Porcupine inhibitors: Novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway
出版年份 2021 全文链接
标题
Porcupine inhibitors: Novel and emerging anti-cancer therapeutics targeting the Wnt signaling pathway
作者
关键词
Wnt signaling, Porcupine, Cancer, LGK974, ETC159, CGX1321
出版物
PHARMACOLOGICAL RESEARCH
Volume 167, Issue -, Pages 105532
出版商
Elsevier BV
发表日期
2021-03-06
DOI
10.1016/j.phrs.2021.105532
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
- (2020) Youn-Sang Jung et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Utilizing porcupine (PORCN) and DKK1 inhibition to improve anti-tumor immunity in a murine model of ovarian cancer.
- (2020) Jaclyn Wall et al. JOURNAL OF CLINICAL ONCOLOGY
- Targeting the β-catenin signaling for cancer therapy
- (2020) Xue Zhang et al. PHARMACOLOGICAL RESEARCH
- Wnt Signaling Drives Prostate Cancer Bone Metastatic Tropism and Invasion
- (2020) Yugang Wang et al. Translational Oncology
- Triazole-Based Inhibitors of the Wnt/β-Catenin Signaling Pathway Improve Glucose and Lipid Metabolisms in Diet-Induced Obese Mice
- (2019) Obinna N. Obianom et al. JOURNAL OF MEDICINAL CHEMISTRY
- Recent Development of Wnt Signaling Pathway Inhibitors for Cancer Therapeutics
- (2019) Jerry Harb et al. Current Oncology Reports
- Modulating Wnt signaling at the root: Porcupine and Wnt acylation
- (2019) Viviana I. Torres et al. PHARMACOLOGY & THERAPEUTICS
- The effects of Wnt inhibition on tumor progression and the tumor microenvironment in a syngeneic mouse model of ovarian cancer.
- (2019) Whitney Goldsberry et al. JOURNAL OF CLINICAL ONCOLOGY
- Inhibition of CBP/β-catenin and porcupine attenuates Wnt signaling and induces apoptosis in head and neck carcinoma cells
- (2019) Robert Kleszcz et al. CELLULAR ONCOLOGY
- A Review of the Role of Wnt in Cancer Immunomodulation
- (2019) Whitney N. Goldsberry et al. Cancers
- Small molecules from natural products targeting the Wnt/β-catenin pathway as a therapeutic strategy
- (2019) Dan Liu et al. BIOMEDICINE & PHARMACOTHERAPY
- PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers
- (2019) Zheng Zhong et al. ONCOGENE
- Current Advance of Therapeutic Agents in Clinical Trials Potentially Targeting Tumor Plasticity
- (2019) Xiao-Guang Yang et al. Frontiers in Oncology
- Mutation Spectrum of Cancer-Associated Genes in Patients With Early Onset of Colorectal Cancer
- (2019) Gulnur Zhunussova et al. Frontiers in Oncology
- Pharmacological interventions targeting Wnt/β-catenin signaling pathway attenuate paclitaxel-induced peripheral neuropathy
- (2019) Kahkashan Resham et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Wnt signaling pathways in myocardial infarction and the therapeutic effects of Wnt pathway inhibitors
- (2018) Wen-bin Fu et al. ACTA PHARMACOLOGICA SINICA
- Targeting WNT signaling in the treatment of osteoporosis
- (2018) Roland Baron et al. CURRENT OPINION IN PHARMACOLOGY
- A Novel PORCN Frameshift Mutation Leading to Focal Dermal Hypoplasia: A Case Report
- (2018) Ceren D. Durmaz et al. CYTOGENETIC AND GENOME RESEARCH
- Discovery and characterization of a potent Wnt and hedgehog signaling pathways dual inhibitor
- (2018) Haikuo Ma et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Itraconazole targets cell cycle heterogeneity in colorectal cancer
- (2018) Simon J.A. Buczacki et al. JOURNAL OF EXPERIMENTAL MEDICINE
- A novel porcupine inhibitor blocks WNT pathways and attenuates cardiac hypertrophy
- (2018) Jiahui Jiang et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Identification of RSPO2 Fusion Mutations and Target Therapy Using a Porcupine Inhibitor
- (2018) Chong Li et al. Scientific Reports
- Activating Wnt/β-catenin signaling pathway for disease therapy: Challenges and opportunities
- (2018) Piao Huang et al. PHARMACOLOGY & THERAPEUTICS
- Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer
- (2018) Xiaofei Cheng et al. BIOMEDICINE & PHARMACOTHERAPY
- Therapeutic Potential of Targeting Wnt/β-Catenin Pathway in Treatment of Colorectal Cancer: Rational and Progress
- (2017) Afsane Bahrami et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors
- (2017) Soo Yei Ho et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma
- (2017) Tuomas Tammela et al. NATURE
- Modulating the wnt signaling pathway with small molecules
- (2017) Freddi Huan Tran et al. PROTEIN SCIENCE
- Inhibition of porcupine prolongs metastasis free survival in a mouse xenograft model of Ewing sarcoma
- (2017) Masanori Hayashi et al. Oncotarget
- Recent developments in the treatment of metastatic colorectal cancer
- (2017) Jonathan M. Loree et al. Therapeutic Advances in Medical Oncology
- SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
- (2017) Antoine Daina et al. Scientific Reports
- Genetically engineered mouse models to evaluate the role of Wnt secretion in bone development and homeostasis
- (2016) Bart O. Williams AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
- Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the ‘reversed’ amide scaffold
- (2016) Zhixiang Xu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Development of a triazole class of highly potent Porcn inhibitors
- (2016) Lin You et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Design, synthesis, and evaluation of potent Wnt signaling inhibitors featuring a fused 3-ring system
- (2016) Zhixiang Xu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Developing drugs that target the Wnt pathway: recent approaches in cancer and neurodegenerative diseases
- (2016) Annalucia Serafino et al. Expert Opinion on Drug Discovery
- Wnt signaling in cancer
- (2016) T Zhan et al. ONCOGENE
- Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors
- (2016) Dai Cheng et al. ACS Medicinal Chemistry Letters
- Wnt Ligands Secreted by Subepithelial Mesenchymal Cells Are Essential for the Survival of Intestinal Stem Cells and Gut Homeostasis
- (2016) Tomas Valenta et al. Cell Reports
- Wnt Signaling in Renal Cell Carcinoma
- (2016) Qi Xu et al. Cancers
- Wnt Signaling in Cancer Stem Cell Biology
- (2016) Felipe de Sousa e Melo et al. Cancers
- Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms
- (2015) Laura Novellasdemunt et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Exploration of the linkage elements of porcupine antagonists led to potent Wnt signaling pathway inhibitors
- (2015) Yan Dong et al. BIOORGANIC & MEDICINAL CHEMISTRY
- The use of porcupine inhibitors to target Wnt-driven cancers
- (2015) Soo Yei Ho et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients
- (2015) Marc van de Wetering et al. CELL
- Targeting the Wnt signaling pathway in colorectal cancer
- (2015) Masaaki Sawa et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Discovery and Optimization of a Porcupine Inhibitor
- (2015) Athisayamani Jeyaraj Duraiswamy et al. JOURNAL OF MEDICINAL CHEMISTRY
- Targeting Wnts at the Source--New Mechanisms, New Biomarkers, New Drugs
- (2015) B. Madan et al. MOLECULAR CANCER THERAPEUTICS
- Wnt addiction of genetically defined cancers reversed by PORCN inhibition
- (2015) B Madan et al. ONCOGENE
- Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer
- (2015) Mari Masuda et al. PHARMACOLOGY & THERAPEUTICS
- Porcupine inhibitor suppresses paracrine Wnt-driven growth ofRnf43;Znrf3-mutant neoplasia
- (2015) Bon-Kyoung Koo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CRISPR/CAS9-Mediated Genome Editing of miRNA-155 Inhibits Proinflammatory Cytokine Production by RAW264.7 Cells
- (2015) Weixia Jing et al. Biomed Research International
- Wnt signaling and osteoporosis
- (2014) Stavros C. Manolagas MATURITAS
- RNF43 is frequently mutated in colorectal and endometrial cancers
- (2014) Marios Giannakis et al. NATURE GENETICS
- Can we safely target the WNT pathway?
- (2014) Michael Kahn NATURE REVIEWS DRUG DISCOVERY
- The Development of Highly Potent Inhibitors for Porcupine
- (2013) Xiaolei Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Wnt Signaling Pathway in Non-Small Cell Lung Cancer
- (2013) D. J. Stewart JNCI-Journal of the National Cancer Institute
- Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma
- (2013) X. Jiang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
- (2013) J. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt/β-catenin pathway in gastric cancer
- (2013) MIN-LI MO et al. Oncology Letters
- Functional Genomic Studies: Insights into the Pathogenesis of Liver Cancer
- (2012) Ze-Guang Han Annual Review of Genomics and Human Genetics
- Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer
- (2012) K. D. Proffitt et al. CANCER RESEARCH
- Wnt/beta-Catenin Signaling and Small Molecule Inhibitors
- (2012) Andrey Voronkov et al. CURRENT PHARMACEUTICAL DESIGN
- Drugging Wnt signalling in cancer
- (2012) Paul Polakis EMBO JOURNAL
- Recurrent R-spondin fusions in colon cancer
- (2012) Somasekar Seshagiri et al. NATURE
- Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
- (2012) Bon-Kyoung Koo et al. NATURE
- The Unusual Case of Porcupine
- (2012) L. Lum et al. SCIENCE
- WNT secretion and signalling in human disease
- (2012) Patrick Herr et al. TRENDS IN MOLECULAR MEDICINE
- Wnt Proteins
- (2012) K. Willert et al. Cold Spring Harbor Perspectives in Biology
- Wnt Signaling in Bone Development and Disease: Making Stronger Bone with Wnts
- (2012) J. B. Regard et al. Cold Spring Harbor Perspectives in Biology
- A review of the evidence for the canonical Wnt pathway in autism spectrum disorders
- (2012) Hans Kalkman Molecular Autism
- Role of the Wnt Pathway in Thyroid Cancer
- (2012) Ana Sastre-Perona et al. Frontiers in Endocrinology
- Drugging the Cancer Stem Cell Compartment: Lessons Learned from the Hedgehog and Wnt Signal Transduction Pathways
- (2011) Michael E. Dodge et al. Annual Review of Pharmacology and Toxicology
- Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells
- (2011) Derk ten Berge et al. NATURE CELL BIOLOGY
- Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease
- (2011) L Crews et al. Cell Death & Disease
- Gene Expression Analysis of Macrophages That Facilitate Tumor Invasion Supports a Role for Wnt-Signaling in Mediating Their Activity in Primary Mammary Tumors
- (2009) L. S. Ojalvo et al. JOURNAL OF IMMUNOLOGY
- Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
- (2009) Baozhi Chen et al. Nature Chemical Biology
- Wnt Signaling Is Regulated by Endoplasmic Reticulum Retention
- (2009) J. Susie Zoltewicz et al. PLoS One
- Oral benfotiamine plus α-lipoic acid normalises complication-causing pathways in type 1 diabetes
- (2008) X. Du et al. DIABETOLOGIA
- Wnt signaling: relevance to β-cell biology and diabetes
- (2008) Hannah J. Welters et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Wnt signaling in ovarian tumorigenesis
- (2007) T.A. GATCLIFFE et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
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