Insights into the chemical logic and enzymatic machinery of NRPS assembly lines

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Cystobactamids: Myxobacterial Topoisomerase Inhibitors Exhibiting Potent Antibacterial Activity

(2014) Sascha Baumann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Assembly Line Polyketide Synthases: Mechanistic Insights and Unsolved Problems

(2014) Chaitan Khosla et al.   BIOCHEMISTRY

Short Pathways to Complexity Generation: Fungal Peptidyl Alkaloid Multicyclic Scaffolds from Anthranilate Building Blocks

(2013) Christopher T. Walsh et al.   ACS Chemical Biology

The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life

(2013) Joris Beld et al.   NATURAL PRODUCT REPORTS

Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain

(2012) Xue Gao et al.   Nature Chemical Biology

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

N-Acylation during Glidobactin Biosynthesis by the Tridomain Nonribosomal Peptide Synthetase Module GlbF

(2010) Heidi J. Imker et al.   CHEMISTRY & BIOLOGY

Natural Products Version 2.0: Connecting Genes to Molecules

(2010) Christopher T. Walsh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of EntF as a serine-activating enzyme

(2010) Janice Reichert et al.   PROTEIN SCIENCE

Cyclopiazonic Acid Biosynthesis inAspergillussp.: Characterization of a Reductase-like R* Domain in Cyclopiazonate Synthetase That Forms and Releasescyclo-Acetoacetyl-l-tryptophan

(2009) Xinyu Liu et al.   BIOCHEMISTRY

A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both  - and  -ketone reduction during chain growth

(2008) C. T. Calderone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Chemical Versatility of Natural-Product Assembly Lines

(2007) Christopher T. Walsh   ACCOUNTS OF CHEMICAL RESEARCH