NLRP3 Inflammasome Is Involved in Q-VD-OPH Induced Necroptosis Following Cerebral Ischemia-Reperfusion Injury

Necrostatin-1 Protects Against Paraquat-Induced Cardiac Contractile Dysfunction via RIP1-RIP3-MLKL-Dependent Necroptosis Pathway

(2018) Liping Zhang et al.   Cardiovascular Toxicology

Low-level light emitting diode (LED) therapy suppresses inflammasome-mediated brain damage in experimental ischemic stroke

(2017) Hae In Lee et al.   Journal of Biophotonics

Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide

(2017) Danish Saleh et al.   JOURNAL OF IMMUNOLOGY

Advanced glycation end products regulate interleukin-1β production in human placenta

(2017) Kotomi SENO et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Necrostatin-1 protects hippocampal neurons against ischemia/reperfusion injury via the RIP3/DAXX signaling pathway in rats

(2017) Rongli Yang et al.   NEUROSCIENCE LETTERS

The Pathogenic Role of NLRP3 Inflammasome Activation in Inflammatory Bowel Diseases of Both Mice and Humans

(2016) Ling Liu et al.   Journal of Crohns & Colitis

NLRP3 Inflammasome Activation in the Brain after Global Cerebral Ischemia and Regulation by 17β-Estradiol

(2016) Roshni Thakkar et al.   Oxidative Medicine and Cellular Longevity

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

(2016) Letteria Minutoli et al.   Oxidative Medicine and Cellular Longevity

Caspase-8 inhibition represses initial human monocyte activation in septic shock model

(2016) Maria Jose Oliva-Martin et al.   Oncotarget

RIP3 induces ischemic neuronal DNA degradation and programmed necrosis in rat via AIF

(2016) Yang Xu et al.   Scientific Reports

Ascorbic Acid Reduces the Adverse Effects of Delayed Administration of Tissue Plasminogen Activator in a Rat Stroke Model

(2015) Mohammad Allahtavakoli et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Rotenone-induced Impairment of Mitochondrial Electron Transport Chain Confers a Selective Priming Signal for NLRP3 Inflammasome Activation

(2015) Ji-Hee Won et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-lipoic acid protects against cerebral ischemia/reperfusion-induced injury in rats

(2015) HOULIANG DENG et al.   Molecular Medicine Reports

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Live to die another way: modes of programmed cell death and the signals emanating from dying cells

(2015) Yaron Fuchs et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Immune interventions in stroke

(2015) Ying Fu et al.   Nature Reviews Neurology

Caspase inhibition impaired the neural stem/progenitor cell response after cortical ischemia in mice

(2015) Ahmed M. Osman et al.   Oncotarget

NLRP3 inflammasome and its inhibitors: a review

(2015) Bo-Zong Shao et al.   Frontiers in Pharmacology

NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes

(2015) Audrey Gustin et al.   PLoS One

Delayed, Long-Term Administration of the Caspase Inhibitor Q-VD-OPh Reduced Brain Injury Induced by Neonatal Hypoxia-Ischemia

(2014) Wei Han et al.   DEVELOPMENTAL NEUROSCIENCE

Reply to Letter Regarding Article, “NLRP3 Inflammasome as a Therapeutic Target in Myocardial Infarction”

(2014) Masafumi Takahashi   International Heart Journal

Lysosomes Integrate Metabolic-Inflammatory Cross-talk in Primary Macrophage Inflammasome Activation

(2014) Kassandra Weber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Q-VD-OPh, a pancaspase inhibitor, reduces trauma-induced apoptosis and improves the recovery of hind-limb function in rats after spinal cord injury

(2014) V. Antar et al.   NEUROCIRUGIA

Necroptosis induced by RIPK3 requires MLKL but not Drp1

(2014) D M Moujalled et al.   Cell Death & Disease

Temporal Trends in Patient Characteristics and Treatment With Intravenous Thrombolysis Among Acute Ischemic Stroke Patients at Get With the Guidelines–Stroke Hospitals

(2013) Lee H. Schwamm et al.  

Gemfibrozil Pretreatment Resulted in a Sexually Dimorphic Outcome in the Rat Models of Global Cerebral Ischemia–Reperfusion via Modulation of Mitochondrial Pro-survival and Apoptotic Cell Death Factors as well as MAPKs

(2013) Fatemeh Mohagheghi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

(2013) D Yang-Wei Fann et al.   Cell Death & Disease

Perfusion Computed Tomography-Guided Intravenous Thrombolysis for Acute Ischemic Stroke beyond 4.5 Hours: A Case-Control Study

(2012) Pablo García-Bermejo et al.   CEREBROVASCULAR DISEASES

Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

(2012) James E. Vince et al.   IMMUNITY

Inflammatory Cytokines in Experimental and Human Stroke

(2012) Kate Lykke Lambertsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NLRP3-Inflammasome Activating DAMPs Stimulate an Inflammatory Response in Glia in the Absence of Priming Which Contributes to Brain Inflammation after Injury

(2012) Catherine Diane Savage et al.   Frontiers in Immunology

Atorvastatin improving renal ischemia reperfusion injury via direct inhibition of active caspase-3 in rats

(2011) John L Haylor et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Dose-dependent effects of the caspase inhibitor Q-VD-OPh on different apoptosis-related processes

(2011) Kateřina Kuželová et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Severe Global Cerebral Ischemia-Induced Programmed Necrosis of Hippocampal CA1 Neurons in Rat Is Prevented by 3-Methyladenine: A Widely Used Inhibitor of Autophagy

(2011) Jin-Ye Wang et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Programmed necrosis: backup to and competitor with apoptosis in the immune system

(2011) Jiahuai Han et al.   NATURE IMMUNOLOGY

Sex Differences in the Response to Poly(ADP-ribose) Polymerase-1 Deletion and Caspase Inhibition After Stroke

(2011) Fudong Liu et al.   STROKE

Modeling Stroke in Mice - Middle Cerebral Artery Occlusion with the Filament Model

(2011) Odilo Engel et al.   Jove-Journal of Visualized Experiments

Neuronal caspase-3 signaling: not only cell death

(2009) M D'Amelio et al.   CELL DEATH AND DIFFERENTIATION