Article
Neurosciences
Yiying Wang, Huajun Sheng, Jing Zhao, Ling Guo, Jianing Liu, Jin Xu, Qian Liu, Juan Huang, Rong Jiang, Shengwei Gan, Guoping Qiu, Weitian Lu, Shiye Xu, Shujuan Zhu
Summary: Alzheimer's disease is a common neurodegenerative illness in aging populations, with psychiatric symptoms becoming increasingly important in its recognition. Injecting A beta(25-35) into the hippocampi of rats resulted in decreased learning and memory ability, increased depression-like behaviors, elevated levels of certain proteins in the PFCs and hippocampi, and the detection of P35/P25-CDK5 complexes, indicating a potential mechanism for cognitive impairment and psychiatric symptoms in AD.
NEUROSCIENCE LETTERS
(2021)
Article
Multidisciplinary Sciences
Ping-Chieh Pao, Jinsoo Seo, Audrey Lee, Oleg Kritskiy, Debasis Patnaik, Jay Penney, Ravikiran M. Raju, Ute Geigenmuller, M. Catarina Silva, Diane E. Lucente, James F. Gusella, Bradford C. Dickerson, Anjanet Loon, Margaret X. Yu, Michael Bula, Melody Yu, Stephen J. Haggarty, Li-Hue Tsai
Summary: In this study, a 12-amino-acid-long peptide fragment derived from Cdk5 (Cdk5i) was identified. The Cdk5i showed high binding affinity toward the Cdk5/p25 complex and reduced Cdk5/p25 kinase activity, offering therapeutic potential for neurodegenerative diseases associated with Cdk5 hyperactivity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Cell Biology
Ping-Chieh Pao, Li-Huei Tsai
Summary: Cdk5 is a proline-directed serine/threonine protein kinase that regulates various cellular processes in neurons, and its dysregulation can compromise normal brain function. Researchers have been focusing on the mechanisms and effects of Cdk5 on the nervous system for nearly three decades, with recent findings highlighting its role in neuronal/synaptic functions. Evidence suggests that aberrant Cdk5 activity is a common theme observed in many neurodegenerative diseases.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Review
Cell Biology
Hesham Essa, Lee Peyton, Whidul Hasan, Brandon Emanuel Leon, Doo-Sup Choi
Summary: Alzheimer's disease, characterized by impaired neurogenesis, affects millions of people worldwide. A beta accumulation and neurofibrillary tangles are key factors leading to neuronal loss, while APP gene expression also plays a significant role in neurogenesis.
Review
Neurosciences
Seyed Khalil Rashidi, Ata Kalirad, Shahram Rafie, Ebrahim Behzad, Mitra Ansari Dezfouli
Summary: MicroRNAs (miRNAs) play a significant role in regulating gene expression and influencing neural development and disorders, particularly in the hippocampus. The abnormal activity of miRNAs in the hippocampus is associated with various neurological disorders and behavioral deficits.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Anthony Kin Yip Liew, Chuin Hau Teo, Tomoko Soga
Summary: This article summarizes the evidence for environmental enrichment (EE) as a neuroprotective strategy and discusses the potential molecular pathways that explain its effects from a biochemical perspective. It also explores the differences in early and late life EE exposure and its potential application in humans.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Michele Longoni Calio, Amanda Cristina Mosini, Darci Souza Marinho, Geisa Nogueira Salles, Fernando Henrique Massinhani, Gui Mi Ko, Marimelia Aparecida Porcionatto
Summary: The study demonstrates that leptin administration can promote neurogenesis in adult and aged mice, leading to significant effects on proliferation and differentiation of newborn cells, while reducing the formation of senile plaques and neurodegenerative damage. By modulating the number of surrounding cells and inhibiting the production of superoxide anions, leptin may potentially serve as a new therapy for Alzheimer's disease.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Virendra Tiwari, Akanksha Mishra, Sonu Singh, Shubha Shukla
Summary: Neural stem cells (NSCs) are the functional and developmental unit of neurogenesis, and they have the ability to self-renew and generate new neurons in different neurogenic niches. Neurogenesis in adult brain is associated with synaptic plasticity, learning, and memory, particularly in the dentate gyrus (DG) of the hippocampus and olfactory bulb. Impaired neurogenesis has been implicated as a culprit in age-associated neurological disorders, including Alzheimer's disease (AD). This review provides evidence for the association between impaired neurogenesis and AD, and discusses the molecular and cellular regulation of neurogenesis in the young and aging brain. The review also summarizes therapeutic strategies for targeting the manipulation of the neural stem cell pool and factors affecting this pool in AD.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Neurosciences
Lili Chen, Qin Qin, Panchuan Huang, Fangli Cao, Maojia Yin, Yachen Xie, Wuchao Wang
Summary: Chronic neuropathic pain may lead to cognitive impairment in elderly patients, possibly due to the inhibitory effect of CCL2/CCR2 signaling on hippocampal neurogenesis.
BRAIN RESEARCH BULLETIN
(2023)
Article
Neurosciences
Israt Jahan, Ryota Adachi, Ryo Egawa, Haruka Nomura, Hiroshi Kuba
Summary: This study reveals that microtubule reorganization via activation of CDK5 plays a role in the plasticity of the axon initial segment (AIS). Treatment with a high-K+ medium shortened the AIS, specifically in neurons tuned to high-frequency sound. CDK5/p35-mediated AIS shortening is achieved by promoting disassembly of microtubules at distal AIS.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Alan Umfress, Ayanabha Chakraborti, Suma Priya Sudarsana Devi, Raegan Adams, Daniel Epstein, Adriana Massicano, Anna Sorace, Sarbjit Singh, M. Iqbal Hossian, Shaida A. Andrabi, David K. Crossman, Nilesh Kumar, M. Shahid Mukhtar, Huiyang Luo, Claire Simpson, Kathryn Abell, Matthew Stokes, Thorsten Wiederhold, Charles Rosen, Hongbing Lu, Amarnath Natarajan, James A. Bibb
Summary: Millions of traumatic brain injuries (TBIs) occur annually, commonly resulting from falls, traffic accidents, and sports-related injuries involving rotational acceleration/deceleration of the brain. This study developed a new model of repetitive rotational head trauma in rodents and demonstrated acute and prolonged pathological, behavioral, and electrophysiological effects of rotational TBI (rTBI). The aberrant activity of Cyclin-dependent kinase 5 (Cdk5) was identified as a principal mediator of rTBI, and pharmacological inhibition of Cdk5 showed promising results in reducing the cognitive and pathological consequences of injury.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Ekaterina A. Rudnitskaya, Tatiana A. Kozlova, Alena O. Burnyasheva, Natalia A. Stefanova, Nataliya G. Kolosova
Summary: Studies suggest that immaturity during early brain development, especially inadequate glial support, may be a primary factor leading to neurodegenerative processes and the manifestation of AD pathology later in life.
Article
Biochemistry & Molecular Biology
Chia-Herng Yue, Muhammet Oner, Chih-Yuan Chiu, Mei-Chih Chen, Chieh-Lin Teng, Hsin-Yi Wang, Jer-Tsong Hsieh, Chih-Ho Lai, Ho Lin
Summary: In our study, we investigated the RET activation and its biochemical interaction with CDK5 in GDNF-induced medullary thyroid cancer proliferation. Additionally, we identified the physical interaction between CDK5 and RET protein in MTC for the first time.Overall, our results suggest that targeting CDK5 may be a promising therapeutic candidate for human medullary thyroid cancer in the near future.
Review
Neurosciences
Kumar Surya, Nivethitha Manickam, Kesavan Swaminathan Jayachandran, Mahesh Kandasamy, Muthuswamy Anusuyadevi
Summary: Alzheimer's disease (AD) is a major form of dementia, with abnormal amyloidogenic event-mediated degeneration of cholinergic neurons in the brain contributing to neuropathological sequelae and behavioral deficits. Impaired adult neurogenesis in the hippocampus is also implicated in dementia, regardless of neurodegeneration. Nourishing the neurogenic process through the Wnt signaling pathway has been identified as a potential therapeutic strategy for memory loss. Resveratrol (RSV) is a Sirtuin1 (SIRT1) enhancer that promotes neuroprotection and neurogenesis in the hippocampus. However, the effects of RSV-mediated SIRT1 enhancement on hippocampal neurogenesis and memory loss through the Wnt signaling pathway in AD have not been fully explored.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Toru Tanaka, Sachiyo Ohashi, Akihiko Takashima, Shunsuke Kobayashi
Summary: This study investigates the mechanism of tau protein phosphorylation under neural excitation conditions, and reveals that the translation and hyper-activation of CDK5 are mediated by dendrite-distributed mRNA in response to glutamatergic stimulation.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Cell & Tissue Engineering
Maria Anna Zipeto, Angela C. Court, Anil Sadarangani, Nathaniel P. Delos Santos, Larisa Balaian, Hye-Jung Chun, Gabriel Pineda, Sheldon R. Morris, Cayla N. Mason, Ifat Geron, Christian Barrett, Daniel J. Goff, Russell Wall, Maurizio Pellecchia, Mark Minden, Kelly A. Frazer, Marco A. Marra, Leslie A. Crews, Qingfei Jiang, Catriona H. M. Jamieson
Article
Cell & Tissue Engineering
Leslie A. Crews, Larisa Balaian, Nathaniel P. Delos Santos, Heather S. Leu, Angela C. Court, Elisa Lazzari, Anil Sadarangani, Maria A. Zipeto, James J. La Clair, Reymundo Villa, Anna Kulidjian, Rainer Storb, Sheldon R. Morris, Edward D. Ball, Michael D. Burkart, Catriona H. M. Jamieson
Article
Oncology
Michela Colombo, Serena Galletti, Gaetano Bulfamante, Monica Falleni, Delfina Tosi, Katia Todoerti, Elisa Lazzari, Leslie A. Crews, Catriona H. M. Jamieson, Sara Ravaioli, Francesco Baccianti, Silvia Garavelli, Natalia Platonova, Antonino Neri, Raffaella Chiaramonte
Article
Multidisciplinary Sciences
Elisa Lazzari, Phoebe K. Mondala, Nathaniel Delos Santos, Amber C. Miller, Gabriel Pineda, Qingfei Jiang, Heather Leu, Shawn A. Ali, Anusha-Preethi Ganesan, Christina N. Wu, Caitlin Costello, Mark Minden, Raffaella Chiaramonte, A. Keith Stewart, Leslie A. Crews, Catriona H. M. Jamieson
NATURE COMMUNICATIONS
(2017)
Meeting Abstract
Hematology
Catriona Jamieson, Qingfei Jiang, Frida Holm, Jane Isquith, Adam Mark, Cayla Mason, Wenxue Ma, Raymond H. Diep, Jessica Pham, Eduardo Reynoso Moreno, Chanond A. Nasamran, Xu Guorong, Amanda Birmingham, Leslie A. Crews, Ludmil Alexandrov, Gabriel Pineda, Thomas Whisenant, Kathleen M. Fisch
Article
Cell & Tissue Engineering
Phoebe K. Mondala, Ashni A. Vora, Tianyuan Zhou, Elisa Lazzari, Luisa Ladel, Xiaolin Luo, Youngsoo Kim, Caitlin Costello, A. Robert MacLeod, Catriona H. M. Jamieson, Leslie A. Crews
Summary: In multiple myeloma, the inflammatory and anti-viral pathways play a role in disease progression and the generation of cancer stem cells. The inhibition of interferon regulatory factor 4 (IRF4) using antisense oligonucleotides (ASOs) shows promise in impairing myeloma cell survival and reducing tumor burden in pre-clinical models. Targeting IRF4 may offer a new strategy for preventing myeloma relapse driven by progenitor cells.
Article
Cell Biology
Qingfei Jiang, Jane Isquith, Luisa Ladel, Adam Mark, Frida Holm, Cayla Mason, Yudou He, Phoebe Mondala, Isabelle Oliver, Jessica Pham, Wenxue Ma, Eduardo Reynoso, Shawn Ali, Isabella Jamieson Morris, Raymond Diep, Chanond Nasamran, Guorong Xu, Roman Sasik, Sara Brin Rosenthal, Amanda Birmingham, Sanja Coso, Gabriel Pineda, Leslie Crews, Mary E. Donohoe, J. Craig Venter, Thomas Whisenant, Ruben A. Mesa, Ludmil B. Alexandrov, Kathleen M. Fisch, Catriona Jamieson
Summary: The study revealed that inflammation-dependent base deaminases play critical roles in the evolution of pre-leukemia stem cells to acute myeloid leukemia stem cells, by increasing mutational burden and promoting stem cell proliferation. This process is regulated by STAT3 editing and isoform switching, as well as ADAR1-mediated splicing deregulation.
Meeting Abstract
Hematology
Phoebe Mondala, Inge Van Der Werf, Larisa Balaian, Kathleen Steel, Luisa Ladel, Cayla Mason, Raymond Diep, Jacqueline Cloos, Gertjan Kaspers, Markus J. van Roosmalen, Ruben Van Boxtel, Warren Chan, Adam Mark, Mary Donohoe, James La Clair, Peggy Wentworth, Kathleen Fisch, Leslie A. Crews, Thomas Whisenant, Michael Burkart, Catriona Jamieson
Meeting Abstract
Hematology
Leslie A. Crews, Phoebe Mondala, Cayla Mason, Larisa Balaian, Wenxue Ma, Jessica Pham, Christina Wu, Peggy Wentworth, James La Clair, Michael Burkart, Catriona Jamieson
Article
Hematology
Sarah A. Holstein, Fotis Asimakopoulos, Abdel Kareem Azab, Giada Bianchi, Manisha Bhutani, Leslie A. Crews, Tom Cupedo, Hannah Giles, Sarah Gooding, Jens Hillengass, Lukas John, Shari Kaiser, Lydia Lee, Kylee Maclachlan, Marcelo C. Pasquini, Flavia Pichiorri, Nina Shah, Monica Shokeen, Brian R. Shy, Eric L. Smith, Raluca Verona, Saad Z. Usmani, Philip L. McCarthy
Summary: This article provides a comprehensive summary of a workshop on immune and cellular therapy in multiple myeloma conducted by the BMT CTN Myeloma Intergroup on January 7, 2022. The workshop included presentations by experts in plasma cell dyscrasias and covered topics such as disease evaluation platforms, pathophysiology insights, therapeutic targets and resistance mechanisms, and cellular therapy for multiple myeloma.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)
Article
Biochemical Research Methods
Ashni A. Vora, Phoebe K. Mondala, Caitlin Costello, A. Robert MacLeod, Leslie A. Crews
Summary: This protocol outlines a method for measuring IRF4 protein expression using fluorescent antibodies for combined cell surface and intranuclear staining. Quantification of IRF4 protein could serve as a valuable prognostic tool for predicting disease severity and sensitivity to IRF4-targeted therapies. The flow-cytometry-based procedure has the potential for rapid translation into a clinically compatible assay.
Meeting Abstract
Hematology
Larissa Balaian, Leslie A. Crews, Cayla Mayson, Frida Holm, Raymond H. Diep, Heather Leu, Anna Kulidjian, Edward D. Ball, Catriona Jamieson
Review
Oncology
Qingfei Jiang, Leslie A. Crews, Frida Holm, Catriona H. M. Jamieson
NATURE REVIEWS CANCER
(2017)
Meeting Abstract
Hematology
Leslie A. Crews, Qingfei Jiang, Larisa Balaian, Heather Leu, Nathan Delos Santos, Angela C. Court, Anil Sadarangani, Sheldon Morris, Rainer F. Storb, Anna Kulidjian, Edward D. Ball, Catriona Jamieson
Meeting Abstract
Hematology
Elisa Lazzari, Leslie A. Crews, Christina Wu, Heather Leu, Raffaella Chiaramonte, Mark D. Minden, Caitlin L. Costello, Catriona Jamieson