期刊
CANCERS
卷 11, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/cancers11060771
关键词
Wnt; beta-catenin; immunomodulation; cancer; immunotherapy; tumor microenvironment
类别
资金
- NIH [R21 CA223126]
Alterations in the Wnt signaling pathway are associated with the advancement of cancers; however, the exact mechanisms responsible remain largely unknown. It has recently been established that heightened intratumoral Wnt signaling correlates with tumor immunomodulation and immune suppression, which likely contribute to the decreased efficacy of multiple cancer therapeutics. Here, we review available literature pertaining to connections between Wnt pathway activation in the tumor microenvironment and local immunomodulation. We focus specifically on preclinical and clinical data supporting the hypothesis that strategies targeting Wnt signaling could act as adjuncts for cancer therapy, either in combination with chemotherapy or immunotherapy, in a variety of tumor types.
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