Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
出版年份 2020 全文链接
标题
Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
作者
关键词
-
出版物
EXPERIMENTAL AND MOLECULAR MEDICINE
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-02-10
DOI
10.1038/s12276-020-0380-6
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Pharmacological inhibition of β-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating Treg cells
- (2019) M. Feng et al. Science Advances
- Perspectives on the role of Wnt biology in cancer
- (2019) Christopher K. Mirabelli et al. Science Signaling
- A phase 1b dose escalation study of ipafricept (OMP 54F28) in combination with paclitaxel and carboplatin in patients with recurrent platinum-sensitive ovarian cancer
- (2019) Kathleen N. Moore et al. GYNECOLOGIC ONCOLOGY
- A first-in-human study investigating biodistribution, safety and recommended dose of a new radiolabeled MAb targeting FZD10 in metastatic synovial sarcoma patients
- (2018) Anne-Laure Giraudet et al. BMC CANCER
- An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
- (2018) Jianfang Liu et al. CELL
- APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway
- (2018) Kenyi Saito-Diaz et al. DEVELOPMENTAL CELL
- PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis
- (2018) Moon Jong Kim et al. DEVELOPMENTAL CELL
- The curious case of vacuolar ATPase: regulation of signaling pathways
- (2018) Sahithi Pamarthy et al. Molecular Cancer
- RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model
- (2018) Anna Mizutani et al. CANCER SCIENCE
- Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin
- (2018) Youn-Sang Jung et al. NATURE CELL BIOLOGY
- TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling
- (2018) Youn-Sang Jung et al. NATURE CELL BIOLOGY
- The lysosome as a cellular centre for signalling, metabolism and quality control
- (2018) Rosalie E. Lawrence et al. NATURE CELL BIOLOGY
- Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review)
- (2017) Masaru Katoh INTERNATIONAL JOURNAL OF ONCOLOGY
- Adenomatous polyposis coli nucleates actin assembly to drive cell migration and microtubule-induced focal adhesion turnover
- (2017) M. Angeles Juanes et al. JOURNAL OF CELL BIOLOGY
- Cellular context-dependent consequences ofApcmutations on gene regulation and cellular behavior
- (2017) Kyoichi Hashimoto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation
- (2017) Claudio Cantù et al. Science Signaling
- A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation
- (2017) Claudio Cantù et al. Science Signaling
- AZ1366: An Inhibitor of Tankyrase and the Canonical Wnt Pathway that Limits the Persistence of Non–Small Cell Lung Cancer Cells Following EGFR Inhibition
- (2016) Hannah A. Scarborough et al. CLINICAL CANCER RESEARCH
- The position of lysosomes within the cell determines their luminal pH
- (2016) Danielle E. Johnson et al. JOURNAL OF CELL BIOLOGY
- Wnt signaling in cancer
- (2016) T Zhan et al. ONCOGENE
- The Function of V-ATPases in Cancer
- (2016) Laura Stransky et al. PHYSIOLOGICAL REVIEWS
- A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC
- (2016) Michael J. Schell et al. Nature Communications
- The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer
- (2016) Kristina Cotter et al. Oncotarget
- Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling
- (2016) So-Young Hwang et al. Cell Reports
- TCF/LEF Transcription Factors: An Update from the Internet Resources
- (2016) Dusan Hrckulak et al. Cancers
- Expression and role of V1A subunit of V-ATPases in gastric cancer cells
- (2015) Pengfei Liu et al. International Journal of Clinical Oncology
- The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies
- (2015) Ke Yang et al. LABORATORY INVESTIGATION
- Wnt addiction of genetically defined cancers reversed by PORCN inhibition
- (2015) B Madan et al. ONCOGENE
- Eukaryotic V-ATPase: Novel structural findings and functional insights
- (2014) Vladimir Marshansky et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Comprehensive analysis of β-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/β-catenin signaling
- (2014) Andreas Herbst et al. BMC GENOMICS
- AXIN1 and AXIN2 variants in gastrointestinal cancers
- (2014) Serina M. Mazzoni et al. CANCER LETTERS
- Multi-targeted therapy of cancer by niclosamide: A new application for an old drug
- (2014) Yonghe Li et al. CANCER LETTERS
- In vivo analysis of formation and endocytosis of the Wnt/ -Catenin signaling complex in zebrafish embryos
- (2014) A. I. H. Hagemann et al. JOURNAL OF CELL SCIENCE
- Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice
- (2014) L. Tumova et al. MOLECULAR CANCER THERAPEUTICS
- Mitotic Wnt Signaling Promotes Protein Stabilization and Regulates Cell Size
- (2014) Sergio P. Acebron et al. MOLECULAR CELL
- Molecular mechanisms of epithelial–mesenchymal transition
- (2014) Samy Lamouille et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
- (2014) H. Clevers et al. SCIENCE
- Signaling mechanisms of the epithelial-mesenchymal transition
- (2014) D. M. Gonzalez et al. Science Signaling
- Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6
- (2014) Jennifer L Stamos et al. eLife
- A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation-Driven Colorectal Tumor Growth
- (2013) T. Lau et al. CANCER RESEARCH
- The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription
- (2013) C. Cantu et al. DEVELOPMENT
- The Development of Highly Potent Inhibitors for Porcupine
- (2013) Xiaolei Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- PAF and EZH2 Induce Wnt/β-Catenin Signaling Hyperactivation
- (2013) Hae-Yun Jung et al. MOLECULAR CELL
- Correction: Analysis of the Proteinaceous Components of the Organic Matrix of Calcitic Sclerites from the Soft Coral Sinularia sp.
- (2013) M. Azizur Rahman et al. PLoS One
- Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
- (2013) J. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Wnt Stabilization of -Catenin Reveals Principles for Morphogen Receptor-Scaffold Assemblies
- (2013) S.-E. Kim et al. SCIENCE
- Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells
- (2013) Oksana Voloshanenko et al. Nature Communications
- Wnt Signaling Regulates the Lineage Differentiation Potential of Mouse Embryonic Stem Cells through Tcf3 Down-Regulation
- (2013) Yaser Atlasi et al. PLoS Genetics
- Modeling Wnt/β-Catenin Target Gene Expression in APC and Wnt Gradients Under Wild Type and Mutant Conditions
- (2013) Uwe Benary et al. Frontiers in Physiology
- Differential WNT Activity in Colorectal Cancer Confers Limited Tumorigenic Potential and Is Regulated by MAPK Signaling
- (2012) D. Horst et al. CANCER RESEARCH
- Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex
- (2012) Vivian S.W. Li et al. CELL
- The many faces and functions of β-catenin
- (2012) Tomas Valenta et al. EMBO JOURNAL
- Salinomycin as a Drug for Targeting Human Cancer Stem Cells
- (2012) Cord Naujokat et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
- (2012) Huai-Xiang Hao et al. NATURE
- Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
- (2012) Bon-Kyoung Koo et al. NATURE
- Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment
- (2012) S. Morrone et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Frizzled and LRP5/6 Receptors for Wnt/ -Catenin Signaling
- (2012) B. T. MacDonald et al. Cold Spring Harbor Perspectives in Biology
- TCF/LEFs and Wnt Signaling in the Nucleus
- (2012) K. M. Cadigan et al. Cold Spring Harbor Perspectives in Biology
- The -Catenin Destruction Complex
- (2012) J. L. Stamos et al. Cold Spring Harbor Perspectives in Biology
- Secreted-frizzled related protein 1 is a transcriptional repression target of the t(8;21) fusion protein in acute myeloid leukemia
- (2011) C. K. Cheng et al. BLOOD
- Porcupine-mediated lipidation is required for Wnt recognition by Wls
- (2011) Patrick Herr et al. DEVELOPMENTAL BIOLOGY
- The Wnt signaling pathways and cell adhesion
- (2011) Nancy Amin Frontiers in Bioscience-Landmark
- Dysregulation of Wnt/β-Catenin Signaling in Gastrointestinal Cancers
- (2011) Bryan D. White et al. GASTROENTEROLOGY
- CREBBP mutations in relapsed acute lymphoblastic leukaemia
- (2011) Charles G. Mullighan et al. NATURE
- Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells
- (2011) Desheng Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes
- (2010) Vincent F. Taelman et al. CELL
- Regulation of Frizzled-Dependent Planar Polarity Signaling by a V-ATPase Subunit
- (2010) Tobias Hermle et al. CURRENT BIOLOGY
- Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors
- (2010) L. Grumolato et al. GENES & DEVELOPMENT
- Disruption of Lysosome Function Promotes Tumor Growth and Metastasis inDrosophila
- (2010) Congwu Chi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1
- (2010) Kyoko Okada et al. JOURNAL OF CELL BIOLOGY
- Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α
- (2010) Curtis A Thorne et al. Nature Chemical Biology
- Requirement of Prorenin Receptor and Vacuolar H+-ATPase-Mediated Acidification for Wnt Signaling
- (2010) C.-M. Cruciat et al. SCIENCE
- A Two-Step Model for Colon Adenoma Initiation and Progression Caused by APC Loss
- (2009) Reid A. Phelps et al. CELL
- Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
- (2009) Bryan T. MacDonald et al. DEVELOPMENTAL CELL
- Evidence that Fold-Change, and Not Absolute Level, of β-Catenin Dictates Wnt Signaling
- (2009) Lea Goentoro et al. MOLECULAR CELL
- Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
- (2009) Shih-Min A. Huang et al. NATURE
- Identification of targets of the Wnt pathway destruction complex in addition to -catenin
- (2009) N.-G. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Opposing Wnt Pathways Orient Cell Polarity during Organogenesis
- (2008) Jennifer L. Green et al. CELL
- Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of -catenin in mice
- (2008) T. Grigoryan et al. GENES & DEVELOPMENT
- Original CIN: reviewing roles for APC in chromosome instability
- (2008) Nasser M. Rusan et al. JOURNAL OF CELL BIOLOGY
- Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling
- (2008) Shunfu Piao et al. PLoS One
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