FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP

Genome-wide association analysis identified splicing single nucleotide polymorphism in CFLAR predictive of triptolide chemo-sensitivity

(2015) Lata Chauhan et al.   BMC GENOMICS

Molecular architecture of the DED chains at the DISC: regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain

(2015) K Schleich et al.   CELL DEATH AND DIFFERENTIATION

Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders

(2015) Norihito Shibata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular FLIP Inhibits Myeloid Cell Activation by Suppressing Selective Innate Signaling

(2015) Yu-Jung Wu et al.   JOURNAL OF IMMUNOLOGY

c-FLIP Protects T Lymphocytes from Apoptosis in the Intrinsic Pathway

(2015) Ming-Xiao He et al.   JOURNAL OF IMMUNOLOGY

Fractional killing arises from cell-to-cell variability in overcoming a caspase activity threshold

(2015) J. Roux et al.   Molecular Systems Biology

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Hyperthermia restores apoptosis induced by death receptors through aggregation-induced c-FLIP cytosolic depletion

(2015) A Morlé et al.   Cell Death & Disease

CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis

(2015) Qi-Quan Huang et al.   Nature Communications

Acute organ failure following the loss of anti-apoptotic cellular FLICE-inhibitory protein involves activation of innate immune receptors

(2014) N Gehrke et al.   CELL DEATH AND DIFFERENTIATION

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

(2014) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

The Long Isoform of Cellular FLIP Is Essential for T Lymphocyte Proliferation through an NF- B-Independent Pathway

(2014) N. Zhang et al.   JOURNAL OF IMMUNOLOGY

c-FLIP Protects Mature T Lymphocytes from TCR-Mediated Killing

(2014) N. Zhang et al.   JOURNAL OF IMMUNOLOGY

A Role for cFLIP in B Cell Proliferation and Stress MAPK Regulation

(2014) H. Zhang et al.   JOURNAL OF IMMUNOLOGY

The Two Faces of Receptor Interacting Protein Kinase-1

(2014) Ricardo Weinlich et al.   MOLECULAR CELL

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

(2014) Pratyusha Mandal et al.   MOLECULAR CELL

Delaying mitotic exit downregulates FLIP expression and strongly sensitizes tumor cells to TRAIL

(2014) T Sánchez-Pérez et al.   ONCOGENE

c-FLIP-Short Reduces Type I Interferon Production and Increases Viremia with Coxsackievirus B3

(2014) Iwona A. Buskiewicz et al.   PLoS One

c-FLIP Protects Eosinophils from TNF-α-Mediated Cell Death In Vivo

(2014) Claire Gordy et al.   PLoS One

Cell fate regulation by gelsolin in human gynecologic cancers

(2014) Mohammad R. Abedini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intra- and Interdimeric Caspase-8 Self-Cleavage Controls Strength and Timing of CD95-Induced Apoptosis

(2014) S. M. Kallenberger et al.   Science Signaling

Functions of caspase 8: The identified and the mysterious

(2014) Guy S. Salvesen et al.   SEMINARS IN IMMUNOLOGY

Constitutive expression of murine c-FLIPR causes autoimmunity in aged mice

(2014) F Ewald et al.   Cell Death & Disease

Systems biology of death receptor networks: live and let die

(2014) I N Lavrik   Cell Death & Disease

Differential affinity of FLIP and procaspase 8 for FADD’s DED binding surfaces regulates DISC assembly

(2014) J. Majkut et al.   Nature Communications

mTOR Complex 2 Is Involved in Regulation of Cbl-Dependent c-FLIP Degradation and Sensitivity of TRAIL-Induced Apoptosis

(2013) L. Zhao et al.   CANCER RESEARCH

Cellular-FLIP, Raji isoform (c-FLIPR) modulates cell death induction upon T-cell activation and infection

(2013) Tanja Telieps et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cellular FLICE-Like Inhibitory Protein Secures Intestinal Epithelial Cell Survival and Immune Homeostasis by Regulating Caspase-8

(2013) Nadine Wittkopf et al.   GASTROENTEROLOGY

Novel Phosphorylation and Ubiquitination Sites Regulate Reactive Oxygen Species-dependent Degradation of Anti-apoptotic c-FLIP Protein

(2013) Rachel P. Wilkie-Grantham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATM kinase activity modulates ITCH E3-ubiquitin ligase activity

(2013) S Santini et al.   ONCOGENE

Diabetic liver injury from streptozotocin is regulated through the caspase-8 homolog cFLIP involving activation of JNK2 and intrahepatic immunocompetent cells

(2013) T Kohl et al.   Cell Death & Disease

Hyperthermia enhances mapatumumab-induced apoptotic death through ubiquitin-mediated degradation of cellular FLIP(long) in human colon cancer cells

(2013) X Song et al.   Cell Death & Disease

Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis

(2013) Ricardo Weinlich et al.   Cell Reports

cFLIP Regulates Skin Homeostasis and Protects against TNF-Induced Keratinocyte Apoptosis

(2013) Diana Panayotova-Dimitrova et al.   Cell Reports

Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP

(2012) Jörn M. Schattenberg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Down-regulation of cellular FLICE-inhibitory protein (Long Form) contributes to apoptosis induced by Hsp90 inhibition in human lung cancer cells

(2012) Qilin Wang et al.   Cancer Cell International

Pick your poison: The Ripoptosome, a cell death platform regulating apoptosis and necroptosis

(2012) Maria Feoktistova et al.   CELL CYCLE

A role for c-FLIPL in the regulation of apoptosis, autophagy and necroptosis in T lymphocytes

(2012) M-X He et al.   CELL DEATH AND DIFFERENTIATION

dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8

(2012) Y Estornes et al.   CELL DEATH AND DIFFERENTIATION

Cbl-b-dependent degradation of FLIPLis involved in ATO-induced autophagy in leukemic K562 and gastric cancer cells

(2012) Guodong Zhang et al.   FEBS LETTERS

The role of death effector domain-containing proteins in acute oxidative cell injury in hepatocytes

(2012) Jörn M. Schattenberg et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tumor Necrosis Factor (TNF) Receptor-associated Factor 7 Is Required for TNFα-induced Jun NH2-terminal Kinase Activation and Promotes Cell Death by Regulating Polyubiquitination and Lysosomal Degradation of c-FLIP Protein

(2012) Ivan Scudiero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

(2012) Laura S. Dickens et al.   MOLECULAR CELL

Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model

(2012) Kolja Schleich et al.   MOLECULAR CELL

c-FLIP Maintains Tissue Homeostasis by Preventing Apoptosis and Programmed Necrosis

(2012) X. Piao et al.   Science Signaling

Survival Function of the FADD-CASPASE-8-cFLIPL Complex

(2012) Christopher P. Dillon et al.   Cell Reports

Effect of Transgenic Overexpression of FLIP on Lymphocytes on Development and Resolution of Experimental Autoimmune Thyroiditis

(2011) Yujiang Fang et al.   AMERICAN JOURNAL OF PATHOLOGY

Cellular FLICE-inhibitory protein protects against cardiac remodelling after myocardial infarction

(2011) Jinfeng Xiao et al.   BASIC RESEARCH IN CARDIOLOGY

FLIPLinduces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

(2011) Cristina Pop et al.   BIOCHEMICAL JOURNAL

Modeling Reveals That Dynamic Regulation of c-FLIP Levels Determines Cell-to-Cell Distribution of CD95-mediated Apoptosis

(2011) Hannu T. Toivonen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo

(2011) Jörn M. Schattenberg et al.   JOURNAL OF HEPATOLOGY

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

(2011) Tencho Tenev et al.   MOLECULAR CELL

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy

(2011) Ahmad R. Safa et al.   Cancers

FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis

(2010) Q.-Q. Huang et al.   BLOOD

Regulation of steady-state neutrophil homeostasis by macrophages

(2010) C. Gordy et al.   BLOOD

Ubiquitin-Specific Protease 8 Links the PTEN-Akt-AIP4 Pathway to the Control of FLIPSStability and TRAIL Sensitivity in Glioblastoma Multiforme

(2010) Amith Panner et al.   CANCER RESEARCH

Cystatin B inhibition of TRAIL-induced apoptosis is associated with the protection of FLIPL from degradation by the E3 ligase itch in human melanoma cells

(2010) F Yang et al.   CELL DEATH AND DIFFERENTIATION

Cellular FLICE-Inhibitory Protein Protects Against Cardiac Remodeling Induced by Angiotensin II in Mice

(2010) Hongliang Li et al.   HYPERTENSION

Itch/AIP4-independent proteasomal degradation of cFLIP induced by the histone deacetylase inhibitor SAHA sensitizes breast tumour cells to TRAIL

(2010) Rosario Yerbes et al.   INVESTIGATIONAL NEW DRUGS

Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL

(2010) Nicolai Fricker et al.   JOURNAL OF CELL BIOLOGY

Expression of Cellular FLIP by B Cells Is Required for Their Participation in an Immune Response

(2010) F. Coffey et al.   JOURNAL OF IMMUNOLOGY

Dynamics within the CD95 death-inducing signaling complex decide life and death of cells

(2010) Leo Neumann et al.   Molecular Systems Biology

c-Flip overexpression affects satellite cell proliferation and promotes skeletal muscle aging

(2010) C Giampietri et al.   Cell Death & Disease

Mind bomb 1 regulation of cFLIP interactions

(2009) Liguo Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein

(2009) N. Ueffing et al.   BLOOD

A Novel PTEN-Dependent Link to Ubiquitination Controls FLIPS Stability and TRAIL Sensitivity in Glioblastoma Multiforme

(2009) A. Panner et al.   CANCER RESEARCH

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Altered thymic selection by overexpressing cellular FLICE inhibitory protein in T cells causes lupus-like syndrome in a BALB/c but not C57BL/6 strain

(2009) G Qiao et al.   CELL DEATH AND DIFFERENTIATION

PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability

(2009) A Kaunisto et al.   CELL DEATH AND DIFFERENTIATION

Mitotic arrest and JNK-induced proteasomal degradation of FLIP and Mcl-1 are key events in the sensitization of breast tumor cells to TRAIL by antimicrotubule agents

(2009) T Sánchez-Pérez et al.   CELL DEATH AND DIFFERENTIATION

Testis atrophy and reduced sperm motility in transgenic mice overexpressing c-FLIPL

(2009) Fabrizio Antonangeli et al.   FERTILITY AND STERILITY

Activation-induced Degradation of FLIPLIs Mediated via the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Macrophages

(2009) Bo Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction between cFLIPLand Itch, a ubiquitin ligase, is obstructed inTrypanosoma cruzi-infected human cells

(2009) Eri Murata et al.   MICROBIOLOGY AND IMMUNOLOGY

Expression profile of a 400-bpStra8promoter region during spermatogenesis

(2009) Fabrizio Antonangeli et al.   MICROSCOPY RESEARCH AND TECHNIQUE

A Model of Partnership Co-Opted by the Homeodomain Protein TGIF and the Itch/AIP4 Ubiquitin Ligase for Effective Execution of TNF-α Cytotoxicity

(2009) Christine Demange et al.   MOLECULAR CELL

A TNF- and c-Cbl-dependent FLIPS-degradation pathway and its function in Mycobacterium tuberculosis–induced macrophage apoptosis

(2009) Manikuntala Kundu et al.   NATURE IMMUNOLOGY

Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein

(2009) M R Abedini et al.   ONCOGENE

Mechanism of procaspase-8 activation by c-FLIPL

(2009) J. W. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mathematical modeling identified c-FLIP as an apoptotic switch in death receptor induced apoptosis

(2008) Lihui Han et al.   APOPTOSIS

c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells

(2008) Travis W. Day et al.   BIOCHEMICAL PHARMACOLOGY

Cisplatin Induces p53-Dependent FLICE-Like Inhibitory Protein Ubiquitination in Ovarian Cancer Cells

(2008) M. R. Abedini et al.   CANCER RESEARCH

Mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment

(2008) N Ueffing et al.   CELL DEATH AND DIFFERENTIATION

Cultured Murine Thyroid Epithelial Cells Expressing Transgenic Fas-Associated Death Domain-Like Interleukin-1β Converting Enzyme Inhibitory Protein Are Protected from Fas-Mediated Apoptosis

(2008) Yujiang Fang et al.   ENDOCRINOLOGY

Down-regulation of the De-ubiquitinating Enzyme Ubiquitin-specific Protease 2 Contributes to Tumor Necrosis Factor-α-induced Hepatocyte Survival

(2008) Florian Haimerl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Flip overexpression reduces cardiac hypertrophy in response to pressure overload

(2008) Claudia Giampietri et al.   JOURNAL OF HYPERTENSION