Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action

A scalable platform to identify fungal secondary metabolites and their gene clusters

(2017) Kenneth D Clevenger et al.   Nature Chemical Biology

The Antibiotic Resistant Target Seeker (ARTS), an exploration engine for antibiotic cluster prioritization and novel drug target discovery

(2017) Mohammad Alanjary et al.   NUCLEIC ACIDS RESEARCH

Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway

(2017) Nicholas Liu et al.   ORGANIC LETTERS

Using PyMOL as a platform for computational drug design

(2017) Shuguang Yuan et al.   Wiley Interdisciplinary Reviews-Computational Molecular Science

Resistance Gene-Guided Genome Mining: Serial Promoter Exchanges in Aspergillus nidulans Reveal the Biosynthetic Pathway for Fellutamide B, a Proteasome Inhibitor

(2016) Hsu-Hua Yeh et al.   ACS Chemical Biology

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

The evolution of genome mining in microbes – a review

(2016) Nadine Ziemert et al.   NATURAL PRODUCT REPORTS

PyMOL and Inkscape Bridge the Data and the Data Visualization

(2016) Shuguang Yuan et al.   STRUCTURE

Potential Corn Yield Losses from Weeds in North America

(2016) Nader Soltani et al.   WEED TECHNOLOGY

Trends in glyphosate herbicide use in the United States and globally

(2016) Charles M. Benbrook   Environmental Sciences Europe

Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining

(2015) Xiaoyu Tang et al.   ACS Chemical Biology

The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities

(2015) Samuel Genheden et al.   Expert Opinion on Drug Discovery

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

(2015) Edward Harder et al.   Journal of Chemical Theory and Computation

Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast

(2015) Man-Cheng Tang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

(2015) Peter J. Rutledge et al.   NATURE REVIEWS MICROBIOLOGY

Secondary metabolites in fungus-plant interactions

(2015) Tünde Pusztahelyi et al.   Frontiers in Plant Science

A Computational Approach to Enzyme Design: Predicting ω-Aminotransferase Catalytic Activity Using Docking and MM-GBSA Scoring

(2014) Sarah Sirin et al.   Journal of Chemical Information and Modeling

Natural Compounds as Next-Generation Herbicides

(2014) F. E. Dayan et al.   PLANT PHYSIOLOGY

The increasing importance of herbicides in worldwide crop production

(2013) Leonard P Gianessi   PEST MANAGEMENT SCIENCE

Global perspective of herbicide-resistant weeds

(2013) Ian Heap   PEST MANAGEMENT SCIENCE

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Molecular Basis for Mycophenolic Acid Biosynthesis in Penicillium brevicompactum

(2011) Torsten Bak Regueira et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Improved Treatment of Ligands and Coupling Effects in Empirical Calculation and Rationalization of pKaValues

(2011) Chresten R. Søndergaard et al.   Journal of Chemical Theory and Computation

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Towards the comprehensive, rapid, and accurate prediction of the favorable tautomeric states of drug-like molecules in aqueous solution

(2010) Jeremy R. Greenwood et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

A vector set for systematic metabolic engineering in Saccharomyces cerevisiae

(2010) Fang Fang et al.   YEAST