标题
Mining and unearthing hidden biosynthetic potential
作者
关键词
-
出版物
Nature Communications
Volume 12, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-06-23
DOI
10.1038/s41467-021-24133-5
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- BiG-SLiCE: A highly scalable tool maps the diversity of 1.2 million biosynthetic gene clusters
- (2021) Satria A Kautsar et al. GigaScience
- Genome mining of oxidation modules in trans-acyltransferase polyketide synthases reveals a culturable source for lobatamides
- (2020) Reiko Ueoka et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Mining Symbionts of Spider-Transmitted Fungus Illuminates Uncharted Biosynthetic Pathways to Cytotoxic Benzolactones
- (2020) Sarah P. Niehs et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Targeted induction of a silent fungal gene cluster encoding the bacteria-specific germination inhibitor fumigermin
- (2020) Maria Cristina Stroe et al. eLife
- Landornamides: Antiviral Ornithine‐Containing Ribosomal Peptides Discovered through Genome Mining
- (2020) Nina M. Bösch et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Biosynthesis of Biscognienyne B Involving a Cytochrome P450‐Dependent Alkynylation
- (2020) Jian‐Ming Lv et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- ARTS 2.0: feature updates and expansion of the Antibiotic Resistant Target Seeker for comparative genome mining
- (2020) Mehmet Direnç Mungan et al. NUCLEIC ACIDS RESEARCH
- A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli
- (2020) Michael Rust et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reconstitution of polythioamide antibiotic backbone formation reveals unusual thiotemplated assembly strategy
- (2020) Kyle L. Dunbar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metagenomic Exploration of the Marine Sponge Mycale hentscheli Uncovers Multiple Polyketide-Producing Bacterial Symbionts
- (2020) Mathew A. Storey et al. mBio
- Chemical Mediators at the Bacterial-Fungal Interface
- (2020) Kirstin Scherlach et al. Annual Review of Microbiology
- Structure and bioactivity of colibactin
- (2020) Kevin M. Wernke et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Oak‐Associated Negativicute Equipped with Ancestral Aromatic Polyketide Synthase Produces Antimycobacterial Dendrubins
- (2020) Keishi Ishida et al. CHEMISTRY-A EUROPEAN JOURNAL
- RRE-Finder: a Genome-Mining Tool for Class-Independent RiPP Discovery
- (2020) Alexander M. Kloosterman et al. mSystems
- Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides
- (2020) Alexander M. Kloosterman et al. PLOS BIOLOGY
- SeMPI 2.0—A Web Server for PKS and NRPS Predictions Combined with Metabolite Screening in Natural Product Databases
- (2020) Paul F. Zierep et al. Metabolites
- Genome-Mined Diels–Alderase Catalyzes Formation of the cis-Octahydrodecalins of Varicidin A and B
- (2019) Dan Tan et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Genome mining identifies cepacin as a plant-protective metabolite of the biopesticidal bacterium Burkholderia ambifaria
- (2019) Alex J. Mullins et al. Nature Microbiology
- rBAN: retro-biosynthetic analysis of nonribosomal peptides
- (2019) Emma Ricart et al. Journal of Cheminformatics
- Opening up the Single-Cell Toolbox for Microbial Natural Products Research
- (2019) Jörn Piel et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Targeted antibiotic discovery through biosynthesis-associated resistance determinants: target directed genome mining
- (2019) Ellis C. O’Neill et al. CRITICAL REVIEWS IN MICROBIOLOGY
- Distinct autocatalytic α-N-methylating precursors expand the borosin RiPP family of peptide natural products
- (2019) Marissa R. Quijano et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Resistance Gene-Directed Genome Mining of 50 Aspergillus Species
- (2019) Inge Kjærbølling et al. mSystems
- Genome Mining Reveals Endopyrroles from a Nonribosomal Peptide Assembly Line Triggered in Fungal–Bacterial Symbiosis
- (2019) Sarah P. Niehs et al. ACS Chemical Biology
- Biosynthesis of Diverse Antimicrobial and Antiproliferative Acyloins in Anaerobic Bacteria
- (2019) Sebastian Schieferdecker et al. ACS Chemical Biology
- A Cyclopropanol Warhead in Malleicyprol Confers Virulence of Human- and Animal-Pathogenic Burkholderia Species
- (2019) Felix Trottmann et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Identification of key enzymes responsible for protolimonoid biosynthesis in plants: Opening the door to azadirachtin production
- (2019) Hannah Hodgson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Novel antimicrobial peptide discovery using machine learning and biophysical selection of minimal bacteriocin domains
- (2019) Francisco R. Fields et al. DRUG DEVELOPMENT RESEARCH
- Genome mining- and synthetic biology-enabled production of hypermodified peptides
- (2019) Agneya Bhushan et al. Nature Chemistry
- A deep learning genome-mining strategy for biosynthetic gene cluster prediction
- (2019) Geoffrey D Hannigan et al. NUCLEIC ACIDS RESEARCH
- Structure elucidation of colibactin and its DNA cross-links
- (2019) Mengzhao Xue et al. SCIENCE
- Genomics-Driven Discovery of NO-Donating Diazeniumdiolate Siderophores in Diverse Plant-Associated Bacteria
- (2019) Ron Hermenau et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- A computational framework to explore large-scale biosynthetic diversity
- (2019) Jorge C. Navarro-Muñoz et al. Nature Chemical Biology
- A metagenomic strategy for harnessing the chemical repertoire of the human microbiome
- (2019) Yuki Sugimoto et al. SCIENCE
- NeuRiPP: Neural network identification of RiPP precursor peptides
- (2019) Emmanuel L. C. de los Santos Scientific Reports
- DeepRiPP integrates multiomics data to automate discovery of novel ribosomally synthesized natural products
- (2019) Nishanth J. Merwin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MetaMiner: A Scalable Peptidogenomics Approach for Discovery of Ribosomal Peptide Natural Products with Blind Modifications from Microbial Communities
- (2019) Liu Cao et al. Cell Systems
- Biosynthesis, Synthesis, and Activities of Barnesin A, a NRPS-PKS Hybrid Produced by an Anaerobic Epsilonproteobacterium
- (2018) Maja Rischer et al. ACS Chemical Biology
- Genome-based identification of a plant-associated marine bacterium as a rich natural product source
- (2018) Reiko Ueoka et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- RiPP antibiotics: biosynthesis and engineering potential
- (2018) Graham A Hudson et al. CURRENT OPINION IN MICROBIOLOGY
- Direct Pathway Cloning (DiPaC) to unlock natural product biosynthetic potential
- (2018) Christian Greunke et al. METABOLIC ENGINEERING
- Natural products from thioester reductase containing biosynthetic pathways
- (2018) Michael W. Mullowney et al. NATURAL PRODUCT REPORTS
- Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species
- (2018) Xue Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria
- (2018) Fabian Panter et al. Chemical Science
- Bipartite interactions, antibiotic production and biosynthetic potential of the Arabidopsis leaf microbiome
- (2018) Eric J. N. Helfrich et al. Nature Microbiology
- An Optimized Synthetic-Bioinformatic Natural Product Antibiotic Sterilizes Multidrug-Resistant Acinetobacter baumannii-Infected Wounds
- (2018) Xavier Vila-Farres et al. mSphere
- Discovery of an Antibacterial Isoindolinone-Containing Tetracyclic Polyketide by Cryptic Gene Activation and Characterization of Its Biosynthetic Gene Cluster
- (2018) Wei Li Thong et al. ACS Chemical Biology
- Genome Editing Reveals Novel Thiotemplated Assembly of Polythioamide Antibiotics in Anaerobic Bacteria
- (2018) Kyle Dunbar et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Genomics-Driven Discovery of a Symbiont-Specific Cyclopeptide from Bacteria Residing in the Rice Seedling Blight Fungus
- (2018) Sarah Niehs et al. CHEMBIOCHEM
- Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action
- (2018) Yan Yan et al. NATURE
- Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system
- (2018) Ron Hermenau et al. Nature Chemical Biology
- Genomics-driven discovery of a linear lipopeptide promoting host colonization by endofungal bacteria
- (2018) Sarah P. Niehs et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Unique Biosynthetic Pathway in Bloom-Forming Cyanobacterial Genus Microcystis Jointly Assembles Cytotoxic Aeruginoguanidines and Microguanidines
- (2018) Claire Pancrace et al. ACS Chemical Biology
- Natural products from anaerobes
- (2018) Jeffrey S. Li et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Gene-guided discovery and engineering of branched cyclic peptides in plants
- (2018) Roland D. Kersten et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Atolypenes, Tricyclic Bacterial Sesterterpenes Discovered Using a Multiplexed In Vitro Cas9-TAR Gene Cluster Refactoring Approach
- (2018) Seong-Hwan Kim et al. ACS Synthetic Biology
- Chromatin mapping identifies BasR, a key regulator of bacteria-triggered production of fungal secondary metabolites
- (2018) Juliane Fischer et al. eLife
- Characterization of the secondary metabolite biosynthetic gene clusters in archaea
- (2018) Shengqin Wang et al. COMPUTATIONAL BIOLOGY AND CHEMISTRY
- Using natural products for drug discovery: the impact of the genomics era
- (2017) Mingzi M Zhang et al. Expert Opinion on Drug Discovery
- Function-related replacement of bacterial siderophore pathways
- (2017) Hilke Bruns et al. ISME Journal
- Antimicrobials Inspired by Nonribosomal Peptide Synthetase Gene Clusters
- (2017) Xavier Vila-Farres et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens
- (2017) Fei Xu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Symbiosis-inspired approaches to antibiotic discovery
- (2017) Navid Adnani et al. NATURAL PRODUCT REPORTS
- Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products
- (2017) Niels S van der Velden et al. Nature Chemical Biology
- CRISPR–Cas9 strategy for activation of silent Streptomyces biosynthetic gene clusters
- (2017) Mingzi M Zhang et al. Nature Chemical Biology
- Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges
- (2017) Vinayak Agarwal et al. Nature Chemical Biology
- The Antibiotic Resistant Target Seeker (ARTS), an exploration engine for antibiotic cluster prioritization and novel drug target discovery
- (2017) Mohammad Alanjary et al. NUCLEIC ACIDS RESEARCH
- PRISM 3: expanded prediction of natural product chemical structures from microbial genomes
- (2017) Michael A. Skinnider et al. NUCLEIC ACIDS RESEARCH
- Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality
- (2017) Gregory C. A. Amos et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Unearthing a sesterterpene biosynthetic repertoire in the Brassicaceae through genome mining reveals convergent evolution
- (2017) Ancheng C. Huang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discovery of the leinamycin family of natural products by mining actinobacterial genomes
- (2017) Guohui Pan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The industrial anaerobe Clostridium acetobutylicum uses polyketides to regulate cellular differentiation
- (2017) Nicolaus A. Herman et al. Nature Communications
- Astellifadiene: Structure Determination by NMR Spectroscopy and Crystalline Sponge Method, and Elucidation of its Biosynthesis
- (2016) Yudai Matsuda et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Discovery of a Mosaic-Like Biosynthetic Assembly Line with a Decarboxylative Off-Loading Mechanism through a Combination of Genome Mining and Imaging
- (2016) Mahsa Mir Mohseni et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Direct Capture Technologies for Genomics-Guided Discovery of Natural Products
- (2016) Andrew N. Chan et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Computational strategies for genome-based natural product discovery and engineering in fungi
- (2016) Theo A.J. van der Lee et al. FUNGAL GENETICS AND BIOLOGY
- Phylogenomic Analysis of Natural Products Biosynthetic Gene Clusters Allows Discovery of Arseno-Organic Metabolites in Model Streptomycetes
- (2016) Pablo Cruz-Morales et al. Genome Biology and Evolution
- Insights into microbial cryptic gene activation and strain improvement: principle, application and technical aspects
- (2016) Kozo Ochi JOURNAL OF ANTIBIOTICS
- Natural product discovery: past, present, and future
- (2016) Leonard Katz et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Natural Products as Sources of New Drugs from 1981 to 2014
- (2016) David J. Newman et al. JOURNAL OF NATURAL PRODUCTS
- Insights into the chemical logic and enzymatic machinery of NRPS assembly lines
- (2016) Christopher T. Walsh NATURAL PRODUCT REPORTS
- Human commensals producing a novel antibiotic impair pathogen colonization
- (2016) Alexander Zipperer et al. NATURE
- A hybrid polyketide–nonribosomal peptide in nematodes that promotes larval survival
- (2016) Qingyao Shou et al. Nature Chemical Biology
- Assembly and clustering of natural antibiotics guides target identification
- (2016) Chad W Johnston et al. Nature Chemical Biology
- Discovery of MRSA active antibiotics using primary sequence from the human microbiome
- (2016) John Chu et al. Nature Chemical Biology
- Plant metabolic clusters - from genetics to genomics
- (2016) Hans-Wilhelm Nützmann et al. NEW PHYTOLOGIST
- Terpene synthase genes in eukaryotes beyond plants and fungi: Occurrence in social amoebae
- (2016) Xinlu Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining
- (2016) Michael A. Skinnider et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multiplexed CRISPR/Cas9- and TAR-Mediated Promoter Engineering of Natural Product Biosynthetic Gene Clusters in Yeast
- (2016) Hahk-Soo Kang et al. ACS Synthetic Biology
- Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining
- (2015) Xiaoyu Tang et al. ACS Chemical Biology
- Bacterial Genome Mining of Enzymatic Tools for Alkyne Biosynthesis
- (2015) Xuejun Zhu et al. ACS Chemical Biology
- Epigenetic Genome Mining of an Endophytic Fungus Leads to the Pleiotropic Biosynthesis of Natural Products
- (2015) Xu-Ming Mao et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Molecular Networking and Pattern-Based Genome Mining Improves Discovery of Biosynthetic Gene Clusters and their Products from Salinispora Species
- (2015) Katherine R. Duncan et al. CHEMISTRY & BIOLOGY
- Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery
- (2015) Jeffrey D. Rudolf et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection
- (2015) Fang Guo et al. METABOLIC ENGINEERING
- Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors
- (2015) Jeremy G. Owen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Plant pathogenic anaerobic bacteria use aromatic polyketides to access aerobic territory
- (2015) G. Shabuer et al. SCIENCE
- Small molecules from the human microbiota
- (2015) M. S. Donia et al. SCIENCE
- Cas9-Assisted Targeting of CHromosome segments CATCH enables one-step targeted cloning of large gene clusters
- (2015) Wenjun Jiang et al. Nature Communications
- Untapped Resources: Biotechnological Potential of Peptides and Secondary Metabolites in Archaea
- (2015) James C. Charlesworth et al. ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL
- De novo synthesis of a sunscreen compound in vertebrates
- (2015) Andrew R Osborn et al. eLife
- Terpenoid Biosynthesis Off the Beaten Track: Unconventional Cyclases and Their Impact on Biomimetic Synthesis
- (2014) Martin Baunach et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters
- (2014) Peter Cimermancic et al. CELL
- A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics
- (2014) Mohamed S. Donia et al. CELL
- NRPquest: Coupling Mass Spectrometry and Genome Mining for Nonribosomal Peptide Discovery
- (2014) Hosein Mohimani et al. JOURNAL OF NATURAL PRODUCTS
- A roadmap for natural product discovery based on large-scale genomics and metabolomics
- (2014) James R Doroghazi et al. Nature Chemical Biology
- High-throughput platform for the discovery of elicitors of silent bacterial gene clusters
- (2014) M. R. Seyedsayamdost PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Atlas of nonribosomal peptide and polyketide biosynthetic pathways reveals common occurrence of nonmodular enzymes
- (2014) H. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pep2Path: Automated Mass Spectrometry-Guided Genome Mining of Peptidic Natural Products
- (2014) Marnix H. Medema et al. PLoS Computational Biology
- Genomics-Driven Discovery of Burkholderic Acid, a Noncanonical, Cryptic Polyketide from Human PathogenicBurkholderiaSpecies
- (2012) Jakob Franke et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Malleilactone, a Polyketide Synthase-Derived Virulence Factor Encoded by the Cryptic Secondary Metabolome of Burkholderia pseudomallei Group Pathogens
- (2012) John B. Biggins et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A genomic approach to the cryptic secondary metabolome of the anaerobic world
- (2012) Anne-Catrin Letzel et al. NATURAL PRODUCT REPORTS
- Regulation of fungal secondary metabolism
- (2012) Axel A. Brakhage NATURE REVIEWS MICROBIOLOGY
- Molecular mechanisms of antibiotic resistance
- (2011) Gerard D. Wright CHEMICAL COMMUNICATIONS
- Closthioamide: An Unprecedented Polythioamide Antibiotic from the Strictly Anaerobic Bacterium Clostridium cellulolyticum
- (2010) Thorger Lincke et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The Biosynthetic Logic of Polyketide Diversity
- (2009) Christian Hertweck ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12
- (2009) Takeshi Hosaka et al. NATURE BIOTECHNOLOGY
- Triggering cryptic natural product biosynthesis in microorganisms
- (2009) Kirstin Scherlach et al. ORGANIC & BIOMOLECULAR CHEMISTRY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now