Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain–barrier disruption after ischemic stroke

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

(2019) Apostolos Polykratis et al.   NATURE CELL BIOLOGY

Obesity and Response to Infliximab in Patients with Inflammatory Bowel Diseases: Pooled Analysis of Individual Participant Data from Clinical Trials

(2018) Siddharth Singh et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

(2018) Emelia J. Benjamin et al.   CIRCULATION

MicroRNA-149-5p regulates blood–brain barrier permeability after transient middle cerebral artery occlusion in rats by targeting S1PR2 of pericytes

(2018) Yan Wan et al.   FASEB JOURNAL

Sema4D/PlexinB1 inhibition ameliorates blood–brain barrier damage and improves outcome after stroke in rats

(2018) Yi-Fan Zhou et al.   FASEB JOURNAL

Inhibitory effect of melatonin on necroptosis via repressing the Ripk3-PGAM5-CypD-mPTP pathway attenuates cardiac microvascular ischemia-reperfusion injury

(2018) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer’s disease-related proteins

(2018) Srikant Rangaraju et al.   Molecular Neurodegeneration

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

(2018) Zhentao Yang et al.   NATURE CELL BIOLOGY

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

(2018) Daichao Xu et al.   CELL

Maladaptive cortical hyperactivity upon recovery from experimental autoimmune encephalomyelitis

(2018) Erik Ellwardt et al.   NATURE NEUROSCIENCE

Necroptosis mediates myofibre death in dystrophin-deficient mice

(2018) Jennifer E. Morgan et al.   Nature Communications

Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease

(2018) J. Scott Crowe et al.   Scientific Reports

The anticonvulsive Phenhydan® suppresses extrinsic cell death

(2018) Caroline Moerke et al.   CELL DEATH AND DIFFERENTIATION

Infliximab for treatment-refractory transverse myelitis following immune therapy and radiation

(2018) Victoria A. Chang et al.   Journal for ImmunoTherapy of Cancer

Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury

(2017) Kwong Tai Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Stroke

(2017) Graeme J Hankey   LANCET

Necroptosis activation in Alzheimer's disease

(2017) Antonella Caccamo et al.   NATURE NEUROSCIENCE

MicroRNA-150 regulates blood–brain barrier permeability via Tie-2 after permanent middle cerebral artery occlusion in rats

(2016) Zhi Fang et al.   FASEB JOURNAL

Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury

(2016) Sanjoy Roychowdhury et al.   HEPATOLOGY

Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy

(2016) Sherry Dadsetan et al.   Journal of Neuroinflammation

HIF-1α triggers long-lasting glutamate excitotoxicity via system xc − in cerebral ischaemia-reperfusion

(2016) Chia-Hung Hsieh et al.   JOURNAL OF PATHOLOGY

Reactive astrocytes undergo M1 microglia/macrohpages-induced necroptosis in spinal cord injury

(2016) Hong Fan et al.   Molecular Neurodegeneration

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

(2016) Boris Strilic et al.   NATURE

Necroptosis in development, inflammation and disease

(2016) Ricardo Weinlich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis

(2016) Shrikant R. Mulay et al.   Nature Communications

Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

(2016) Yejie Shi et al.   Nature Communications

Receptor interacting protein 3-induced RGC-5 cell necroptosis following oxygen glucose deprivation

(2015) Wei Ding et al.   BMC NEUROSCIENCE

A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau

(2015) Lei Pei et al.   CEREBRAL CORTEX

Blood−brain barrier breakdown and neovascularization processes after stroke and traumatic brain injury

(2015) Roshini Prakash et al.   CURRENT OPINION IN NEUROLOGY

Brain endothelial TAK1 and NEMO safeguard the neurovascular unit

(2015) Dirk A. Ridder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner

(2015) Jie Pan et al.   Journal of Neuroinflammation

High Serum MiR-130a Levels Are Associated with Severe Perihematomal Edema and Predict Adverse Outcome in Acute ICH

(2015) Meng-Die Wang et al.   MOLECULAR NEUROBIOLOGY

The molecular relationships between apoptosis, autophagy and necroptosis

(2015) Najoua Lalaoui et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Role of Neurexin-1β and Neuroligin-1 in Cognitive Dysfunction After Subarachnoid Hemorrhage in Rats

(2015) Haitao Shen et al.   STROKE

Activation of Necroptosis in Multiple Sclerosis

(2015) Dimitry Ofengeim et al.   Cell Reports

Perivascular microglia promote blood vessel disintegration in the ischemic penumbra

(2014) Valérie Jolivel et al.   ACTA NEUROPATHOLOGICA

C-Type Natriuretic Peptide Modulates Permeability of the Blood–Brain Barrier

(2014) Manoj Bohara et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microglial Responses after Ischemic Stroke and Intracerebral Hemorrhage

(2013) Roslyn A. Taylor et al.   Clinical & Developmental Immunology

Interferon-γ-Induced Necrosis: An Antitumor Biotherapeutic Perspective

(2013) Siddharth Balachandran et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Blood-brain barrier disruption is associated with increased mortality after endovascular therapy

(2013) J.-P. Desilles et al.   NEUROLOGY

Microglia during development and aging

(2013) G. Jean Harry   PHARMACOLOGY & THERAPEUTICS

Guidelines for the Early Management of Patients With Acute Ischemic Stroke

(2013) Edward C. Jauch et al.   STROKE

Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia

(2013) S J Kim et al.   Cell Death & Disease

Galectin-1 Deactivates Classically Activated Microglia and Protects from Inflammation-Induced Neurodegeneration

(2012) Sarah C. Starossom et al.   IMMUNITY

Programmed necrosis: backup to and competitor with apoptosis in the immune system

(2011) Jiahuai Han et al.   NATURE IMMUNOLOGY

Plasmalemma Permeability and Necrotic Cell Death Phenotypes After Intracerebral Hemorrhage in Mice

(2011) Xiaoxia Zhu et al.   STROKE

The release of microparticles by Jurkat leukemia T cells treated with staurosporine and related kinase inhibitors to induce apoptosis

(2010) Anirudh J. Ullal et al.   APOPTOSIS

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function

(2010) eMalick G. Njie et al.   NEUROBIOLOGY OF AGING

Blood-brain barrier breakdown and repair by Src after thrombin-induced injury

(2009) Da-Zhi Liu et al.   ANNALS OF NEUROLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Cerebral Ischemia–Reperfusion Injury in Rats—A 3 T MRI Study on Biphasic Blood–Brain Barrier Opening and the Dynamics of Edema Formation

(2009) Deepu R Pillai et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tumor Necrosis Factor   Mediates Lipopolysaccharide-Induced Microglial Toxicity to Developing Oligodendrocytes When Astrocytes Are Present

(2008) J. Li et al.   JOURNAL OF NEUROSCIENCE