Necrostatin-1 Suppresses Autophagy and Apoptosis in Mice Traumatic Brain Injury Model

Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness

(2014) Robert S.B. Clark et al.   Autophagy

An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid

(2014) Yan Wang et al.   Autophagy

PARP and RIP 1 are required for autophagy induced by 11'-deoxyverticillin A, which precedes caspase-dependent apoptosis

(2011) Nan Zhang et al.   Autophagy

Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice

(2011) C.-L. Luo et al.   NEUROSCIENCE

Necrostatin-1 ameliorates symptoms in R6/2 transgenic mouse model of Huntington's disease

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The role of PARP activation in glutamate-induced necroptosis in HT-22 cells

(2010) Xingshun Xu et al.   BRAIN RESEARCH

Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury

(2010) Xingshun Xu et al.   BRAIN RESEARCH

Necroptosis as an alternative form of programmed cell death

(2010) Dana E Christofferson et al.   CURRENT OPINION IN CELL BIOLOGY

Characterisation of neuronal cell death in acute and delayed in vitro ischemia (oxygen–glucose deprivation) models

(2010) Bruno P. Meloni et al.   JOURNAL OF NEUROSCIENCE METHODS

Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis

(2009) Weidong Han et al.   APOPTOSIS

RIP Kinases at the Crossroads of Cell Death and Survival

(2009) Wim Declercq et al.   CELL

Changes in autophagy proteins in a rat model of controlled cortical impact induced brain injury

(2008) Shankar Sadasivan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice

(2008) Zerong You et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Classification of Traumatic Brain Injury for Targeted Therapies

(2008) Kathryn E. Saatman et al.   JOURNAL OF NEUROTRAUMA

Moderate and severe traumatic brain injury in adults

(2008) Andrew IR Maas et al.   LANCET NEUROLOGY

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

(2008) Eisuke Itakura et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

Antigen-mediated T cell expansion regulated by parallel pathways of death

(2008) I. L. Ch'en et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells

(2008) B. D. Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA