期刊
CANCERS
卷 8, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/cancers8070060
关键词
Wnt signaling; cancer; stem cells; cancer stem cells; cancer stem cell niche; Wnt inhibition; targeted therapy
类别
资金
- Academic Medical Center (Amsterdam)
- European Research Council (ERG-StG) [638193]
- Dutch Cancer Society (KWF) [UVA2014-7245]
- Worldwide Cancer Research [14-1164]
- Dutch Digestive Foundation [MLDS-CDG 14-03]
- Netherlands Organization for Scientific Research (NWO) [Vidi 016.156.308]
- European Research Council (ERC) [638193] Funding Source: European Research Council (ERC)
- Worldwide Cancer Research [14-1164] Funding Source: researchfish
Aberrant regulation of Wnt signaling is a common theme seen across many tumor types. Decades of research have unraveled the epigenetic and genetic alterations that result in elevated Wnt pathway activity. More recently, it has become apparent that Wnt signaling levels identify stem-like tumor cells that are responsible for fueling tumor growth. As therapeutic targeting of these tumor stem cells is an intense area of investigation, a concise understanding on how Wnt activity relates to cancer stem cell traits is needed. This review attempts at summarizing the intricacies between Wnt signaling and cancer stem cell biology with a special emphasis on colorectal cancer.
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