Flotillin-mediated endocytosis and ALIX–syntenin-1–mediated exocytosis protect the cell membrane from damage caused by necroptosis

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

(2017) Seongmin Yoon et al.   IMMUNITY

Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome

(2017) Yan Ren et al.   JOURNAL OF MEDICINAL CHEMISTRY

Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?

(2017) Lauren S. Whyte et al.   JOURNAL OF NEUROCHEMISTRY

Necroptosis activation in Alzheimer's disease

(2017) Antonella Caccamo et al.   NATURE NEUROSCIENCE

Syntenin mediates SRC function in exosomal cell-to-cell communication

(2017) Naga Sailaja Imjeti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatidylserine externalization, “necroptotic bodies” release, and phagocytosis during necroptosis

(2017) Sefi Zargarian et al.   PLOS BIOLOGY

Syntenin: Key player in cancer exosome biogenesis and uptake?

(2016) Joanna Fares et al.   Cell Adhesion & Migration

New structural insight of C-terminal region of Syntenin-1, enhancing the molecular dimerization and inhibitory function related on Syndecan-4 signaling

(2016) Youngsil Choi et al.   Scientific Reports

Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells

(2014) Christian Fork et al.   BASIC RESEARCH IN CARDIOLOGY

Ars Moriendi; the art of dying well - new insights into the molecular pathways of necroptotic cell death

(2014) J. M. Murphy et al.   EMBO REPORTS

Flotillins in intercellular adhesion - from cellular physiology to human diseases

(2014) S. Bodin et al.   JOURNAL OF CELL SCIENCE

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

The Role of Flotillins in Regulating Aβ Production, Investigated Using Flotillin 1-/-, Flotillin 2-/- Double Knockout Mice

(2014) Vassilis Bitsikas et al.   PLoS One

ESCRT Machinery Is Required for Plasma Membrane Repair

(2014) A. J. Jimenez et al.   SCIENCE

A Plug Release Mechanism for Membrane Permeation by MLKL

(2014) Lijing Su et al.   STRUCTURE

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

(2013) Xin Chen et al.   CELL RESEARCH

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Flotillin-1/Reggie-2 Protein Plays Dual Role in Activation of Receptor-tyrosine Kinase/Mitogen-activated Protein Kinase Signaling

(2012) Monia Amaddii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Proteomic analysis of lipid raft-enriched membranes isolated from internal organelles

(2011) Chloe N. Poston et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

The roles of flotillin microdomains - endocytosis and beyond

(2011) G. P. Otto et al.   JOURNAL OF CELL SCIENCE

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE