Article
Oncology
Jiali Li, Lili Lan, Yuru Xu, Shenghui Liu, Meng Liu, Guobin Hu, Ganxun Wu, Yan Zhao, Jian Shi, Jingtian Wang, Yixin Sun, Zhanlong Wang, Ruili Zhao
Summary: The aim of this study was to evaluate the expression of TNIK and p-TNIK in PTC and compare them with benign thyroid tumors and normal tissues. The results showed that both TNIK and p-TNIK were significantly upregulated in PTC tissues, and p-TNIK was associated with extrathyroidal extension. This suggests that TNIK and p-TNIK may play crucial roles in the carcinogenesis and progression of PTC.
Article
Cell Biology
Lushun Ma, Rui Li, Zhiwei Yao, Bo Wang, Yong Liu, Chunxiang Liu, Heng Wang, Shuxian Chen, Daqing Sun
Summary: This study identified two natural small molecules as potential inhibitors of TNIK through computer-assisted virtual screening and molecular dynamics simulation. These compounds exhibited high affinity and excellent pharmacological properties, providing valuable insights for the development of new colorectal cancer targeting drugs.
Article
Cardiac & Cardiovascular Systems
Bram W. van Os, Pascal J. H. Kusters, Myrthe den Toom, Linda Beckers, Claudia M. van Tiel, Winnie G. Vos, Elize de Jong, Arnd Kieser, Cindy van Roomen, Christoph J. Binder, Myrthe E. Reiche, Menno P. de Winther, Laura A. Bosmans, Esther Lutgens
Summary: This study investigates the role of B cell-specific TNIK deficiency in atherosclerosis. The results show that the lack of B cell TNIK does not affect atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Neurosciences
Ruixue Yuan, Yaojing Li, Yingmei Fu, Ailing Ning, Dongxiang Wang, Ran Zhang, Shunying Yu, Qingqing Xu
Summary: The study indicates that TNIK regulates the effects of antipsychotics on proteins through the Wnt/β-catenin signaling pathway. By modulating the levels of TNIK, the regulation of antipsychotics on Wnt pathway proteins in U251 cells can be affected.
PSYCHOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Toru Hirozane, Mari Masuda, Teppei Sugano, Tetsuya Sekita, Naoko Goto, Toru Aoyama, Takato Sakagami, Yuko Uno, Hideki Moriyama, Masaaki Sawa, Naofumi Asano, Masaya Nakamura, Morio Matsumoto, Robert Nakayama, Tadashi Kondo, Akira Kawai, Eisuke Kobayashi, Tesshi Yamada
Summary: The study demonstrated that TNIK could be a potential therapeutic target in osteosarcoma, as its inhibition suppressed cell proliferation, altered metabolic network direction, and converted cell phenotype. These findings offer a new direction for osteosarcoma treatment.
Article
Chemistry, Medicinal
Yueshan Li, Liting Zhang, Ruicheng Yang, Zeen Qiao, Ming Wu, Chong Huang, Chenyu Tian, Xinling Luo, Wei Yang, Yun Zhang, Linli Li, Shengyong Yang
Summary: This study reports the discovery of a series of new TNIK inhibitors, with compound 21k being the most active one. This compound showed strong activity in inhibiting colorectal cancer cell proliferation and migration, and exhibited significant antitumor activity in animal models, with favorable pharmacokinetic properties. These findings suggest that 21k could be a promising drug candidate targeting TNIK.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Cyrollah Disoma, Yuzheng Zhou, Shanni Li, Jian Peng, Zanxian Xia
Summary: The Wnt/β-catenin signaling pathway plays a crucial role in colorectal carcinogenesis, but no clinically approved therapies targeting this pathway currently exist. New modulators of the pathway are involved not only in cancer initiation but also in chemoresistance, epithelial-mesenchymal transition, and cancer stem cell renewal. CDX2 shows potential as a promising molecular target for colorectal cancer therapeutics, although further studies are needed to determine its significance. Overall, the regulation of the Wnt/β-catenin signaling pathway remains complex and not fully understood, posing a major barrier to the development of targeted chemotherapeutic agents.
Review
Medicine, Research & Experimental
Yong Ji, Jian Lv, Di Sun, Yufeng Huang
Summary: This review explores the significant role of the Wnt/β-catenin signaling pathway in colorectal cancer tumorigenesis, metastasis, and recurrence, as well as its potential value in diagnosis and therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Oncology
Shenglan Liu, Junhong Wu, Xiaolu Lu, Caiyao Guo, Qisheng Zheng, Yu Wang, Qiao Hu, Shuigen Bian, Li Luo, Qilai Cheng, Zhiping Liu, Wei Dai
Summary: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality and has limited effective druggable targets. Targeting cancer stem cells (CSCs) may provide a promising strategy against CRC. Cyclin-dependent kinase 12 (CDK12) is involved in the self-renewal of CSCs and may serve as a potential therapeutic target. In this study, CDK12 was found to be required for CRC survival, and its activation promoted tumor initiation, outgrowth, metastasis, and self-renewal of CRC CSCs through Wnt/beta-catenin signaling. The study suggests that CDK12 is a potential druggable target for CRC treatment.
EXPERIMENTAL CELL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Michal Caspi, Amnon Wittenstein, Michal Kazelnik, Yarden Shor-Nareznoy, Rina Rosin-Arbesfeld
Summary: The Wnt pathway plays a crucial role in regulating embryogenic developmental processes and tissue homeostasis via beta-catenin. Dysregulation of this pathway has been implicated in carcinogenesis, particularly in colorectal cancer. While the Wnt cascade is an attractive target for therapeutic intervention against CRC, its complexity and challenges need to be addressed for effective treatment.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Multidisciplinary Sciences
Katsutoshi Sato, Amol A. Padgaonkar, Stacey J. Baker, Stephen C. Cosenza, Olga Rechkoblit, D. R. C. Venkata Subbaiah, Josep Domingo-Domenech, Alison Bartkowski, Elisa R. Port, Aneel K. Aggarwal, M. V. Ramana Reddy, Hanna Y. Irie, E. Premkumar Reddy
Summary: Finding therapeutic strategies for aggressive triple negative breast cancer (TNBC) is an important challenge in clinical practice. Here, the authors identify a multi-kinase inhibitor with antitumor activity and able overcome chemotherapy resistance of TNBC in vivo.
NATURE COMMUNICATIONS
(2021)
Review
Oncology
Iram Fatima, Susmita Barman, Rajani Rai, Kristina W. Thiel, Vishal Chandra
Summary: The role of Wnt signaling in endometrial carcinoma, including its activation mechanisms and links to cell cycle regulation, hormonal pathways, and other signaling cascades, remains a significant research focus. Therapeutic interference with Wnt signaling poses a challenge, and further advancements in drug discovery are needed.
Review
Biochemistry & Molecular Biology
Antonios N. Gargalionis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou
Summary: STAT3 plays a critical role in the development of colorectal cancer by enhancing tumor cell proliferation and growth through inflammatory mechanisms. However, the mechanisms underlying the role of STAT3 in tumor immunity are not fully understood, and STAT3 inhibitors have not yet been widely used in clinical practice.
Article
Cell Biology
Huangheng Tao, Yixiang Liao, Youji Yan, Zhiwen He, Jiajie Zhou, Xinghuan Wang, Jianping Peng, Shangze Li, Tao Liu
Summary: This study revealed that high expression of BRCC3 in bladder cancer promotes tumorigenesis by targeting the TRAF2 protein, while genetic ablation of BRCC3 significantly blocks proliferation and migration of bladder cancer cells. RNA-Seq analysis shows down-regulation of NF-kappa B signaling in BRCC3-deficient cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hui Zhao, Tianqi Ming, Shun Tang, Shan Ren, Han Yang, Maolun Liu, Qiu Tao, Haibo Xu
Summary: The Wnt signaling pathway is a complex network involved in embryonic development and cancer, as well as normal physiological processes. It plays a crucial role in cell differentiation and the progression of colorectal cancer.