Retinal Ganglion Cells Die by Necroptotic Mechanisms in a Site-Specific Manner in a Rat Blunt Ocular Injury Model

Targeting RIPK1 for the treatment of human diseases

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The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis

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Caspase-2 is a negative regulator of necroptosis

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A novel RIPK1 inhibitor that prevents retinal degeneration in a rat glaucoma model

(2017) Yun-Ju Do et al.   EXPERIMENTAL CELL RESEARCH

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

(2017) Stephanie A. Conos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necroptosis in neurodegenerative diseases: a potential therapeutic target

(2017) Shuo Zhang et al.   Cell Death & Disease

Role for RIP1 in mediating necroptosis in experimental intracerebral hemorrhage model both in vivo and in vitro

(2017) Haitao Shen et al.   Cell Death & Disease

Axonal Degeneration: RIPK1 Multitasking in ALS

(2016) Kristin Politi et al.   CURRENT BIOLOGY

Nec‐1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice

(2016) Seung‐Hoon Yang et al.   EMBO Molecular Medicine

Evaluating retinal ganglion cell loss and dysfunction

(2016) Ben Mead et al.   EXPERIMENTAL EYE RESEARCH

NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration

(2016) Ishaq A. Viringipurampeer et al.   HUMAN MOLECULAR GENETICS

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

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Necroptosis in development, inflammation and disease

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RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

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Necroptosis in Niemann–Pick disease, type C1: a potential therapeutic target

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MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome

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Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis

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Is there treatment for traumatic optic neuropathy?

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Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

The diverse role of RIP kinases in necroptosis and inflammation

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RIP Kinase-Mediated Necrosis as an Alternative Mechanisms of Photoreceptor Death

(2015) Yusuke Murakami et al.   Oncotarget

Retinal ganglion cell (RGC) programmed necrosis contributes to ischemia–reperfusion-induced retinal damage

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Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

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Necroptosis inhibitor necrostatin-1 promotes cell protection and physiological function in traumatic spinal cord injury

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Necroptosis

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Comparative Evaluation of Methods for Estimating Retinal Ganglion Cell Loss in Retinal Sections and Wholemounts

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Necroptosis in health and diseases

(2014) Wen Zhou et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Traumatic Optic Neuropathy and Second Optic Nerve Injuries

(2014) William Marshall Guy et al.   JAMA Ophthalmology

Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration

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Unexpected low-dose toxicity of the universal solvent DMSO

(2013) Joana Galvao et al.   FASEB JOURNAL

The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina

(2013) Allen R. Rodriguez et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Visual Outcomes after Blunt Ocular Trauma

(2013) Richard J. Blanch et al.   OPHTHALMOLOGY

Caspase-2 Is Upregulated after Sciatic Nerve Transection and Its Inhibition Protects Dorsal Root Ganglion Neurons from Apoptosis after Serum Withdrawal

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A mouse model of ocular blast injury that induces closed globe anterior and posterior pole damage

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Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration

(2012) Y. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

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Brain derived neurotrophic factor maintains Brn3a expression in axotomized rat retinal ganglion cells

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Ocular neuroprotection by siRNA targeting caspase-2

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Ophthalmic injuries in British Armed Forces in Iraq and Afghanistan

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Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis

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Surveillance of traumatic optic neuropathy in the UK

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Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model

(2009) Daniel M. Rosenbaum et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice

(2008) Zerong You et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

Combat Ocular Trauma Visual Outcomes during Operations Iraqi and Enduring Freedom

(2008) Eric D. Weichel et al.   OPHTHALMOLOGY