Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells

Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses

(2015) Sarang Tartey et al.   JOURNAL OF IMMUNOLOGY

Chromatin Contributions to the Regulation of Innate Immunity

(2014) Stephen T. Smale et al.   Annual Review of Immunology

Akirin2 is critical for inducing inflammatory genes by bridging I B-  and the SWI/SNF complex

(2014) S. Tartey et al.   EMBO JOURNAL

Akirin specifies NF- B selectivity of Drosophila innate immune response via chromatin remodeling

(2014) F. Bonnay et al.   EMBO JOURNAL

Dectin-2 Is a Direct Receptor for Mannose-Capped Lipoarabinomannan of Mycobacteria

(2014) Akiko Yonekawa et al.   IMMUNITY

Transcriptional Control of Inflammatory Responses

(2014) S. T. Smale et al.   Cold Spring Harbor Perspectives in Biology

Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I, Healthy Subjects Study of Intravenous OPN-305, a Humanized Anti-TLR2 Antibody

(2013) M Reilly et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

(2013) Kari Ann Shirey et al.   NATURE

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

(2013) T. Kondo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation

(2012) Hazel Tye et al.   CANCER CELL

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

(2012) Dianne H. Dapito et al.   CANCER CELL

The HumanTLRInnate Immune Gene Family Is Differentially Influenced by DNA Stress andp53Status in Cancer Cells

(2012) Maria Shatz et al.   CANCER RESEARCH

Recognition of Profilin by Toll-like Receptor 12 Is Critical for Host Resistance to Toxoplasma gondii

(2012) A. Alicia Koblansky et al.   IMMUNITY

Cutting Edge: TLR13 Is a Receptor for Bacterial RNA

(2012) A. Hidmark et al.   JOURNAL OF IMMUNOLOGY

Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain

(2012) Takashi Shichita et al.   NATURE MEDICINE

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR13 Recognizes Bacterial 23S rRNA Devoid of Erythromycin Resistance-Forming Modification

(2012) M. Oldenburg et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer

(2011) B. Salaun et al.   CANCER RESEARCH

Activation of Toll-like Receptor 5 on Breast Cancer Cells by Flagellin Suppresses Cell Proliferation and Tumor Growth

(2011) Z. Cai et al.   CANCER RESEARCH

Role of microRNAs in lymphoid biology and disease

(2011) Muller Fabbri et al.   CURRENT OPINION IN HEMATOLOGY

VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis

(2011) Friedrich Horak   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity

(2011) Peng Zhou et al.   FASEB JOURNAL

A Common Polymorphism in TLR3 Confers Natural Resistance to HIV-1 Infection

(2011) M. Sironi et al.   JOURNAL OF IMMUNOLOGY

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

The C Allele of rs5743836 Polymorphism in the Human TLR9 Promoter Links IL-6 and TLR9 Up-Regulation and Confers Increased B-Cell Proliferation

(2011) Agostinho Carvalho et al.   PLoS One

Toll-Like Receptor 6 Ser249Pro Polymorphism Is Associated With Lower Left Ventricular Wall Thickness and Inflammatory Response in Hypertensive Women

(2010) M. L. Sales et al.   AMERICAN JOURNAL OF HYPERTENSION

TLR9 Polymorphisms Are Associated with Altered IFN-γ Levels in Children with Cerebral Malaria

(2010) Nadia A. Sam-Agudu et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

HMGB1 and RAGE in Inflammation and Cancer

(2010) Gary P. Sims et al.   Annual Review of Immunology

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Impact of Toll-like receptor 4 polymorphisms on risk of cancer

(2010) Anton G. Kutikhin   HUMAN IMMUNOLOGY

A Novel Toll-like Receptor That Recognizes Vesicular Stomatitis Virus

(2010) Zhongcheng Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The adaptor molecule CARD9 is essential for tuberculosis control

(2010) Anca Dorhoi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toll-like receptor 7 rs179008/Gln11Leu gene variants in chronic hepatitis C virus infection

(2010) Eva Askar et al.   JOURNAL OF MEDICAL VIROLOGY

Significant association between toll-like receptor gene polymorphisms and gallbladder cancer

(2010) Kshitij Srivastava et al.   LIVER INTERNATIONAL

Toll-like receptor 8 and 9 polymorphisms in Crimean-Congo hemorrhagic fever

(2010) Aynur Engin et al.   MICROBES AND INFECTION

Evaluation of Toll-like receptors 3 (c.1377C/T) and 9 (G2848A) gene polymorphisms in cervical cancer susceptibility

(2010) Saumya Pandey et al.   MOLECULAR BIOLOGY REPORTS

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

(2010) Teresa Fernandes-Alnemri et al.   NATURE IMMUNOLOGY

The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a β-catenin-dependent pathway

(2010) Pengyuan Yang et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Tumor-Associated Macrophages and Survival in Classic Hodgkin's Lymphoma

(2010) Christian Steidl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

(2010) T. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus

(2010) N. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression

(2009) Djin-Ye Oh et al.   AIDS

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Poly I:C-Induced Activation of NK Cells by CD8 + Dendritic Cells via the IPS-1 and TRIF-Dependent Pathways

(2009) T. Miyake et al.   JOURNAL OF IMMUNOLOGY

Polymorphism N248S in the Human Toll‐Like Receptor 1 Gene Is Related to Leprosy and Leprosy Reactions

(2009) Ron P. Schuring et al.   JOURNAL OF INFECTIOUS DISEASES

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells

(2009) Giuseppe Mancuso et al.   NATURE IMMUNOLOGY

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

(2009) Ping-Hui Tseng et al.   NATURE IMMUNOLOGY

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

(2009) Andrea Ablasser et al.   NATURE IMMUNOLOGY

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

(2009) Hendrik Poeck et al.   NATURE IMMUNOLOGY

Causes and consequences of microRNA dysregulation in cancer

(2009) Carlo M. Croce   NATURE REVIEWS GENETICS

Toll-like Receptor 1 Polymorphisms Affect Innate Immune Responses and Outcomes in Sepsis

(2008) Mark M. Wurfel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Activation of Toll-like receptor 2 by a novel preparation of cell wall skeleton from Mycobacterium bovis BCG Tokyo (SMP-105) sufficiently enhances immune responses against tumors

(2008) Masashi Murata   CANCER SCIENCE

An Exploratory Study of Systemic Administration of the Toll-like Receptor-7 Agonist 852A in Patients with Refractory Metastatic Melanoma

(2008) R. Dummer et al.   CLINICAL CANCER RESEARCH

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

(2008) Satoshi Uematsu et al.   NATURE IMMUNOLOGY

An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models

(2008) L. G. Burdelya et al.   SCIENCE

Genetic Association and Expression Studies Indicate a Role of Toll-Like Receptor 8 in Pulmonary Tuberculosis

(2008) Sonia Davila et al.   PLoS Genetics

Increased expression of Toll-like receptor 5 during progression of cervical neoplasia

(2007) W.Y. KIM et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER