophil hyperactivation correlates with Alzheimer's disease progression

(2018) Yuan Dong et al.   ANNALS OF NEUROLOGY

RIP3 deficiency protects against traumatic brain injury (TBI) through suppressing oxidative stress, inflammation and apoptosis: Dependent on AMPK pathway

(2018) Zai-Ming Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation

(2018) Hiroaki Fuji et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection

(2018) Felipe A. Pinho-Ribeiro et al.   CELL

Current Mechanistic Concepts in Ischemia and Reperfusion Injury

(2018) Meng-Yu Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Increased miR-124-3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons

(2018) Shan Huang et al.   FASEB JOURNAL

Inflammation in CNS neurodegenerative diseases

(2018) Jodie Stephenson et al.   IMMUNOLOGY

Novel genes associated with amyotrophic lateral sclerosis: diagnostic and clinical implications

(2018) Ruth Chia et al.   LANCET NEUROLOGY

Inflammation and fibrosis

(2018) Matthias Mack   MATRIX BIOLOGY

Protective Effects of Curcumin Against Ischemia-Reperfusion Injury in the Nervous System

(2018) Kowsar Bavarsad et al.   MOLECULAR NEUROBIOLOGY

Japanese encephalitis — the prospects for new treatments

(2018) Lance Turtle et al.   Nature Reviews Neurology

Dabrafenib, an inhibitor of RIP3 kinase-dependent necroptosis, reduces ischemic brain injury

(2018) Hsiao-Huei Chen et al.   Neural Regeneration Research

Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study

(2018) Peter Parbo et al.   NEUROBIOLOGY OF DISEASE

NLRP3 Inflammasome Is Involved in Q-VD-OPH Induced Necroptosis Following Cerebral Ischemia-Reperfusion Injury

(2018) Xue Teng et al.   NEUROCHEMICAL RESEARCH

Sulforaphane attenuates microglia-mediated neuronal necroptosis through down-regulation of MAPK/NF-κB signaling pathways in LPS-activated BV-2 microglia

(2018) Sisi Qin et al.   PHARMACOLOGICAL RESEARCH

Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis

(2018) Palak Amin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson’s disease

(2018) Qian Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Checkpoints in TNF-Induced Cell Death: Implications in Inflammation and Cancer

(2018) Alessandro Annibaldi et al.   TRENDS IN MOLECULAR MEDICINE

Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson’s Disease Models

(2018) Angelo Iannielli et al.   Cell Reports

Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma

(2018) Reka P. Toth et al.   Frontiers in Immunology

Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection

(2018) Sue Tsai et al.   Cell Metabolism

Modulation of three key innate immune pathways for the most common retinal degenerative diseases

(2018) Isha Akhtar‐Schäfer et al.   EMBO Molecular Medicine

Loss of Microglial Parkin Inhibits Necroptosis and Contributes to Neuroinflammation

(2018) Pedro Elói Antunes Dionísio et al.   MOLECULAR NEUROBIOLOGY

Coupling Between Interleukin-1R1 and Necrosome Complex Involves in Hemin-Induced Neuronal Necroptosis After Intracranial Hemorrhage

(2018) Xiang Chu et al.   STROKE

21st century management and prevention of stroke

(2018) The Lancet   LANCET

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation

(2018) Elodie Lafont et al.   NATURE CELL BIOLOGY

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

(2018) Junying Yuan et al.   NATURE REVIEWS NEUROSCIENCE

Oxidative stress damage circumscribed to the central temporal retinal pigment epithelium in early experimental non-exudative age-related macular degeneration

(2018) Hernán H. Dieguez et al.   FREE RADICAL BIOLOGY AND MEDICINE

A novel RIPK1 inhibitor that prevents retinal degeneration in a rat glaucoma model

(2017) Yun-Ju Do et al.   EXPERIMENTAL CELL RESEARCH

Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells

(2017) Sarang Tartey et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

An Inflammatory Perspective on Necroptosis

(2017) Conor J. Kearney et al.   MOLECULAR CELL

Up-regulated Ectonucleotidases in Fas-Associated Death Domain Protein– and Receptor-Interacting Protein Kinase 1–Deficient Jurkat Leukemia Cells Counteract Extracellular ATP/AMP Accumulation via Pannexin-1 Channels during Chemotherapeutic Drug-Induced Apoptosis

(2017) Andrea M. Boyd-Tressler et al.   MOLECULAR PHARMACOLOGY

Necroptosis activation in Alzheimer's disease

(2017) Antonella Caccamo et al.   NATURE NEUROSCIENCE

RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease

(2017) Dimitry Ofengeim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

(2017) Marietta Zille et al.   STROKE

Necroptosis in neurodegenerative diseases: a potential therapeutic target

(2017) Shuo Zhang et al.   Cell Death & Disease

Role for RIP1 in mediating necroptosis in experimental intracerebral hemorrhage model both in vivo and in vitro

(2017) Haitao Shen et al.   Cell Death & Disease

Vinpocetine Inhibits NF-κB-Dependent Inflammation in Acute Ischemic Stroke Patients

(2017) Fang Zhang et al.   Translational Stroke Research

MLKL Mediated Necroptosis Accelerates JEV-Induced Neuroinflammation in Mice

(2017) Peiyu Bian et al.   Frontiers in Microbiology

New Insights into the Crosstalk between NMDARs and Iron: Implications for Understanding Pathology of Neurological Diseases

(2017) Huamin Xu et al.   Frontiers in Molecular Neuroscience

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

Catecholamines and cognition after traumatic brain injury

(2016) Peter O. Jenkins et al.   BRAIN

Dissecting How CD4 T Cells Are Lost During HIV Infection

(2016) Gilad Doitsh et al.   Cell Host & Microbe

Axonal Degeneration: RIPK1 Multitasking in ALS

(2016) Kristin Politi et al.   CURRENT BIOLOGY

Nec‐1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice

(2016) Seung‐Hoon Yang et al.   EMBO Molecular Medicine

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

(2016) Silvia Alvarez-Diaz et al.   IMMUNITY

Neuroinflammation: the devil is in the details

(2016) Damon J. DiSabato et al.   JOURNAL OF NEUROCHEMISTRY

The effect of concomitant peripheral injury on traumatic brain injury pathobiology and outcome

(2016) Stuart J. McDonald et al.   Journal of Neuroinflammation

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

(2016) Boris Strilic et al.   NATURE

Maternal immune activation: Implications for neuropsychiatric disorders

(2016) M. L. Estes et al.   SCIENCE

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

(2016) Yasushi Ito et al.   SCIENCE

Therapeutic hypothermia attenuates tissue damage and cytokine expression after traumatic brain injury by inhibiting necroptosis in the rat

(2016) Tao Liu et al.   Scientific Reports

FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP

(2015) Yuichi Tsuchiya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Necrostatin-1 protection of dopaminergic neurons

(2015) Yan-bo Cheng et al.   Neural Regeneration Research

Necrostatin-1 Ameliorates Intracerebral Hemorrhage-Induced Brain Injury in Mice Through Inhibiting RIP1/RIP3 Pathway

(2015) Xingfen Su et al.   NEUROCHEMICAL RESEARCH

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

(2015) Kate E. Lawlor et al.   Nature Communications

Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia

(2015) Norberto González-Juarbe et al.   PLoS Pathogens

Dysfunctional HIV-Specific CD8+ T Cell Proliferation Is Associated with Increased Caspase-8 Activity and Mediated by Necroptosis

(2014) Gaurav D. Gaiha et al.   IMMUNITY

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

(2014) Diane B. Re et al.   NEURON

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Necroptosis Takes Place in Human Immunodeficiency Virus Type-1 (HIV-1)-Infected CD4+ T Lymphocytes

(2014) Ting Pan et al.   PLoS One

Necroptosis in health and diseases

(2014) Wen Zhou et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Traumatic brain injury carries long term health risks, finds study

(2014) M. Limb   BMJ-British Medical Journal

Necroptosis Mediates TNF-Induced Toxicity of Hippocampal Neurons

(2014) Shan Liu et al.   Biomed Research International

Is SOD1 loss of function involved in amyotrophic lateral sclerosis?

(2013) Rachele A. Saccon et al.   BRAIN

Determination of apoptotic and necrotic cell death in vitro and in vivo

(2013) Tom Vanden Berghe et al.   METHODS

Early management of severe traumatic brain injury

(2012) Jeffrey V Rosenfeld et al.   LANCET

Necrostatin-1 Suppresses Autophagy and Apoptosis in Mice Traumatic Brain Injury Model

(2012) Yao-Qi Wang et al.   NEUROCHEMICAL RESEARCH

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

(2012) N Takahashi et al.   Cell Death & Disease

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

(2011) S. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NecroX as a novel class of mitochondrial reactive oxygen species and ONOO− scavenger

(2010) Hyoung Jin Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

MicroRNA-155 prevents necrotic cell death in human cardiomyocyte progenitor cells via targeting RIP1

(2010) Jia Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia

(2010) An-Gaëlle Ceulemans et al.   Journal of Neuroinflammation

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs

(2009) J Silke et al.   CELL DEATH AND DIFFERENTIATION

CNS Inflammation and Macrophage/Microglial Biology Associated with HIV-1 Infection

(2009) Anjana Yadav et al.   Journal of Neuroimmune Pharmacology

Inflammatory mechanisms in ischemic stroke: therapeutic approaches

(2009) Shaheen E Lakhan et al.   Journal of Translational Medicine

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice

(2008) Zerong You et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Moderate and severe traumatic brain injury in adults

(2008) Andrew IR Maas et al.   LANCET NEUROLOGY

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY