标题
Using natural products for drug discovery: the impact of the genomics era
作者
关键词
-
出版物
Expert Opinion on Drug Discovery
Volume 12, Issue 5, Pages 475-487
出版商
Informa UK Limited
发表日期
2017-03-04
DOI
10.1080/17460441.2017.1303478
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- DNA sequencing technologies: 2006–2016
- (2017) Elaine R Mardis Nature Protocols
- Computational strategies for genome-based natural product discovery and engineering in fungi
- (2016) Theo A.J. van der Lee et al. FUNGAL GENETICS AND BIOLOGY
- Natural product discovery: past, present, and future
- (2016) Leonard Katz et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Natural Products as Sources of New Drugs from 1981 to 2014
- (2016) David J. Newman et al. JOURNAL OF NATURAL PRODUCTS
- Natural Product Discovery through Improved Functional Metagenomics in Streptomyces
- (2016) Hala A. Iqbal et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The evolution of genome mining in microbes – a review
- (2016) Nadine Ziemert et al. NATURAL PRODUCT REPORTS
- Engineering microbial hosts for production of bacterial natural products
- (2016) Mingzi M. Zhang et al. NATURAL PRODUCT REPORTS
- Recent advances in engineering nonribosomal peptide assembly lines
- (2016) M. Winn et al. NATURAL PRODUCT REPORTS
- New tools for reconstruction and heterologous expression of natural product biosynthetic gene clusters
- (2016) Yunzi Luo et al. NATURAL PRODUCT REPORTS
- Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology
- (2016) Kira J. Weissman NATURAL PRODUCT REPORTS
- Human commensals producing a novel antibiotic impair pathogen colonization
- (2016) Alexander Zipperer et al. NATURE
- Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
- (2016) Mingxun Wang et al. NATURE BIOTECHNOLOGY
- Polyketide and nonribosomal peptide retro-biosynthesis and global gene cluster matching
- (2016) Chris A Dejong et al. Nature Chemical Biology
- Discovery of MRSA active antibiotics using primary sequence from the human microbiome
- (2016) John Chu et al. Nature Chemical Biology
- Single-cell genome sequencing: current state of the science
- (2016) Charles Gawad et al. NATURE REVIEWS GENETICS
- Synthetic biology to access and expand nature's chemical diversity
- (2016) Michael J. Smanski et al. NATURE REVIEWS MICROBIOLOGY
- Plant metabolic clusters - from genetics to genomics
- (2016) Hans-Wilhelm Nützmann et al. NEW PHYTOLOGIST
- Multiplexed CRISPR/Cas9- and TAR-Mediated Promoter Engineering of Natural Product Biosynthetic Gene Clusters in Yeast
- (2016) Hahk-Soo Kang et al. ACS Synthetic Biology
- One-step high-efficiency CRISPR/Cas9-mediated genome editing in Streptomyces
- (2015) He Huang et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Engineering of Secondary Metabolism
- (2015) Sarah E. O'Connor Annual Review of Genetics
- Highly efficient editing of the actinorhodin polyketide chain length factor gene in Streptomyces coelicolor M145 using CRISPR/Cas9-CodA(sm) combined system
- (2015) Hu Zeng et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- One chromosome, one contig: complete microbial genomes from long-read sequencing and assembly
- (2015) Sergey Koren et al. CURRENT OPINION IN MICROBIOLOGY
- Identification and analysis of the bacterial endosymbiont specialized for production of the chemotherapeutic natural product ET-743
- (2015) Michael M. Schofield et al. ENVIRONMENTAL MICROBIOLOGY
- Insights from 20 years of bacterial genome sequencing
- (2015) Miriam Land et al. FUNCTIONAL & INTEGRATIVE GENOMICS
- Culture-independent discovery of natural products from soil metagenomes
- (2015) Micah Katz et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Connecting Phenotype and Chemotype: High-Content Discovery Strategies for Natural Products Research
- (2015) Kenji L. Kurita et al. JOURNAL OF NATURAL PRODUCTS
- Targeted Metagenomics: Finding Rare Tryptophan Dimer Natural Products in the Environment
- (2015) Fang-Yuan Chang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Investigation of Interspecies Interactions within Marine Micromonosporaceae Using an Improved Co-Culture Approach
- (2015) Navid Adnani et al. Marine Drugs
- Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection
- (2015) Fang Guo et al. METABOLIC ENGINEERING
- A new antibiotic kills pathogens without detectable resistance
- (2015) Losee L. Ling et al. NATURE
- Minimum Information about a Biosynthetic Gene cluster
- (2015) Marnix H Medema et al. Nature Chemical Biology
- Computational approaches to natural product discovery
- (2015) Marnix H Medema et al. Nature Chemical Biology
- The re-emergence of natural products for drug discovery in the genomics era
- (2015) Alan L. Harvey et al. NATURE REVIEWS DRUG DISCOVERY
- Discovery of microbial natural products by activation of silent biosynthetic gene clusters
- (2015) Peter J. Rutledge et al. NATURE REVIEWS MICROBIOLOGY
- Highly efficient CRISPR/Cas9-mediated TAR cloning of genes and chromosomal loci from complex genomes in yeast
- (2015) Nicholas C.O. Lee et al. NUCLEIC ACIDS RESEARCH
- antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters
- (2015) Tilmann Weber et al. NUCLEIC ACIDS RESEARCH
- Genome-guided investigation of plant natural product biosynthesis
- (2015) Franziska Kellner et al. PLANT JOURNAL
- Evolution of chemical diversity by coordinated gene swaps in type II polyketide gene clusters
- (2015) Maureen E. Hillenmeyer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors
- (2015) Jeremy G. Owen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Variable genetic architectures produce virtually identical molecules in bacterial symbionts of fungus-growing ants
- (2015) Clarissa S. Sit et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Plant diterpene synthases: exploring modularity and metabolic diversity for bioengineering
- (2015) Philipp Zerbe et al. TRENDS IN BIOTECHNOLOGY
- Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics
- (2015) Pierre-Yves Colin et al. Nature Communications
- CRISPR-Cas9 Based Engineering of Actinomycetal Genomes
- (2015) Yaojun Tong et al. ACS Synthetic Biology
- Motif-independent de novo detection of secondary metabolite gene clusters—toward identification from filamentous fungi
- (2015) Myco Umemura et al. Frontiers in Microbiology
- Reprogramming Nonribosomal Peptide Synthetases for “Clickable” Amino Acids
- (2014) Hajo Kries et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Rational Design of Modular Polyketide Synthases: Morphing the Aureothin Pathway into a Luteoreticulin Assembly Line
- (2014) Yuki Sugimoto et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters
- (2014) Peter Cimermancic et al. CELL
- A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics
- (2014) Mohamed S. Donia et al. CELL
- Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2
- (2014) Ekaterina Gavrish et al. CHEMISTRY & BIOLOGY
- In silico tools for the analysis of antibiotic biosynthetic pathways
- (2014) Tilmann Weber INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
- NP/MS since 1970: from the basement to the bench top
- (2014) Guy T. Carter NATURAL PRODUCT REPORTS
- Emerging capabilities of mass spectrometry for natural products
- (2014) Alan K. Jarmusch et al. NATURAL PRODUCT REPORTS
- An environmental bacterial taxon with a large and distinct metabolic repertoire
- (2014) Micheal C. Wilson et al. NATURE
- Functional optimization of gene clusters by combinatorial design and assembly
- (2014) Michael J Smanski et al. NATURE BIOTECHNOLOGY
- A microbial biomanufacturing platform for natural and semisynthetic opioids
- (2014) Kate Thodey et al. Nature Chemical Biology
- De novo biosynthesis of terminal alkyne-labeled natural products
- (2014) Xuejun Zhu et al. Nature Chemical Biology
- Escherichia coli as a cell factory for heterologous production of nonribosomal peptides and polyketides
- (2014) Jian Li et al. New Biotechnology
- Improved Lanthipeptide Detection and Prediction for antiSMASH
- (2014) Kai Blin et al. PLoS One
- High-throughput platform for the discovery of elicitors of silent bacterial gene clusters
- (2014) M. R. Seyedsayamdost PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A
- (2014) Kazuya Yamanaka et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High-Efficiency Multiplex Genome Editing of Streptomyces Species Using an Engineered CRISPR/Cas System
- (2014) Ryan E. Cobb et al. ACS Synthetic Biology
- A Systematic Computational Analysis of Biosynthetic Gene Cluster Evolution: Lessons for Engineering Biosynthesis
- (2014) Marnix H. Medema et al. PLoS Computational Biology
- Activation and identification of five clusters for secondary metabolites inStreptomyces albus J1074
- (2014) Carlos Olano et al. Microbial Biotechnology
- Arimetamycin A: Improving Clinically Relevant Families of Natural Products through Sequence-Guided Screening of Soil Metagenomes
- (2013) Hahk-Soo Kang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Multiplexing of Combinatorial Chemistry in Antimycin Biosynthesis: Expansion of Molecular Diversity and Utility
- (2013) Yan Yan et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Bacterium Induces Cryptic Meroterpenoid Pathway in the Pathogenic FungusAspergillus fumigatus
- (2013) Claudia C. König et al. CHEMBIOCHEM
- Insights into the phylogeny and coding potential of microbial dark matter
- (2013) Christian Rinke et al. NATURE
- High-level semi-synthetic production of the potent antimalarial artemisinin
- (2013) C. J. Paddon et al. NATURE
- BAGEL3: automated identification of genes encoding bacteriocins and (non-)bactericidal posttranslationally modified peptides
- (2013) Auke J. van Heel et al. NUCLEIC ACIDS RESEARCH
- MS/MS networking guided analysis of molecule and gene cluster families
- (2013) D. D. Nguyen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules
- (2013) R. D. Kersten et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products
- (2013) J. G. Owen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Expanding the Fluorine Chemistry of Living Systems Using Engineered Polyketide Synthase Pathways
- (2013) M. C. Walker et al. SCIENCE
- Discovery of a family of γ-aminobutyrate ureas via rational derepression of a silent bacterial gene cluster
- (2013) John D. Sidda et al. Chemical Science
- Interspecies Interactions Stimulate Diversification of the Streptomyces coelicolor Secreted Metabolome
- (2013) M. F. Traxler et al. mBio
- Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster
- (2013) Yunzi Luo et al. Nature Communications
- Selective Enrichment of Environmental DNA Libraries for Genes Encoding Nonribosomal Peptides and Polyketides by Phosphopantetheine Transferase-Dependent Complementation of Siderophore Biosynthesis
- (2012) Zachary Charlop-Powers et al. ACS Chemical Biology
- Neutral Loss Fragmentation Pattern Based Screening for Arginine-Rich Natural Products in Xenorhabdus and Photorhabdus
- (2012) Sebastian W. Fuchs et al. ANALYTICAL CHEMISTRY
- Learning from nature: new approaches to the metabolic engineering of plant defense pathways
- (2012) Jan Jirschitzka et al. CURRENT OPINION IN BIOTECHNOLOGY
- A functional screen for recovery of 4′-phosphopantetheinyl transferase and associated natural product biosynthesis genes from metagenome libraries
- (2012) J. G. Owen et al. ENVIRONMENTAL MICROBIOLOGY
- Two Separate Gene Clusters Encode the Biosynthetic Pathway for the Meroterpenoids Austinol and Dehydroaustinol in Aspergillus nidulans
- (2012) Hsien-Chun Lo et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A genomic approach to the cryptic secondary metabolome of the anaerobic world
- (2012) Anne-Catrin Letzel et al. NATURAL PRODUCT REPORTS
- Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting
- (2012) Jun Fu et al. NATURE BIOTECHNOLOGY
- The Natural Product Domain Seeker NaPDoS: A Phylogeny Based Bioinformatic Tool to Classify Secondary Metabolite Gene Diversity
- (2012) Nadine Ziemert et al. PLoS One
- Genome streamlining and chemical defense in a coral reef symbiosis
- (2012) J. C. Kwan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Myxoprincomide: A Natural Product from Myxococcus xanthus Discovered by Comprehensive Analysis of the Secondary Metabolome
- (2011) Niña Socorro Cortina et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Directed Evolution of the Nonribosomal Peptide Synthetase AdmK Generates New Andrimid Derivatives In Vivo
- (2011) Bradley S. Evans et al. CHEMISTRY & BIOLOGY
- Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler
- (2011) Zengyi Shao et al. Molecular BioSystems
- A close relationship between primary nucleotides sequence structure and the composition of functional genes in the genome of prokaryotes
- (2011) Juan A.L. Garcia et al. MOLECULAR PHYLOGENETICS AND EVOLUTION
- A mass spectrometry–guided genome mining approach for natural product peptidogenomics
- (2011) Roland D Kersten et al. Nature Chemical Biology
- antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
- (2011) Marnix H. Medema et al. NUCLEIC ACIDS RESEARCH
- Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens
- (2011) L. Laureti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Expanding Small-Molecule Functional Metagenomics through Parallel Screening of Broad-Host-Range Cosmid Environmental DNA Libraries in Diverse Proteobacteria
- (2010) J. W. Craig et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- Mycolic Acid-Containing Bacteria Induce Natural-Product Biosynthesis inStreptomycesSpecies
- (2010) Hiroyasu Onaka et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- Use of Ichip for High-Throughput In Situ Cultivation of "Uncultivable" Microbial Species
- (2010) D. Nichols et al. APPLIED AND ENVIRONMENTAL MICROBIOLOGY
- SMURF: Genomic mapping of fungal secondary metabolite clusters
- (2010) Nora Khaldi et al. FUNGAL GENETICS AND BIOLOGY
- Aspernidine A and B, prenylated isoindolinone alkaloids from the model fungus Aspergillus nidulans
- (2010) Kirstin Scherlach et al. JOURNAL OF ANTIBIOTICS
- Rare earth elements activate the secondary metabolite–biosynthetic gene clusters in Streptomyces coelicolor A3(2)
- (2010) Yukinori Tanaka et al. JOURNAL OF ANTIBIOTICS
- Tailoring Enzyme-Rich Environmental DNA Clones: A Source of Enzymes for Generating Libraries of Unnatural Natural Products
- (2010) Jacob J. Banik et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis
- (2010) Carlos Olano et al. NATURAL PRODUCT REPORTS
- NMR of natural products at the ‘nanomole-scale’
- (2010) Tadeusz F. Molinski NATURAL PRODUCT REPORTS
- Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli
- (2010) P. K. Ajikumar et al. SCIENCE
- Natural Products from Environmental DNA Hosted inRalstonia metallidurans
- (2009) Jeffrey W. Craig et al. ACS Chemical Biology
- Automated genome mining for natural products
- (2009) Michael HT Li et al. BMC BIOINFORMATICS
- Identifying Natural Product Biosynthetic Genes from a Soil Metagenome by Using T7 Phage Selection
- (2009) Keya Zhang et al. CHEMBIOCHEM
- Functional metagenomics for enzyme discovery: challenges to efficient screening
- (2009) Taku Uchiyama et al. CURRENT OPINION IN BIOTECHNOLOGY
- Development of an Analysis Program of Type I Polyketide Synthase Gene Clusters Using Homology Search and Profile Hidden Markov Model
- (2009) Kiejung Park JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
- Myxobacteria—‘microbial factories’ for the production of bioactive secondary metabolites
- (2009) Silke C. Wenzel et al. Molecular BioSystems
- Genomic basis for natural product biosynthetic diversity in the actinomycetes
- (2009) Markus Nett et al. NATURAL PRODUCT REPORTS
- Epigenome manipulation as a pathway to new natural product scaffolds and their congeners
- (2009) Robert H. Cichewicz NATURAL PRODUCT REPORTS
- Programming cells by multiplex genome engineering and accelerated evolution
- (2009) Harris H. Wang et al. NATURE
- Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12
- (2009) Takeshi Hosaka et al. NATURE BIOTECHNOLOGY
- Chromatin-level regulation of biosynthetic gene clusters
- (2009) Jin Woo Bok et al. Nature Chemical Biology
- NtcA—A negative regulator of secondary metabolite biosynthesis in Sorangium cellulosum
- (2008) S. Rachid et al. JOURNAL OF BIOTECHNOLOGY
- Extracellular signalling, translational control, two repressors and an activator all contribute to the regulation of methylenomycin production inStreptomyces coelicolor
- (2008) Sean O'Rourke et al. MOLECULAR MICROBIOLOGY
- Epigenetic remodeling of the fungal secondary metabolome
- (2008) Russell B. Williams et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- A chemical epigenetics approach for engineering the in situbiosynthesis of a cryptic natural product from Aspergillus niger
- (2008) Jon C. Henrikson et al. ORGANIC & BIOMOLECULAR CHEMISTRY
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started