Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease

Upregulation of the p53-p21 pathway by G2019S LRRK2 contributes to the cellular senescence and accumulation of α-synuclein

(2019) Dong Hwan Ho et al.   CELL CYCLE

Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study

(2019) Ronald B Postuma et al.   BRAIN

Necrosis, apoptosis, necroptosis, three modes of action of dopaminergic neuron neurotoxins

(2019) Noëlle Callizot et al.   PLoS One

New insights into the inflamed tumor immune microenvironment of gastric cancer with lymphoid stroma: from morphology and digital analysis to gene expression

(2018) Irene Gullo et al.   Gastric Cancer

Superoxide dismutating molecules rescue the toxic effects of PINK1 and parkin loss

(2018) Alice Biosa et al.   HUMAN MOLECULAR GENETICS

Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy

(2018) Amel Karaa et al.   NEUROLOGY

The Parkinson Pandemic—A Call to Action

(2018) E. Ray Dorsey et al.   JAMA Neurology

Astrocytes, Microglia, and Parkinson's Disease

(2018) Eun-Hye Joe et al.   Experimental Neurobiology

Recruitment of calbindin into nigral dopamine neurons protects against MPTP-Induced parkinsonism

(2018) Ken-ichi Inoue et al.   MOVEMENT DISORDERS

Kinetic Modeling of pH-Dependent Oxidation of Dopamine by Iron and Its Relevance to Parkinson's Disease

(2018) Yingying Sun et al.   Frontiers in Neuroscience

Epidemiology of Parkinson’s disease

(2017) Ole-Bjørn Tysnes et al.   JOURNAL OF NEURAL TRANSMISSION

Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2017) Valery L Feigin et al.   LANCET NEUROLOGY

Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson's disease brain

(2017) Sian Genoud et al.   Metallomics

Cell Death Pathways: a Novel Therapeutic Approach for Neuroscientists

(2017) G. Morris et al.   MOLECULAR NEUROBIOLOGY

Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson’s disease

(2017) James A. Duce et al.   Molecular Neurodegeneration

Aging and Parkinson's disease: Different sides of the same coin?

(2017) Timothy J. Collier et al.   MOVEMENT DISORDERS

Neuromelanin, one of the most overlooked molecules in modern medicine, is not a spectator

(2017) RobertL Haining et al.   Neural Regeneration Research

The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis

(2017) Heather D.E. Booth et al.   TRENDS IN NEUROSCIENCES

Phase IIb Study of Intranasal Glutathione in Parkinson’s Disease

(2017) Laurie K. Mischley et al.   Journal of Parkinsons Disease

Oxidative stress and cellular pathologies in Parkinson’s disease

(2017) Lesly Puspita et al.   Molecular Brain

Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease

(2017) Antonio Martin-Bastida et al.   Scientific Reports

Creatine synthesis and exchanges between brain cells: What can be learned from human creatine deficiencies and various experimental models?

(2016) Layane Hanna-El-Daher et al.   AMINO ACIDS

Activation of apoptosis signalling pathways by reactive oxygen species

(2016) Maureen Redza-Dutordoir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Iron and dopamine: a toxic couple

(2016) Dominic J. Hare et al.   BRAIN

Microglia antioxidant systems and redox signalling

(2016) F Vilhardt et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anti-Oxidants in Parkinson's Disease Therapy: A Critical Point of View

(2016) Roberta Filograna et al.   Current Neuropharmacology

The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane

(2016) Mark P.A. Luna-Vargas et al.   FEBS Journal

Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson's disease

(2016) Shounak Baksi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Adaptive regulation of the brain’s antioxidant defences by neurons and astrocytes

(2016) Paul S. Baxter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial dysfunction associated with glucocerebrosidase deficiency

(2016) Matthew E. Gegg et al.   NEUROBIOLOGY OF DISEASE

Meta-analysis of brain iron levels of Parkinson’s disease patients determined by postmortem and MRI measurements

(2016) Jian-Yong Wang et al.   Scientific Reports

Post-translational modification of α-synuclein in Parkinson׳s disease

(2015) Paul J. Barrett et al.   BRAIN RESEARCH

Effect of Creatine Monohydrate on Clinical Progression in Patients With Parkinson Disease

(2015) Karl Kieburtz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dopamine Transporter Activity Is Modulated by α-Synuclein

(2015) Brittany Butler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of  -Amyloid Precursor Protein

(2015) S. Ayton et al.   JOURNAL OF NEUROSCIENCE

Pioglitazone in early Parkinson's disease: a phase 2, multicentre, double-blind, randomised trial

(2015)   LANCET NEUROLOGY

α-synuclein interacts with SOD1 and promotes its oligomerization

(2015) Anika M. Helferich et al.   Molecular Neurodegeneration

Aging causes morphological alterations in astrocytes and microglia in human substantia nigra pars compacta

(2015) H.J. Jyothi et al.   NEUROBIOLOGY OF AGING

Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders

(2015) Joanna Ruszkiewicz et al.   NEUROCHEMISTRY INTERNATIONAL

Direct in vivo imaging of ferrous iron dyshomeostasis in ageing Caenorhabditis elegans

(2015) Simon A. James et al.   Chemical Science

Oxidative stress and Parkinson’s disease

(2015) Javier Blesa et al.   Frontiers in Neuroanatomy

Evidence for beneficial effects of vitamin E

(2015) Etsuo Niki   KOREAN JOURNAL OF INTERNAL MEDICINE

Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?

(2014) Amy Reeve et al.   AGEING RESEARCH REVIEWS

Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance

(2014) Ana I. Rojo et al.   ANTIOXIDANTS & REDOX SIGNALING

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Dopamine receptor mapping with PET imaging in Parkinson’s disease

(2014) Flavia Niccolini et al.   JOURNAL OF NEUROLOGY

Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein

(2014) Sudhakar Raja Subramaniam et al.   NEUROBIOLOGY OF DISEASE

β-Amyloid Precursor Protein Does Not Possess Ferroxidase Activity but Does Stabilize the Cell Surface Ferrous Iron Exporter Ferroportin

(2014) Bruce X. Wong et al.   PLoS One

Parkinson’s disease: animal models and dopaminergic cell vulnerability

(2014) Javier Blesa et al.   Frontiers in Neuroanatomy

A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease

(2014) et al.   JAMA Neurology

Energy Failure

(2013) Divya Pathak et al.   ANNALS OF NEUROLOGY

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Complexity of dopamine metabolism

(2013) Johannes Meiser et al.   Cell Communication and Signaling

Glutathione metabolism and Parkinson's disease

(2013) Michelle Smeyne et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antioxidants as therapies: can we improve on nature?

(2013) Michael P. Murphy   FREE RADICAL BIOLOGY AND MEDICINE

Mammalian SOD2 is exclusively located in mitochondria and not present in peroxisomes

(2013) Srikanth Karnati et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Copper pathology in vulnerable brain regions in Parkinson's disease

(2013) Katherine M. Davies et al.   NEUROBIOLOGY OF AGING

Increased vulnerability of parkin knock down PC12 cells to hydrogen peroxide toxicity: The role of salsolinol and NM-salsolinol

(2013) Yang Su et al.   NEUROSCIENCE

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease

(2013) Eleftheria K. Pissadaki et al.   Frontiers in Computational Neuroscience

Mitochondrial Biology and Parkinson's Disease

(2013) C. Perier et al.   Cold Spring Harbor Perspectives in Medicine

Programmed Cell Death in Parkinson's Disease

(2013) K. Venderova et al.   Cold Spring Harbor Perspectives in Medicine

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

(2012) Scott Ayton et al.   ANNALS OF NEUROLOGY

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Antioxidant Therapy: Current Status and Future Prospects

(2012) O. Firuzi et al.   CURRENT MEDICINAL CHEMISTRY

Tools to study distinct metal pools in biology

(2012) Elizabeth J. New   DALTON TRANSACTIONS

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

(2012) Nicole Exner et al.   EMBO JOURNAL

Mitochondrial redox signalling at a glance

(2012) Yvonne Collins et al.   JOURNAL OF CELL SCIENCE

GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area

(2012) Stefanie Reyes et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The hypoxia imaging agent Cu II (atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease

(2012) Lin W. Hung et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

Dopamine Oxidation and Autophagy

(2012) Patricia Muñoz et al.   Parkinsons Disease

Three functional facets of calbindin D-28k

(2012) Hartmut Schmidt   Frontiers in Molecular Neuroscience

Creatine as an antioxidant

(2011) Piero Sestili et al.   AMINO ACIDS

Nigral pathology and parkinsonian signs in elders without Parkinson disease

(2011) Aron S. Buchman et al.   ANNALS OF NEUROLOGY

Oxidation Chemistry of Catecholamines and Neuronal Degeneration: An Update

(2011) A. Napolitano et al.   CURRENT MEDICINAL CHEMISTRY

A pilot trial of deferiprone for neurodegeneration with brain iron accumulation

(2011) G. Abbruzzese et al.   HAEMATOLOGICA

ATP13A2 regulates mitochondrial bioenergetics through macroautophagy

(2011) Aaron M. Gusdon et al.   NEUROBIOLOGY OF DISEASE

Increased Oxidative Damage and Decreased Antioxidant Function in Aging Human Substantia Nigra Compared to Striatum: Implications for Parkinson’s Disease

(2011) C. Venkateshappa et al.   NEUROCHEMICAL RESEARCH

Novel Therapies Targeting Inner Mitochondrial Membrane—From Discovery to Clinical Development

(2011) Hazel H. Szeto et al.   PHARMACEUTICAL RESEARCH

Integrated Analysis of Gene Expression, CpG Island Methylation, and Gene Copy Number in Breast Cancer Cells by Deep Sequencing

(2011) Zhifu Sun et al.   PLoS One

Clinical progression in Parkinson disease and the neurobiology of axons

(2010) Hsiao-Chun Cheng et al.   ANNALS OF NEUROLOGY

Import, Maturation, and Function of SOD1 and Its Copper Chaperone CCS in the Mitochondrial Intermembrane Space

(2010) Hibiki Kawamata et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative Damage Increases and Antioxidant Gene Expression Decreases with Aging in the Mouse Ovary

(2010) J. Lim et al.   BIOLOGY OF REPRODUCTION

Iron species-mediated dopamine oxidation, proteasome inhibition, and dopaminergic cell demise: Implications for iron-related dopaminergic neuron degeneration

(2010) Zhi Dong Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: preclinical Parkinson disease

(2010) Isidre Ferrer et al.   JOURNAL OF NEURAL TRANSMISSION

A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

(2010) Barry J. Snow et al.   MOVEMENT DISORDERS

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

Accumulation of Non-Transferrin-Bound Iron by Neurons, Astrocytes, and Microglia

(2010) Glenda M. Bishop et al.   NEUROTOXICITY RESEARCH

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

(2010) L.-Y. Hao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Cell death pathways in Parkinson’s disease: proximal triggers, distal effectors, and final steps

(2009) Oren A. Levy et al.   APOPTOSIS

DJ-1 binds to mitochondrial complex I and maintains its activity

(2009) Takuya Hayashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

(2009) Vanessa A. Morais et al.   EMBO Molecular Medicine

Parthanatos, a messenger of death

(2009) Karen Kate David   Frontiers in Bioscience-Landmark

The Parkinson Disease Protein Leucine-Rich Repeat Kinase 2 Transduces Death Signals via Fas-Associated Protein with Death Domain and Caspase-8 in a Cellular Model of Neurodegeneration

(2009) C. C.-Y. Ho et al.   JOURNAL OF NEUROSCIENCE

Randomized, double-blind, pilot evaluation of intravenous glutathione in Parkinson's disease

(2009) Robert A. Hauser et al.   MOVEMENT DISORDERS

Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease

(2008) Luigi Zecca et al.   ACTA NEUROPATHOLOGICA

Dietary Iron Intake and Risk of Parkinson's Disease

(2008) G. Logroscino et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Incidental Lewy Body Disease and Preclinical Parkinson Disease

(2008) Anthony DelleDonne et al.   ARCHIVES OF NEUROLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Glutathione and Parkinson's disease: Is this the elephant in the room?

(2008) Gail D. Zeevalk et al.   BIOMEDICINE & PHARMACOTHERAPY

The comparative biology of neuromelanin and lipofuscin in the human brain

(2008) K. L. Double et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial association of alpha-synuclein causes oxidative stress

(2008) M. S. Parihar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Use of Statins and the Risk of Parkinson???s Disease

(2008) Claudia Becker et al.   DRUG SAFETY

The Mechanism of Mitochondrial Superoxide Production by the Cytochromebc1Complex

(2008) Stefan Dröse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration

(2008) Vincent Ries et al.   JOURNAL OF NEUROCHEMISTRY

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE

Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys

(2008) Nicholas M. Kanaan et al.   NEUROBIOLOGY OF AGING

Midbrain iron content in early Parkinson disease: A potential biomarker of disease status

(2008) W. R. W. Martin et al.   NEUROLOGY

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

(2008) J. Salazar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Characteristics of Human Substantia Nigra Neuromelanin and Synthetic Dopamine Melanins

(2003) K. L. Double et al.   JOURNAL OF NEUROCHEMISTRY